DE69535375D1 - Lösliche polypeptidfraktionen des lag-3-proteins; verfahren zur herstellung; therapeutische zusamensetzung; antiidiotypischer antikörper - Google Patents
Lösliche polypeptidfraktionen des lag-3-proteins; verfahren zur herstellung; therapeutische zusamensetzung; antiidiotypischer antikörperInfo
- Publication number
- DE69535375D1 DE69535375D1 DE69535375T DE69535375T DE69535375D1 DE 69535375 D1 DE69535375 D1 DE 69535375D1 DE 69535375 T DE69535375 T DE 69535375T DE 69535375 T DE69535375 T DE 69535375T DE 69535375 D1 DE69535375 D1 DE 69535375D1
- Authority
- DE
- Germany
- Prior art keywords
- lag
- protein
- soluble polypeptide
- production
- therapeutic composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 102000017578 LAG3 Human genes 0.000 title abstract 3
- 101150030213 Lag3 gene Proteins 0.000 title abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 3
- 229920001184 polypeptide Polymers 0.000 title abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 2
- 230000001225 therapeutic effect Effects 0.000 title 1
- 150000001413 amino acids Chemical class 0.000 abstract 2
- 230000037430 deletion Effects 0.000 abstract 1
- 238000012217 deletion Methods 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 108020001580 protein domains Proteins 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Cell Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Toxicology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Transplantation (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9405643 | 1994-05-06 | ||
FR9405643 | 1994-05-06 | ||
PCT/FR1995/000593 WO1995030750A2 (fr) | 1994-05-06 | 1995-05-05 | Fractions polypeptidiques solubles de la proteine lag-3; procede de production; composition therapeutique; anticorps anti-idiotype |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69535375D1 true DE69535375D1 (de) | 2007-03-15 |
DE69535375T2 DE69535375T2 (de) | 2007-11-08 |
Family
ID=9463004
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69535375T Expired - Lifetime DE69535375T2 (de) | 1994-05-06 | 1995-05-05 | Lösliche polypeptidfraktionen des lag-3-proteins; verfahren zur herstellung; therapeutische zusamensetzung; antiidiotypischer antikörper |
Country Status (18)
Country | Link |
---|---|
US (3) | US5955300A (de) |
EP (1) | EP0758383B1 (de) |
JP (1) | JP3700859B2 (de) |
KR (1) | KR100257466B1 (de) |
CN (1) | CN1110557C (de) |
AT (1) | ATE352617T1 (de) |
BR (1) | BR9507618A (de) |
CA (1) | CA2189657C (de) |
DE (1) | DE69535375T2 (de) |
DK (1) | DK0758383T3 (de) |
ES (1) | ES2281899T3 (de) |
IL (1) | IL113617A (de) |
MX (1) | MX9605365A (de) |
NO (1) | NO325828B1 (de) |
PT (1) | PT758383E (de) |
RU (1) | RU2178306C2 (de) |
WO (1) | WO1995030750A2 (de) |
ZA (1) | ZA953629B (de) |
Families Citing this family (48)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU701375B2 (en) * | 1995-07-21 | 1999-01-28 | Institut Gustave Roussy | Methods for detecting, identifying, isolating, and selectively labelling and targeting Th1 lymphocytes by means of the LAG-3 protein |
ATE320488T1 (de) * | 1996-11-28 | 2006-04-15 | Roussy Inst Gustave | Mutanten des lag-3 proteins, ihre expression und verwendung |
PT941329E (pt) * | 1996-11-29 | 2004-11-30 | Applied Research Systems | Metodo para prevenir a rejeicao de enxertos em transplantacao e para produzir uma celula-hospedeiro para terapia genetica universal utilizando activacao de linfocitos (lag-3) |
EP0900841A1 (de) * | 1997-06-18 | 1999-03-10 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Spleissvarianten von LAG-3 |
EP0893507A1 (de) | 1997-07-25 | 1999-01-27 | Institut Gustave Roussy | Verwendung von MHC Klass II Liganden (CD4 und LAG-3) als Adjuvanz für Impfungen und von LAG-3 in der Behandlung von Krebs |
US6660843B1 (en) † | 1998-10-23 | 2003-12-09 | Amgen Inc. | Modified peptides as therapeutic agents |
US6434012B2 (en) * | 2000-02-11 | 2002-08-13 | Tyco Electronics Logistics Ag | Circuit board interconnect |
WO2001083525A2 (en) * | 2000-05-03 | 2001-11-08 | Amgen Inc. | Modified peptides, comprising an fc domain, as therapeutic agents |
CA2476518A1 (en) * | 2002-02-22 | 2003-09-04 | Genentech, Inc. | Compositions and methods for the treatment of immune related diseases |
JP2006523226A (ja) † | 2003-02-28 | 2006-10-12 | ザ ジョンズ ホプキンス ユニバーシティ | T細胞調節方法 |
FR2868781B1 (fr) * | 2004-04-13 | 2008-02-22 | Immutep | Composition de vaccin comprenant un ligand cmh de classe ii couple a un antigene, procede de preparation et utilisations |
EP2044949A1 (de) | 2007-10-05 | 2009-04-08 | Immutep | Verwendung von rekombinantem LAG-3 oder Derivaten daraus zur Auslösung einer Monozyten-Immunreaktion |
AR072999A1 (es) * | 2008-08-11 | 2010-10-06 | Medarex Inc | Anticuerpos humanos que se unen al gen 3 de activacion linfocitaria (lag-3) y los usos de estos |
UY34887A (es) * | 2012-07-02 | 2013-12-31 | Bristol Myers Squibb Company Una Corporacion Del Estado De Delaware | Optimización de anticuerpos que se fijan al gen de activación de linfocitos 3 (lag-3) y sus usos |
LT3178849T (lt) | 2013-09-20 | 2019-06-10 | Bristol-Myers Squibb Company | Anti-lag-3 antikūnų ir anti-pd-1 antikūnų derinys, skirtas navikų gydymui |
GB201322626D0 (en) | 2013-12-19 | 2014-02-05 | Immutep S A | Combined preparations for the treatment of cancer |
JOP20200094A1 (ar) | 2014-01-24 | 2017-06-16 | Dana Farber Cancer Inst Inc | جزيئات جسم مضاد لـ pd-1 واستخداماتها |
KR20240110004A (ko) | 2014-03-14 | 2024-07-12 | 노파르티스 아게 | Lag-3에 대한 항체 분자 및 그의 용도 |
TW202132337A (zh) | 2014-05-28 | 2021-09-01 | 美商艾吉納斯公司 | 抗糖皮質素誘導性tnfr家族相關性受體(gitr)抗體類及使用彼等之方法 |
TWI693232B (zh) | 2014-06-26 | 2020-05-11 | 美商宏觀基因股份有限公司 | 與pd-1和lag-3具有免疫反應性的共價結合的雙抗體和其使用方法 |
JO3663B1 (ar) * | 2014-08-19 | 2020-08-27 | Merck Sharp & Dohme | الأجسام المضادة لمضاد lag3 وأجزاء ربط الأنتيجين |
GB201500374D0 (en) | 2015-01-09 | 2015-02-25 | Immutep S A | Combined preparations for the treatment of cancer |
MA41463A (fr) * | 2015-02-03 | 2017-12-12 | Anaptysbio Inc | Anticorps dirigés contre le gène d'activation 3 des lymphocytes (lag-3) |
TWI773646B (zh) | 2015-06-08 | 2022-08-11 | 美商宏觀基因股份有限公司 | 結合lag-3的分子和其使用方法 |
EP3943098A3 (de) | 2015-07-16 | 2022-05-11 | Biokine Therapeutics Ltd. | Zusammensetzungen und verfahren zur behandlung von krebs |
GEP20227419B (en) | 2015-07-30 | 2022-10-10 | Macrogenics Inc | Pd-1-binding molecules and methods of use thereof |
EP3331919A1 (de) | 2015-08-07 | 2018-06-13 | GlaxoSmithKline Intellectual Property Development Limited | Kombinationstherapie mit anti-ctla-4-antikörpern |
TWI756187B (zh) | 2015-10-09 | 2022-03-01 | 美商再生元醫藥公司 | 抗lag3抗體及其用途 |
WO2017087780A1 (en) | 2015-11-20 | 2017-05-26 | Regeneron Pharmaceuticals, Inc. | Non-human animals having a humanized lymphocyte-activation gene 3 |
SG11201804265XA (en) | 2015-12-02 | 2018-06-28 | Agenus Inc | Antibodies and methods of use thereof |
MA44082A (fr) | 2015-12-14 | 2018-10-24 | Macrogenics Inc | Molécules bispécifiques présentant une immunoréactivité par rapport à pd-1 et à ctla-4 et leurs procédés d'utilisation |
CA3008244A1 (en) | 2015-12-16 | 2017-06-22 | Merck Sharp & Dohme Corp. | Anti-lag3 antibodies and antigen-binding fragments |
CA3012833A1 (en) * | 2016-02-04 | 2017-08-10 | Trianni, Inc. | Enhanced production of immunoglobulins |
TW201803905A (zh) | 2016-06-20 | 2018-02-01 | 克馬伯有限公司 | 用於免疫腫瘤學之多重專一性抗體 |
DK3476399T3 (da) | 2016-06-23 | 2022-05-30 | Jiangsu Hengrui Medicine Co | Lag-3-antistof, antigenbindende fragment deraf og farmaceutisk anvendelse deraf |
CN117586403A (zh) | 2016-10-11 | 2024-02-23 | 艾吉纳斯公司 | 抗lag-3抗体及其使用方法 |
TWI784976B (zh) | 2016-10-13 | 2022-12-01 | 大陸商正大天晴藥業集團股份有限公司 | 抗lag-3抗體及組成物 |
TW201829462A (zh) | 2016-11-02 | 2018-08-16 | 英商葛蘭素史克智慧財產(第二)有限公司 | 結合蛋白 |
SG11201907208XA (en) | 2017-02-10 | 2019-09-27 | Regeneron Pharma | Radiolabeled anti-lag3 antibodies for immuno-pet imaging |
EA201992350A1 (ru) | 2017-04-05 | 2020-03-23 | Симфоген А/С | Комбинированные лекарственные средства, нацеленные на pd-1, tim-3 и lag-3 |
US11339218B2 (en) * | 2017-05-10 | 2022-05-24 | Zhejiang Shimai Pharmaceutical Co., Ltd. | Human monoclonal antibodies against LAG3 and uses thereof |
WO2018222722A2 (en) | 2017-05-30 | 2018-12-06 | Bristol-Myers Squibb Company | Compositions comprising an anti-lag-3 antibody or an anti-lag-3 antibody and an anti-pd-1 or anti-pd-l1 antibody |
CN110720039A (zh) | 2017-05-30 | 2020-01-21 | 百时美施贵宝公司 | Lag-3阳性肿瘤的治疗 |
CA3073733A1 (en) | 2017-08-30 | 2019-03-07 | Phanes Therapeutics, Inc. | Anti-lag-3 antibodies and uses thereof |
RU2771384C2 (ru) * | 2017-12-22 | 2022-05-04 | Цзянсу Хэнжуй Медсин Ко., Лтд. | Фармацевтическая композиция, содержащая антитело к lag-3, и ее применение |
EP3969040A1 (de) | 2019-05-13 | 2022-03-23 | Regeneron Pharmaceuticals, Inc. | Kombination von pd-1-inhibitoren und lag-3-inhibitoren zur erhöhung der wirksamkeit bei der behandlung von krebs |
CN115340606B (zh) * | 2019-05-31 | 2023-12-19 | 瑞阳(苏州)生物科技有限公司 | 与人lag-3蛋白结合的抗体及其编码基因和应用 |
CN110950966B (zh) * | 2019-12-13 | 2020-12-11 | 启辰生生物科技(珠海)有限公司 | 融合蛋白、编码核酸和细胞及用途 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE721983T1 (de) | 1988-01-22 | 2002-07-04 | Zymogenetics, Inc. | Verfahren zur herstellung von biologisch-aktive Dimerpeptiden |
US5116964A (en) | 1989-02-23 | 1992-05-26 | Genentech, Inc. | Hybrid immunoglobulins |
FR2656800B1 (fr) * | 1990-01-08 | 1992-05-15 | Roussy Inst Gustave | Nouvelles proteines produits par les lymphocytes humains, sequence d'adn codant pour ces proteines et applications pharmaceutiques et biologiques. |
US5976877A (en) | 1990-01-08 | 1999-11-02 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Proteins produced by human lymphocytes DNA sequence encoding these proteins and their pharmaceutical and biological uses |
JPH06508501A (ja) * | 1990-07-02 | 1994-09-29 | ブリストル―マイアーズ スクイブ カンパニー | B細胞上のcd28レセプターに対するリガンドおよび該リガンドを用いた細胞間相互作用の調節方法 |
-
1995
- 1995-05-05 KR KR1019960706281A patent/KR100257466B1/ko not_active IP Right Cessation
- 1995-05-05 DE DE69535375T patent/DE69535375T2/de not_active Expired - Lifetime
- 1995-05-05 DK DK95920125T patent/DK0758383T3/da active
- 1995-05-05 ES ES95920125T patent/ES2281899T3/es not_active Expired - Lifetime
- 1995-05-05 BR BR9507618A patent/BR9507618A/pt not_active IP Right Cessation
- 1995-05-05 WO PCT/FR1995/000593 patent/WO1995030750A2/fr active IP Right Grant
- 1995-05-05 ZA ZA953629A patent/ZA953629B/xx unknown
- 1995-05-05 IL IL113617A patent/IL113617A/en not_active IP Right Cessation
- 1995-05-05 MX MX9605365A patent/MX9605365A/es active IP Right Grant
- 1995-05-05 US US08/737,271 patent/US5955300A/en not_active Ceased
- 1995-05-05 US US09/931,103 patent/USRE38313E1/en not_active Expired - Lifetime
- 1995-05-05 CN CN95193718A patent/CN1110557C/zh not_active Expired - Lifetime
- 1995-05-05 JP JP52872995A patent/JP3700859B2/ja not_active Expired - Lifetime
- 1995-05-05 AT AT95920125T patent/ATE352617T1/de active
- 1995-05-05 RU RU96123299/14A patent/RU2178306C2/ru active
- 1995-05-05 CA CA002189657A patent/CA2189657C/fr not_active Expired - Lifetime
- 1995-05-05 EP EP95920125A patent/EP0758383B1/de not_active Expired - Lifetime
- 1995-05-05 PT PT95920125T patent/PT758383E/pt unknown
-
1996
- 1996-11-04 NO NO19964650A patent/NO325828B1/no not_active IP Right Cessation
-
1998
- 1998-04-13 US US09/058,555 patent/US6143273A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
NO964650L (no) | 1997-01-06 |
WO1995030750A3 (fr) | 1995-12-21 |
AU2570195A (en) | 1995-11-29 |
US5955300A (en) | 1999-09-21 |
DK0758383T3 (da) | 2007-05-29 |
US6143273A (en) | 2000-11-07 |
MX9605365A (es) | 1997-12-31 |
ZA953629B (en) | 1996-11-05 |
CA2189657A1 (fr) | 1995-11-16 |
NO325828B1 (no) | 2008-07-28 |
NO964650D0 (no) | 1996-11-04 |
DE69535375T2 (de) | 2007-11-08 |
ATE352617T1 (de) | 2007-02-15 |
KR970702917A (ko) | 1997-06-10 |
JP3700859B2 (ja) | 2005-09-28 |
KR100257466B1 (ko) | 2000-07-01 |
EP0758383A1 (de) | 1997-02-19 |
BR9507618A (pt) | 1997-08-19 |
CN1110557C (zh) | 2003-06-04 |
AU708825B2 (en) | 1999-08-12 |
USRE38313E1 (en) | 2003-11-11 |
WO1995030750A2 (fr) | 1995-11-16 |
CN1155904A (zh) | 1997-07-30 |
IL113617A (en) | 2007-09-20 |
RU2178306C2 (ru) | 2002-01-20 |
IL113617A0 (en) | 1995-08-31 |
CA2189657C (fr) | 2002-03-12 |
EP0758383B1 (de) | 2007-01-24 |
JPH09508023A (ja) | 1997-08-19 |
PT758383E (pt) | 2007-05-31 |
ES2281899T3 (es) | 2007-10-01 |
WO1995030750A8 (fr) | 1999-07-29 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |