DE69528065T2 - Azazyklohexapeptid-verbindungen - Google Patents

Azazyklohexapeptid-verbindungen

Info

Publication number
DE69528065T2
DE69528065T2 DE69528065T DE69528065T DE69528065T2 DE 69528065 T2 DE69528065 T2 DE 69528065T2 DE 69528065 T DE69528065 T DE 69528065T DE 69528065 T DE69528065 T DE 69528065T DE 69528065 T2 DE69528065 T2 DE 69528065T2
Authority
DE
Germany
Prior art keywords
azazyklohexapeptid
connections
utilities
antibiotic
seq
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69528065T
Other languages
English (en)
Other versions
DE69528065D1 (de
Inventor
James M Balkovec
Frances A Bouffard
Milton L Hammond
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Application granted granted Critical
Publication of DE69528065D1 publication Critical patent/DE69528065D1/de
Publication of DE69528065T2 publication Critical patent/DE69528065T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/08—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis for Pneumocystis carinii
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/27—Cyclic peptide or cyclic protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Display Devices Of Pinball Game Machines (AREA)
  • Absorbent Articles And Supports Therefor (AREA)
DE69528065T 1994-09-16 1995-09-12 Azazyklohexapeptid-verbindungen Expired - Lifetime DE69528065T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30797994A 1994-09-16 1994-09-16
PCT/US1995/011520 WO1996008266A1 (en) 1994-09-16 1995-09-12 Aza cyclohexapeptide compounds

Publications (2)

Publication Number Publication Date
DE69528065D1 DE69528065D1 (de) 2002-10-10
DE69528065T2 true DE69528065T2 (de) 2003-04-10

Family

ID=23192005

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69528065T Expired - Lifetime DE69528065T2 (de) 1994-09-16 1995-09-12 Azazyklohexapeptid-verbindungen

Country Status (8)

Country Link
US (1) US5668105A (de)
EP (1) EP0781141B1 (de)
JP (1) JP3657989B2 (de)
AT (1) ATE223226T1 (de)
AU (1) AU692308B2 (de)
DE (1) DE69528065T2 (de)
ES (1) ES2181790T3 (de)
WO (1) WO1996008266A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5905097A (en) * 1993-01-08 1999-05-18 The Dow Chemical Company High-strength breathable films of block copolymer lattices
JP3118466B2 (ja) * 1994-08-23 2000-12-18 メルク エンド カンパニー インコーポレーテッド シクロヘキサペプチジルリポペプチドの側鎖誘導体の改良製造方法
US5552521A (en) * 1995-02-10 1996-09-03 Merck & Co., Inc. Process for preparing certain aza cyclohexapeptides
KR19990044489A (ko) * 1995-09-07 1999-06-25 로렌스 티. 마이젠헬더 환식 구충제
US5696084A (en) * 1996-08-16 1997-12-09 Abbott Laboratories Amino-lipopetide antifungal agents
EP1073675B1 (de) * 1998-04-23 2007-01-03 Aventis Pharma Deutschland GmbH Verfahren zur reduzierung von echinocandin-peptiden zu deren c4-monodeoxyhomotyrosin analoga
FR2833596B1 (fr) * 2001-12-14 2005-02-18 Aventis Pharma Sa Procede de preparation de derives d'echinocandine
US8048853B2 (en) 2008-06-13 2011-11-01 Xellia Pharmaceuticals Aps Process for preparing pharmaceutical compound and intermediates thereof
KR20110011704A (ko) 2008-06-25 2011-02-08 테바 기오기스제르갸르 자르트쾨렌 뮈쾨되 레스즈베니타르사사그 카스포펀진 불순물 ａ를 함유하지 않는 카스포펀진
CA2888625A1 (en) 2012-11-20 2014-05-30 Fresenius Kabi Usa, Llc Caspofungin acetate formulations

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5021341A (en) * 1990-03-12 1991-06-04 Merck & Co., Inc. Antibiotic agent produced by the cultivation of Zalerion microorganism in the presence of mannitol
US5306708A (en) * 1990-12-19 1994-04-26 Merck & Co., Inc. Antibiotic agent
MY136593A (en) * 1992-03-19 2008-10-31 Lilly Co Eli Cyclic peptide antifungal agents and process for preparation thereof
GB2271571A (en) * 1992-10-19 1994-04-20 Merck & Co Inc Aminoalkyl ether of cyclohexapeptidylamine compounds
US5378804A (en) * 1993-03-16 1995-01-03 Merck & Co., Inc. Aza cyclohexapeptide compounds
JP3118466B2 (ja) * 1994-08-23 2000-12-18 メルク エンド カンパニー インコーポレーテッド シクロヘキサペプチジルリポペプチドの側鎖誘導体の改良製造方法
US5552521A (en) * 1995-02-10 1996-09-03 Merck & Co., Inc. Process for preparing certain aza cyclohexapeptides

Also Published As

Publication number Publication date
JPH10505836A (ja) 1998-06-09
DE69528065D1 (de) 2002-10-10
JP3657989B2 (ja) 2005-06-08
US5668105A (en) 1997-09-16
WO1996008266A1 (en) 1996-03-21
ATE223226T1 (de) 2002-09-15
AU692308B2 (en) 1998-06-04
EP0781141A4 (de) 1998-11-18
EP0781141A1 (de) 1997-07-02
AU3630395A (en) 1996-03-29
EP0781141B1 (de) 2002-09-04
ES2181790T3 (es) 2003-03-01

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: MERCK SHARP & DOHME CORP., NEW JERSEY, N.J., US

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Effective date: 20121213

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