DE69534632D1 - Clorimazole metabolite in den behandlung vom sichelzellanämie - Google Patents
Clorimazole metabolite in den behandlung vom sichelzellanämieInfo
- Publication number
- DE69534632D1 DE69534632D1 DE69534632T DE69534632T DE69534632D1 DE 69534632 D1 DE69534632 D1 DE 69534632D1 DE 69534632 T DE69534632 T DE 69534632T DE 69534632 T DE69534632 T DE 69534632T DE 69534632 D1 DE69534632 D1 DE 69534632D1
- Authority
- DE
- Germany
- Prior art keywords
- lemenia
- clorimazole
- sickle
- metabolite
- treatment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/02—Halogenated hydrocarbons
- A61K31/025—Halogenated hydrocarbons carbocyclic
- A61K31/03—Halogenated hydrocarbons carbocyclic aromatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/075—Ethers or acetals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/075—Ethers or acetals
- A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
- A61K31/10—Sulfides; Sulfoxides; Sulfones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/15—Oximes (>C=N—O—); Hydrazines (>N—N<); Hydrazones (>N—N=) ; Imines (C—N=C)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US30787494A | 1994-09-16 | 1994-09-16 | |
PCT/US1995/011822 WO1996008242A2 (en) | 1994-09-16 | 1995-09-15 | Clotrimazole metabolites in the treatment of sickle cell disease |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69534632D1 true DE69534632D1 (de) | 2005-12-29 |
DE69534632T2 DE69534632T2 (de) | 2006-06-14 |
Family
ID=23191532
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69534632T Expired - Fee Related DE69534632T2 (de) | 1994-09-16 | 1995-09-15 | Clotrimazol-Metaboliten bei der Behandlung von Sichelzellenkrankheit |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP0781128B1 (de) |
DE (1) | DE69534632T2 (de) |
WO (1) | WO1996008242A2 (de) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6028103A (en) * | 1994-09-16 | 2000-02-22 | Children's Medical Center Corporation | Triaryl methane compounds and analogues thereof useful for the treatment or prevention of sickle cell disease or diseases characterized by abnormal cell proliferation |
US7531573B2 (en) * | 1994-09-16 | 2009-05-12 | Children's Medical Center Corporation | Use of triaryl methane compounds for inhibiting unwanted cellular proliferation associated with inflammatory disease |
WO1997034589A1 (en) * | 1996-03-20 | 1997-09-25 | President And Fellows Of Harvard College | Triaryl methane compounds for sickle cell disease |
US5889038A (en) * | 1996-03-20 | 1999-03-30 | Children's Hospital | Methods and products for treating diarrhea and scours: use of clotrimazole and related aromatic compounds |
AU2962297A (en) * | 1996-05-24 | 1998-01-05 | Neurosearch A/S | Phenyl derivatives useful as blockers of chloride channels |
EP0906273B1 (de) | 1996-05-24 | 2002-10-16 | Neurosearch A/S | Saure gruppen enthaltende phenylderivate, ihre herstellung und ihre verwendung als chloridkanalblocker |
EP1052990A2 (de) | 1997-11-14 | 2000-11-22 | Neurosearch A/S | Chemische verbindungen mit ionenkanalblockierender aktivität zur behandlung von dysfunktionen des immunsystems |
US6800658B2 (en) | 1997-11-20 | 2004-10-05 | Children's Medical Center Corporation | Substituted diphenyl indanone, indane and indole compounds and analogues thereof useful for the treatment of prevention of diseases characterized by abnormal cell proliferation |
US6291449B1 (en) | 1998-09-23 | 2001-09-18 | Children's Medical Center Corporation | Use of 11-phenyl-dibenzazepine compounds to treat diarrhea or scours |
JP2001523720A (ja) * | 1997-11-20 | 2001-11-27 | チルドレンズ メディカル センター コーポレーション | 鎌状赤血球病、異常な細胞増殖によって特徴づけられる炎症性疾患、下痢症および伝染性下痢症の治療または予防用の置換11−フェニル−ジベンザゼピン化合物の使用。 |
JP2001523717A (ja) * | 1997-11-20 | 2001-11-27 | チルドレンズ メディカル センター コーポレーション | 異常細胞増殖、下痢および白痢によって特徴付けられる鎌状細胞病、炎症性の疾病を治療または予防するための置換ジフェニルインダノン、インダンおよびインドール化合物の使用 |
US6992079B2 (en) | 1997-11-20 | 2006-01-31 | President Fellows of Harvard College | Substituted 11-phenyl-dibenzazepine compounds useful for the treatment or prevention of diseases characterized by abnormal cell proliferation |
ES2293699T3 (es) | 1997-11-20 | 2008-03-16 | President And Fellows Of Harvard College | Compuesto 11-fenil-dibenzazepino substituidos utiles para el tratamiento o prevencion de enfermedades caracterizadas por proliferacion celular anormal. |
CN103102284A (zh) * | 2011-11-09 | 2013-05-15 | 南京大学 | 4-三氟甲基-2,6-二硝基苯水杨醛肟类衍生物的制备及其在抗癌治疗药物中的应用 |
US20240024335A1 (en) | 2020-12-11 | 2024-01-25 | Sanquin IP B.V. | Treatment and prevention of anaemia of inflammation |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS56110615A (en) * | 1980-02-06 | 1981-09-01 | Yutaka Idota | Treating and preventing agent against disease of respiratory organ of chicken |
US5273992A (en) * | 1992-11-02 | 1993-12-28 | Beth Israel Hospital Assoc. Inc. | Method for reducing sickle erythrocyte dehydration and delaying the occurrence of erythrocyte sickling in-situ |
-
1995
- 1995-09-15 WO PCT/US1995/011822 patent/WO1996008242A2/en active IP Right Grant
- 1995-09-15 DE DE69534632T patent/DE69534632T2/de not_active Expired - Fee Related
- 1995-09-15 EP EP95933842A patent/EP0781128B1/de not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP0781128B1 (de) | 2005-11-23 |
EP0781128A2 (de) | 1997-07-02 |
WO1996008242A3 (en) | 1996-05-09 |
WO1996008242A2 (en) | 1996-03-21 |
DE69534632T2 (de) | 2006-06-14 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |