DE69610709T2 - N-aroyl-glycin-hydroxamsäure-derivate und verwandte verbindungen - Google Patents
N-aroyl-glycin-hydroxamsäure-derivate und verwandte verbindungenInfo
- Publication number
- DE69610709T2 DE69610709T2 DE69610709T DE69610709T DE69610709T2 DE 69610709 T2 DE69610709 T2 DE 69610709T2 DE 69610709 T DE69610709 T DE 69610709T DE 69610709 T DE69610709 T DE 69610709T DE 69610709 T2 DE69610709 T2 DE 69610709T2
- Authority
- DE
- Germany
- Prior art keywords
- aroyl
- acid derivatives
- related compounds
- hydroxamic acid
- glycine hydroxamic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/401—Proline; Derivatives thereof, e.g. captopril
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/52—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
- C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/10—Systems containing only non-condensed rings with a five-membered ring the ring being unsaturated
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US152495P | 1995-07-26 | 1995-07-26 | |
PCT/IB1996/000451 WO1997005105A1 (en) | 1995-07-26 | 1996-05-14 | N-(aroyl)glycine hydroxamic acid derivatives and related compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69610709D1 DE69610709D1 (de) | 2000-11-23 |
DE69610709T2 true DE69610709T2 (de) | 2001-02-22 |
Family
ID=21696482
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69610709T Expired - Fee Related DE69610709T2 (de) | 1995-07-26 | 1996-05-14 | N-aroyl-glycin-hydroxamsäure-derivate und verwandte verbindungen |
Country Status (21)
Country | Link |
---|---|
US (2) | US6225351B1 (de) |
EP (1) | EP0850215B1 (de) |
JP (1) | JP3131225B2 (de) |
KR (1) | KR100332273B1 (de) |
CN (1) | CN1090614C (de) |
AT (1) | ATE197038T1 (de) |
AU (1) | AU711755B2 (de) |
CA (1) | CA2227237C (de) |
DE (1) | DE69610709T2 (de) |
DK (1) | DK0850215T3 (de) |
ES (1) | ES2151156T3 (de) |
GR (1) | GR3034969T3 (de) |
HK (1) | HK1018047A1 (de) |
IL (1) | IL118889A (de) |
MX (1) | MX9800710A (de) |
NO (1) | NO310230B1 (de) |
NZ (1) | NZ305940A (de) |
PT (1) | PT850215E (de) |
TW (1) | TW401389B (de) |
WO (1) | WO1997005105A1 (de) |
ZA (1) | ZA966314B (de) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5698579A (en) * | 1993-07-02 | 1997-12-16 | Celgene Corporation | Cyclic amides |
US5801195A (en) | 1994-12-30 | 1998-09-01 | Celgene Corporation | Immunotherapeutic aryl amides |
US5728845A (en) | 1995-08-29 | 1998-03-17 | Celgene Corporation | Immunotherapeutic nitriles |
KR19990001101A (ko) * | 1997-06-12 | 1999-01-15 | 손경식 | 캐테콜 아미노산 유도체, 이의 제조방법 및 그를 함유한 약제 조성물 |
HUP0003761A3 (en) | 1997-07-31 | 2001-04-28 | Celgene Corp Warren | Substituted alkanohydroxamic acids and pharmaceutical compositions containing them |
US6020358A (en) * | 1998-10-30 | 2000-02-01 | Celgene Corporation | Substituted phenethylsulfones and method of reducing TNFα levels |
DK1212089T3 (da) | 1999-08-21 | 2006-07-24 | Altana Pharma Ag | Synergistisk kombination af Roflumilast og Salmeterol |
US6667316B1 (en) | 1999-11-12 | 2003-12-23 | Celgene Corporation | Pharmaceutically active isoindoline derivatives |
US6699899B1 (en) | 1999-12-21 | 2004-03-02 | Celgene Corporation | Substituted acylhydroxamic acids and method of reducing TNFα levels |
US6326388B1 (en) | 1999-12-21 | 2001-12-04 | Celgene Corporation | Substituted 1,3,4-oxadiazoles and a method of reducing TNF-alpha level |
US8030343B2 (en) | 2000-06-08 | 2011-10-04 | Celgene Corporation | Pharmaceutically active isoindoline derivatives |
IT1317049B1 (it) * | 2000-06-23 | 2003-05-26 | Sigma Tau Ind Farmaceuti | Composti utili per la preparazione di medicamenti ad attivita'inibitrice della fosfodiesterasi iv. |
WO2004007444A2 (en) * | 2002-07-11 | 2004-01-22 | Vicuron Pharmaceuticals, Inc. | N-hydroxyamide derivatives possessing antibacterial activity |
CA2851462A1 (en) * | 2003-01-08 | 2004-07-29 | University Of Washington | Antibacterial agents |
US7244759B2 (en) | 2004-07-28 | 2007-07-17 | Celgene Corporation | Isoindoline compounds and methods of making and using the same |
JP2009506069A (ja) | 2005-08-26 | 2009-02-12 | ブレインセルス,インコーポレイティド | ムスカリン性受容体調節による神経発生 |
EP2258358A3 (de) | 2005-08-26 | 2011-09-07 | Braincells, Inc. | Neurogenese mit Acetylcholinesterasehemmer |
JP2009512711A (ja) | 2005-10-21 | 2009-03-26 | ブレインセルス,インコーポレイティド | Pde阻害による神経新生の調節 |
AU2006308889A1 (en) | 2005-10-31 | 2007-05-10 | Braincells, Inc. | GABA receptor mediated modulation of neurogenesis |
EP2338878A3 (de) * | 2005-12-15 | 2011-11-16 | Vicuron Pharmaceuticals, Inc. | N-Hydroxyamidderivate mit antibakterieller Wirkung |
US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
AU2007249399A1 (en) | 2006-05-09 | 2007-11-22 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
US7678808B2 (en) | 2006-05-09 | 2010-03-16 | Braincells, Inc. | 5 HT receptor mediated neurogenesis |
US7998971B2 (en) | 2006-09-08 | 2011-08-16 | Braincells Inc. | Combinations containing a 4-acylaminopyridine derivative |
US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
CA2934114A1 (en) | 2007-06-12 | 2008-12-18 | Achaogen, Inc. | Antibacterial agents |
CA2711426C (en) | 2008-01-08 | 2018-05-22 | Lantheus Medical Imaging, Inc. | N-alkoxyamide conjugates as imaging agents |
EP2196465A1 (de) | 2008-12-15 | 2010-06-16 | Almirall, S.A. | (3-oxo)pyridazin-4-ylurea-Derivate als PDE4 Hemmern |
WO2010099217A1 (en) | 2009-02-25 | 2010-09-02 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
EP2226323A1 (de) | 2009-02-27 | 2010-09-08 | Almirall, S.A. | Neuartige Tetrahydropyrazol[3,4-c]isochinolin-5-amin-Derivate |
EP2380890A1 (de) | 2010-04-23 | 2011-10-26 | Almirall, S.A. | Neue 7,8-Dihydro-1,6-Naphthyridin-5(6H)-on-Derivate als PDE4 Inhibitoren |
EP2394998A1 (de) | 2010-05-31 | 2011-12-14 | Almirall, S.A. | 3-(5-Amino-6-oxo-1,6-dihydropyridazin-3-yl)-biphenyl Derivate als PDE4 Inhibitoren |
EP2804603A1 (de) | 2012-01-10 | 2014-11-26 | President and Fellows of Harvard College | Betazellen-replikation für promoterverbindungen und verwendungsverfahren dafür |
EP2847168A1 (de) | 2012-05-10 | 2015-03-18 | Achaogen, Inc. | Antibakterielle wirkstoffe |
CN108821999A (zh) * | 2018-04-26 | 2018-11-16 | 南昌大学 | 一种氨基酸异羟肟酸类氨肽酶n抑制剂及制备方法 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3732295A (en) * | 1969-11-25 | 1973-05-08 | Dompe Farmaceutici Spa | Trimethoxybenzoyl-aminoalkanoic acids |
US3692827A (en) * | 1970-06-26 | 1972-09-19 | Inst Chemioterapico Italiano S | Derivatives of aminoalkanoic acids |
GB1418595A (en) * | 1973-02-14 | 1975-12-24 | Ss Pharmaceutical Co | N- 2-alkoxybenzoyl- amino acids and a process for producing the same |
US4193926A (en) | 1974-03-20 | 1980-03-18 | Schering Aktiengesellschaft | 4-(Polyalkoxy phenyl)-2-pyrrolidones |
US4728670A (en) | 1986-06-04 | 1988-03-01 | E. R. Squibb & Sons, Inc. | Biphenyl hydroxamic acids |
CA1316935C (en) | 1987-12-09 | 1993-04-27 | Hiromitsu Saito | Hydroxamic acid derivatives |
DE3823299A1 (de) | 1988-07-07 | 1990-01-11 | Schering Ag | Substituierte phenyl-pyrrolidin-2-one, -oxazolidin-2-one und -imidazolidin-2-one, ihre herstellung sowie verwendung in arzneimitteln |
US5068251A (en) | 1988-12-16 | 1991-11-26 | Abbott Laboratories | Lipoxygenase inhibiting compounds |
KR900016822A (ko) | 1990-04-20 | 1990-11-14 | 하라 레이노스께 | 슬라이드 프로젝터 |
US5124455A (en) | 1990-08-08 | 1992-06-23 | American Home Products Corporation | Oxime-carbamates and oxime-carbonates as bronchodilators and anti-inflammatory agents |
FR2669029B1 (fr) * | 1990-11-14 | 1994-09-02 | Adir | Nouveaux derives de la n-benzoyl proline, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
DE69309030T2 (de) * | 1992-06-15 | 1997-09-25 | Celltech Therapeutics Ltd | Trisubstituierte phenylderivate als selektive phosphodiesterase iv inhibitoren |
HUT72656A (en) * | 1992-07-28 | 1996-05-28 | Rhone Poulenc Rorer Ltd | Inhibitors of c-amp phosphodiesterase and tnf, their preparation pharmaceuticals contg. them and their use |
AU7467294A (en) * | 1993-08-20 | 1995-03-21 | Banyu Pharmaceutical Co., Ltd. | Tyrosine kinase inhibitor |
-
1996
- 1996-05-14 ES ES96911095T patent/ES2151156T3/es not_active Expired - Lifetime
- 1996-05-14 JP JP09507392A patent/JP3131225B2/ja not_active Expired - Fee Related
- 1996-05-14 NZ NZ305940A patent/NZ305940A/xx unknown
- 1996-05-14 KR KR1019980700531A patent/KR100332273B1/ko not_active IP Right Cessation
- 1996-05-14 DE DE69610709T patent/DE69610709T2/de not_active Expired - Fee Related
- 1996-05-14 WO PCT/IB1996/000451 patent/WO1997005105A1/en active IP Right Grant
- 1996-05-14 US US09/011,462 patent/US6225351B1/en not_active Expired - Fee Related
- 1996-05-14 EP EP96911095A patent/EP0850215B1/de not_active Expired - Lifetime
- 1996-05-14 CA CA002227237A patent/CA2227237C/en not_active Expired - Fee Related
- 1996-05-14 AU AU54079/96A patent/AU711755B2/en not_active Ceased
- 1996-05-14 PT PT96911095T patent/PT850215E/pt unknown
- 1996-05-14 MX MX9800710A patent/MX9800710A/es not_active IP Right Cessation
- 1996-05-14 AT AT96911095T patent/ATE197038T1/de not_active IP Right Cessation
- 1996-05-14 DK DK96911095T patent/DK0850215T3/da active
- 1996-05-14 CN CN96195846A patent/CN1090614C/zh not_active Expired - Fee Related
- 1996-05-16 TW TW085105815A patent/TW401389B/zh not_active IP Right Cessation
- 1996-07-18 IL IL11888996A patent/IL118889A/xx not_active IP Right Cessation
- 1996-07-25 ZA ZA9606314A patent/ZA966314B/xx unknown
-
1998
- 1998-01-23 NO NO19980313A patent/NO310230B1/no not_active Application Discontinuation
- 1998-12-02 HK HK98112662A patent/HK1018047A1/xx not_active IP Right Cessation
-
2000
- 2000-11-30 GR GR20000402672T patent/GR3034969T3/el not_active IP Right Cessation
-
2001
- 2001-01-25 US US09/769,702 patent/US6384236B1/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US6384236B1 (en) | 2002-05-07 |
KR100332273B1 (ko) | 2002-06-20 |
US6225351B1 (en) | 2001-05-01 |
IL118889A0 (en) | 1996-10-31 |
AU5407996A (en) | 1997-02-26 |
TW401389B (en) | 2000-08-11 |
ATE197038T1 (de) | 2000-11-15 |
CA2227237C (en) | 2005-12-13 |
MX9800710A (es) | 1998-04-30 |
ZA966314B (en) | 1998-01-26 |
EP0850215A1 (de) | 1998-07-01 |
CN1192201A (zh) | 1998-09-02 |
HK1018047A1 (en) | 1999-12-10 |
ES2151156T3 (es) | 2000-12-16 |
DE69610709D1 (de) | 2000-11-23 |
KR19990035870A (ko) | 1999-05-25 |
AU711755B2 (en) | 1999-10-21 |
NO310230B1 (no) | 2001-06-11 |
JP3131225B2 (ja) | 2001-01-31 |
GR3034969T3 (en) | 2001-02-28 |
NO980313D0 (no) | 1998-01-23 |
EP0850215B1 (de) | 2000-10-18 |
NO980313L (no) | 1998-03-23 |
US20020055543A1 (en) | 2002-05-09 |
CN1090614C (zh) | 2002-09-11 |
DK0850215T3 (da) | 2000-11-20 |
WO1997005105A1 (en) | 1997-02-13 |
IL118889A (en) | 2003-12-10 |
PT850215E (pt) | 2001-03-30 |
CA2227237A1 (en) | 1997-02-13 |
JPH10511695A (ja) | 1998-11-10 |
NZ305940A (en) | 1999-05-28 |
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