DE69837387D1 - (d)-METHADON, EIN NICHT-OPIOIDES SCHMERZMITTEL - Google Patents

(d)-METHADON, EIN NICHT-OPIOIDES SCHMERZMITTEL

Info

Publication number
DE69837387D1
DE69837387D1 DE69837387T DE69837387T DE69837387D1 DE 69837387 D1 DE69837387 D1 DE 69837387D1 DE 69837387 T DE69837387 T DE 69837387T DE 69837387 T DE69837387 T DE 69837387T DE 69837387 D1 DE69837387 D1 DE 69837387D1
Authority
DE
Germany
Prior art keywords
alpha
subject
methadone
normethadol
acetylmethadol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69837387T
Other languages
English (en)
Other versions
DE69837387T2 (de
Inventor
Charles E Inturrisi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cornell Research Foundation Inc
Original Assignee
Cornell Research Foundation Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cornell Research Foundation Inc filed Critical Cornell Research Foundation Inc
Application granted granted Critical
Publication of DE69837387D1 publication Critical patent/DE69837387D1/de
Publication of DE69837387T2 publication Critical patent/DE69837387T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Addiction (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69837387T 1997-01-22 1998-01-21 (d)-METHADON, EIN NICHT-OPIOIDES SCHMERZMITTEL Expired - Lifetime DE69837387T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US3530897P 1997-01-22 1997-01-22
US35308P 1997-01-22
PCT/US1998/001088 WO1998031358A1 (en) 1997-01-22 1998-01-21 d-METHADONE, A NONOPIOID ANALGESIC

Publications (2)

Publication Number Publication Date
DE69837387D1 true DE69837387D1 (de) 2007-05-03
DE69837387T2 DE69837387T2 (de) 2007-12-13

Family

ID=21881853

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69837387T Expired - Lifetime DE69837387T2 (de) 1997-01-22 1998-01-21 (d)-METHADON, EIN NICHT-OPIOIDES SCHMERZMITTEL

Country Status (12)

Country Link
US (1) US6008258A (de)
EP (1) EP1003494B1 (de)
JP (2) JP4514241B2 (de)
AT (1) ATE357226T1 (de)
AU (1) AU6244898A (de)
CA (1) CA2278422C (de)
DE (1) DE69837387T2 (de)
DK (1) DK1003494T3 (de)
ES (1) ES2283049T3 (de)
MA (1) MA24794A1 (de)
PT (1) PT1003494E (de)
WO (1) WO1998031358A1 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999045906A1 (en) * 1998-03-09 1999-09-16 Trustees Of Tufts College Treatment of compulsive behaviours in man and animals
US20060167114A1 (en) * 1998-03-09 2006-07-27 Louis Shuster Treatment of stereotypic, self-injurious and compulsive behaviors in man and animals using antagonists of NMDA receptors
US20070197651A1 (en) * 1998-03-09 2007-08-23 Tufts University Treatment of stereotypic, self-injurious and compulsive behaviors in man and animals using antagonists of NMDA receptors
IL140834A0 (en) * 1998-07-16 2002-02-10 Sloan Kettering Inst Cancer Topical compositions comprising an opioid analgesic and an nmda antagonist
US6897242B1 (en) * 1999-02-24 2005-05-24 Judson J. Somerville Non-racemic mixtures of d- and l- methadone and method of treating pain
AU2001251374A1 (en) * 2000-04-07 2001-10-23 Ultramed International, Inc. Maintaining abstinence after detoxification from opiate addiction
CA2407683C (en) 2000-04-28 2010-04-13 Memorial Sloan-Kettering Cancer Center Topical anesthetic/opioid formulations and uses thereof
US7820688B2 (en) 2001-04-27 2010-10-26 Memorial Sloan-Kettering Cancer Center Topical anesthetic/opioid formulations and uses thereof
CN1642547A (zh) * 2002-01-16 2005-07-20 恩多制药公司 治疗中枢神经***障碍的药物组合物和方法
WO2003061594A2 (en) * 2002-01-23 2003-07-31 The Regents Of The University Of California Methods and compositions for reducing the development of drug tolerance and/or physical dependence
US20050187239A1 (en) * 2002-03-27 2005-08-25 Pastenark Gavril W. Synergistic l-methadone compositions and methods of use thereof
AU2003301808A1 (en) * 2002-05-13 2004-06-07 Endo Pharmaceuticals Inc. Abuse-resistant opioid dosage form
CA2497975A1 (en) * 2002-09-09 2004-03-18 Endo Pharmaceuticals Inc. Combined immediate release and extended release analgesic composition
US20040180915A1 (en) * 2003-03-14 2004-09-16 Xanodyne Pharmacal, Inc. Methadone-containing compositions for parenteral administration and method of use thereof
US20040202717A1 (en) 2003-04-08 2004-10-14 Mehta Atul M. Abuse-resistant oral dosage forms and method of use thereof
US20100010096A1 (en) * 2006-10-27 2010-01-14 John Charin Somberg Methadone chiral isolate as an improved pharmaceutical
US20100048605A1 (en) * 2006-12-11 2010-02-25 University Of Kentucky Research Foundation Synergistic effects of combinations of nornicotine and opioids for the treatment of pain
US9468611B2 (en) 2012-09-27 2016-10-18 Relmada Therapeutics, Inc. d-Methadone for the treatment of psychiatric symptoms
JP2020506231A (ja) 2017-01-31 2020-02-27 パオロ エル マンフレディ 神経系の障害並びにその症状及び徴候の処置又は予防のため並びに疾患及び細胞の老化並びにその症状及び徴候に対する細胞保護のための化合物
US20180280294A1 (en) * 2017-03-31 2018-10-04 Depco, Inc. Therapeutic putty having analgesics and/or counterirritants

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3895056A (en) * 1972-12-26 1975-07-15 Lilly Co Eli Alpha-d1-4-acetoxy-1-methyl-3,3-diphenylhexylamine and salts
US5321012A (en) * 1993-01-28 1994-06-14 Virginia Commonwealth University Medical College Inhibiting the development of tolerance to and/or dependence on a narcotic addictive substance
US5352683A (en) * 1993-03-05 1994-10-04 Virginia Commonwealth University Medical College Of Virginia Method for the treatment of chronic pain
CA2115792C (en) * 1993-03-05 2005-11-01 David J. Mayer Method for the treatment of pain

Also Published As

Publication number Publication date
US6008258A (en) 1999-12-28
JP2001508797A (ja) 2001-07-03
EP1003494B1 (de) 2007-03-21
PT1003494E (pt) 2007-06-06
CA2278422A1 (en) 1998-07-23
ATE357226T1 (de) 2007-04-15
EP1003494A1 (de) 2000-05-31
ES2283049T3 (es) 2007-10-16
AU6244898A (en) 1998-08-07
WO1998031358A1 (en) 1998-07-23
EP1003494A4 (de) 2002-10-16
JP2010013477A (ja) 2010-01-21
MA24794A1 (fr) 1999-12-31
DK1003494T3 (da) 2007-07-16
CA2278422C (en) 2007-11-13
DE69837387T2 (de) 2007-12-13
JP4514241B2 (ja) 2010-07-28

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8328 Change in the person/name/address of the agent

Representative=s name: MAIWALD PATENTANWALTSGESELLSCHAFT MBH, 80335 MUENC