DE731086C - Process for the preparation of durable solutions of calcium gluconate or lactate - Google Patents
Process for the preparation of durable solutions of calcium gluconate or lactateInfo
- Publication number
- DE731086C DE731086C DEI64233D DEI0064233D DE731086C DE 731086 C DE731086 C DE 731086C DE I64233 D DEI64233 D DE I64233D DE I0064233 D DEI0064233 D DE I0064233D DE 731086 C DE731086 C DE 731086C
- Authority
- DE
- Germany
- Prior art keywords
- calcium
- solutions
- magnesium
- lactate
- gluconate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Description
Verfahren zur Herstellung haltbarer Lösungen von Calciumgluconat oder -lactat Durch das Patent 726 635 wird ein Verfahren zur Herstellung von haltbaren, für Injektionszwecke brauchbaren Lösungen mit einem hohen Calciumgehalt geschützt. Das Verfahren besteht darin, daß man Lösungen von Calcimnsalzen der Gluconsäure oder Milchsäure unter Mitverwendung von Calciumhypophosphit herstellt. Diesen Lösungen kann man einen für medizinische Zwecke erwünschten Gehalt an Magnesium durch Zusatz von Magnesiumhypophosphit geben.Process for making durable solutions of calcium gluconate or -lactate Patent 726 635 describes a process for the production of durable, solutions with a high calcium content suitable for injection purposes. The method consists in making solutions of the calcium salts of gluconic acid or lactic acid using calcium hypophosphite. These solutions you can add a magnesium content that is desirable for medical purposes of magnesium hypophosphite.
Es wurde gefunden, daß die Haltbarkeit der Calciurnsalzlösiingen auch dann aufrechterhalten bleibt, wenn diese das Magnesium nicht nur in Form des Hypophosphits, sondern auch in Form anderer löslicher Magnesiumsalze enthalten. Jedoch müssen solche löslichen Magnesiumsalze vermieden werden, deren Säureion bereits als Calciumsalz vorliegt. Magnesiumgluconat hat somit als Zusatz auszuscheiden, wenn man eine Calciumgluconatlösung herzustellen beabsichtigt; das gleiche gilt für Magnesiulmlactat, wenn man von Calciumlactatlö:sungen ausgeht. Solche Lösungen kristallisieren leicht aus. Diese Regel war nicht ohne weiteres zu vermuten, da sie für die unterphosphorige Säure als Säureion nach den Angaben des Patents 726 635 nicht zutriftt. It has been found that the shelf life of the calcium salt solutions is maintained even if this is not just the magnesium in the form of the Hypophosphite, but also in the form of other soluble magnesium salts. However, such soluble magnesium salts must be avoided, their acid ion already is present as a calcium salt. Magnesium gluconate has to be excreted as an additive, if one intends to prepare a calcium gluconate solution; the same goes for for magnesium lactate, assuming calcium lactate solutions. Such solutions easily crystallize. This rule was not to be suspected without further ado they for hypophosphorous acid as acid ion according to the information in patent 726 635 does not drift.
Der Zusatz anderer Magnesiumsalze als Magnesiumhypophosphit hat unter anderem den Vorteil, in der Menge der eingebrachten unterphosphorigen Säure nicht von derjenigen des eingeführten Magnesiums abhängig zu sein, was für therapeutische Zwecke von Bedeutung ist. The addition of magnesium salts other than magnesium hypophosphite has under among other things, the advantage is not in the amount of hypophosphorous acid introduced depends on that of the imported magnesium to be what is of importance for therapeutic purposes.
Claims (1)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DEI64233D DE731086C (en) | 1939-03-30 | 1939-03-30 | Process for the preparation of durable solutions of calcium gluconate or lactate |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DEI64233D DE731086C (en) | 1939-03-30 | 1939-03-30 | Process for the preparation of durable solutions of calcium gluconate or lactate |
Publications (1)
Publication Number | Publication Date |
---|---|
DE731086C true DE731086C (en) | 1943-02-08 |
Family
ID=7196083
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DEI64233D Expired DE731086C (en) | 1939-03-30 | 1939-03-30 | Process for the preparation of durable solutions of calcium gluconate or lactate |
Country Status (1)
Country | Link |
---|---|
DE (1) | DE731086C (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1012031B (en) * | 1955-12-23 | 1957-07-11 | Merck Ag E | Process for stabilizing solutions of ascorbic acid and calcium salts, preferably calcium gluconate |
DE1030515B (en) * | 1954-11-29 | 1958-05-22 | Alpine Chemische A G | Process for the production of stable injectable solutions of an easily water-soluble magnesium double salt of ascorbic acid and salicylic acid |
-
1939
- 1939-03-30 DE DEI64233D patent/DE731086C/en not_active Expired
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1030515B (en) * | 1954-11-29 | 1958-05-22 | Alpine Chemische A G | Process for the production of stable injectable solutions of an easily water-soluble magnesium double salt of ascorbic acid and salicylic acid |
DE1012031B (en) * | 1955-12-23 | 1957-07-11 | Merck Ag E | Process for stabilizing solutions of ascorbic acid and calcium salts, preferably calcium gluconate |
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