DE69533615D1 - Anthracyclin Prodrugs, Verfahren zu deren Herstellung und deren Verwendung in der selektiven Chemotherapie - Google Patents

Anthracyclin Prodrugs, Verfahren zu deren Herstellung und deren Verwendung in der selektiven Chemotherapie

Info

Publication number
DE69533615D1
DE69533615D1 DE69533615T DE69533615T DE69533615D1 DE 69533615 D1 DE69533615 D1 DE 69533615D1 DE 69533615 T DE69533615 T DE 69533615T DE 69533615 T DE69533615 T DE 69533615T DE 69533615 D1 DE69533615 D1 DE 69533615D1
Authority
DE
Germany
Prior art keywords
preparation
derivatives
anthracycline
selective chemotherapy
disclosed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69533615T
Other languages
English (en)
Other versions
DE69533615T2 (de
Inventor
Ruben Gerardus George Leenders
Eric Wilhelmus Petrus Damen
Johan Wilhelm Scheeren
Hidde Jacob Haisma
Pieter Herman Johannes Houba
Vos Dick De
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmachemie BV
Original Assignee
Pharmachemie BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmachemie BV filed Critical Pharmachemie BV
Publication of DE69533615D1 publication Critical patent/DE69533615D1/de
Application granted granted Critical
Publication of DE69533615T2 publication Critical patent/DE69533615T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE69533615T 1995-06-27 1995-06-27 Anthracyclin Prodrugs, Verfahren zu deren Herstellung und deren Verwendung in der selektiven Chemotherapie Expired - Fee Related DE69533615T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP95201747A EP0751144B1 (de) 1995-06-27 1995-06-27 Anthracyclin Prodrugs, Verfahren zu deren Herstellung und deren Verwendung in der selektiven Chemotherapie

Publications (2)

Publication Number Publication Date
DE69533615D1 true DE69533615D1 (de) 2004-11-11
DE69533615T2 DE69533615T2 (de) 2005-10-13

Family

ID=8220425

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69533615T Expired - Fee Related DE69533615T2 (de) 1995-06-27 1995-06-27 Anthracyclin Prodrugs, Verfahren zu deren Herstellung und deren Verwendung in der selektiven Chemotherapie

Country Status (9)

Country Link
US (1) US5710135A (de)
EP (1) EP0751144B1 (de)
JP (1) JPH0912591A (de)
AT (1) ATE278700T1 (de)
CA (1) CA2178684A1 (de)
DE (1) DE69533615T2 (de)
DK (1) DK0751144T3 (de)
ES (1) ES2227536T3 (de)
PT (1) PT751144E (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19720312A1 (de) * 1997-05-15 1998-11-19 Hoechst Ag Zubereitung mit erhöhter in vivo Verträglichkeit
WO1999030727A1 (en) 1997-12-17 1999-06-24 Enzon, Inc. Polymeric prodrugs of amino- and hydroxyl-containing bioactive agents
US6180095B1 (en) 1997-12-17 2001-01-30 Enzon, Inc. Polymeric prodrugs of amino- and hydroxyl-containing bioactive agents
US6624142B2 (en) 1997-12-30 2003-09-23 Enzon, Inc. Trimethyl lock based tetrapartate prodrugs
US5965119A (en) * 1997-12-30 1999-10-12 Enzon, Inc. Trialkyl-lock-facilitated polymeric prodrugs of amino-containing bioactive agents
US6214330B1 (en) 1998-07-13 2001-04-10 Enzon, Inc. Coumarin and related aromatic-based polymeric prodrugs
US6043367A (en) * 1998-09-30 2000-03-28 Roffler; Steve Proactive antitumor compounds
CA2428018A1 (en) * 2000-12-01 2002-06-06 Enzon, Inc. Tetrapartate prodrugs
EP1362053B1 (de) * 2001-02-20 2007-11-14 Enzon, Inc. Terminal verzweigte, polymere linker und diese enthaltende polymere konjugate
US7345023B2 (en) * 2001-08-14 2008-03-18 Valderm Aps Treatment of hyperproliferative conditions of body surfaces
US20040038904A1 (en) * 2002-05-21 2004-02-26 Angela Ogden Method of treating multiple sclerosis
EP2281578A3 (de) 2002-07-15 2011-04-13 Board of Regents, The University of Texas System Ausgewählte Antikörper und Duramycin-Peptide mit Bindung an anionische Phospholipide und Aminophospholipide und ihre Verwendung bei der Behandlung von Virusinfektionen und Krebs
EA034136B1 (ru) 2007-11-09 2020-01-09 Перигрин Фармасьютикалз, Инк. Изолированное антитело, которое связывается с vegf, и его применения
EP2098533A1 (de) * 2008-03-07 2009-09-09 Pharmachemie B.V. Ester aus Glucuronid-Prodrugs von Anthracyclinen und Verfahren zu deren Herstellung und Verwendung bei der tumorselektiven Chemotherapie
US8889193B2 (en) 2010-02-25 2014-11-18 The Johns Hopkins University Sustained delivery of therapeutic agents to an eye compartment
WO2012039979A2 (en) 2010-09-10 2012-03-29 The Johns Hopkins University Rapid diffusion of large polymeric nanoparticles in the mammalian brain
US9327037B2 (en) 2011-02-08 2016-05-03 The Johns Hopkins University Mucus penetrating gene carriers
CN104936620B (zh) 2012-01-19 2019-08-09 约翰霍普金斯大学 增强粘膜渗透的纳米粒子调配物
CA2867381C (en) * 2012-03-16 2016-09-20 The Johns Hopkins University Controlled release formulations for the delivery of hif-1 inhibitors
CN104394891B (zh) 2012-03-16 2019-04-16 约翰霍普金斯大学 用于递送活性剂的非线性多嵌段共聚物-药物结合物
EP2849728A1 (de) 2012-05-04 2015-03-25 The Johns Hopkins University Arzneimittelträger auf lipidbasis zur schnellen penetration durch schleimauskleidungen
US9533068B2 (en) 2012-05-04 2017-01-03 The Johns Hopkins University Drug loaded microfiber sutures for ophthalmic application
CN103910875B (zh) * 2012-12-31 2017-06-13 张雅珍 蒽环类抗生素偶联非线性多嵌段共聚物及其制备方法和应用
WO2014124006A1 (en) 2013-02-05 2014-08-14 The Johns Hopkins University Nanoparticles for magnetic resonance imaging tracking and methods of making and using thereof
WO2015127389A1 (en) 2014-02-23 2015-08-27 The Johns Hopkins University Hypotonic enema formulations and methods of use
KR20170106460A (ko) 2015-01-27 2017-09-20 더 존스 홉킨스 유니버시티 점막표면에서 활성제의 향상된 수송을 위한 저장성 하이드로겔 제제

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0005316A1 (de) * 1978-03-27 1979-11-14 Discovision Associates Optisches Gerät und Verfahren zur Aufzeichnung von Information und mit diesem Gerät gebildeter Aufzeichnungsträger; optisches Gerät zum Auslesen der aufgezeichneten Information
DE4002888A1 (de) 1990-02-01 1991-08-08 Behringwerke Ag Anthracyclin-glycosyl-prodrugs, verfahren zu ihrer herstellung und ihre verwendung in kombination mit funktionalisierten tumorspezifischen enzymkonjugaten
FR2676058B1 (fr) * 1991-04-30 1994-02-25 Hoechst Lab Prodrogues glycosylees, leur procede de preparation et leur utilisation dans le traitement des cancers.
DE4236237A1 (de) 1992-10-27 1994-04-28 Behringwerke Ag Prodrugs, ihre Herstellung und Verwendung als Arzneimittel

Also Published As

Publication number Publication date
DK0751144T3 (da) 2004-12-27
EP0751144A1 (de) 1997-01-02
JPH0912591A (ja) 1997-01-14
CA2178684A1 (en) 1996-12-28
PT751144E (pt) 2004-12-31
DE69533615T2 (de) 2005-10-13
EP0751144B1 (de) 2004-10-06
ES2227536T3 (es) 2005-04-01
ATE278700T1 (de) 2004-10-15
US5710135A (en) 1998-01-20

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee