DE69819998D1 - Verfahren zur chemischen Synthese von Oligonukleotiden - Google Patents

Verfahren zur chemischen Synthese von Oligonukleotiden

Info

Publication number
DE69819998D1
DE69819998D1 DE69819998T DE69819998T DE69819998D1 DE 69819998 D1 DE69819998 D1 DE 69819998D1 DE 69819998 T DE69819998 T DE 69819998T DE 69819998 T DE69819998 T DE 69819998T DE 69819998 D1 DE69819998 D1 DE 69819998D1
Authority
DE
Germany
Prior art keywords
oligonucleotides
chemical synthesis
synthesis
chemical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69819998T
Other languages
English (en)
Other versions
DE69819998T2 (de
Inventor
Yoshihiro Hayakawa
Masanori Kataoka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Japan Science and Technology Agency
Original Assignee
Japan Science and Technology Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Japan Science and Technology Corp filed Critical Japan Science and Technology Corp
Application granted granted Critical
Publication of DE69819998D1 publication Critical patent/DE69819998D1/de
Publication of DE69819998T2 publication Critical patent/DE69819998T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Saccharide Compounds (AREA)
DE69819998T 1997-09-05 1998-09-04 Verfahren zur chemischen Synthese von Oligonukleotiden Expired - Fee Related DE69819998T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP24129297 1997-09-05
JP9241292A JPH1180185A (ja) 1997-09-05 1997-09-05 オリゴヌクレオチドの化学合成法

Publications (2)

Publication Number Publication Date
DE69819998D1 true DE69819998D1 (de) 2004-01-08
DE69819998T2 DE69819998T2 (de) 2004-09-02

Family

ID=17072109

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69819998T Expired - Fee Related DE69819998T2 (de) 1997-09-05 1998-09-04 Verfahren zur chemischen Synthese von Oligonukleotiden

Country Status (5)

Country Link
US (1) US6040439A (de)
EP (1) EP0906917B1 (de)
JP (1) JPH1180185A (de)
CA (1) CA2246909C (de)
DE (1) DE69819998T2 (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6274725B1 (en) 1998-06-02 2001-08-14 Isis Pharmaceuticals, Inc. Activators for oligonucleotide synthesis
US6929907B2 (en) 1999-12-31 2005-08-16 North Carolina State University Methods and compositions for determining the purity of chemically synthesized nucleic acids
EP1721908A4 (de) * 2004-03-01 2009-12-16 Japan Science & Tech Agency Neues verfahren zur synthese von nukleinsäuren ohne schützen der nukleotidbasen
RU2440364C2 (ru) * 2004-12-15 2012-01-20 Гириндус Аг Синтез фосфитилированных соединений с использованием четвертичного гетероциклического активатора
KR101437824B1 (ko) * 2005-03-04 2014-10-02 기린두스 악티엔게젤샤프트 올리고뉴클레오티드의 합성
IL185439A0 (en) * 2005-03-04 2008-01-06 Girindus Ag Synthesis of oligonucleotides
US9670517B1 (en) 2012-01-16 2017-06-06 Integrated Dna Technologies, Inc. Synthesis of long nucleic acid sequences
EP3102676A1 (de) 2013-12-09 2016-12-14 Integrated DNA Technologies Inc. Lange nukleinsäuresequenzen mit variablen regionen
US10155944B2 (en) 2015-08-05 2018-12-18 Integrated Dna Technologies, Inc. Tailed primer for cloned products used in library construction
US11293029B2 (en) 2015-12-07 2022-04-05 Zymergen Inc. Promoters from Corynebacterium glutamicum
US11208649B2 (en) 2015-12-07 2021-12-28 Zymergen Inc. HTP genomic engineering platform
ES2928728T3 (es) 2015-12-07 2022-11-22 Zymergen Inc Mejora de cepas microbianas mediante una plataforma de ingeniería genómica HTP
US9988624B2 (en) 2015-12-07 2018-06-05 Zymergen Inc. Microbial strain improvement by a HTP genomic engineering platform
KR102345898B1 (ko) 2016-06-30 2022-01-03 지머젠 인코포레이티드 글루코오스 투과 효소 라이브러리를 생성하는 방법 및 이의 용도
KR102345899B1 (ko) 2016-06-30 2021-12-31 지머젠 인코포레이티드 박테리아 헤모글로빈 라이브러리를 생성하는 방법 및 이의 용도
JP2020520645A (ja) 2017-05-19 2020-07-16 ザイマージェン インコーポレイテッド Ｎａｄｐｈの増大を導く生合成経路のゲノム工学
EP3635112A2 (de) 2017-06-06 2020-04-15 Zymergen, Inc. Genomische htp-engineering-plattform zur verbesserung von pilzstämmen
CA3064619A1 (en) 2017-06-06 2018-12-13 Zymergen Inc. A high-throughput (htp) genomic engineering platform for improving saccharopolyspora spinosa
JP2020524494A (ja) 2017-06-06 2020-08-20 ザイマージェン インコーポレイテッド ハイスループットトランスポゾン変異誘発
ES2875579T3 (es) 2017-06-06 2021-11-10 Zymergen Inc Plataforma de ingeniería genómica de HTP para mejorar Escherichia coli
CN111902540A (zh) 2018-03-20 2020-11-06 齐默尔根公司 用于中国仓鼠卵巢细胞基因工程改造的htp平台
KR20210018219A (ko) 2018-06-06 2021-02-17 지머젠 인코포레이티드 발효 및 생산 중 곰팡이 형태를 제어하기 위한 신호 전달에 포함된 유전자의 조작
JP2022177332A (ja) * 2019-10-24 2022-12-01 日東電工株式会社 オリゴヌクレオチドを製造する方法
WO2021095874A1 (ja) * 2019-11-13 2021-05-20 日本新薬株式会社 オリゴ核酸化合物の製造方法
US11479779B2 (en) 2020-07-31 2022-10-25 Zymergen Inc. Systems and methods for high-throughput automated strain generation for non-sporulating fungi

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5077285A (en) * 1989-07-31 1991-12-31 Merck & Co., Inc. Imidazole compounds and their use as transglutaminase inhibitors
US5955600A (en) * 1996-12-27 1999-09-21 Isis Pharmaceuticals, Inc. Method for the synthesis of nucleotide or oligonucleotide phosphoramidites

Also Published As

Publication number Publication date
EP0906917A2 (de) 1999-04-07
DE69819998T2 (de) 2004-09-02
EP0906917A3 (de) 1999-09-22
US6040439A (en) 2000-03-21
JPH1180185A (ja) 1999-03-26
CA2246909A1 (en) 1999-03-05
EP0906917B1 (de) 2003-11-26
CA2246909C (en) 2003-12-02

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee