DE69927943D1 - Verfahren zur herstellung von cefpodoxim-proxetil diastereoisomeren - Google Patents

Verfahren zur herstellung von cefpodoxim-proxetil diastereoisomeren

Info

Publication number
DE69927943D1
DE69927943D1 DE69927943T DE69927943T DE69927943D1 DE 69927943 D1 DE69927943 D1 DE 69927943D1 DE 69927943 T DE69927943 T DE 69927943T DE 69927943 T DE69927943 T DE 69927943T DE 69927943 D1 DE69927943 D1 DE 69927943D1
Authority
DE
Germany
Prior art keywords
proxetiled
cefpodoxim
diastereoisomers
production
proxetiled diastereoisomers
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69927943T
Other languages
English (en)
Other versions
DE69927943T2 (de
Inventor
Julia Greil
Johannes Ludescher
Klaus Totschnig
Siegfried Wolf
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of DE69927943D1 publication Critical patent/DE69927943D1/de
Application granted granted Critical
Publication of DE69927943T2 publication Critical patent/DE69927943T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
    • C07D501/34—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
DE69927943T 1998-01-09 1999-01-07 Verfahren zur herstellung von cefpodoxim-proxetil diastereoisomeren Expired - Fee Related DE69927943T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AT0002198A AT413383B (de) 1998-01-09 1998-01-09 Verfahren zur isolierung eines diastereoisomerengemisches von cefpodoxim proxetil
AT2198 1998-01-09
PCT/EP1999/000057 WO1999035149A1 (en) 1998-01-09 1999-01-07 Process for the preparation of cefpodoxime proxetil diastereoisomers

Publications (2)

Publication Number Publication Date
DE69927943D1 true DE69927943D1 (de) 2005-12-01
DE69927943T2 DE69927943T2 (de) 2006-07-27

Family

ID=3479444

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69927943T Expired - Fee Related DE69927943T2 (de) 1998-01-09 1999-01-07 Verfahren zur herstellung von cefpodoxim-proxetil diastereoisomeren

Country Status (10)

Country Link
US (1) US6489470B1 (de)
EP (1) EP1045852B1 (de)
JP (1) JP3911124B2 (de)
KR (1) KR100407584B1 (de)
CN (1) CN1142938C (de)
AT (2) AT413383B (de)
AU (1) AU2615999A (de)
DE (1) DE69927943T2 (de)
ES (1) ES2251826T3 (de)
WO (1) WO1999035149A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT408226B (de) 1999-05-05 2001-09-25 Biochemie Gmbh Kristalliner 7-(2-(2-formylaminothiazol-4-yl)-2
IN191496B (de) * 1999-07-30 2003-12-06 Ranbaxy Lab Ltd
EP1373276A4 (de) 2001-02-27 2005-03-02 Ranbaxy Lab Ltd Verfahren zur herstellung von cefpodoxim-proxetil
US20060009639A1 (en) * 2002-11-22 2006-01-12 Orchid Chemicals & Pharmaceuticals Limited Process for the preparation of cefpodoxime proxetil
ES2291547T3 (es) * 2002-12-20 2008-03-01 Lupin Limited Un procedimiento para la preparacion de cefpodoxima proxetil.
WO2004060896A1 (en) * 2003-01-06 2004-07-22 Lupin Limited A process for the manufacture of cefpodoxime proxetil
EP1915139A1 (de) * 2005-05-16 2008-04-30 Elan Pharma International Limited Nanoteilchenförmige und kontrolliert freigesetzte zusammensetzungen mit einem cephalosporin
JP5829952B2 (ja) * 2011-03-08 2015-12-09 株式会社ダイセル フォトレジスト製造用組成物の製造方法
EP2520578A1 (de) 2011-05-06 2012-11-07 Lupin Limited Verfahren zur Reinigung von Cephalosporinen
CN109232609B (zh) * 2018-09-27 2021-07-02 浙江普洛得邦制药有限公司 一种制备高纯度头孢泊肟酯的方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4409215A (en) 1979-11-19 1983-10-11 Fujisawa Pharmaceutical Co., Ltd. 7-Acylamino-3-substituted cephalosporanic acid derivatives and processes for the preparation thereof
EP0076528B1 (de) 1980-02-18 1990-05-23 Roussel-Uclaf Oximderivate von 3-alkyloxy oder 3-alkylthiomethyl-7-amino thiazolylacetamidocephalosporansaure und ihre Herstellung
US4486425A (en) 1980-09-30 1984-12-04 Sankyo Company Limited 7-[2-(2-Aminothiazol-4-yl)-2-(syn)-methoxyiminoacetamido]-3-methoxymethyl-3-cephem-4-carboxylates
JPS5896091A (ja) 1981-12-01 1983-06-07 Sankyo Co Ltd ３−アルコキシメチルセフアロスポリン類の製造法
EP0531875B1 (de) * 1991-09-07 2004-03-24 Aventis Pharma Deutschland GmbH Diastereomer des 3-Cephem-4-carbonsäure-1-(-isopropoxycarbonyloxy)ethylesters und Verfahren zu dessen Herstellung
AT408226B (de) * 1999-05-05 2001-09-25 Biochemie Gmbh Kristalliner 7-(2-(2-formylaminothiazol-4-yl)-2

Also Published As

Publication number Publication date
KR100407584B1 (ko) 2003-12-01
US6489470B1 (en) 2002-12-03
KR20010024823A (ko) 2001-03-26
CN1142938C (zh) 2004-03-24
EP1045852A1 (de) 2000-10-25
AT413383B (de) 2006-02-15
EP1045852B1 (de) 2005-10-26
ATA2198A (de) 2005-07-15
JP2002500226A (ja) 2002-01-08
JP3911124B2 (ja) 2007-05-09
CN1288466A (zh) 2001-03-21
WO1999035149A1 (en) 1999-07-15
AU2615999A (en) 1999-07-26
ATE307817T1 (de) 2005-11-15
DE69927943T2 (de) 2006-07-27
ES2251826T3 (es) 2006-05-01

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee