DE69910762D1 - Antipicornavirale verbindungen, deren herstellung und verwendung - Google Patents

Antipicornavirale verbindungen, deren herstellung und verwendung

Info

Publication number
DE69910762D1
DE69910762D1 DE69910762T DE69910762T DE69910762D1 DE 69910762 D1 DE69910762 D1 DE 69910762D1 DE 69910762 T DE69910762 T DE 69910762T DE 69910762 T DE69910762 T DE 69910762T DE 69910762 D1 DE69910762 D1 DE 69910762D1
Authority
DE
Germany
Prior art keywords
production
antipicornaviral compounds
antipicornaviral
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69910762T
Other languages
English (en)
Other versions
DE69910762T2 (de
Inventor
Scott Dragovich
Timothy Marakovits
Jay Prins
Girish Tikhe
Evan Webber
Ru Zhou
O Johnson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Agouron Pharmaceuticals LLC
Original Assignee
Agouron Pharmaceuticals LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agouron Pharmaceuticals LLC filed Critical Agouron Pharmaceuticals LLC
Application granted granted Critical
Publication of DE69910762D1 publication Critical patent/DE69910762D1/de
Publication of DE69910762T2 publication Critical patent/DE69910762T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/18—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyridine Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
DE69910762T 1998-04-30 1999-01-05 Antipicornavirale verbindungen, deren herstellung und verwendung Expired - Fee Related DE69910762T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US8382898P 1998-04-30 1998-04-30
US83828P 1998-04-30
US9835898P 1998-08-28 1998-08-28
US98358P 1998-08-28
PCT/US1999/000260 WO1999057135A1 (en) 1998-04-30 1999-01-05 Antipicornaviral compounds, their preparation and use

Publications (2)

Publication Number Publication Date
DE69910762D1 true DE69910762D1 (de) 2003-10-02
DE69910762T2 DE69910762T2 (de) 2004-03-11

Family

ID=26769788

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69910762T Expired - Fee Related DE69910762T2 (de) 1998-04-30 1999-01-05 Antipicornavirale verbindungen, deren herstellung und verwendung
DE69928140T Expired - Lifetime DE69928140D1 (de) 1998-04-30 1999-01-05 Antipicornavirale Verbindungen, deren Herstellung und Verwendung

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69928140T Expired - Lifetime DE69928140D1 (de) 1998-04-30 1999-01-05 Antipicornavirale Verbindungen, deren Herstellung und Verwendung

Country Status (34)

Country Link
US (3) US6531452B1 (de)
EP (1) EP1073672B1 (de)
JP (1) JP2003526600A (de)
KR (1) KR20010043004A (de)
CN (1) CN1198838C (de)
AP (1) AP2000001934A0 (de)
AT (2) ATE308557T1 (de)
AU (1) AU768539B2 (de)
BG (1) BG104899A (de)
BR (1) BR9910573A (de)
CA (1) CA2326763A1 (de)
DE (2) DE69910762T2 (de)
DK (1) DK1073672T3 (de)
EA (1) EA003856B1 (de)
EE (1) EE200000621A (de)
ES (1) ES2205760T3 (de)
GE (1) GEP20022824B (de)
HK (1) HK1034722A1 (de)
HR (1) HRP20000623A2 (de)
HU (1) HUP0400624A2 (de)
IL (1) IL138609A0 (de)
IS (1) IS5633A (de)
LT (1) LT4846B (de)
LV (1) LV12666B (de)
NO (1) NO20005411L (de)
NZ (1) NZ507633A (de)
OA (1) OA11503A (de)
PL (1) PL351250A1 (de)
PT (1) PT1073672E (de)
SI (1) SI20428A (de)
SK (1) SK284714B6 (de)
TR (1) TR200003159T2 (de)
WO (1) WO1999057135A1 (de)
YU (1) YU66000A (de)

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PL351250A1 (en) 1998-04-30 2003-04-07 Agouron Pharma Antipicornaviral compounds, their preparation and use
US6355807B1 (en) 1999-08-24 2002-03-12 Agouron Pharmaceuticals, Inc. Efficient synthetic routes for the preparation of rhinovirus protease inhibitors and key intermediates
US6774243B2 (en) 1999-08-24 2004-08-10 Agouron Pharmaceuticals, Inc. Efficient synthetic routes for the preparation of rhinovirus protease inhibitors and key intermediates
PE20010517A1 (es) * 1999-08-24 2001-05-16 Agouron Pharma Las rutas sinteticas eficientes para la preparacion de los inhibidores de la proteasa del rinovirus y los intermedios claves
PA8507801A1 (es) * 1999-12-03 2002-08-26 Agouron Pharma Compuestos y composiciones antipicornavirales, sus usos farmaceuticos y los materiales para su sintesis
PE20011277A1 (es) 2000-04-14 2002-01-07 Agouron Pharma Compuestos y composiciones antipicornavirales, sus usos farmaceuticos y los materiales para su sintesis
MXPA02012456A (es) 2000-06-14 2004-01-26 Agouron Pharma Compuestos y composiciones antipicornavirales, sus usos farmaceuticos y materiales para su sintesis.
WO2004093860A1 (en) * 2003-04-21 2004-11-04 Pfizer Inc. Inhibitors of sars related coronavirus proteinase
US20040235952A1 (en) * 2003-05-05 2004-11-25 Agouron Pharmaceuticals, Inc. Inhibitors of severe acute respiratory syndrome (SARS) 3C-like proteinase
CN1922137A (zh) * 2003-12-31 2007-02-28 太景生物科技股份有限公司 蛋白酶抑制剂
US7462594B2 (en) 2003-12-31 2008-12-09 Taigen Biotechnology Co., Ltd. Peptide-like compounds that inhibit coronaviral 3CL and flaviviridae viral proteases
CN100363346C (zh) * 2004-10-22 2008-01-23 清华大学 冠状病毒主蛋白酶的小分子抑制剂、制备方法及其应用
US7893657B2 (en) * 2006-12-19 2011-02-22 Anand Kumar Chavakula Multi-power charger and battery backup system
KR100891699B1 (ko) 2007-04-10 2009-04-03 광주과학기술원 7-아미노-4-((ｓ)-3-(4-플루오로페닐)-2-((r)-3-메틸-2-(5-메틸이소옥사졸-3-카복사미도)부탄아미도)프로판아미도)-7-옥소-2-헵테노에이트 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 바이러스성 질환의 예방 및 치료용 약학적 조성물
US7741327B2 (en) 2008-04-16 2010-06-22 Hoffmann-La Roche Inc. Pyrrolidinone glucokinase activators
JP2011524340A (ja) 2008-05-21 2011-09-01 ニュー・ワールド・ラボラトリーズ・インコーポレイテッド 選択的カスパーゼ阻害剤およびその使用
WO2010133000A1 (en) 2009-05-21 2010-11-25 New World Laboratories Inc. Selective caspase inhibitors and uses thereof
US8178689B2 (en) 2010-06-17 2012-05-15 Hoffman-La Roche Inc. Tricyclic compounds
US9944674B2 (en) 2011-04-15 2018-04-17 Genesis Technologies Limited Selective cysteine protease inhibitors and uses thereof
CN102838523A (zh) * 2011-06-23 2012-12-26 南开大学 抗肠病毒71(ev71)戊内酰胺类化合物及其制备方法和用途
CN103145608B (zh) * 2011-12-07 2015-09-02 南开大学 抗肠病毒71(ev71)己内酰胺类化合物及其制备方法和用途
RU2518314C2 (ru) * 2012-08-30 2014-06-10 Общество С Ограниченной Ответственностью "Фарминтерпрайсез" Способ и средство активации irf-3 для лечения и профилактики заболеваний, вызываемых (+) phk-содержащими вирусами
CN110105348A (zh) * 2019-03-08 2019-08-09 南开大学 新型迈克尔受体类肠病毒71型抑制剂的制备及用途
CA3139977A1 (en) 2019-06-05 2020-12-10 Raymond F. Schinazi Peptidomimetics for the treatment of coronavirus and picornavirus infections
CA3174069A1 (en) 2020-03-06 2021-09-10 Pfizer Inc. Methods of inhibiting sars-cov-2 replication and treating coronavirus disease 2019
CN116648240A (zh) * 2021-01-22 2023-08-25 中国人民解放军军事科学院军事医学研究院 一种环肽类病毒蛋白酶抑制剂，其制备方法，及其在抗病毒药物中的应用

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PE20010517A1 (es) 1999-08-24 2001-05-16 Agouron Pharma Las rutas sinteticas eficientes para la preparacion de los inhibidores de la proteasa del rinovirus y los intermedios claves
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PA8507801A1 (es) 1999-12-03 2002-08-26 Agouron Pharma Compuestos y composiciones antipicornavirales, sus usos farmaceuticos y los materiales para su sintesis

Also Published As

Publication number Publication date
KR20010043004A (ko) 2001-05-25
DE69910762T2 (de) 2004-03-11
HUP0400624A2 (hu) 2004-06-28
LT4846B (lt) 2001-10-25
LT2000109A (en) 2001-05-25
EA200001133A1 (ru) 2001-08-27
PT1073672E (pt) 2004-01-30
IL138609A0 (en) 2001-10-31
HRP20000623A2 (en) 2001-04-30
AU2028799A (en) 1999-11-23
NZ507633A (en) 2003-10-31
CN1311793A (zh) 2001-09-05
PL351250A1 (en) 2003-04-07
US6531452B1 (en) 2003-03-11
EP1073672A1 (de) 2001-02-07
GEP20022824B (en) 2002-10-25
CN1198838C (zh) 2005-04-27
EP1073672B1 (de) 2003-08-27
ATE248186T1 (de) 2003-09-15
JP2003526600A (ja) 2003-09-09
SK16042000A3 (sk) 2001-05-10
NO20005411D0 (no) 2000-10-27
US20030130204A1 (en) 2003-07-10
BG104899A (en) 2001-08-31
SI20428A (sl) 2001-06-30
DE69928140D1 (de) 2005-12-08
DK1073672T3 (da) 2003-12-08
LV12666A (en) 2001-05-20
TR200003159T2 (tr) 2001-09-21
LV12666B (lv) 2001-11-20
ATE308557T1 (de) 2005-11-15
SK284714B6 (sk) 2005-09-08
NO20005411L (no) 2000-10-27
OA11503A (en) 2004-05-10
HK1034722A1 (en) 2001-11-02
AP2000001934A0 (en) 2000-12-31
IS5633A (is) 2000-09-22
EA003856B1 (ru) 2003-10-30
AU768539B2 (en) 2003-12-18
ES2205760T3 (es) 2004-05-01
US6995142B2 (en) 2006-02-07
CA2326763A1 (en) 1999-11-11
US20060046966A1 (en) 2006-03-02
BR9910573A (pt) 2001-01-16
WO1999057135A1 (en) 1999-11-11
YU66000A (sh) 2003-12-31
EE200000621A (et) 2002-06-17

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