DE69701923T2 - 3-(Piperid-4-yl)-1,2-benzisoxazol- und 3-(Piperazin-4-yl)-1,2-benzisoxazol-Derivate als Antipsychotika - Google Patents
3-(Piperid-4-yl)-1,2-benzisoxazol- und 3-(Piperazin-4-yl)-1,2-benzisoxazol-Derivate als AntipsychotikaInfo
- Publication number
- DE69701923T2 DE69701923T2 DE69701923T DE69701923T DE69701923T2 DE 69701923 T2 DE69701923 T2 DE 69701923T2 DE 69701923 T DE69701923 T DE 69701923T DE 69701923 T DE69701923 T DE 69701923T DE 69701923 T2 DE69701923 T2 DE 69701923T2
- Authority
- DE
- Germany
- Prior art keywords
- benzisoxazole
- piperid
- antipsychotics
- piperazin
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- ZDFQBFVFCPABKQ-UHFFFAOYSA-N 3-piperazin-1-yl-1,2-benzoxazole Chemical class C1CNCCN1C1=NOC2=CC=CC=C12 ZDFQBFVFCPABKQ-UHFFFAOYSA-N 0.000 title 1
- KEIQPPQTKPFHLZ-UHFFFAOYSA-N 3-piperidin-4-yl-1,2-benzoxazole Chemical compound C1CNCCC1C1=NOC2=CC=CC=C12 KEIQPPQTKPFHLZ-UHFFFAOYSA-N 0.000 title 1
- 239000000164 antipsychotic agent Substances 0.000 title 1
- 229940005529 antipsychotics Drugs 0.000 title 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000003287 optical effect Effects 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9606866A FR2749304B1 (fr) | 1996-06-04 | 1996-06-04 | Nouveaux derives du 3-(piperid-4-yl)1,2-benzisoxazole et du 3-(piperazin-4-yl)1,2-benzisoxazole, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69701923D1 DE69701923D1 (de) | 2000-06-15 |
DE69701923T2 true DE69701923T2 (de) | 2000-12-14 |
Family
ID=9492694
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69701923T Expired - Fee Related DE69701923T2 (de) | 1996-06-04 | 1997-06-04 | 3-(Piperid-4-yl)-1,2-benzisoxazol- und 3-(Piperazin-4-yl)-1,2-benzisoxazol-Derivate als Antipsychotika |
Country Status (19)
Country | Link |
---|---|
US (1) | US5780474A (de) |
EP (1) | EP0811622B1 (de) |
JP (1) | JPH1059967A (de) |
CN (1) | CN1073565C (de) |
AT (1) | ATE192745T1 (de) |
AU (1) | AU715266B2 (de) |
BR (1) | BR9703447A (de) |
CA (1) | CA2207835C (de) |
DE (1) | DE69701923T2 (de) |
DK (1) | DK0811622T3 (de) |
ES (1) | ES2148916T3 (de) |
FR (1) | FR2749304B1 (de) |
GR (1) | GR3033996T3 (de) |
HU (1) | HUP9700992A3 (de) |
NO (1) | NO308360B1 (de) |
NZ (1) | NZ314992A (de) |
PL (1) | PL187005B1 (de) |
PT (1) | PT811622E (de) |
ZA (1) | ZA974919B (de) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9286294B2 (en) | 1992-12-09 | 2016-03-15 | Comcast Ip Holdings I, Llc | Video and digital multimedia aggregator content suggestion engine |
US7168084B1 (en) | 1992-12-09 | 2007-01-23 | Sedna Patent Services, Llc | Method and apparatus for targeting virtual objects |
US6263443B1 (en) * | 1997-10-11 | 2001-07-17 | Agere Systems Guardian Corp. | Simplified data link protocol processor |
WO1999040067A2 (en) * | 1998-02-09 | 1999-08-12 | Duphar International Research B.V. | Benzisoxazole derivatives having d4-antagonistic activity |
US9924234B2 (en) | 1998-07-23 | 2018-03-20 | Comcast Ip Holdings I, Llc | Data structure and methods for providing an interactive program |
AU5006699A (en) * | 1998-07-23 | 2000-02-14 | Diva Systems Corporation | Interactive user interface |
US6754905B2 (en) | 1998-07-23 | 2004-06-22 | Diva Systems Corporation | Data structure and methods for providing an interactive program guide |
US6107313A (en) * | 1998-10-02 | 2000-08-22 | Combichem, Inc. | Dopamine receptor antagonists |
US7096487B1 (en) | 1999-10-27 | 2006-08-22 | Sedna Patent Services, Llc | Apparatus and method for combining realtime and non-realtime encoded content |
US6904610B1 (en) | 1999-04-15 | 2005-06-07 | Sedna Patent Services, Llc | Server-centric customized interactive program guide in an interactive television environment |
US6754271B1 (en) | 1999-04-15 | 2004-06-22 | Diva Systems Corporation | Temporal slice persistence method and apparatus for delivery of interactive program guide |
US7253165B2 (en) * | 1999-09-14 | 2007-08-07 | Aventis Pharmaceuticals Inc. | Benzisoxazolyl-, pyridoisoxazolyl-and benzthienyl-phenoxy derivatives useful as D4 antagonists |
US7091199B1 (en) | 1999-09-14 | 2006-08-15 | Aventis Pharmaceuticals Inc. | Thienoisoxazole phenoxy unsubstituted ethyl and propyl derivatives useful as d4 antagonists |
US7125903B1 (en) | 1999-09-14 | 2006-10-24 | Aventis Pharmaceuticals Inc. | Thienoisoxazolyl-and thienylpyrrazolyl-phenoxy substituted propyl derivatives useful as D4 antagonists |
AU7479400A (en) * | 1999-09-14 | 2001-04-17 | Aventis Pharmaceuticals Inc. | Benzisoxazolyl-, pyridoisoxazolyl- and benzthienyl-phenoxy derivatives useful as d4 antagonists |
ATE359669T1 (de) | 1999-10-27 | 2007-05-15 | Sedna Patent Services Llc | Vielfache videoströme unter verwendung von slice- basierter kodierung |
FR2803298A1 (fr) * | 1999-12-30 | 2001-07-06 | Adir | Nouvelles urees lineaires ou cycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
WO2002026708A1 (fr) * | 2000-09-27 | 2002-04-04 | Toray Industries, Inc. | Composes conenant de l'azote et inhibiteurs de ccr3 contenant ces composes en tant que principe actif |
US7908628B2 (en) | 2001-08-03 | 2011-03-15 | Comcast Ip Holdings I, Llc | Video and digital multimedia aggregator content coding and formatting |
US7793326B2 (en) | 2001-08-03 | 2010-09-07 | Comcast Ip Holdings I, Llc | Video and digital multimedia aggregator |
US20050203130A1 (en) * | 2003-12-02 | 2005-09-15 | Erik Buntinx | Use of D4 and 5-HT2A antagonists, inverse agonists or partial agonists |
EP1547650A1 (de) * | 2003-12-02 | 2005-06-29 | B & B Beheer NV | Verwendung von D4 und 5-HT2A Antagonisten, inverse Agonisten order partielle Agonisten |
US20050119249A1 (en) * | 2003-12-02 | 2005-06-02 | Erik Buntinx | Method of treating neurodegenerative diseases using D4 and 5-HT2A antagonists, inverse agonists or partial agonists |
US7855195B2 (en) * | 2003-12-02 | 2010-12-21 | Pharmaneuroboost N.V. | Method of treating mental disorders using D4 and 5-HT2A antagonists, inverse agonists or partial agonists |
US7884096B2 (en) * | 2003-12-02 | 2011-02-08 | Pharmaneuroboost N.V. | Method of treating mental disorders using of D4 and 5-HT2A antagonists, inverse agonists or partial agonists |
CA2547639A1 (en) * | 2003-12-02 | 2005-06-16 | B&B Beheer Nv | Use of d4 and 5-ht2a antagonists, inverse agonists or partial agonists |
US8816090B2 (en) * | 2005-02-25 | 2014-08-26 | Pfizer Inc. | Benzisoxazole derivatives |
JP2012502947A (ja) * | 2008-09-23 | 2012-02-02 | エフ.ホフマン−ラ ロシュ アーゲー | ドーパミンD3受容体の調節剤として有用なベンゾ[d]イソオキサゾール−3−イル−ピペラジン誘導体 |
JP2012502948A (ja) * | 2008-09-23 | 2012-02-02 | エフ.ホフマン−ラ ロシュ アーゲー | ドーパミンd3受容体の調節剤として有用なイソオキサゾロ[4,5]ピリジン−3−イル−ピペラジン誘導体 |
US9154813B2 (en) | 2011-06-09 | 2015-10-06 | Comcast Cable Communications, Llc | Multiple video content in a composite video stream |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE754641A (fr) * | 1969-08-11 | 1971-02-10 | Geigy Ag J R | Derives de l'imidazolidinone et medicaments contenant de tels derives |
US4352811A (en) * | 1981-11-12 | 1982-10-05 | Hoechst-Roussel Pharmaceuticals Inc. | 3-(1-Substituted-4-piperidyl)-1,2-benzisoxazoles |
US4458076A (en) * | 1983-05-31 | 1984-07-03 | Hoechst-Roussel Pharmaceuticals | 3-(4-Piperidinyl)-1,2-benzisothiazoles |
CA1335289C (en) * | 1987-10-26 | 1995-04-18 | Fujio Antoku | Piperidinyl benzisoxazole derivatives, their production and pharmaceutical use |
US5776963A (en) * | 1989-05-19 | 1998-07-07 | Hoechst Marion Roussel, Inc. | 3-(heteroaryl)-1- (2,3-dihydro-1h-isoindol-2-yl)alkyl!pyrrolidines and 3-(heteroaryl)-1- (2,3-dihydro-1h-indol-1-yl)alkyl!pyrrolidines and related compounds and their therapeutic untility |
CN1050604C (zh) * | 1993-02-04 | 2000-03-22 | 明治制果株式会社 | 具有抗精神病作用的化合物 |
-
1996
- 1996-06-04 FR FR9606866A patent/FR2749304B1/fr not_active Expired - Lifetime
-
1997
- 1997-05-28 JP JP9138264A patent/JPH1059967A/ja not_active Withdrawn
- 1997-06-02 NO NO972510A patent/NO308360B1/no not_active IP Right Cessation
- 1997-06-02 AU AU24649/97A patent/AU715266B2/en not_active Ceased
- 1997-06-03 NZ NZ314992A patent/NZ314992A/xx unknown
- 1997-06-03 PL PL97320325A patent/PL187005B1/pl not_active IP Right Cessation
- 1997-06-03 CA CA002207835A patent/CA2207835C/fr not_active Expired - Fee Related
- 1997-06-03 US US08/868,116 patent/US5780474A/en not_active Expired - Fee Related
- 1997-06-03 CN CN97105471A patent/CN1073565C/zh not_active Expired - Fee Related
- 1997-06-03 HU HU9700992A patent/HUP9700992A3/hu unknown
- 1997-06-04 EP EP97401243A patent/EP0811622B1/de not_active Expired - Lifetime
- 1997-06-04 PT PT97401243T patent/PT811622E/pt unknown
- 1997-06-04 DE DE69701923T patent/DE69701923T2/de not_active Expired - Fee Related
- 1997-06-04 AT AT97401243T patent/ATE192745T1/de not_active IP Right Cessation
- 1997-06-04 ZA ZA9704919A patent/ZA974919B/xx unknown
- 1997-06-04 DK DK97401243T patent/DK0811622T3/da active
- 1997-06-04 ES ES97401243T patent/ES2148916T3/es not_active Expired - Lifetime
- 1997-06-04 BR BR9703447A patent/BR9703447A/pt not_active IP Right Cessation
-
2000
- 2000-07-21 GR GR20000401682T patent/GR3033996T3/el not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
AU715266B2 (en) | 2000-01-20 |
NZ314992A (en) | 1999-05-28 |
AU2464997A (en) | 1997-12-11 |
CN1171401A (zh) | 1998-01-28 |
GR3033996T3 (en) | 2000-11-30 |
NO308360B1 (no) | 2000-09-04 |
NO972510D0 (no) | 1997-06-02 |
EP0811622A1 (de) | 1997-12-10 |
US5780474A (en) | 1998-07-14 |
CN1073565C (zh) | 2001-10-24 |
NO972510L (no) | 1997-12-05 |
DE69701923D1 (de) | 2000-06-15 |
PT811622E (pt) | 2000-08-31 |
FR2749304B1 (fr) | 1998-06-26 |
FR2749304A1 (fr) | 1997-12-05 |
BR9703447A (pt) | 1998-11-10 |
ATE192745T1 (de) | 2000-05-15 |
JPH1059967A (ja) | 1998-03-03 |
ES2148916T3 (es) | 2000-10-16 |
HU9700992D0 (en) | 1997-07-28 |
CA2207835C (fr) | 2001-10-02 |
HUP9700992A2 (hu) | 1998-12-28 |
CA2207835A1 (fr) | 1997-12-04 |
DK0811622T3 (da) | 2000-09-11 |
PL320325A1 (en) | 1997-12-08 |
ZA974919B (en) | 1997-12-30 |
EP0811622B1 (de) | 2000-05-10 |
HUP9700992A3 (en) | 1999-03-29 |
PL187005B1 (pl) | 2004-04-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8327 | Change in the person/name/address of the patent owner |
Owner name: LES LABORATOIRES SERVIER, NEUILLY SUR SEINE, FR |
|
8339 | Ceased/non-payment of the annual fee |