DE69812959D1 - Verfahren zur herstellung von 2'-fluoro-5-methyl-beta-l-arabino-furanosyluridin - Google Patents

Verfahren zur herstellung von 2'-fluoro-5-methyl-beta-l-arabino-furanosyluridin

Info

Publication number
DE69812959D1
DE69812959D1 DE69812959T DE69812959T DE69812959D1 DE 69812959 D1 DE69812959 D1 DE 69812959D1 DE 69812959 T DE69812959 T DE 69812959T DE 69812959 T DE69812959 T DE 69812959T DE 69812959 D1 DE69812959 D1 DE 69812959D1
Authority
DE
Germany
Prior art keywords
furanosyluridine
arabino
fluoro
beta
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69812959T
Other languages
English (en)
Other versions
DE69812959T2 (de
Inventor
K Chu
Yong S Choi
Jinfa Du
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Georgia Research Foundation Inc UGARF
Original Assignee
University of Georgia Research Foundation Inc UGARF
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Georgia Research Foundation Inc UGARF filed Critical University of Georgia Research Foundation Inc UGARF
Publication of DE69812959D1 publication Critical patent/DE69812959D1/de
Application granted granted Critical
Publication of DE69812959T2 publication Critical patent/DE69812959T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H9/00—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
    • C07H9/02—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical the hetero ring containing only oxygen as ring hetero atoms
    • C07H9/04—Cyclic acetals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/02—Monosaccharides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
DE69812959T 1997-07-23 1998-07-23 Verfahren zur herstellung von 2'-fluoro-5-methyl-beta-l-arabino-furanosyluridin Expired - Lifetime DE69812959T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US5348897P 1997-07-23 1997-07-23
US53488P 1997-07-23
PCT/US1998/015375 WO1999005158A1 (en) 1997-07-23 1998-07-23 PROCESS FOR THE PREPARATION OF 2'-FLUORO-5-METHYL-β -L-ARABINOFURANOSYLURIDINE

Publications (2)

Publication Number Publication Date
DE69812959D1 true DE69812959D1 (de) 2003-05-08
DE69812959T2 DE69812959T2 (de) 2004-03-04

Family

ID=21984622

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69831619T Expired - Lifetime DE69831619T2 (de) 1997-07-23 1998-07-23 Verfahren zur Herstellung von L-Ribose
DE69812959T Expired - Lifetime DE69812959T2 (de) 1997-07-23 1998-07-23 Verfahren zur herstellung von 2'-fluoro-5-methyl-beta-l-arabino-furanosyluridin

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE69831619T Expired - Lifetime DE69831619T2 (de) 1997-07-23 1998-07-23 Verfahren zur Herstellung von L-Ribose

Country Status (21)

Country Link
US (2) US6512107B2 (de)
EP (2) EP1327637B1 (de)
KR (1) KR100247505B1 (de)
CN (1) CN1113892C (de)
AR (1) AR009092A1 (de)
AT (2) ATE304547T1 (de)
AU (1) AU8758298A (de)
BR (1) BR9810804B1 (de)
DE (2) DE69831619T2 (de)
DK (1) DK1327637T3 (de)
ES (2) ES2249678T3 (de)
ID (1) ID20624A (de)
IL (1) IL121730A (de)
IN (1) IN186807B (de)
MY (1) MY117314A (de)
PT (2) PT998482E (de)
SA (1) SA98180771B1 (de)
SI (1) SI1327637T1 (de)
TR (1) TR199701051A2 (de)
TW (1) TW434252B (de)
WO (2) WO1999005157A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW434252B (en) 1997-07-23 2001-05-16 Univ Georgia Res Found Process for the preparation of 2'-fluoro-5-methyl-β-L-arabino-furanosyluridine
KR100449618B1 (ko) * 1998-03-27 2004-11-16 부광약품 주식회사 2'-플루오로-5-메틸-β-L-아라비노푸라노실유리딘의 제조방법
US6462191B1 (en) * 2000-07-13 2002-10-08 Air Products And Chemicals, Inc. Synthesis of 2-deoxy-2-fluoro-arabinose derivatives
BR0208517A (pt) * 2001-03-30 2005-02-01 Triangle Pharmaceuticals Inc Processo para a preparação de nucleosìdeos de 2'-halo-sg(b) l-arabinofuranosila
KR100487992B1 (ko) * 2001-10-25 2005-05-09 부광약품 주식회사 2'-플루오로-5-메틸-β-엘-아라비노푸라노실유리딘의 황유도체
WO2003053360A2 (en) * 2001-12-20 2003-07-03 Pharmassett Ltd. Treatment of ebv and khsv infection and associated abnormal cellular proliferation
KR100976778B1 (ko) 2003-04-17 2010-08-18 부광약품 주식회사 1-（2'-플루오로-베타-엘-아라비노푸라노실）티민의 황 유도체를 유효 활성 성분으로 하는 b형 간염 바이러스 치료제
NZ554442A (en) 2004-09-14 2011-05-27 Pharmasset Inc Preparation of 2'fluoro-2'-alkyl-substituted or other optionally substituted ribofuranosyl pyrimidines and purines and their derivatives
JP5149168B2 (ja) * 2005-06-07 2013-02-20 エール ユニヴァーシティ Ｌｆｍａｕおよびｌｄｔを用いる癌および他の症状または病状の処置方法
PL2159224T3 (pl) 2007-06-18 2012-12-31 Ruyuan Wei Xiang Tech Co Ltd Tiazolilohydropirymidyny podstawione bromofenylem
GB0907551D0 (en) 2009-05-01 2009-06-10 Univ Dundee Treatment or prophylaxis of proliferative conditions
JP2021512953A (ja) 2018-02-02 2021-05-20 メイベリックス オンコロジー インコーポレイテッド ゲムシタビンモノホスフェートの小分子薬物コンジュゲート
CN109320564B (zh) * 2018-10-26 2022-05-31 浙江晟格生物科技有限公司 一种l-来苏糖的制备工艺
CN109467541A (zh) * 2018-11-17 2019-03-15 扬州工业职业技术学院 一种绿色合成克拉夫定药物中间体的方法
CN109467583A (zh) * 2018-11-17 2019-03-15 扬州工业职业技术学院 一种克拉夫定的绿色合成工艺

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3714473A1 (de) * 1987-04-30 1988-11-10 Basf Ag Kontinuierliches verfahren zur epimerisierung von zuckern, insbesondere von d-arabinose zu d-ribose
EP0400064B1 (de) 1988-02-09 1993-04-21 Uop Festkatalysatoren für kontinuierliche epimerisierung von aldose und aldoseanalogen
DE4002727A1 (de) * 1990-01-31 1991-08-01 Bayer Ag Mischungen aus waessrigen polymerdispersionen
US5587362A (en) 1994-01-28 1996-12-24 Univ. Of Ga Research Foundation L-nucleosides
US5808040A (en) 1995-01-30 1998-09-15 Yale University L-nucleosides incorporated into polymeric structure for stabilization of oligonucleotides
TW434252B (en) 1997-07-23 2001-05-16 Univ Georgia Res Found Process for the preparation of 2'-fluoro-5-methyl-β-L-arabino-furanosyluridine

Also Published As

Publication number Publication date
ID20624A (id) 1999-01-28
ES2195370T3 (es) 2003-12-01
PT998482E (pt) 2003-08-29
EP0998482B1 (de) 2003-04-02
DE69831619D1 (de) 2005-10-20
KR100247505B1 (ko) 2000-03-15
ES2249678T3 (es) 2006-04-01
IL121730A (en) 2005-03-20
PT1327637E (pt) 2005-11-30
IN186807B (de) 2001-11-10
EP1327637B1 (de) 2005-09-14
KR19990013297A (ko) 1999-02-25
US20030139593A1 (en) 2003-07-24
WO1999005158A1 (en) 1999-02-04
IL121730A0 (en) 1998-02-22
TR199701051A3 (tr) 1999-03-22
EP0998482A1 (de) 2000-05-10
BR9810804B1 (pt) 2012-01-10
AU8758298A (en) 1999-02-16
SI1327637T1 (sl) 2005-12-31
TW434252B (en) 2001-05-16
US20020062018A1 (en) 2002-05-23
MY117314A (en) 2004-06-30
EP1327637A1 (de) 2003-07-16
AR009092A1 (es) 2000-03-08
WO1999005157A1 (en) 1999-02-04
TR199701051A2 (xx) 1999-03-22
DE69812959T2 (de) 2004-03-04
ATE236187T1 (de) 2003-04-15
DK1327637T3 (da) 2006-01-16
CN1206012A (zh) 1999-01-27
DE69831619T2 (de) 2006-06-14
US6894159B2 (en) 2005-05-17
SA98180771B1 (ar) 2006-10-29
ATE304547T1 (de) 2005-09-15
BR9810804A (pt) 2000-09-12
US6512107B2 (en) 2003-01-28
CN1113892C (zh) 2003-07-09

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