DE69740173D1 - Immunologische methoden zur behandlung von gastrointestinalem krebs - Google Patents

Immunologische methoden zur behandlung von gastrointestinalem krebs

Info

Publication number: DE69740173D1
Authority: DE; Germany
Prior art keywords: treatment; gastrointestinal cancer; immunological methods; gastrin; amidated
Prior art date: 1996-02-08
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE69740173T

Other languages

English (en)

Inventor

Philip C Gevas

Stephen L Karr

Stephen Grimes

Dov Michaeli

Susan A Watson

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Cancer Advances Inc

Original Assignee

Cancer Advances Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-02-08

Filing date

1997-02-07

Publication date

2011-05-26

1997-02-07 Application filed by Cancer Advances Inc filed Critical Cancer Advances Inc

2011-05-26 Application granted granted Critical

2011-05-26 Publication of DE69740173D1 publication Critical patent/DE69740173D1/de

2017-02-08 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

206010017993 Gastrointestinal neoplasms Diseases 0.000 title abstract 2
230000001900 immune effect Effects 0.000 title 1
DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 abstract 2
108010066264 gastrin 17 Proteins 0.000 abstract 2
GKDWRERMBNGKCZ-RNXBIMIWSA-N gastrin-17 Chemical compound C([C@@H](C(=O)NCC(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H]1N(CCC1)C(=O)CNC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 GKDWRERMBNGKCZ-RNXBIMIWSA-N 0.000 abstract 2
102400000921 Gastrin Human genes 0.000 abstract 1
239000004471 Glycine Substances 0.000 abstract 1
230000001419 dependent effect Effects 0.000 abstract 1
108010063604 gastrin immunogen Proteins 0.000 abstract 1
108010017400 glycine-extended gastrin 17 Proteins 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/595—Gastrins; Cholecystokinins [CCK]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Immunology (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Gastroenterology & Hepatology (AREA)
Biochemistry (AREA)
Endocrinology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Zoology (AREA)
Toxicology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

DE69740173T 1996-02-08 1997-02-07 Immunologische methoden zur behandlung von gastrointestinalem krebs Expired - Lifetime DE69740173D1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US1141196P	1996-02-08	1996-02-08
PCT/US1997/002029 WO1997028821A1 (en)	1996-02-08	1997-02-07	Immunological methods for the treatment of gastrointestinal cancer

Publications (1)

Publication Number	Publication Date
DE69740173D1 true DE69740173D1 (de)	2011-05-26

Family

ID=21750270

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE69740173T Expired - Lifetime DE69740173D1 (de)	1996-02-08	1997-02-07	Immunologische methoden zur behandlung von gastrointestinalem krebs

Country Status (9)

Country	Link
US (1)	US20050025770A1 (de)
EP (1)	EP0889735B1 (de)
JP (3)	JP2000504692A (de)
AT (1)	ATE505202T1 (de)
DE (1)	DE69740173D1 (de)
DK (1)	DK0889735T3 (de)
ES (1)	ES2361474T3 (de)
PT (1)	PT889735E (de)
WO (1)	WO1997028821A1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PT889735E (pt) *	1996-02-08	2011-07-19	Cancer Advances Inc	Métodos imunológicos para o tratamento do cancro gastrointestinal
NZ500748A (en) *	1997-05-12	2001-06-29	Aphton Corp	Methods for the treatment of gastrin-dependent tumours comprising active or passive immunisation with an anti-CCK-B/gastrin receptor immunogen or anti-CCK-B/gastrin receptor antibodies
US20040001842A1 (en) *	1997-05-12	2004-01-01	Dov Michaeli	Immunogenic compositions to the CCK-B/gastrin receptor and methods for the treatment of tumors
DE69935977T2 (de) *	1998-05-15	2008-01-10	Receptor Biologix, Inc., Palo Alto	Vorbeugung und Behandlung von Hypergastrinämie
EP1897556A1 (de) *	1998-05-15	2008-03-12	Receptor Biologix, Inc.	Vorbeugung und Behandlung von Hypergastrinämie
US20030068326A1 (en) *	1998-05-15	2003-04-10	Aphton Corporation	Method for the treatment of gastroesophageal reflux disease
JP2005508838A (ja) *	2001-03-23	2005-04-07	アフトンコーポレーション	膵癌の組合せ治療
US20090191232A1 (en) *	2001-05-04	2009-07-30	Gevas Philip C	Combination therapy for the treatment of tumors
AU2002326356A1 (en) *	2001-07-09	2003-01-29	Aphton Corporation	Treatment and prevention of cancerous and pre-cancerous conditions of the liver, lung and esophagus
US20050169979A1 (en) *	2002-07-03	2005-08-04	Dov Michaeli	Liposomal vaccine
US7235376B2 (en) *	2003-03-28	2007-06-26	Receptor Biologix, Inc.	Gastrin hormone immunoassays
WO2005095459A2 (en) *	2004-03-29	2005-10-13	Receptor Biologix, Inc.	Monoclonal antibodies to gastrin hormone
EP2567974A3 (de) *	2004-09-22	2013-05-22	Cancer Advances, Inc.,	Monoklonale Antikörper gegen Progastrin
JP5558660B2 (ja)	2007-05-11	2014-07-23	日東電工株式会社	両面接着性感圧接着シート
US8674064B2 (en) *	2010-03-03	2014-03-18	Onkologix Ltd	Immunogenic compositions against human progastrin peptides
CN101797382B (zh)	2010-03-03	2013-11-20	戚胜美	抗人前胃液素多肽免疫组合物
JP6395816B2 (ja) *	2013-05-21	2018-09-26	ティーワイジー・オンコロジー・リミテッド	ガストリンペプチド免疫原組成物
JP6525909B2 (ja)	2016-03-15	2019-06-05	中外炉工業株式会社	工業炉
CA3066756A1 (en)	2017-06-15	2018-12-20	Cancer Advances Inc.	Compositions and methods for inducing humoral and cellular immunities against tumors and cancer

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US39911A (en) *		1863-09-15		Improvement in corset skirt-supporters
US1842A (en) *		1840-10-31		Machine fob cutting corks
US68326A (en) *		1867-08-27		Alcibiades j
US58040A (en) *		1866-09-18		Improvement in making bolts
US187152A (en) *		1877-02-06		Improvement in clothes-wringers
US21786A (en) *		1858-10-12		Improvement in the manufacture of sugar
US20119A (en) *		1858-04-27		Improvement in raking and delivering attachments to harvesters
US91574A (en) *		1869-06-22		Improvement in water-closet valves
US86941A (en) *		1869-02-16		Improvement in corn-planter
US95028A (en) *		1869-09-21		Improved process for preserving eggs
US140962A (en) *		1873-07-15		Improvement in feeding paper to printing-presses
US69966A (en) *		1867-10-22		Joseph chadwick
US4526716A (en) *	1981-11-20	1985-07-02	The Ohio State University	Antigenic modification of polypeptides
US4691006A (en) *	1983-03-04	1987-09-01	Ohio State University	Antigenic modification of polypeptides
US4384995A (en) *	1980-01-16	1983-05-24	The Ohio State University	Antigenic modification of polypeptides
IT1179894B (it) *	1984-12-27	1987-09-16	Rotta Research Lab	Proglumide e composizioni farmaceutiche che la contengono per l impiego nella terapia di affezioni neoplastiche
US6861510B1 (en) *	1989-01-24	2005-03-01	Aphton Corporation	Immunogenic compositions against gastrin peptides
US5023077A (en) *	1989-01-24	1991-06-11	Aphton Corporation	Immunogenic compositions and methods for the treatment and prevention of gastric and duodenal ulcer disease
ATE114160T1 (de) *	1989-01-24	1994-12-15	Aphton Corp	Immunogenische zusammensetzungen gegen gastrin- peptide.
US5319073A (en) *	1992-02-07	1994-06-07	The United States Of America, As Represented By The Department Of Health & Human Services	Method of purifying cholecystokinin receptor protein
US5759551A (en) *	1993-04-27	1998-06-02	United Biomedical, Inc.	Immunogenic LHRH peptide constructs and synthetic universal immune stimulators for vaccines
US5468494A (en)	1993-11-12	1995-11-21	Aphton Corp.	Immunogenic compositions against human gastrin 17
US5688506A (en) *	1994-01-27	1997-11-18	Aphton Corp.	Immunogens against gonadotropin releasing hormone
FI97304C (fi) *	1994-11-16	1996-11-25	Locus Genex Oy	Menetelmä mahasyövän riskin seulonnaksi
US6359114B1 (en) *	1995-06-07	2002-03-19	Aphton Corp.	System for method for the modification and purification of proteins
PT889735E (pt) *	1996-02-08	2011-07-19	Cancer Advances Inc	Métodos imunológicos para o tratamento do cancro gastrointestinal
NZ500748A (en) *	1997-05-12	2001-06-29	Aphton Corp	Methods for the treatment of gastrin-dependent tumours comprising active or passive immunisation with an anti-CCK-B/gastrin receptor immunogen or anti-CCK-B/gastrin receptor antibodies
WO2000050059A1 (en) *	1999-02-24	2000-08-31	The Uab Research Foundation	Taxane derivatives for targeted therapy of cancer

1997
- 1997-02-07 PT PT97905858T patent/PT889735E/pt unknown
- 1997-02-07 DK DK97905858.3T patent/DK0889735T3/da active
- 1997-02-07 DE DE69740173T patent/DE69740173D1/de not_active Expired - Lifetime
- 1997-02-07 WO PCT/US1997/002029 patent/WO1997028821A1/en active Application Filing
- 1997-02-07 EP EP97905858A patent/EP0889735B1/de not_active Expired - Lifetime
- 1997-02-07 AT AT97905858T patent/ATE505202T1/de active
- 1997-02-07 ES ES97905858T patent/ES2361474T3/es not_active Expired - Lifetime
- 1997-02-07 JP JP9528702A patent/JP2000504692A/ja not_active Withdrawn
2004
- 2004-01-20 US US10/762,226 patent/US20050025770A1/en not_active Abandoned
2006
- 2006-11-16 JP JP2006310647A patent/JP5200251B2/ja not_active Expired - Lifetime
2011
- 2011-02-21 JP JP2011034753A patent/JP5200269B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
EP0889735A1 (de)	1999-01-13
ES2361474T3 (es)	2011-06-17
EP0889735B1 (de)	2011-04-13
JP2000504692A (ja)	2000-04-18
WO1997028821A1 (en)	1997-08-14
JP5200269B2 (ja)	2013-06-05
PT889735E (pt)	2011-07-19
JP2007126461A (ja)	2007-05-24
ATE505202T1 (de)	2011-04-15
DK0889735T3 (da)	2011-08-08
JP2012097062A (ja)	2012-05-24
US20050025770A1 (en)	2005-02-03
JP5200251B2 (ja)	2013-06-05

Publication	Publication Date	Title
DE69740173D1 (de)	2011-05-26	Immunologische methoden zur behandlung von gastrointestinalem krebs
ATE480566T1 (de)	2010-09-15	Immuntherapeutische zusammensetzung und verfahren zur behandlung von prostatakrebs
NO983999L (no)	1998-11-02	Peptidimmunogener for vaksinasjon mot og behandling av allergi
WO1997028821B1 (en)	1997-10-02	Immunological methods for the treatment of gastrointestinal cancer
DE69129302D1 (de)	1998-05-28	Inhibitoren des tumorwachstums aus geweben, methoden ihrer herstellung und verwendungen
ATE410446T1 (de)	2008-10-15	Zusammensetzungen zur behandlung und diagnose von eierstockkrebs
DE3877834D1 (de)	1993-03-11	Verfahren zur behandlung von abgasen.
HUP0002760A2 (hu)	2000-12-28	CCK-B/gasztrin-receptor elleni ellenanyagok termelődését kiváltó immunogén készítmények, és alkalmazásuk tumorok kezelésére
DE50310283D1 (de)	2008-09-18	Verfahren zur identifizierung von immunreaktiven peptiden
DE69626423D1 (de)	2003-04-03	Verfahren und zusammensetzung zur umgestaltung multi-epitopischer antigene um die immunantwort einzuleiten
BR9809656A (pt)	2000-07-11	Composição imunopotencializante
ATE166230T1 (de)	1998-06-15	Verwendung von anti-icam antikörpern zur herstellung eines präparats für die behandlung von endotoxinschock
ATE347561T1 (de)	2006-12-15	Behandlung von entzündungskrankheiten
ATE128986T1 (de)	1995-10-15	Antigen sf-25 des darm-adenokarzinoms sowie antikörper, die dieses antigen erkennen.
ZA972757B (en)	1998-01-30	Porphyromonas gingivalis antigents for the diagnosis and treatment of periodontitis.
HK1021228A1 (en)	2000-06-02	In vitro method for determining the presence of hepatocellular carcinoma
DE69633506D1 (de)	2004-11-04	Transepithelialer transport von molekularspezien
DK0991945T3 (da)	2004-07-26	Fremgangsmåde til identifikation af tumor-antigener med antistoffer i serum
ATE475710T1 (de)	2010-08-15	Zusammensetzungen und verfahren für die therapie und diagnose von ovariumkrebs
ATE87316T1 (de)	1993-04-15	Von protein ps2 abgeleitete peptide.
DE3883808D1 (de)	1993-10-14	Testsatz, Extraktionsvorrichtung und Verfahren zur Bestimmung von Streptococcus-A-Antigen.
DK0809653T3 (da)	2001-11-19	Helicobacter pylori-antigen
HUP9904404A1 (hu)	2000-05-28	Eljárás laphám-karcinómák diagnosztizálására és kezelésére