DE69634691D1 - Tricyclische amid-derivate verwendbar als g-protein funktion inhibitoren und für die behandlung von proliferativen erkrankungen - Google Patents

Tricyclische amid-derivate verwendbar als g-protein funktion inhibitoren und für die behandlung von proliferativen erkrankungen

Info

Publication number
DE69634691D1
DE69634691D1 DE69634691T DE69634691T DE69634691D1 DE 69634691 D1 DE69634691 D1 DE 69634691D1 DE 69634691 T DE69634691 T DE 69634691T DE 69634691 T DE69634691 T DE 69634691T DE 69634691 D1 DE69634691 D1 DE 69634691D1
Authority
DE
Germany
Prior art keywords
tricyclic
treatment
proliferative diseases
protein function
function inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69634691T
Other languages
English (en)
Other versions
DE69634691T2 (de
Inventor
J Doll
George Njoroge
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme Corp
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of DE69634691D1 publication Critical patent/DE69634691D1/de
Application granted granted Critical
Publication of DE69634691T2 publication Critical patent/DE69634691T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE69634691T 1995-03-24 1996-03-21 Tricyclische amid-derivate verwendbar als g-protein funktion inhibitoren und für die behandlung von proliferativen erkrankungen Expired - Fee Related DE69634691T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/410,443 US5700806A (en) 1995-03-24 1995-03-24 Tricyclic amide and urea compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
US410443 1995-03-24
PCT/US1996/003313 WO1996030362A1 (en) 1995-03-24 1996-03-21 Tricyclic amide and urea compounds useful for inhibition of g-protein function and for treatment of proliferative diseases

Publications (2)

Publication Number Publication Date
DE69634691D1 true DE69634691D1 (de) 2005-06-09
DE69634691T2 DE69634691T2 (de) 2006-02-23

Family

ID=23624755

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69634691T Expired - Fee Related DE69634691T2 (de) 1995-03-24 1996-03-21 Tricyclische amid-derivate verwendbar als g-protein funktion inhibitoren und für die behandlung von proliferativen erkrankungen

Country Status (15)

Country Link
US (2) US5700806A (de)
EP (1) EP0815099B1 (de)
JP (1) JP3095781B2 (de)
KR (1) KR19980703256A (de)
AR (1) AR002722A1 (de)
AT (1) ATE294791T1 (de)
AU (1) AU711238B2 (de)
CA (1) CA2216163C (de)
DE (1) DE69634691T2 (de)
ES (1) ES2238689T3 (de)
HU (1) HUP9801331A3 (de)
IL (1) IL117602A0 (de)
NZ (1) NZ305137A (de)
TW (1) TW349097B (de)
WO (1) WO1996030362A1 (de)

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Also Published As

Publication number Publication date
ATE294791T1 (de) 2005-05-15
AR002722A1 (es) 1998-04-29
IL117602A0 (en) 1996-07-23
HUP9801331A3 (en) 1999-06-28
JPH10505104A (ja) 1998-05-19
MX9707232A (es) 1997-11-29
US5807852A (en) 1998-09-15
CA2216163A1 (en) 1996-10-03
EP0815099B1 (de) 2005-05-04
JP3095781B2 (ja) 2000-10-10
NZ305137A (en) 1999-04-29
US5700806A (en) 1997-12-23
ES2238689T3 (es) 2005-09-01
WO1996030362A1 (en) 1996-10-03
TW349097B (en) 1999-01-01
AU711238B2 (en) 1999-10-07
HUP9801331A2 (hu) 1999-05-28
EP0815099A1 (de) 1998-01-07
KR19980703256A (ko) 1998-10-15
AU5307696A (en) 1996-10-16
CA2216163C (en) 2001-06-05
DE69634691T2 (de) 2006-02-23

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