DE69711188D1 - Dibenzodihydropyridincarbonsäureester und ihre anwendung in chemolumineszenz-untersuchungsverfahren - Google Patents

Dibenzodihydropyridincarbonsäureester und ihre anwendung in chemolumineszenz-untersuchungsverfahren

Info

Publication number
DE69711188D1
DE69711188D1 DE69711188T DE69711188T DE69711188D1 DE 69711188 D1 DE69711188 D1 DE 69711188D1 DE 69711188 T DE69711188 T DE 69711188T DE 69711188 T DE69711188 T DE 69711188T DE 69711188 D1 DE69711188 D1 DE 69711188D1
Authority
DE
Germany
Prior art keywords
alkyl
pct
dibenzodihydropyridine
aryl
chemoluminescence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69711188T
Other languages
English (en)
Other versions
DE69711188T2 (de
Inventor
Marjorie Jacquemijns
Gijsbert Zomer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nederlanden Staat
Nederlanden Welzijn Volksgezondheid en Cultuur Minister van
Original Assignee
Nederlanden Staat
Nederlanden Welzijn Volksgezondheid en Cultuur Minister van
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nederlanden Staat, Nederlanden Welzijn Volksgezondheid en Cultuur Minister van filed Critical Nederlanden Staat
Publication of DE69711188D1 publication Critical patent/DE69711188D1/de
Application granted granted Critical
Publication of DE69711188T2 publication Critical patent/DE69711188T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/10—Aza-phenanthrenes
    • C07D221/12—Phenanthridines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • C12Q1/28—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase involving peroxidase
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/968—High energy substrates, e.g. fluorescent, chemiluminescent, radioactive
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/975—Kit

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Cosmetics (AREA)
DE69711188T 1996-07-16 1997-07-15 Dibenzodihydropyridincarbonsäureester und ihre anwendung in chemolumineszenz-untersuchungsverfahren Expired - Lifetime DE69711188T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP96202022 1996-07-16
PCT/NL1997/000417 WO1998002421A1 (en) 1996-07-16 1997-07-15 Dibenzodihydropyridinecarboxylic esters and their use in chemiluminescent assay methods

Publications (2)

Publication Number Publication Date
DE69711188D1 true DE69711188D1 (de) 2002-04-25
DE69711188T2 DE69711188T2 (de) 2002-09-05

Family

ID=8224199

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69711188T Expired - Lifetime DE69711188T2 (de) 1996-07-16 1997-07-15 Dibenzodihydropyridincarbonsäureester und ihre anwendung in chemolumineszenz-untersuchungsverfahren

Country Status (10)

Country Link
US (1) US6030803A (de)
EP (1) EP0915851B1 (de)
JP (1) JP3338061B2 (de)
AT (1) ATE214697T1 (de)
CA (1) CA2261032C (de)
DE (1) DE69711188T2 (de)
DK (1) DK0915851T3 (de)
ES (1) ES2171964T3 (de)
PT (1) PT915851E (de)
WO (1) WO1998002421A1 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997026245A1 (en) 1996-01-16 1997-07-24 Lumigen, Inc. Compounds, compositions and methods for generating chemiluminescence with phosphatase enzymes
US6410732B2 (en) 1996-01-16 2002-06-25 Lumigen, Inc. Processing and synthetic intermediates for preparing N-arylacridancarboxylic acid derivatives
JP4672144B2 (ja) * 1998-08-11 2011-04-20 シーメンス・ヘルスケア・ダイアグノスティックス・インコーポレーテッド 近赤外化学発光性アクリジニウム化合物およびその使用。
US7186568B1 (en) 2000-06-26 2007-03-06 Lumigen Inc. Electrochemiluminescence from acridan compounds
US6897036B2 (en) * 2002-06-06 2005-05-24 Lumigen, Inc. Fluorescent detection of peroxidase enzymes
US7319041B2 (en) * 2002-09-27 2008-01-15 Siemens Medical Solutions Diagnostic Applications of acridinium compounds and derivatives in homogeneous assays
US7309615B2 (en) 2002-09-27 2007-12-18 Siemens Medical Solutions Diagnostic High quantum yield acridinium compounds and their uses in improving assay sensitivity
US7732153B2 (en) 2006-05-09 2010-06-08 Beckman Coulter, Inc. Nonseparation assay methods
US7799534B2 (en) 2006-05-09 2010-09-21 Beckman Coulter, Inc. Nonseparation assay methods
CA3184105A1 (en) 2007-07-27 2009-02-05 Armagen Inc. Methods and compositions for increasing alpha-l-iduronidase activity in the cns
US20100240070A1 (en) * 2007-11-07 2010-09-23 Beckman Coulter, Inc. Nonseparation Assay Methods Using Peroxide Generating Enzymes
JP5844643B2 (ja) 2009-02-27 2016-01-20 ベックマン コールター， インコーポレイテッド 液相ホモジニアスアッセイ
EP2401393A1 (de) 2009-02-27 2012-01-04 Beckman Coulter, Inc. Testverfahren ohne trennung mit selektiven signalinhibitoren
US20110097723A1 (en) * 2009-09-19 2011-04-28 Qun Liu Methods and reagents for analyte detection
WO2011044542A1 (en) 2009-10-09 2011-04-14 Armagen Technologies, Inc. Methods and compositions for increasing iduronate 2-sulfatase activity in the cns
WO2012028167A2 (en) 2010-05-20 2012-03-08 Innohyphen Bv Acridinium ester chemiluminescence upon reductive triggering
CN104230804B (zh) * 2014-08-30 2016-05-25 云南民族大学 化学发光物aps-5关键中间体的制备方法
US10538589B2 (en) 2015-01-14 2020-01-21 Armagen Inc. Methods and compositions for increasing N-acetylglucosaminidase (NAGLU) activity in the CNS using a fusion antibody comprising an anti-human insulin receptor antibody and NAGLU
JP7055975B2 (ja) 2018-07-13 2022-04-19 スリーエム イノベイティブ プロパティズ カンパニー 特異的結合化学発光アッセイ
CN112400025A (zh) 2018-07-13 2021-02-23 3M创新有限公司 测定

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3645292C2 (de) * 1986-08-22 1997-12-11 Hoechst Ag Chemilumineszenzimmunoassays und ein Verfahren zu ihrer Herstellung
NZ227506A (en) * 1987-12-31 1992-06-25 London Diagnostics Inc Specific binding assays using chemiluminescent compounds
US4950613A (en) * 1988-02-26 1990-08-21 Gen-Probe Incorporated Proteted chemiluminescent labels
JP2859451B2 (ja) * 1991-01-11 1999-02-17 太平洋セメント株式会社 Ｎ−フルオロピリジニウム塩の製造方法
US5491072A (en) * 1993-05-17 1996-02-13 Lumigen, Inc. N-alkylacridan carboxyl derivatives useful for chemiluminescent detection

Also Published As

Publication number Publication date
WO1998002421A1 (en) 1998-01-22
JPH11514006A (ja) 1999-11-30
PT915851E (pt) 2002-09-30
DK0915851T3 (da) 2002-04-29
EP0915851B1 (de) 2002-03-20
DE69711188T2 (de) 2002-09-05
US6030803A (en) 2000-02-29
CA2261032C (en) 2003-11-25
ATE214697T1 (de) 2002-04-15
ES2171964T3 (es) 2002-09-16
CA2261032A1 (en) 1998-01-22
JP3338061B2 (ja) 2002-10-28
EP0915851A1 (de) 1999-05-19

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