DE69938256D1 - - Google Patents
Info
- Publication number
- DE69938256D1 DE69938256D1 DE69938256T DE69938256T DE69938256D1 DE 69938256 D1 DE69938256 D1 DE 69938256D1 DE 69938256 T DE69938256 T DE 69938256T DE 69938256 T DE69938256 T DE 69938256T DE 69938256 D1 DE69938256 D1 DE 69938256D1
- Authority
- DE
- Germany
- Prior art keywords
- phosphodiesterase
- useful
- illnesses
- glaucoma
- thrombosis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/16—Central respiratory analeptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/317—Chemical structure of the backbone with an inverted bond, e.g. a cap structure
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/321—2'-O-R Modification
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Virology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Pulmonology (AREA)
- Neurosurgery (AREA)
- Immunology (AREA)
- Neurology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Dermatology (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Urology & Nephrology (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Cardiology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US22358698A | 1998-12-30 | 1998-12-30 | |
US36462699A | 1999-07-29 | 1999-07-29 | |
PCT/US1999/029976 WO2000040714A2 (en) | 1998-12-30 | 1999-12-15 | Therapeutic phosphodiesterase inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
DE69938256D1 true DE69938256D1 (de) | 2008-04-10 |
Family
ID=26917934
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69938256T Expired - Lifetime DE69938256D1 (de) | 1998-12-30 | 1999-12-15 |
Country Status (8)
Country | Link |
---|---|
US (1) | US20030045490A1 (de) |
EP (1) | EP1141278B1 (de) |
JP (1) | JP4787409B2 (de) |
AT (1) | ATE387498T1 (de) |
AU (1) | AU781577B2 (de) |
CA (1) | CA2357950C (de) |
DE (1) | DE69938256D1 (de) |
WO (1) | WO2000040714A2 (de) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7833529B1 (en) | 1999-01-07 | 2010-11-16 | Zymogenetics, Inc. | Methods for inhibiting B lymphocyte proliferation with soluble ztnf4 receptor |
US20030054531A1 (en) * | 2001-03-19 | 2003-03-20 | Decode Genetics Ehf, | Human stroke gene |
EP2351765A3 (de) | 2001-07-10 | 2012-02-22 | Lakewood-Amedex, Inc | Oligonukleotidhaltige pharmakologische zusammensetzungen und deren verwendung |
CA2492032A1 (en) * | 2001-07-15 | 2003-08-14 | Keck Graduate Institute | Gene expression analysis using nicking agents |
FR2828693B1 (fr) * | 2001-08-14 | 2004-06-18 | Exonhit Therapeutics Sa | Nouvelle cible moleculaire de la neurotoxicite |
JP2006500068A (ja) * | 2002-09-25 | 2006-01-05 | デコード ジェネティクス イーエッチエフ. | ヒト脳卒中の罹患性遺伝子;治療法 |
WO2004042076A2 (en) * | 2002-11-08 | 2004-05-21 | Bayer Healthcare Ag | Diagnostics and therapeutics for diseases associated with human phosphodiesterase 4a (pde4a) |
AU2003301894A1 (en) * | 2002-11-08 | 2004-06-07 | Bayer Healthcare Ag | Diagnostics and therapeutics for diseases associated with human phosphodiesterase 4d (pde4d) |
AU2004275903B2 (en) | 2003-09-29 | 2012-04-12 | Topigen Pharmaceutique Inc. | Oligonucleotide compositions and methods for treating disease including inflammatory conditions |
AR059945A1 (es) * | 2005-08-09 | 2008-05-14 | Zymogenetics Inc | Metodos para tratar afecciones malignas de celulas b que utilizan una molecula de fusion taci-ig |
JP5118037B2 (ja) * | 2005-08-09 | 2013-01-16 | ザイモジェネティクス, インコーポレイテッド | Taci融合分子を用いた異常細胞増殖の処置及び予防のための方法 |
CA2625153A1 (en) | 2005-10-21 | 2007-04-26 | Braincells, Inc. | Modulation of neurogenesis by pde inhibition |
US8673873B1 (en) * | 2005-12-28 | 2014-03-18 | Alcon Research, Ltd. | RNAi-mediated inhibition of phosphodiesterase type 4 for treatment of cAMP-related ocular disorders |
UA98462C2 (ru) | 2006-05-15 | 2012-05-25 | Арес Трейдинг С.А. | Способы лечения аутоиммунных заболеваний с использованием слитой молекулы taci-ig |
WO2007134451A1 (en) | 2006-05-19 | 2007-11-29 | Topigen Pharmaceuticals Inc. | Oligonucleotides affecting expression of phosphodiesterases |
WO2008137751A2 (en) * | 2007-05-02 | 2008-11-13 | Sirna Therapeutics, Inc. | Rna interference mediated inhibition of cyclic nucleotide type 4 phosphodiesterase (pde4b) gene expression using short interfering nucleic acid (sina) |
EP2152877A2 (de) * | 2007-05-02 | 2010-02-17 | Sirna Therapeutics Inc. | Rna-interferenz-vermittelte hemmung der genexpression von cyclisches-nukleotid-phosphodiesterase typ 4 ( pde4b) unter verwendung von sina (short interfering nucleic acid) |
US20090137506A1 (en) * | 2007-05-02 | 2009-05-28 | Sirna Therapeutics, Inc. | RNA Interference Mediated Inhibition of Cyclic Nucleotide Type 4 Phosphodiesterase (PDE4B) Gene Expression Using Short Interfering Nucleic Acid (siNA) |
WO2008137775A2 (en) * | 2007-05-02 | 2008-11-13 | Sirna Therapeutics, Inc. | RNA INTERFERENCE MEDIATED INHIBITION OF CYCLIC NUCLEOTIDE TYPE 4 PHOSPHODIESTERASE (PDE4B) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) |
US8244352B2 (en) * | 2008-06-19 | 2012-08-14 | Cardiac Pacemakers, Inc. | Pacing catheter releasing conductive liquid |
EP3880256A4 (de) * | 2018-11-14 | 2022-08-03 | The Board of Trustees of the Leland Stanford Junior University | Targeting von makapp-pde4d3-komplexen bei neurodegenerativen erkrankungen |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2089376C (en) * | 1990-08-13 | 2010-05-04 | Phillip Dan Cook | Sugar modified oligonucleotides that detect and modulate gene expression |
IL108206A0 (en) * | 1993-01-06 | 1994-04-12 | Univ Johns Hopkins | Oligomers having improved stability at acid ph |
US5510239A (en) * | 1993-10-18 | 1996-04-23 | Isis Pharmaceuticals, Inc. | Oligonucleotide modulation of multidrug resistance-associated protein |
WO1996020281A1 (en) * | 1994-12-23 | 1996-07-04 | Celltech Therapeutics Limited | Human phosphodiesterase type ivc, and its production and use |
CN1163493C (zh) * | 1995-05-19 | 2004-08-25 | 协和发酵工业株式会社 | 含氧杂环化合物 |
US5849902A (en) * | 1996-09-26 | 1998-12-15 | Oligos Etc. Inc. | Three component chimeric antisense oligonucleotides |
JP4688294B2 (ja) * | 1998-12-30 | 2011-05-25 | オリゴス・イーティーシー・インコーポレイテッド | 酸安定性骨格で修飾された末端がブロックされた核酸及びその治療的使用 |
-
1999
- 1999-12-15 AT AT99968130T patent/ATE387498T1/de not_active IP Right Cessation
- 1999-12-15 AU AU24808/00A patent/AU781577B2/en not_active Ceased
- 1999-12-15 EP EP99968130A patent/EP1141278B1/de not_active Expired - Lifetime
- 1999-12-15 WO PCT/US1999/029976 patent/WO2000040714A2/en active IP Right Grant
- 1999-12-15 CA CA2357950A patent/CA2357950C/en not_active Expired - Fee Related
- 1999-12-15 DE DE69938256T patent/DE69938256D1/de not_active Expired - Lifetime
- 1999-12-15 JP JP2000592411A patent/JP4787409B2/ja not_active Expired - Fee Related
-
2002
- 2002-02-19 US US10/076,597 patent/US20030045490A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
AU781577B2 (en) | 2005-06-02 |
EP1141278B1 (de) | 2008-02-27 |
ATE387498T1 (de) | 2008-03-15 |
EP1141278A2 (de) | 2001-10-10 |
US20030045490A1 (en) | 2003-03-06 |
JP4787409B2 (ja) | 2011-10-05 |
WO2000040714A3 (en) | 2000-11-02 |
CA2357950A1 (en) | 2000-07-13 |
CA2357950C (en) | 2013-07-23 |
WO2000040714A2 (en) | 2000-07-13 |
JP2002534086A (ja) | 2002-10-15 |
AU2480800A (en) | 2000-07-24 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE69938256D1 (de) | ||
MXPA04000179A (es) | Oligonucleotidos sinteticos de hebra doble para inhibicion especifica de expresion de gene. | |
HK1129103A1 (en) | Prodrugs of gaba analogs, compositions and uses thereof gaba | |
TNSN04082A1 (en) | N,n'-substituted-1,3-diamino-2-hydroxypropane derivatives | |
PT1446387E (pt) | Derivados de aril-1,4-pirazina substituídos | |
MY130489A (en) | Substituted aryl 1, 4-pyrazine derivatives | |
WO2004014881A3 (en) | '1,2,4'oxadiazoles as modulators of metabotropic glutamate receptor-5 | |
WO2003013437A3 (en) | Compositions and methods for the prevention and treatment of huntington's disease | |
WO2004014953A3 (en) | Anti-myelin associated glycoprotein (mag) antibodies | |
WO2003057670A3 (en) | Indoles as naaladase inhibitors | |
NO20043085L (no) | Fremgangsmater og sammensetninger for behandling av forstyrrelser i sentralnervesystemet | |
WO2003072593A3 (en) | Bone targeting peptides | |
WO2005014814A3 (en) | 5’-and 3’-capped aptamers and uses therefor | |
CA2474511A1 (en) | Benzofuran and benzothiophene derivatives useful in the treatment of hyper-proliferative disorders | |
WO2002081745A3 (en) | Genes involved in osteogenesis, and methods of use | |
WO2002004677A8 (en) | Methods for diagnosis and treatment of psychiatric disorders | |
WO2003089622A3 (en) | Novel genes, compositions, and methods for modulating the unfolded protein response | |
SE9503117L (sv) | Ny användning av padlockprober | |
HUP0100044A1 (hu) | A humán Ha-ras gén egy szakaszával komplementer, módosított antiszensz oligonukleotidok | |
MXPA03010728A (es) | Moleculas de proteina-2 relacionadas con b7 y uso de las mismas. | |
WO2002057418A3 (en) | Methods of producing polyketide synthase mutants and compositions and uses thereof | |
WO2005039480A3 (en) | AChE ANTISENSE DEOXYOLIGONUCLEOTIDE AS AN ANTI-INFLAMMATORY AGENT | |
IL147953A0 (en) | Derivatives and pharmaceutical compositions of n-hydroxymethyl tetramethylcyclopropyl-carboxamide, having anti-epileptic, neurological, and cns activity, and method for their preparation | |
WO2002049663A3 (en) | Compositions and methods for manipulating glial progenitor cells and treating neurological deficits | |
WO2002033058A3 (en) | Novel cysteine proteases and uses thereof |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8332 | No legal effect for de |