DE69933856D1 - Verwendung von ribozymen zur bestimmung der funktion von genen - Google Patents
Verwendung von ribozymen zur bestimmung der funktion von genenInfo
- Publication number
- DE69933856D1 DE69933856D1 DE69933856T DE69933856T DE69933856D1 DE 69933856 D1 DE69933856 D1 DE 69933856D1 DE 69933856 T DE69933856 T DE 69933856T DE 69933856 T DE69933856 T DE 69933856T DE 69933856 D1 DE69933856 D1 DE 69933856D1
- Authority
- DE
- Germany
- Prior art keywords
- nucleic acid
- target nucleic
- phenotype
- expression
- function
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
- C12N2310/111—Antisense spanning the whole gene, or a large part of it
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/12—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes
- C12N2310/121—Hammerhead
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
- C12N2799/027—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a retrovirus
Landscapes
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Saccharide Compounds (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2399298A | 1998-02-13 | 1998-02-13 | |
PCT/US1999/003166 WO1999041371A1 (en) | 1998-02-13 | 1999-02-12 | Use of ribozymes for functionating genes |
Publications (1)
Publication Number | Publication Date |
---|---|
DE69933856D1 true DE69933856D1 (de) | 2006-12-14 |
Family
ID=21818282
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69933856T Expired - Lifetime DE69933856D1 (de) | 1998-02-13 | 1999-02-12 | Verwendung von ribozymen zur bestimmung der funktion von genen |
Country Status (7)
Country | Link |
---|---|
US (2) | US6803194B1 (de) |
EP (1) | EP1053317B1 (de) |
AT (1) | ATE344322T1 (de) |
AU (1) | AU2678999A (de) |
CA (1) | CA2319112C (de) |
DE (1) | DE69933856D1 (de) |
WO (1) | WO1999041371A1 (de) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9824544D0 (en) | 1998-11-09 | 1999-01-06 | Medical Res Council | Screening system |
EP0781331B1 (de) | 1994-08-20 | 2008-09-03 | Gendaq Limited | Verbesserung in bezug auf bindungsproteine bei der erkennung von dna |
GB9710809D0 (en) | 1997-05-23 | 1997-07-23 | Medical Res Council | Nucleic acid binding proteins |
US6410248B1 (en) | 1998-01-30 | 2002-06-25 | Massachusetts Institute Of Technology | General strategy for selecting high-affinity zinc finger proteins for diverse DNA target sites |
AU746454B2 (en) | 1998-03-02 | 2002-05-02 | Massachusetts Institute Of Technology | Poly zinc finger proteins with improved linkers |
US6977154B1 (en) | 1998-03-17 | 2005-12-20 | Gendaq Limited | Nucleic acid binding proteins |
US7070934B2 (en) | 1999-01-12 | 2006-07-04 | Sangamo Biosciences, Inc. | Ligand-controlled regulation of endogenous gene expression |
US6599692B1 (en) | 1999-09-14 | 2003-07-29 | Sangamo Bioscience, Inc. | Functional genomics using zinc finger proteins |
US7013219B2 (en) | 1999-01-12 | 2006-03-14 | Sangamo Biosciences, Inc. | Regulation of endogenous gene expression in cells using zinc finger proteins |
US6534261B1 (en) | 1999-01-12 | 2003-03-18 | Sangamo Biosciences, Inc. | Regulation of endogenous gene expression in cells using zinc finger proteins |
US6453242B1 (en) | 1999-01-12 | 2002-09-17 | Sangamo Biosciences, Inc. | Selection of sites for targeting by zinc finger proteins and methods of designing zinc finger proteins to bind to preselected sites |
US20030104526A1 (en) | 1999-03-24 | 2003-06-05 | Qiang Liu | Position dependent recognition of GNN nucleotide triplets by zinc fingers |
US6794136B1 (en) | 2000-11-20 | 2004-09-21 | Sangamo Biosciences, Inc. | Iterative optimization in the design of binding proteins |
US7030215B2 (en) | 1999-03-24 | 2006-04-18 | Sangamo Biosciences, Inc. | Position dependent recognition of GNN nucleotide triplets by zinc fingers |
AU776576B2 (en) * | 1999-12-06 | 2004-09-16 | Sangamo Biosciences, Inc. | Methods of using randomized libraries of zinc finger proteins for the identification of gene function |
AU2693501A (en) | 2000-01-24 | 2001-07-31 | Gendaq Ltd | Nucleic acid binding polypeptides characterized by flexible linkers connected nucleic acid binding modules |
US7067317B2 (en) | 2000-12-07 | 2006-06-27 | Sangamo Biosciences, Inc. | Regulation of angiogenesis with zinc finger proteins |
WO2002046412A2 (en) | 2000-12-07 | 2002-06-13 | Sangamo Biosciences, Inc. | Regulation of angiogenesis with zinc finger proteins |
WO2002057294A2 (en) | 2001-01-22 | 2002-07-25 | Sangamo Biosciences, Inc. | Zinc finger proteins for dna binding and gene regulation in plants |
US20040110177A1 (en) * | 2001-02-02 | 2004-06-10 | Axel Ullrich | Method for identifying functional nucleic acids |
US7262054B2 (en) | 2002-01-22 | 2007-08-28 | Sangamo Biosciences, Inc. | Zinc finger proteins for DNA binding and gene regulation in plants |
GB0202543D0 (en) * | 2002-02-04 | 2002-03-20 | Isis Innovation | Model systems |
US7157274B2 (en) * | 2002-06-24 | 2007-01-02 | Cytonome, Inc. | Method and apparatus for sorting particles |
US9943847B2 (en) | 2002-04-17 | 2018-04-17 | Cytonome/St, Llc | Microfluidic system including a bubble valve for regulating fluid flow through a microchannel |
US20070065808A1 (en) * | 2002-04-17 | 2007-03-22 | Cytonome, Inc. | Method and apparatus for sorting particles |
US6976590B2 (en) * | 2002-06-24 | 2005-12-20 | Cytonome, Inc. | Method and apparatus for sorting particles |
US6808075B2 (en) | 2002-04-17 | 2004-10-26 | Cytonome, Inc. | Method and apparatus for sorting particles |
ATE419865T1 (de) * | 2002-08-14 | 2009-01-15 | Silence Therapeutics Ag | Verwendung von protein-kinase-n-beta |
US7361635B2 (en) | 2002-08-29 | 2008-04-22 | Sangamo Biosciences, Inc. | Simultaneous modulation of multiple genes |
WO2004072261A2 (en) * | 2003-02-11 | 2004-08-26 | Immusol Incorporated | Sirna libraries optimized for predetermined protein families |
FR2852021B1 (fr) * | 2003-03-04 | 2007-12-07 | Methodes et outils pour le criblage d'arn actifs in cellulo | |
US7510856B2 (en) * | 2003-03-25 | 2009-03-31 | Hyman Edward D | Method for plasmid preparation by conversion of open circular plasmid to supercoiled plasmid |
US20050084938A1 (en) * | 2003-03-25 | 2005-04-21 | Hyman Edward D. | Method for plasmid preparation by conversion of open circular plasmid to supercoiled plasmid |
US9260693B2 (en) | 2004-12-03 | 2016-02-16 | Cytonome/St, Llc | Actuation of parallel microfluidic arrays |
Family Cites Families (49)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US94324A (en) * | 1869-08-31 | Samuel lawrence | ||
US5504200A (en) | 1983-04-15 | 1996-04-02 | Mycogen Plant Science, Inc. | Plant gene expression |
US5190931A (en) | 1983-10-20 | 1993-03-02 | The Research Foundation Of State University Of New York | Regulation of gene expression by employing translational inhibition of MRNA utilizing interfering complementary MRNA |
US5272065A (en) | 1983-10-20 | 1993-12-21 | Research Foundation Of State University Of New York | Regulation of gene expression by employing translational inhibition of MRNA utilizing interfering complementary MRNA |
GB8626879D0 (en) | 1986-11-11 | 1986-12-10 | Ici Plc | Dna |
US4987071A (en) | 1986-12-03 | 1991-01-22 | University Patents, Inc. | RNA ribozyme polymerases, dephosphorylases, restriction endoribonucleases and methods |
US5116742A (en) | 1986-12-03 | 1992-05-26 | University Patents, Inc. | RNA ribozyme restriction endoribonucleases and methods |
US5037746A (en) | 1986-12-03 | 1991-08-06 | University Patents, Inc. | RNA ribozyme polymerases, and methods |
US5866701A (en) | 1988-09-20 | 1999-02-02 | The Board Of Regents For Northern Illinois University Of Dekalb | HIV targeted hairpin ribozymes |
US5217879A (en) | 1989-01-12 | 1993-06-08 | Washington University | Infectious Sindbis virus vectors |
US5364678A (en) * | 1989-10-17 | 1994-11-15 | Malden Mills Industries, Inc. | Windproof and water resistant composite fabric with barrier layer |
US5670488A (en) | 1992-12-03 | 1997-09-23 | Genzyme Corporation | Adenovirus vector for gene therapy |
US5180818A (en) | 1990-03-21 | 1993-01-19 | The University Of Colorado Foundation, Inc. | Site specific cleavage of single-stranded dna |
JPH06502988A (ja) | 1990-07-26 | 1994-04-07 | ファウンデーション・フォー・リサーチ・アンド・テクノロジー ― ヘラス(エフオー.アール.ティー.エイチ.)インスティテュート・オブ・モレキュラー・バイオロジー・アンド・バイオテクノロジー | ポータブルリボザイムカセット、それを含有するdna配列、これらdna配列によりコードされるリボザイム、およびこれらリボザイムを含有する組成物 |
CZ49693A3 (en) | 1990-09-24 | 1994-02-16 | Gen Hospital Corp | Method for testing of a compound capability to inhibit onco-protein activity |
US5217889A (en) | 1990-10-19 | 1993-06-08 | Roninson Igor B | Methods and applications for efficient genetic suppressor elements |
US5173414A (en) | 1990-10-30 | 1992-12-22 | Applied Immune Sciences, Inc. | Production of recombinant adeno-associated virus vectors |
US5496698A (en) * | 1992-08-26 | 1996-03-05 | Ribozyme Pharmaceuticals, Inc. | Method of isolating ribozyme targets |
EP1195442A3 (de) | 1992-12-04 | 2002-07-31 | Innovir Laboratories, Inc. | Signalverstärkung mittels Ribozyme im Diagnoseverfahren |
EP0694068B1 (de) | 1993-03-09 | 2003-02-12 | The Board Of Trustees Of The University Of Illinois | Mit chemotherapeutische zusammensetzungenassoziierten genetischen suppressor-elementen |
CA2163129A1 (en) | 1993-05-17 | 1994-11-24 | Flossie Wong-Staal | Ribozyme gene therapy for hiv infection and aids |
US6133028A (en) | 1993-05-28 | 2000-10-17 | Transgene S.A. | Defective adenoviruses and corresponding complementation lines |
FR2705686B1 (fr) | 1993-05-28 | 1995-08-18 | Transgene Sa | Nouveaux adénovirus défectifs et lignées de complémentation correspondantes. |
US5834256A (en) | 1993-06-11 | 1998-11-10 | Cell Genesys, Inc. | Method for production of high titer virus and high efficiency retroviral mediated transduction of mammalian cells |
US5589362A (en) | 1993-06-14 | 1996-12-31 | Basf Aktiengesellschaft | Tetracycline regulated transcriptional modulators with altered DNA binding specificities |
US6514745B1 (en) * | 1993-07-19 | 2003-02-04 | The Regents Of The University Of California | Oncoprotein protein kinase |
US5631236A (en) | 1993-08-26 | 1997-05-20 | Baylor College Of Medicine | Gene therapy for solid tumors, using a DNA sequence encoding HSV-Tk or VZV-Tk |
US5667969A (en) | 1993-11-12 | 1997-09-16 | University Research Corporation | Alteration of sequence of a deleterious target molecule by ribozyme catalyzed trans-splicing |
AU1257495A (en) | 1993-11-18 | 1995-06-06 | Chiron Corporation | Compositions and methods for utilizing conditionally lethal genes |
FR2712603B1 (fr) | 1993-11-18 | 1996-02-09 | Centre Nat Rech Scient | Virus recombinants, préparation et utilisation en thérapie génique. |
FR2712602B1 (fr) | 1993-11-18 | 1996-02-09 | Centre Nat Rech Scient | Virus recombinants, préparation et utilisation en thérapie génique. |
US6130092A (en) | 1994-07-04 | 2000-10-10 | Max-Planck Gesellschaft Zur Forderung Der Wissenschaften E.V. | Ribozyme gene library and method for making |
DE4424762C1 (de) * | 1994-07-04 | 1995-07-27 | Max Planck Gesellschaft | Ribozym-Bibliothek, ihre Herstellung und ihre Verwendung |
DE69531387T2 (de) | 1994-08-16 | 2004-04-22 | Crucell Holland B.V. | Von Adenovirus abgeleitete rekombinante Vektoren, für Gentherapie |
FR2723697B1 (fr) | 1994-08-17 | 1996-09-20 | Rhone Poulenc Rorer Sa | Methode de traitement de la restenose par la therapie genique |
US5599706A (en) | 1994-09-23 | 1997-02-04 | Stinchcomb; Dan T. | Ribozymes targeted to apo(a) mRNA |
JPH11505724A (ja) | 1995-06-02 | 1999-05-25 | エム・アンド・イー・バイオテク・エー/エス | 生物活性ペプチド及び核酸の同定方法 |
KR100449181B1 (ko) | 1995-06-15 | 2005-01-24 | 크루셀 홀란드 비.브이. | 유전자요법에사용할수있는사람의재조합아데노바이러스패키징시스템 |
US5679523A (en) | 1995-11-16 | 1997-10-21 | The Board Of Trustees Of The Leland Stanford Junior University | Method for concurrent disruption of expression of multiple alleles of mammalian genes |
AU1707497A (en) | 1996-01-23 | 1997-08-20 | Rigel Pharmaceuticals, Inc. | Methods for screening for transdominant intracellular effector peptides and rna molecules |
US6255071B1 (en) | 1996-09-20 | 2001-07-03 | Cold Spring Harbor Laboratory | Mammalian viral vectors and their uses |
US6025192A (en) | 1996-09-20 | 2000-02-15 | Cold Spring Harbor Laboratory | Modified retroviral vectors |
GB2319773B (en) | 1996-11-30 | 2000-08-23 | Aea Technology Plc | Antisense vector |
US6605429B1 (en) * | 1997-01-23 | 2003-08-12 | Immusol, Incorporated | Gene functional analysis and discovery using randomized or target-specific ribozyme gene vector libraries |
JP2001525667A (ja) | 1997-05-09 | 2001-12-11 | リボザイム・ファーマシューティカルズ・インコーポレーテッド | C−rafの発現レベルに関係した疾患または状態の酵素核酸処置 |
US6183959B1 (en) * | 1997-07-03 | 2001-02-06 | Ribozyme Pharmaceuticals, Inc. | Method for target site selection and discovery |
US6391311B1 (en) | 1998-03-17 | 2002-05-21 | Genentech, Inc. | Polypeptides having homology to vascular endothelial cell growth factor and bone morphogenetic protein 1 |
DK2016951T3 (da) | 1998-03-17 | 2012-09-24 | Genentech Inc | VEGF- og BMP1-homologe polypeptider |
WO2002048403A2 (en) | 2000-12-11 | 2002-06-20 | Hk Pharmaceuticals, Inc. | Multiplexed protein expression and activity assay |
-
1999
- 1999-02-12 CA CA002319112A patent/CA2319112C/en not_active Expired - Fee Related
- 1999-02-12 AT AT99907019T patent/ATE344322T1/de not_active IP Right Cessation
- 1999-02-12 AU AU26789/99A patent/AU2678999A/en not_active Abandoned
- 1999-02-12 DE DE69933856T patent/DE69933856D1/de not_active Expired - Lifetime
- 1999-02-12 US US09/601,970 patent/US6803194B1/en not_active Expired - Fee Related
- 1999-02-12 EP EP99907019A patent/EP1053317B1/de not_active Expired - Lifetime
- 1999-02-12 WO PCT/US1999/003166 patent/WO1999041371A1/en active IP Right Grant
-
2002
- 2002-09-16 US US10/244,715 patent/US20030087288A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CA2319112A1 (en) | 1999-08-19 |
CA2319112C (en) | 2003-10-28 |
EP1053317A1 (de) | 2000-11-22 |
AU2678999A (en) | 1999-08-30 |
ATE344322T1 (de) | 2006-11-15 |
WO1999041371A1 (en) | 1999-08-19 |
US6803194B1 (en) | 2004-10-12 |
US20030087288A1 (en) | 2003-05-08 |
EP1053317B1 (de) | 2006-11-02 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8332 | No legal effect for de |