DE69737496D1 - SIALYL-LEWISa UND SIALYL LEWISx EPITOP-ANALOGE - Google Patents
SIALYL-LEWISa UND SIALYL LEWISx EPITOP-ANALOGEInfo
- Publication number
- DE69737496D1 DE69737496D1 DE69737496T DE69737496T DE69737496D1 DE 69737496 D1 DE69737496 D1 DE 69737496D1 DE 69737496 T DE69737496 T DE 69737496T DE 69737496 T DE69737496 T DE 69737496T DE 69737496 D1 DE69737496 D1 DE 69737496D1
- Authority
- DE
- Germany
- Prior art keywords
- sialyl
- lewisa
- lewisx
- epitop
- analogue
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
- C07H3/06—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH23096 | 1996-01-30 | ||
| PCT/EP1997/000222 WO1997028173A1 (en) | 1996-01-30 | 1997-01-17 | SIALYL-LEWISa AND SIALYL-LEWISx EPITOPE ANALOGUES |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE69737496D1 true DE69737496D1 (de) | 2007-05-03 |
Family
ID=4182259
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69737496T Expired - Lifetime DE69737496D1 (de) | 1996-01-30 | 1997-01-17 | SIALYL-LEWISa UND SIALYL LEWISx EPITOP-ANALOGE |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US6169077B1 (de) |
| EP (1) | EP0886640B1 (de) |
| AT (1) | ATE357452T1 (de) |
| AU (1) | AU1542397A (de) |
| DE (1) | DE69737496D1 (de) |
| WO (1) | WO1997028173A1 (de) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1001961T3 (da) * | 1997-08-08 | 2005-05-23 | Aventis Pharma Gmbh | Substituerede derivater af tetrahydrofuran og fremgangsmåde til deres fremstilling |
| SE9904581D0 (sv) * | 1999-12-15 | 1999-12-15 | A & Science Invest Ab | A novel helicobacter pylori-binding substance and use thereof |
| US7481790B2 (en) * | 2000-12-27 | 2009-01-27 | Advanced Cardiovascular Systems, Inc. | Vessel enlargement by arteriogenic factor delivery |
| AU2003249641B2 (en) | 2002-05-16 | 2009-08-20 | Glycomimetics, Inc. | Compounds and methods for inhibiting selectin-mediated function |
| AU2003245595A1 (en) * | 2002-07-03 | 2004-01-23 | Glycomimetics, Inc. | Compositions and methods for diagnosis and therapy of medical conditions involving angiogenesis |
| JP2006515306A (ja) * | 2002-12-20 | 2006-05-25 | グリコミメティクス， インコーポレイテッド | Ｐｓｅｕｄｏｍｏｎａｓ細菌感染の処置のためのオリゴ糖およびその結合体 |
| US20040219158A1 (en) * | 2003-05-02 | 2004-11-04 | Glycomimetics, Inc. | Compositions and methods for diagnosis and therapy of medical conditions involving infection with pseudomonas bacteria |
| JP2007524658A (ja) * | 2003-11-19 | 2007-08-30 | グリコミメティクス， インコーポレイテッド | Ｅ−およびｐ−セレクチンの両方のための糖模倣物アンタゴニスト |
| ATE383367T1 (de) * | 2003-11-19 | 2008-01-15 | Glycomimetics Inc | Spezifischer antagonist sowohl für e- als auch p- selektine |
| US8201377B2 (en) * | 2004-11-05 | 2012-06-19 | Faus Group, Inc. | Flooring system having multiple alignment points |
| US20090036386A1 (en) * | 2005-05-25 | 2009-02-05 | Glycomimetics, Inc | Heterobifunctional compounds for selectin inhibition |
| US7517980B2 (en) * | 2005-08-09 | 2009-04-14 | Glycomimetics, Inc. | Glycomimetric inhibitors of the PA-IL lectin, PA-IIL lectin or both the lectins from Pseudomonas |
| SI2264043T1 (en) | 2005-09-02 | 2018-01-31 | Glycomimetics, Inc. | HETEROBIFUNCTIONAL PAN-SELECTINE INHIBITORS |
| WO2007143052A1 (en) * | 2006-06-01 | 2007-12-13 | Glycomimetics, Inc. | Galactosides and thiodigalactosides as inhibitors of pa-il lectin from pseudomonas |
| WO2008060378A2 (en) | 2006-10-12 | 2008-05-22 | Glycomimetics, Inc. | Glycomimetic replacements for hexoses and n-acetyl hexosamines |
| EP2457573A1 (de) * | 2007-02-09 | 2012-05-30 | GlycoMimetics, Inc. | Verfahren zur Verwendung von Glykomimetika für Hexosen und N-Acetyl-Hexosamine |
| US8039442B2 (en) | 2007-07-18 | 2011-10-18 | Glycomimetics, Inc. | Compounds and methods for treatment of sickle cell disease or complications associated therewith |
| US8895510B2 (en) * | 2008-04-08 | 2014-11-25 | Glycomimetics, Inc. | Pan-selectin inhibitor with enhanced pharmacokinetic activity |
| AU2009257536B2 (en) * | 2008-06-13 | 2015-07-02 | Glycomimetics, Inc. | Treatment of cancers of the blood using selected glycomimetic compounds |
| CN102421441B (zh) * | 2009-05-01 | 2015-04-01 | 糖模拟物有限公司 | E-选择蛋白和cxcr4趋化因子受体的异双功能抑制剂 |
| WO2012037034A1 (en) | 2010-09-14 | 2012-03-22 | Glycomimetics, Inc. | E-selectin antagonists |
| JP2015500887A (ja) | 2011-12-22 | 2015-01-08 | グリコミメティクス， インコーポレイテッド | Ｅ−セレクチンアンタゴニスト化合物、組成物および使用方法 |
| GB201214736D0 (en) | 2012-08-17 | 2012-10-03 | Isis Innovation | Inflammation imaging and therapy |
| HUE038423T2 (hu) | 2012-12-07 | 2018-10-29 | Glycomimetics Inc | E-szelektin antagonistákat felhasználó vegyületek, készítmények és eljárások vérképzõ sejtek mobilizációjára |
| PT3227310T (pt) | 2014-12-03 | 2019-11-06 | Glycomimetics Inc | Inibidores heterobifuncionais de e-selectinas e recetores de quimiocina cxcr4 |
| CA3009836A1 (en) | 2016-01-22 | 2017-07-27 | Glycomimetics, Inc. | Glycomimetic inhibitors of pa-il and pa-iil lectins |
| US11291678B2 (en) | 2016-03-02 | 2022-04-05 | Glycomimetics, Inc | Methods for the treatment and/or prevention of cardiovascular disease by inhibition of E-selectin |
| EP3497131B1 (de) | 2016-08-08 | 2022-03-09 | GlycoMimetics, Inc. | Kombination von t-zell-checkpoint-inhibitoren mit e-selectin- oder cxcr4-inhibitoren oder mit heterobifunktionellen e-selectin- wie auch cxcr4-inhibitoren |
| KR102653723B1 (ko) | 2016-10-07 | 2024-04-01 | 글리코미메틱스, 인크. | 매우 강력한 다량체성 e-셀렉틴 길항물질 |
| US11197877B2 (en) | 2017-03-15 | 2021-12-14 | Glycomimetics. Inc. | Galactopyranosyl-cyclohexyl derivauves as E-selectin antagonists |
| US11712446B2 (en) | 2017-11-30 | 2023-08-01 | Glycomimetics, Inc. | Methods of mobilizing marrow infiltrating lymphocytes and uses thereof |
| CA3085356A1 (en) | 2017-12-29 | 2019-07-04 | Glycomimetics, Inc. | Heterobifunctional inhibitors of e-selectin and galectin-3 |
| BR112020018184A2 (pt) | 2018-03-05 | 2021-02-02 | Glycomimetics, Inc. | usos de compostos |
| US11845771B2 (en) | 2018-12-27 | 2023-12-19 | Glycomimetics, Inc. | Heterobifunctional inhibitors of E-selectin and galectin-3 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4925796A (en) * | 1986-03-07 | 1990-05-15 | Massachusetts Institute Of Technology | Method for enhancing glycoprotein stability |
| SE9301677L (sv) | 1993-05-14 | 1994-11-18 | Kurt G I Nilsson | Syntesmetod |
| WO1994026760A1 (en) | 1993-05-14 | 1994-11-24 | Cytel Corporation | SIALYL Lex ANALOGUES AS INHIBITORS OF CELLULAR ADHESION |
-
1997
- 1997-01-17 AU AU15423/97A patent/AU1542397A/en not_active Abandoned
- 1997-01-17 AT AT97901546T patent/ATE357452T1/de not_active IP Right Cessation
- 1997-01-17 DE DE69737496T patent/DE69737496D1/de not_active Expired - Lifetime
- 1997-01-17 EP EP97901546A patent/EP0886640B1/de not_active Expired - Lifetime
- 1997-01-17 US US09/117,482 patent/US6169077B1/en not_active Expired - Lifetime
- 1997-01-17 WO PCT/EP1997/000222 patent/WO1997028173A1/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| US6169077B1 (en) | 2001-01-02 |
| EP0886640B1 (de) | 2007-03-21 |
| ATE357452T1 (de) | 2007-04-15 |
| WO1997028173A1 (en) | 1997-08-07 |
| EP0886640A1 (de) | 1998-12-30 |
| AU1542397A (en) | 1997-08-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8332 | No legal effect for de |