DE69715188D1 - Verfahren und zwischenprodukte zur herstellung von 4-trifluoromethylbiphenyl-2-carbonsaüre,(2-(2h-(1,2,4) triazol-3-ylmethyl)-1,2,3,4-tetrahydro-isoquinolin-6-yl)-amide - Google Patents

Verfahren und zwischenprodukte zur herstellung von 4-trifluoromethylbiphenyl-2-carbonsaüre,(2-(2h-(1,2,4) triazol-3-ylmethyl)-1,2,3,4-tetrahydro-isoquinolin-6-yl)-amide

Info

Publication number
DE69715188D1
DE69715188D1 DE69715188T DE69715188T DE69715188D1 DE 69715188 D1 DE69715188 D1 DE 69715188D1 DE 69715188 T DE69715188 T DE 69715188T DE 69715188 T DE69715188 T DE 69715188T DE 69715188 D1 DE69715188 D1 DE 69715188D1
Authority
DE
Germany
Prior art keywords
trifluoromethylbiphenyl
isoquinolin
triazol
ylmethyl
tetrahydro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69715188T
Other languages
English (en)
Other versions
DE69715188T2 (de
Inventor
John Urban
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Application granted granted Critical
Publication of DE69715188D1 publication Critical patent/DE69715188D1/de
Publication of DE69715188T2 publication Critical patent/DE69715188T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
DE69715188T 1996-04-30 1997-03-13 Verfahren und zwischenprodukte zur herstellung von 4-trifluoromethylbiphenyl-2-carbonsaüre,(2-(2h-(1,2,4) triazol-3-ylmethyl)-1,2,3,4-tetrahydro-isoquinolin-6-yl)-amide Expired - Fee Related DE69715188T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1649596P 1996-04-30 1996-04-30
PCT/IB1997/000254 WO1997041111A1 (en) 1996-04-30 1997-03-13 Processes and intermediates for preparing 4'-trifluoromethylbiphenyl-2-carboxylic acid [2-(2h-[1,2,4]triazol-3-ylmethyl)-1,2,3,4-tetrahydro-isoquinolin-6-yl]-amide

Publications (2)

Publication Number Publication Date
DE69715188D1 true DE69715188D1 (de) 2002-10-10
DE69715188T2 DE69715188T2 (de) 2003-01-02

Family

ID=21777423

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69715188T Expired - Fee Related DE69715188T2 (de) 1996-04-30 1997-03-13 Verfahren und zwischenprodukte zur herstellung von 4-trifluoromethylbiphenyl-2-carbonsaüre,(2-(2h-(1,2,4) triazol-3-ylmethyl)-1,2,3,4-tetrahydro-isoquinolin-6-yl)-amide

Country Status (23)

Country Link
US (1) US5998623A (de)
EP (1) EP0902785B1 (de)
JP (1) JPH11507959A (de)
KR (1) KR20000065152A (de)
CN (1) CN1216988A (de)
AR (1) AR006876A1 (de)
AT (1) ATE223400T1 (de)
AU (1) AU711279B2 (de)
BR (1) BR9709137A (de)
CA (1) CA2252621C (de)
CZ (1) CZ346498A3 (de)
DE (1) DE69715188T2 (de)
DK (1) DK0902785T3 (de)
ES (1) ES2180935T3 (de)
HU (1) HUP9902157A3 (de)
ID (1) ID17294A (de)
IL (1) IL126202A0 (de)
PL (1) PL329739A1 (de)
PT (1) PT902785E (de)
TR (1) TR199802163T2 (de)
WO (1) WO1997041111A1 (de)
YU (1) YU16297A (de)
ZA (1) ZA973696B (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6197798B1 (en) 1998-07-21 2001-03-06 Novartis Ag Amino-benzocycloalkane derivatives
IL139450A0 (en) * 1999-11-10 2001-11-25 Pfizer Prod Inc Methods of administering apo b-secretion/mtp inhibitors
IL139449A0 (en) * 1999-11-10 2001-11-25 Pfizer Prod Inc Use of apo b secretion/mtp inhibitors
CA2324800A1 (en) * 1999-11-10 2001-05-10 Mary Anne Hickman Use of apo b secretion/mtp inhibitors
CA2324801A1 (en) * 1999-11-10 2001-05-10 Andrew Gordon Swick Use of apo b secretion/mtp inhibitors and anti-obesity agents
DE60110896T2 (de) * 2000-01-18 2006-01-12 Novartis Ag Carboxamide und ihre verwendung als inhibitoren des mikrosomalen triglycerid-transfer-proteins und der apolipoprotein b (apo b) sekretion
WO2002014276A1 (fr) * 2000-08-10 2002-02-21 Tanabe Seiyaku Co., Ltd. Composes a base de benzoylaminoisoindoline, leurs procedes de preparation et produits intermediaires utilises dans leur synthese
WO2002014277A1 (fr) * 2000-08-10 2002-02-21 Tanabe Seiyaku Co., Ltd. Composes de biphenylcarboxamidoisoindoline, procedes de preparation de ceux-ci et produits intermediaires destines a la synthese de ceux-ci
SI1725234T1 (sl) 2004-03-05 2013-04-30 The Trustees Of The University Of Pennsylvania Postopki zdravljenja nepravilnosti ali bolezni povezanih s hiperlipidemijo in hiperholesterolemijo z minimiziranjem stranskih uäśinkov
WO2008075949A1 (en) * 2006-12-20 2008-06-26 Friesland Brands B.V. Modulation of human microsomal triglyceride transfer protein (mtp or mttp) gene expression by food-grade/ingested dietary microorganisms

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5595872A (en) * 1992-03-06 1997-01-21 Bristol-Myers Squibb Company Nucleic acids encoding microsomal trigyceride transfer protein
CA2091102C (en) * 1992-03-06 2009-05-26 John R. Ii Wetterau Microsomal triglyceride transfer protein
IL110172A (en) * 1993-07-22 2001-10-31 Lilly Co Eli Bicycle compounds and pharmaceuticals containing them
MX9709914A (es) * 1995-06-07 1998-03-31 Pfizer Derivados de acido bifenil-2-carboxilico-tetrahidro-isoquinolin-6-ilo, su preparacion y el uso de los mismos.
EP0832069B1 (de) * 1995-06-07 2003-03-05 Pfizer Inc. Biphenyl-2-carbonsäure-tetrahydro-isochinolin-6-yl amid derivate, deren hestellung und deren verwendung als inhibitoren des mikrosomalen triglycerid-transfer-proteins und/oder der apolipoprotein b (apo b) sekretion

Also Published As

Publication number Publication date
PT902785E (pt) 2002-12-31
ATE223400T1 (de) 2002-09-15
CA2252621C (en) 2002-09-03
CA2252621A1 (en) 1997-11-06
US5998623A (en) 1999-12-07
JPH11507959A (ja) 1999-07-13
AU2226697A (en) 1997-11-19
AR006876A1 (es) 1999-09-29
AU711279B2 (en) 1999-10-07
DE69715188T2 (de) 2003-01-02
PL329739A1 (en) 1999-04-12
WO1997041111A1 (en) 1997-11-06
EP0902785A1 (de) 1999-03-24
CN1216988A (zh) 1999-05-19
TR199802163T2 (xx) 1999-02-22
KR20000065152A (ko) 2000-11-06
CZ346498A3 (cs) 1999-09-15
BR9709137A (pt) 1999-08-03
EP0902785B1 (de) 2002-09-04
YU16297A (sh) 1999-09-27
HUP9902157A2 (hu) 2000-04-28
HUP9902157A3 (en) 2000-07-28
ID17294A (id) 1997-12-18
ES2180935T3 (es) 2003-02-16
DK0902785T3 (da) 2002-10-07
ZA973696B (en) 1998-10-29
IL126202A0 (en) 1999-05-09

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