DE69924369D1 - Synthese von poly(propylenfumarat)durch azetylierung von propylenglykol in anwesenheit eines protonenfängers - Google Patents
Synthese von poly(propylenfumarat)durch azetylierung von propylenglykol in anwesenheit eines protonenfängersInfo
- Publication number
- DE69924369D1 DE69924369D1 DE69924369T DE69924369T DE69924369D1 DE 69924369 D1 DE69924369 D1 DE 69924369D1 DE 69924369 T DE69924369 T DE 69924369T DE 69924369 T DE69924369 T DE 69924369T DE 69924369 D1 DE69924369 D1 DE 69924369D1
- Authority
- DE
- Germany
- Prior art keywords
- fumarate
- propylene
- produced
- propylene glycol
- poly
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
- C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
- C08G63/12—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from polycarboxylic acids and polyhydroxy compounds
- C08G63/52—Polycarboxylic acids or polyhydroxy compounds in which at least one of the two components contains aliphatic unsaturation
- C08G63/56—Polyesters derived from ester-forming derivatives of polycarboxylic acids or of polyhydroxy compounds other than from esters thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/0047—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L24/0073—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material with a macromolecular matrix
- A61L24/0084—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material with a macromolecular matrix containing fillers of phosphorus-containing inorganic compounds, e.g. apatite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/046—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
- C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
- C08G63/12—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from polycarboxylic acids and polyhydroxy compounds
- C08G63/52—Polycarboxylic acids or polyhydroxy compounds in which at least one of the two components contains aliphatic unsaturation
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Surgery (AREA)
- Medicinal Chemistry (AREA)
- Transplantation (AREA)
- Composite Materials (AREA)
- Dermatology (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Materials Engineering (AREA)
- Polyesters Or Polycarbonates (AREA)
- Materials For Medical Uses (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US8140598P | 1998-04-10 | 1998-04-10 | |
US8130898P | 1998-04-10 | 1998-04-10 | |
US8218298P | 1998-04-16 | 1998-04-16 | |
PCT/US1999/007912 WO1999052469A1 (en) | 1998-04-10 | 1999-04-09 | Synthesis of poly(propylene fumarate) by acylation of propylene glycol in the presence of a proton scavenger |
Publications (1)
Publication Number | Publication Date |
---|---|
DE69924369D1 true DE69924369D1 (de) | 2005-04-28 |
Family
ID=27373944
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69924369T Expired - Fee Related DE69924369D1 (de) | 1998-04-10 | 1999-04-09 | Synthese von poly(propylenfumarat)durch azetylierung von propylenglykol in anwesenheit eines protonenfängers |
Country Status (7)
Country | Link |
---|---|
US (2) | US6124373A (de) |
EP (1) | EP1079869B1 (de) |
JP (1) | JP2002539275A (de) |
AT (1) | ATE291444T1 (de) |
CA (1) | CA2327730A1 (de) |
DE (1) | DE69924369D1 (de) |
WO (1) | WO1999052469A1 (de) |
Families Citing this family (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6486232B1 (en) * | 1997-04-18 | 2002-11-26 | Cambridge Scientific, Inc. | Bioerodible polymeric semi-interpenetrating network alloys for internal fixation devices and bone cements |
ATE291444T1 (de) | 1998-04-10 | 2005-04-15 | Univ Wm Marsh Rice | Synthese von poly(propylenfumarat)durch azetylierung von propylenglykol in anwesenheit eines protonenfängers |
KR100696408B1 (ko) * | 1999-04-16 | 2007-03-19 | 더블유엠. 마쉬 라이스 유니버시티 | 폴리(에틸렌글리콜)과 가교결합을 이룬 폴리(프로필렌푸마레이트) |
US6884778B2 (en) * | 2000-04-14 | 2005-04-26 | William Marsh Rice University | Biocompatible macromers |
DE10032220A1 (de) | 2000-07-03 | 2002-01-24 | Sanatis Gmbh | Magnesium-ammonium-phosphat-Zemente, deren Herstellung und Verwendung |
US6849223B2 (en) * | 2001-04-19 | 2005-02-01 | Case Western Reserve University | Fabrication of a polymeric prosthetic implant |
WO2003002490A2 (en) * | 2001-06-28 | 2003-01-09 | Wm. Marsh Rice University | Photocrosslinking of diethyl fumarate/poly(propylene fumarate) biomaterials |
US7629388B2 (en) | 2001-11-20 | 2009-12-08 | William Marsh Rice University | Synthesis and characterization of biodegradable cationic poly(propylene fumarate-co-ethylene glycol) copolymer hydrogels modified with agmatine for enhanced cell adhesion |
EP1499267A4 (de) * | 2002-02-05 | 2008-10-29 | Depuy Mitek Inc | Bioresorbierbare osteokonduktive zusammensetzungen für die knochenregeneration |
US6884432B2 (en) * | 2002-04-25 | 2005-04-26 | Mayo Foundation For Medical Education And Research | Blend, cross-linkable poly(propylene fumarate) for immobilization and controlled drug delivery |
US7273523B2 (en) * | 2002-06-07 | 2007-09-25 | Kyphon Inc. | Strontium-apatite-cement-preparations, cements formed therefrom, and uses thereof |
US20070065652A1 (en) * | 2003-03-13 | 2007-03-22 | Willaim Marsh Rice University | Composite injectable and pre-fabricated bone replacement material and method for the production of such bone replacement material |
WO2004080357A1 (es) | 2003-03-14 | 2004-09-23 | Ferreyro Irigoyen Roque Humber | Dispositivo hidraulico de inyección de cemento oseo en la vertebroplastiá percutánea |
US8066713B2 (en) | 2003-03-31 | 2011-11-29 | Depuy Spine, Inc. | Remotely-activated vertebroplasty injection device |
US8415407B2 (en) | 2004-03-21 | 2013-04-09 | Depuy Spine, Inc. | Methods, materials, and apparatus for treating bone and other tissue |
AU2004255225A1 (en) * | 2003-07-01 | 2005-01-20 | Mayo Foundation For Medical Education And Research | Self-crosslinkable poly(caprolactone fumarate) |
US7252686B2 (en) * | 2003-08-13 | 2007-08-07 | Boston Scientific Scimed | Methods for reducing bone compression fractures using wedges |
WO2005030034A2 (en) | 2003-09-26 | 2005-04-07 | Depuy Spine, Inc. | Device for delivering viscous material |
US20060018949A1 (en) * | 2004-04-07 | 2006-01-26 | Bausch & Lomb Incorporated | Injectable biodegradable drug delivery system |
MXPA06012420A (es) | 2004-04-27 | 2007-03-28 | Kyphon Inc | Composiciones de sustitucion del hueso y metodos de uso de las mismas. |
EP1786343B1 (de) | 2004-07-30 | 2012-05-02 | Depuy Spine, Inc. | Gerät zur behandlung von knochen und anderem gewebe |
AU2005304567B2 (en) * | 2004-11-12 | 2011-10-27 | Mayo Foundation For Medical Education And Research | Photocrosslinkable poly(caprolactone fumarate) |
WO2006055940A2 (en) * | 2004-11-18 | 2006-05-26 | Mayo Foundation For Medical Education And Research | Block copolymers of polycaprolactone and poly (propylene fumarate) |
US8912247B2 (en) * | 2005-04-29 | 2014-12-16 | Mayo Foundation For Medical Education And Research | Hydrophilic/hydrophobic polymer networks based on poly(caprolactone fumarate), poly(ethylene glycol fumarate), and copolymers thereof |
US9381024B2 (en) | 2005-07-31 | 2016-07-05 | DePuy Synthes Products, Inc. | Marked tools |
US9918767B2 (en) | 2005-08-01 | 2018-03-20 | DePuy Synthes Products, Inc. | Temperature control system |
US7651701B2 (en) * | 2005-08-29 | 2010-01-26 | Sanatis Gmbh | Bone cement composition and method of making the same |
US8360629B2 (en) | 2005-11-22 | 2013-01-29 | Depuy Spine, Inc. | Mixing apparatus having central and planetary mixing elements |
US7754005B2 (en) * | 2006-05-02 | 2010-07-13 | Kyphon Sarl | Bone cement compositions comprising an indicator agent and related methods thereof |
US7507286B2 (en) * | 2006-06-08 | 2009-03-24 | Sanatis Gmbh | Self-foaming cement for void filling and/or delivery systems |
ES2547854T3 (es) * | 2006-06-29 | 2015-10-09 | Depuy Spine, Inc. | Biopsia de hueso integrada y aparato de terapia |
EP2068898A4 (de) | 2006-09-14 | 2011-07-20 | Depuy Spine Inc | Knochenzement und anwendungsverfahren dafür |
WO2008039382A2 (en) * | 2006-09-21 | 2008-04-03 | Kyphon Sarl | Diammonium phosphate and other ammonium salts and their use in preventing clotting |
ES2587573T3 (es) * | 2006-10-19 | 2016-10-25 | Depuy Spine, Inc. | Sistema de liberación de fluidos y método relacionado |
US20080195223A1 (en) * | 2006-11-03 | 2008-08-14 | Avram Allan Eddin | Materials and Methods and Systems for Delivering Localized Medical Treatments |
PT2022446E (pt) * | 2007-07-30 | 2012-07-04 | Purzer Pharmaceutical Co Ltd | Cimento ósseo biodegradável e método de o manufacturar |
US20090286907A1 (en) * | 2008-01-23 | 2009-11-19 | Beltz Mark W | Fumaric Acid/Diol Polyesters and Their Manufacture and Use |
US7968616B2 (en) * | 2008-04-22 | 2011-06-28 | Kyphon Sarl | Bone cement composition and method |
US20130184835A1 (en) | 2010-07-09 | 2013-07-18 | Board Of Regents Of The Unversity Of Texas System | Biodegradable scaffolds |
JP6027533B2 (ja) | 2010-08-20 | 2016-11-16 | ケース ウェスタン リザーブ ユニバーシティCase Western Reserve University | インプラントの連続デジタル光処理による付加的製造 |
US11865785B2 (en) * | 2010-08-20 | 2024-01-09 | H. David Dean | Continuous digital light processing additive manufacturing of implants |
EP3139962B1 (de) | 2014-05-05 | 2020-12-23 | Advanced Medical Solutions Israel (Sealantis) Ltd | Biologische kleb- und dichtstoffe und verfahren zur verwendung davon |
BR112017010057B1 (pt) * | 2014-11-18 | 2022-11-29 | The Ohio State University | Método para produzir um polímero de polipropileno fumarato para uso em impressão 3d |
WO2018144849A1 (en) | 2017-02-02 | 2018-08-09 | The University Of Akron | Functionalized poly(propylene fumarate) polymers made by ring opening polymerization using magnesium catalysts |
GB2594243A (en) * | 2020-04-15 | 2021-10-27 | Arterius Ltd | A bone cement |
WO2022015989A1 (en) * | 2020-07-15 | 2022-01-20 | The University Of Akron | Synthesis of poly (propylene maleate-co-succinate) by the time-dependent reduction of poly (propylene maleate) double bonds mediated by zinc and acetic acid |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3701748A (en) | 1966-07-20 | 1972-10-31 | Rohm & Haas | Unsaturated polyester resinous compositions |
GB1225803A (de) * | 1967-06-02 | 1971-03-24 | ||
US5286763A (en) * | 1983-03-22 | 1994-02-15 | Massachusetts Institute Of Technology | Bioerodible polymers for drug delivery in bone |
US4722948A (en) * | 1984-03-16 | 1988-02-02 | Dynatech Corporation | Bone replacement and repair putty material from unsaturated polyester resin and vinyl pyrrolidone |
US5989579A (en) | 1986-10-02 | 1999-11-23 | Escalon Medical Corp. | Ocular insert with anchoring protrusions |
US4843112A (en) * | 1987-03-12 | 1989-06-27 | The Beth Israel Hospital Association | Bioerodable implant composition |
US4888413A (en) | 1988-01-11 | 1989-12-19 | Domb Abraham J | Poly(propylene glycol fumarate) compositions for biomedical applications |
AU639645B2 (en) | 1989-10-10 | 1993-07-29 | Wm. Wrigley Jr. Company | Gradual release structures made from fiber spinning techniques |
FR2661682B1 (fr) | 1990-05-04 | 1993-12-10 | Norsolor | Nouvelles compositions resineuses a base de resines polyesters non saturees et de nouveaux additifs anti-retrait. |
KR100266912B1 (ko) | 1992-02-28 | 2000-12-01 | 파라비 레이 | 조직접촉물질이며 방출조절운반체인 광중합성 생분해성 하이드로겔 |
US5733951A (en) * | 1994-04-28 | 1998-03-31 | Yaszemski; Michael J. | Poly(propylene fumarate) |
US5527864A (en) * | 1995-08-08 | 1996-06-18 | Suggs; Laura J. | Poly(propylene fumarate-co-ethylene oxide) |
DE69615811T2 (de) | 1995-12-25 | 2002-04-04 | Sharp Kk | Abbildungssystem |
US5998362A (en) | 1996-09-12 | 1999-12-07 | Merck & Co., Inc. | Conjugates useful in the treatment of prostate cancer |
US6071982A (en) | 1997-04-18 | 2000-06-06 | Cambridge Scientific, Inc. | Bioerodible polymeric semi-interpenetrating network alloys for surgical plates and bone cements, and method for making same |
US5854382A (en) | 1997-08-18 | 1998-12-29 | Meadox Medicals, Inc. | Bioresorbable compositions for implantable prostheses |
ATE291444T1 (de) | 1998-04-10 | 2005-04-15 | Univ Wm Marsh Rice | Synthese von poly(propylenfumarat)durch azetylierung von propylenglykol in anwesenheit eines protonenfängers |
-
1999
- 1999-04-09 AT AT99915349T patent/ATE291444T1/de not_active IP Right Cessation
- 1999-04-09 EP EP99915349A patent/EP1079869B1/de not_active Expired - Lifetime
- 1999-04-09 JP JP2000543082A patent/JP2002539275A/ja active Pending
- 1999-04-09 WO PCT/US1999/007912 patent/WO1999052469A1/en active IP Right Grant
- 1999-04-09 US US09/289,361 patent/US6124373A/en not_active Expired - Lifetime
- 1999-04-09 DE DE69924369T patent/DE69924369D1/de not_active Expired - Fee Related
- 1999-04-09 CA CA002327730A patent/CA2327730A1/en not_active Abandoned
-
2000
- 2000-10-04 US US09/678,816 patent/US6355755B1/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP1079869B1 (de) | 2005-03-23 |
WO1999052469A1 (en) | 1999-10-21 |
JP2002539275A (ja) | 2002-11-19 |
EP1079869A4 (de) | 2002-08-07 |
WO1999052469A9 (en) | 2000-03-23 |
ATE291444T1 (de) | 2005-04-15 |
US6355755B1 (en) | 2002-03-12 |
CA2327730A1 (en) | 1999-10-21 |
EP1079869A1 (de) | 2001-03-07 |
US6124373A (en) | 2000-09-26 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8339 | Ceased/non-payment of the annual fee |