DE69606696T2 - Selektives verfahren zur deacylierung von acylverbindungen - Google Patents
Selektives verfahren zur deacylierung von acylverbindungenInfo
- Publication number
- DE69606696T2 DE69606696T2 DE69606696T DE69606696T DE69606696T2 DE 69606696 T2 DE69606696 T2 DE 69606696T2 DE 69606696 T DE69606696 T DE 69606696T DE 69606696 T DE69606696 T DE 69606696T DE 69606696 T2 DE69606696 T2 DE 69606696T2
- Authority
- DE
- Germany
- Prior art keywords
- deacylating
- selective method
- acyl compounds
- statins
- fermentation broth
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 238000000034 method Methods 0.000 title abstract 3
- 150000003855 acyl compounds Chemical class 0.000 title 1
- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 abstract 2
- 238000000855 fermentation Methods 0.000 abstract 2
- 230000004151 fermentation Effects 0.000 abstract 2
- 239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 abstract 2
- 230000020176 deacylation Effects 0.000 abstract 1
- 238000005947 deacylation reaction Methods 0.000 abstract 1
- 239000012535 impurity Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/62—Carboxylic acid esters
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrane Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US186095P | 1995-08-03 | 1995-08-03 | |
| EP95202125 | 1995-08-03 | ||
| PCT/EP1996/003495 WO1997006128A1 (en) | 1995-08-03 | 1996-08-05 | Selective process for the deacylation of acylated compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69606696D1 DE69606696D1 (de) | 2000-03-23 |
| DE69606696T2 true DE69606696T2 (de) | 2000-08-17 |
Family
ID=26139544
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69606696T Expired - Fee Related DE69606696T2 (de) | 1995-08-03 | 1996-08-05 | Selektives verfahren zur deacylierung von acylverbindungen |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP0784605B1 (de) |
| JP (1) | JPH11501218A (de) |
| CN (1) | CN1078583C (de) |
| AT (1) | ATE189804T1 (de) |
| AU (1) | AU6820096A (de) |
| CA (1) | CA2201729C (de) |
| DE (1) | DE69606696T2 (de) |
| DK (1) | DK0784605T3 (de) |
| ES (1) | ES2145479T3 (de) |
| GR (1) | GR3033402T3 (de) |
| HU (1) | HU221636B1 (de) |
| MX (1) | MX9702403A (de) |
| PT (1) | PT784605E (de) |
| SI (1) | SI0784605T1 (de) |
| WO (1) | WO1997006128A1 (de) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0251582A (ja) * | 1988-08-12 | 1990-02-21 | Kyokado Eng Co Ltd | 地盤注入用薬液 |
| US6165757A (en) * | 1997-02-20 | 2000-12-26 | Dsm N.V. | Nitrogen feed in statin fermentation |
| EP0877089A1 (de) * | 1997-05-07 | 1998-11-11 | Gist-Brocades B.V. | Verfahren zur Herstellung eines Inhibitors der Hmg-Coa Reduktase |
| SI9800046A (sl) | 1998-02-18 | 1999-08-31 | LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. | Postopek za pridobivanje inhibitorjev HMG-CoA reduktaze visoke čistosti |
| WO2002030415A1 (en) * | 2000-10-05 | 2002-04-18 | Biogal Gyogyszergyar Rt | Pravastatin sodium substantially free of pravastatin lactone and epi-pravastatin, and compositions containing same |
| JP3236282B1 (ja) * | 2000-10-16 | 2001-12-10 | 三共株式会社 | プラバスタチンを精製する方法 |
| EP1477471A1 (de) * | 2003-05-14 | 2004-11-17 | Chunghwa Chemical Synthesis & Biotech Co., Ltd. | Verfahren zur Reinigung von Pravastin-Natrium aus einer Fermentationsbrühe |
| DE04811862T1 (de) | 2003-11-24 | 2006-03-02 | Teva Gyogyszergyar Reszvenytarsasag | Verfahren zur Reinigung von Pravastatin |
| TWI307360B (en) | 2004-12-03 | 2009-03-11 | Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag | Process for constructing strain having compactin hydroxylation ability |
| CN104311517B (zh) * | 2014-10-17 | 2017-06-06 | 上海应用技术学院 | 他汀内酯脱水化合物及其用途 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5159104A (en) * | 1991-05-01 | 1992-10-27 | Merck & Co., Inc. | Process to simvastatin ester |
| GB2255974A (en) * | 1991-05-24 | 1992-11-25 | Merck & Co Inc | Enzymatic deacylation of simvastatin |
-
1996
- 1996-08-05 DK DK96928423T patent/DK0784605T3/da active
- 1996-08-05 DE DE69606696T patent/DE69606696T2/de not_active Expired - Fee Related
- 1996-08-05 SI SI9630191T patent/SI0784605T1/xx unknown
- 1996-08-05 ES ES96928423T patent/ES2145479T3/es not_active Expired - Lifetime
- 1996-08-05 HU HU9702444A patent/HU221636B1/hu not_active IP Right Cessation
- 1996-08-05 JP JP9508131A patent/JPH11501218A/ja not_active Ceased
- 1996-08-05 AT AT96928423T patent/ATE189804T1/de not_active IP Right Cessation
- 1996-08-05 EP EP96928423A patent/EP0784605B1/de not_active Expired - Lifetime
- 1996-08-05 CA CA002201729A patent/CA2201729C/en not_active Expired - Fee Related
- 1996-08-05 WO PCT/EP1996/003495 patent/WO1997006128A1/en active IP Right Grant
- 1996-08-05 MX MX9702403A patent/MX9702403A/es unknown
- 1996-08-05 CN CN96191024A patent/CN1078583C/zh not_active Expired - Fee Related
- 1996-08-05 PT PT96928423T patent/PT784605E/pt unknown
- 1996-08-05 AU AU68200/96A patent/AU6820096A/en not_active Abandoned
-
2000
- 2000-05-11 GR GR20000401090T patent/GR3033402T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| JPH11501218A (ja) | 1999-02-02 |
| HUP9702444A3 (en) | 1999-10-28 |
| EP0784605A1 (de) | 1997-07-23 |
| DK0784605T3 (da) | 2000-07-31 |
| CN1164851A (zh) | 1997-11-12 |
| MX9702403A (es) | 1997-06-28 |
| CA2201729C (en) | 2002-03-12 |
| ATE189804T1 (de) | 2000-03-15 |
| CA2201729A1 (en) | 1997-02-20 |
| SI0784605T1 (en) | 2000-08-31 |
| PT784605E (pt) | 2000-08-31 |
| EP0784605B1 (de) | 2000-02-16 |
| ES2145479T3 (es) | 2000-07-01 |
| CN1078583C (zh) | 2002-01-30 |
| GR3033402T3 (en) | 2000-09-29 |
| HU221636B1 (hu) | 2002-12-28 |
| DE69606696D1 (de) | 2000-03-23 |
| HUP9702444A1 (hu) | 1998-04-28 |
| WO1997006128A1 (en) | 1997-02-20 |
| AU6820096A (en) | 1997-03-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8327 | Change in the person/name/address of the patent owner |
Owner name: PLUS CHEMICALS B.V., MIJDRECHT, NL |
|
| 8327 | Change in the person/name/address of the patent owner |
Owner name: PLUS CHEMICALS SA, LUGANO, CH |
|
| 8339 | Ceased/non-payment of the annual fee |