DE69634437D1 - Vegf-c-rezeptorligand - Google Patents
Vegf-c-rezeptorligandInfo
- Publication number
- DE69634437D1 DE69634437D1 DE69634437T DE69634437T DE69634437D1 DE 69634437 D1 DE69634437 D1 DE 69634437D1 DE 69634437 T DE69634437 T DE 69634437T DE 69634437 T DE69634437 T DE 69634437T DE 69634437 D1 DE69634437 D1 DE 69634437D1
- Authority
- DE
- Germany
- Prior art keywords
- ligands
- vegf
- receptor ligand
- flt4
- cdnas
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000003446 ligand Substances 0.000 title abstract 5
- 102000009520 Vascular Endothelial Growth Factor C Human genes 0.000 title 1
- 108010073923 Vascular Endothelial Growth Factor C Proteins 0.000 title 1
- 108020004635 Complementary DNA Proteins 0.000 abstract 1
- 101150009958 FLT4 gene Proteins 0.000 abstract 1
- 102000016663 Vascular Endothelial Growth Factor Receptor-3 Human genes 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 102000027426 receptor tyrosine kinases Human genes 0.000 abstract 1
- 108091008598 receptor tyrosine kinases Proteins 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Dermatology (AREA)
- Cell Biology (AREA)
- Vascular Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
- Pens And Brushes (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
Applications Claiming Priority (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US510133 | 1983-07-01 | ||
US08/510,133 US6221839B1 (en) | 1994-11-14 | 1995-08-01 | FIt4 ligand and methods of use |
US585895 | 1996-01-12 | ||
US08/585,895 US6245530B1 (en) | 1995-08-01 | 1996-01-12 | Receptor ligand |
US601132 | 1996-02-14 | ||
US08/601,132 US6403088B1 (en) | 1995-08-01 | 1996-02-14 | Antibodies reactive with VEGF-C, a ligand for the Flt4 receptor tyrosine kinase (VEGFR-3) |
US671573 | 1996-06-28 | ||
US08/671,573 US6645933B1 (en) | 1995-08-01 | 1996-06-28 | Receptor ligand VEGF-C |
PCT/FI1996/000427 WO1997005250A2 (en) | 1995-08-01 | 1996-08-01 | Receptor ligand vegf-c |
Publications (3)
Publication Number | Publication Date |
---|---|
DE69634437D1 true DE69634437D1 (de) | 2005-04-14 |
DE69634437T2 DE69634437T2 (de) | 2006-04-13 |
DE69634437T3 DE69634437T3 (de) | 2011-02-17 |
Family
ID=27504489
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69634437T Expired - Lifetime DE69634437T3 (de) | 1995-08-01 | 1996-08-01 | Vegf-c-rezeptorligand |
Country Status (12)
Country | Link |
---|---|
US (2) | US6645933B1 (de) |
EP (2) | EP0842273B2 (de) |
AT (1) | ATE290594T1 (de) |
AU (1) | AU711578B2 (de) |
CA (1) | CA2228248A1 (de) |
DE (1) | DE69634437T3 (de) |
DK (1) | DK0842273T3 (de) |
ES (1) | ES2238694T5 (de) |
HK (1) | HK1014984A1 (de) |
NZ (1) | NZ313647A (de) |
PT (1) | PT842273E (de) |
WO (1) | WO1997005250A2 (de) |
Families Citing this family (78)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6824777B1 (en) | 1992-10-09 | 2004-11-30 | Licentia Ltd. | Flt4 (VEGFR-3) as a target for tumor imaging and anti-tumor therapy |
US6107046A (en) * | 1992-10-09 | 2000-08-22 | Orion Corporation | Antibodies to Flt4, a receptor tyrosine kinase and uses thereof |
US7186688B1 (en) | 1994-03-08 | 2007-03-06 | Human Genome Sciences, Inc. | Methods of stimulating angiogenesis in a patient by administering vascular endothelial growth factor 2 |
US6608182B1 (en) * | 1994-03-08 | 2003-08-19 | Human Genome Sciences, Inc. | Human vascular endothelial growth factor 2 |
US7109308B1 (en) * | 1994-03-08 | 2006-09-19 | Human Genome Sciences, Inc. | Antibodies to human vascular endothelial growth factor 2 |
US6040157A (en) * | 1994-03-08 | 2000-03-21 | Human Genome Sciences, Inc. | Vascular endothelial growth factor 2 |
AU696764B2 (en) * | 1994-03-08 | 1998-09-17 | Human Genome Sciences, Inc. | Vascular endothelial growth factor 2 |
US6734285B2 (en) | 1994-03-08 | 2004-05-11 | Human Genome Sciences, Inc. | Vascular endothelial growth factor 2 proteins and compositions |
US5932540A (en) | 1994-03-08 | 1999-08-03 | Human Genome Sciences, Inc. | Vascular endothelial growth factor 2 |
US7153827B1 (en) | 1994-03-08 | 2006-12-26 | Human Genome Sciences, Inc. | Vascular endothelial growth factor 2 and methods of use |
US6818220B1 (en) | 1994-11-14 | 2004-11-16 | Licentia Ltd. | Vascular endothelial growth factor C (VEGF-C) protein and gene mutants thereof, and uses thereof |
US6245530B1 (en) | 1995-08-01 | 2001-06-12 | Ludwig Institute For Cancer Research | Receptor ligand |
US6645933B1 (en) | 1995-08-01 | 2003-11-11 | Helsinki University Licensing Ltd. Oy | Receptor ligand VEGF-C |
WO1998033917A1 (en) * | 1994-11-14 | 1998-08-06 | The Ludwig Institute For Cancer Research | Vascular endothelial growth factor c (vegf-c) protein and gene, mutants thereof, and uses thereof |
US6130071A (en) * | 1997-02-05 | 2000-10-10 | Helsinki University Licensing, Ltd. | Vascular endothelial growth factor C (VEGF-C) ΔCys156 protein and gene, and uses thereof |
US6403088B1 (en) | 1995-08-01 | 2002-06-11 | Helsinki University Licensing, Ltd. | Antibodies reactive with VEGF-C, a ligand for the Flt4 receptor tyrosine kinase (VEGFR-3) |
US6221839B1 (en) | 1994-11-14 | 2001-04-24 | Helsinki University Licensing Ltd. Oy | FIt4 ligand and methods of use |
US7423125B2 (en) | 1995-08-01 | 2008-09-09 | Vegenics Limited | Antibodies to VEGF-C |
US6361946B1 (en) | 1997-02-05 | 2002-03-26 | Licentia Ltd | Vascular endothelial growth factor C (VEGF-C) protein and gene, mutants thereof, and uses thereof |
US6451764B1 (en) * | 1995-09-08 | 2002-09-17 | Genentech, Inc. | VEGF-related protein |
ATE290077T1 (de) | 1995-09-29 | 2005-03-15 | Univ Siena | Regulierte gene und ihre verwendungen |
US6994989B1 (en) | 1995-11-08 | 2006-02-07 | Immunex Corp. | FLK-1 binding proteins |
AU1116297A (en) | 1995-11-08 | 1997-05-29 | Immunex Corporation | Flk-1 binding protein |
DE69733204T3 (de) | 1996-07-15 | 2012-03-08 | Chugai Seiyaku K.K. | Neuartige vegf-ähnliche faktoren |
ES2251740T3 (es) | 1996-08-23 | 2006-05-01 | Ludwig Institute For Cancer Research | Factor de crecimiento de celulas de endotelio vascular d recombinante (vegf-d). |
GB9708265D0 (en) * | 1997-04-24 | 1997-06-18 | Nycomed Imaging As | Contrast agents |
US20060171907A1 (en) * | 1996-11-21 | 2006-08-03 | The Procter & Gamble Company | Oral care compositions providing enhanced whitening and stain prevention |
US7125714B2 (en) | 1997-02-05 | 2006-10-24 | Licentia Ltd. | Progenitor cell materials and methods |
NZ514872A (en) * | 1997-04-25 | 2005-01-28 | Collateral Therapeutics | Truncated VEGF-B, VRF-2, VEGF-C, PlGF, VEGF-3, poxvirus ORF-1 and poxvirus ORF-2 proteins |
SG117417A1 (en) | 1998-02-06 | 2005-12-29 | Collateral Therpeutics Inc | Variants of the angiogenic factor vascular endothelial cell growth factor: vegf |
JP2002505873A (ja) * | 1998-03-13 | 2002-02-26 | ヒューマン ジノーム サイエンシーズ, インコーポレイテッド | 血管内皮増殖因子2 |
CA2331601A1 (en) * | 1998-03-27 | 1999-10-07 | Charles Little | Vegf and vegf-c as infant formula supplements |
CA2345276C (en) | 1998-10-09 | 2011-03-29 | Ludwig Institute For Cancer Research | Flt4 (vegfr-3) as a target for tumor imaging and anti-tumor therapy |
US6958147B1 (en) | 1998-10-26 | 2005-10-25 | Licentia Ltd | Use of VEGF-C to prevent restenosis |
US6783953B1 (en) | 1998-12-22 | 2004-08-31 | Janssen Pharmaceutica N.V. | Vascular endothelial growth factor-X |
US7223724B1 (en) * | 1999-02-08 | 2007-05-29 | Human Genome Sciences, Inc. | Use of vascular endothelial growth factor to treat photoreceptor cells |
WO2000058511A1 (en) * | 1999-03-26 | 2000-10-05 | Ludwig Institute For Cancer Research | Screening and therapy for lymphatic disorders involving the flt4 receptor tyrosine kinase (vegfr-3) |
US6764820B2 (en) | 1999-03-26 | 2004-07-20 | Ludwig Institute For Cancer Research | Screening for lymphatic disorders involving the FLT4 receptor tyrosine kinase (VEGFR-3) |
US7740841B1 (en) | 2000-01-28 | 2010-06-22 | Sunnybrook Health Science Center | Therapeutic method for reducing angiogenesis |
AU3988401A (en) * | 2000-02-25 | 2001-09-03 | Ludwig Inst Cancer Res | Materials and methods involving hybrid vascular endothelial growth factor dnas and proteins |
JP2004505619A (ja) * | 2000-08-04 | 2004-02-26 | ヒューマン ジノーム サイエンシーズ, インコーポレイテッド | 血管内皮増殖因子2 |
WO2002029087A2 (en) * | 2000-10-02 | 2002-04-11 | St. Elizabeth's Medical Center Of Boston, Inc. | Use of lymphangiogenic agents to treat lymphatic disorders |
AU2884102A (en) | 2000-12-07 | 2002-06-18 | Sangamo Biosciences Inc | Regulation of angiogenesis with zinc finger proteins |
US7067317B2 (en) | 2000-12-07 | 2006-06-27 | Sangamo Biosciences, Inc. | Regulation of angiogenesis with zinc finger proteins |
US20030211988A1 (en) * | 2001-01-09 | 2003-11-13 | Epstein Stephen E | Enhancing lymph channel development and treatment of lymphatic obstructive disease |
US7611711B2 (en) * | 2001-01-17 | 2009-11-03 | Vegenics Limited | VEGFR-3 inhibitor materials and methods |
CA2435503C (en) | 2001-01-19 | 2011-02-22 | Ludwig Institute For Cancer Research | Flt4(vegfr-3) as a target for tumor imaging and anti-tumor therapy |
US20030176674A1 (en) * | 2001-04-13 | 2003-09-18 | Rosen Craig A. | Vascular endothelial growth factor 2 |
EP1385864B1 (de) | 2001-04-13 | 2010-06-09 | Human Genome Sciences, Inc. | Anti-VEGF-2 Antikörper |
US7402312B2 (en) | 2001-04-13 | 2008-07-22 | Human Genome Sciences, Inc. | Antibodies to vascular endothelial growth factor 2 (VEGF-2) |
US20050232921A1 (en) * | 2001-04-13 | 2005-10-20 | Rosen Craig A | Vascular endothelial growth factor 2 |
CA2453161A1 (en) * | 2001-07-12 | 2003-01-23 | Ludwig Institute For Cancer Research | Lymphatic endothelial cells materials and methods |
US20030113324A1 (en) * | 2001-10-01 | 2003-06-19 | Kari Alitalo | Neuropilin/VEGF-C/VEGFR-3 materials and methods |
US20040214766A1 (en) * | 2001-10-01 | 2004-10-28 | Kari Alitalo | VEGF-C or VEGF-D materials and methods for treatment of neuropathologies |
US8623822B2 (en) | 2002-03-01 | 2014-01-07 | Bracco Suisse Sa | KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy |
US7666979B2 (en) * | 2002-03-01 | 2010-02-23 | Bracco International B.V. | Methods for preparing multivalent constructs for therapeutic and diagnostic applications and methods of preparing the same |
US7211240B2 (en) * | 2002-03-01 | 2007-05-01 | Bracco International B.V. | Multivalent constructs for therapeutic and diagnostic applications |
WO2004065621A1 (en) | 2002-03-01 | 2004-08-05 | Dyax Corp. | Kdr and vegf/kdr binding peptides and their use in diagnosis and therapy |
US7261876B2 (en) | 2002-03-01 | 2007-08-28 | Bracco International Bv | Multivalent constructs for therapeutic and diagnostic applications |
US7985402B2 (en) * | 2002-03-01 | 2011-07-26 | Bracco Suisse Sa | Targeting vector-phospholipid conjugates |
US7794693B2 (en) | 2002-03-01 | 2010-09-14 | Bracco International B.V. | Targeting vector-phospholipid conjugates |
US20050250700A1 (en) * | 2002-03-01 | 2005-11-10 | Sato Aaron K | KDR and VEGF/KDR binding peptides |
US20040120950A1 (en) * | 2002-12-20 | 2004-06-24 | Kari Alitalo | Modulation of VEGF-C/VEGFR-3 interactions in the treatment of rheumatoid arthritis |
WO2004070018A2 (en) * | 2003-02-04 | 2004-08-19 | Ludwig Institute For Cancer Research | Vegf-b and pdgf modulation of stem cells |
SI2949658T1 (sl) | 2003-03-03 | 2018-10-30 | Dyax Corp. | Peptidi, ki specifično vežejo HGF receptor (cMet) in njihove uporabe |
WO2005011722A2 (en) * | 2003-06-12 | 2005-02-10 | Ludwig Institute For Cancer Research | Use of vegf-c or vegf-d in reconstructive surgery |
US20050032697A1 (en) * | 2003-06-12 | 2005-02-10 | Kari Alitalo | Heparin binding VEGFR-3 ligands |
WO2005087177A2 (en) * | 2004-03-05 | 2005-09-22 | Ludwig Institute For Cancer Research | Chimeric anti-vegf-d antibodies and humanized anti-vegf-d antibodies and methods of using same |
US20050282233A1 (en) * | 2004-03-05 | 2005-12-22 | Ludwig Institute For Cancer Research | Multivalent antibody materials and methods for VEGF/PDGF family of growth factors |
EP2314614B1 (de) | 2005-02-28 | 2015-11-25 | Sangamo BioSciences, Inc. | Anti-angiogene Verfahren und Zusammensetzungen |
ES2363758T3 (es) | 2005-08-15 | 2011-08-16 | Vegenics Pty Ltd | Vegf y pdgf modificados con propiedades angiogénicas mejoradas. |
US20080267924A1 (en) * | 2007-02-07 | 2008-10-30 | Vegenics Limited | Autologous lymph node transfer in combination with vegf-c or vegf-d growth factor therapy to treat secondary lymphedema and to improve reconstructive surgery |
WO2011154308A1 (en) | 2010-06-08 | 2011-12-15 | Proyecto De Biomedicina Cima, S.L. | New compositions and cell therapy methods for the treatment of cirrhosis |
WO2012088563A1 (en) * | 2010-11-24 | 2012-07-05 | Vegenics Pty Limited | Vegfr-2-specific forms of vegf-d and vegf-c and uses thereof |
JP6261617B2 (ja) | 2013-02-14 | 2018-01-17 | ユーシーエル ビジネス ピーエルシー | 嚢胞性腎疾患の処置に使用されるリンパ管新生を誘発する作用物質 |
EP2956476B1 (de) | 2013-02-18 | 2019-12-25 | Vegenics Pty Limited | Ligandbindende moleküle und verwendungen davon |
EP2994758B1 (de) | 2013-05-08 | 2017-12-20 | Opthea Limited | Biomarker für altersbedingte makuladegeneration (amd) |
EP3110940A1 (de) * | 2014-02-28 | 2017-01-04 | Bayer Animal Health GmbH | Immunstimulierende plasmide |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4959314A (en) | 1984-11-09 | 1990-09-25 | Cetus Corporation | Cysteine-depleted muteins of biologically active proteins |
US5332671A (en) | 1989-05-12 | 1994-07-26 | Genetech, Inc. | Production of vascular endothelial cell growth factor and DNA encoding same |
US5219739A (en) | 1989-07-27 | 1993-06-15 | Scios Nova Inc. | DNA sequences encoding bVEGF120 and hVEGF121 and methods for the production of bovine and human vascular endothelial cell growth factors, bVEGF120 and hVEGF121 |
DE69034135T3 (de) | 1989-12-22 | 2012-08-23 | Laboratoires Serono S.A. | DNS-Konstrukten zur Aktivierung und Veränderung der Expression von endogenen Genen |
DE69229454T2 (de) | 1991-03-28 | 2000-01-05 | Merck & Co., Inc. | Untereinheit-C des vaskulären endothelialen Zellwachstumsfaktors |
CA2092695A1 (en) | 1991-05-15 | 1992-11-16 | Oliver Smithies | Genomic modifications with homologous dna targeting |
US5326695A (en) | 1992-05-15 | 1994-07-05 | Ludwig Institute For Cancer Research | Platelet derived growth factor agonists |
TW402639B (en) | 1992-12-03 | 2000-08-21 | Transkaryotic Therapies Inc | Protein production and protein delivery |
US5932540A (en) | 1994-03-08 | 1999-08-03 | Human Genome Sciences, Inc. | Vascular endothelial growth factor 2 |
US6040157A (en) | 1994-03-08 | 2000-03-21 | Human Genome Sciences, Inc. | Vascular endothelial growth factor 2 |
US6608182B1 (en) | 1994-03-08 | 2003-08-19 | Human Genome Sciences, Inc. | Human vascular endothelial growth factor 2 |
AU696764B2 (en) | 1994-03-08 | 1998-09-17 | Human Genome Sciences, Inc. | Vascular endothelial growth factor 2 |
GB9410534D0 (en) | 1994-05-26 | 1994-07-13 | Lynxvale Ltd | Improvements in or relating to growth factor inhibitors |
WO1995033772A1 (en) | 1994-06-09 | 1995-12-14 | Kari Alitalo | Flt4 receptor tyrosine kinase and its use in diagnosis and therapy |
US5814464A (en) | 1994-10-07 | 1998-09-29 | Regeneron Pharma | Nucleic acids encoding TIE-2 ligand-2 |
US6645933B1 (en) | 1995-08-01 | 2003-11-11 | Helsinki University Licensing Ltd. Oy | Receptor ligand VEGF-C |
US6130071A (en) | 1997-02-05 | 2000-10-10 | Helsinki University Licensing, Ltd. | Vascular endothelial growth factor C (VEGF-C) ΔCys156 protein and gene, and uses thereof |
US5607918A (en) | 1995-03-01 | 1997-03-04 | Ludwig Institute For Cancer Research | Vascular endothelial growth factor-B and DNA coding therefor |
IL117645A (en) | 1995-03-30 | 2005-08-31 | Genentech Inc | Vascular endothelial cell growth factor antagonists for use as medicaments in the treatment of age-related macular degeneration |
WO1996039421A1 (en) | 1995-06-06 | 1996-12-12 | Human Genome Sciences, Inc. | Human vascular endothelial growth factor 3 |
US6361946B1 (en) * | 1997-02-05 | 2002-03-26 | Licentia Ltd | Vascular endothelial growth factor C (VEGF-C) protein and gene, mutants thereof, and uses thereof |
US6451764B1 (en) | 1995-09-08 | 2002-09-17 | Genentech, Inc. | VEGF-related protein |
AU1116297A (en) | 1995-11-08 | 1997-05-29 | Immunex Corporation | Flk-1 binding protein |
-
1996
- 1996-06-28 US US08/671,573 patent/US6645933B1/en not_active Expired - Fee Related
- 1996-08-01 EP EP96925768A patent/EP0842273B2/de not_active Expired - Lifetime
- 1996-08-01 AT AT96925768T patent/ATE290594T1/de not_active IP Right Cessation
- 1996-08-01 DE DE69634437T patent/DE69634437T3/de not_active Expired - Lifetime
- 1996-08-01 WO PCT/FI1996/000427 patent/WO1997005250A2/en active IP Right Grant
- 1996-08-01 AU AU66169/96A patent/AU711578B2/en not_active Withdrawn - After Issue
- 1996-08-01 PT PT96925768T patent/PT842273E/pt unknown
- 1996-08-01 CA CA002228248A patent/CA2228248A1/en not_active Abandoned
- 1996-08-01 ES ES96925768T patent/ES2238694T5/es not_active Expired - Lifetime
- 1996-08-01 DK DK96925768T patent/DK0842273T3/da active
- 1996-08-01 NZ NZ313647A patent/NZ313647A/en unknown
- 1996-08-01 EP EP05101466A patent/EP1612268A1/de not_active Withdrawn
-
1998
- 1998-11-20 HK HK98112169A patent/HK1014984A1/xx not_active IP Right Cessation
-
2000
- 2000-08-02 US US09/631,092 patent/US6730658B1/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP1612268A1 (de) | 2006-01-04 |
PT842273E (pt) | 2005-07-29 |
NZ313647A (en) | 2001-06-29 |
DE69634437T2 (de) | 2006-04-13 |
WO1997005250A2 (en) | 1997-02-13 |
DE69634437T3 (de) | 2011-02-17 |
EP0842273A2 (de) | 1998-05-20 |
JP4324709B2 (ja) | 2009-09-02 |
AU711578B2 (en) | 1999-10-14 |
ATE290594T1 (de) | 2005-03-15 |
ES2238694T5 (es) | 2010-12-21 |
EP0842273B1 (de) | 2005-03-09 |
AU6616996A (en) | 1997-02-26 |
HK1014984A1 (en) | 1999-10-08 |
JPH11510689A (ja) | 1999-09-21 |
CA2228248A1 (en) | 1997-02-13 |
US6730658B1 (en) | 2004-05-04 |
DK0842273T3 (da) | 2005-07-04 |
ES2238694T3 (es) | 2005-09-01 |
WO1997005250A3 (en) | 1997-04-10 |
US6645933B1 (en) | 2003-11-11 |
EP0842273B2 (de) | 2010-07-14 |
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Owner name: VEGENICS LTD., TOORAK, VICTORIA, AU |
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8366 | Restricted maintained after opposition proceedings |