DE69524738D1 - Verzweigte polyoxyalkyl makromoleküle, verfahren zu ihrer herstellung und ihre verwendung - Google Patents

Verzweigte polyoxyalkyl makromoleküle, verfahren zu ihrer herstellung und ihre verwendung

Info

Publication number
DE69524738D1
DE69524738D1 DE69524738T DE69524738T DE69524738D1 DE 69524738 D1 DE69524738 D1 DE 69524738D1 DE 69524738 T DE69524738 T DE 69524738T DE 69524738 T DE69524738 T DE 69524738T DE 69524738 D1 DE69524738 D1 DE 69524738D1
Authority
DE
Germany
Prior art keywords
macromolecules
production
branched
polyoxyalkyl
nucleus
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69524738T
Other languages
English (en)
Other versions
DE69524738T2 (de
Inventor
Luigia Gozzini
Monica Muttoni
Haen Christoph De
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bracco Imaging SpA
Original Assignee
Bracco Imaging SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco Imaging SpA filed Critical Bracco Imaging SpA
Application granted granted Critical
Publication of DE69524738D1 publication Critical patent/DE69524738D1/de
Publication of DE69524738T2 publication Critical patent/DE69524738T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/06—Macromolecular compounds, carriers being organic macromolecular compounds, i.e. organic oligomeric, polymeric, dendrimeric molecules
    • A61K51/065—Macromolecular compounds, carriers being organic macromolecular compounds, i.e. organic oligomeric, polymeric, dendrimeric molecules conjugates with carriers being macromolecules
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/34—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from hydroxy compounds or their metallic derivatives
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G83/00—Macromolecular compounds not provided for in groups C08G2/00 - C08G81/00
    • C08G83/002—Dendritic macromolecules
    • C08G83/003—Dendrimers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nanotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Optics & Photonics (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
  • Polyethers (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
DE69524738T 1994-03-18 1995-03-14 Verzweigte polyoxyalkyl makromoleküle, verfahren zu ihrer herstellung und ihre verwendung Expired - Lifetime DE69524738T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITMI940512A IT1270994B (it) 1994-03-18 1994-03-18 Macromolecole ramificate a struttura poliossialchilica e loro usi
PCT/EP1995/000943 WO1995025763A1 (en) 1994-03-18 1995-03-14 Branched polyoxaalkyl macromolecules, process for making them and their uses

Publications (2)

Publication Number Publication Date
DE69524738D1 true DE69524738D1 (de) 2002-01-31
DE69524738T2 DE69524738T2 (de) 2002-06-13

Family

ID=11368259

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69524738T Expired - Lifetime DE69524738T2 (de) 1994-03-18 1995-03-14 Verzweigte polyoxyalkyl makromoleküle, verfahren zu ihrer herstellung und ihre verwendung

Country Status (14)

Country Link
US (1) US5780644A (de)
EP (1) EP0750649B1 (de)
JP (1) JPH09510489A (de)
KR (1) KR970701748A (de)
AT (1) ATE211155T1 (de)
AU (1) AU689244B2 (de)
CA (1) CA2185647A1 (de)
DE (1) DE69524738T2 (de)
FI (1) FI963646A (de)
IL (1) IL113004A (de)
IT (1) IT1270994B (de)
NO (1) NO312901B1 (de)
WO (1) WO1995025763A1 (de)
ZA (1) ZA952165B (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH10510822A (ja) * 1994-12-21 1998-10-20 ノバルティス アクチェンゲゼルシャフト オリゴヌクレオチド−デンドリマー複合体
IT1277414B1 (it) * 1995-08-02 1997-11-10 Bracco Spa Uso di macromolecole di tipo dendrimerico come catalizzatori o coadiuvanti delle reazioni in condizioni di trasferimento di fase
IT1277596B1 (it) * 1995-09-15 1997-11-11 Bracco Spa Composti macromolecolari di tipo dendrimerico
WO1997014740A1 (en) 1995-10-19 1997-04-24 Receptagen Corporation Discrete-length polyethylene glycols
DE19624705A1 (de) * 1996-06-20 1998-01-08 Deutsches Krebsforsch Dendrimere auf Saccharid-Basis
US6214988B1 (en) 1999-01-03 2001-04-10 Schlumberger Technology Corporation Process for making an HMX product
US6428724B1 (en) 1999-05-26 2002-08-06 Schlumberger Technology Corporation Granulation process
US6201117B1 (en) 1999-05-26 2001-03-13 Schlumberger Technology Corporation Process for making a 1,3,5,7-tetraalkanoyl-1,3,5,7-tetraazacyclooctane
US6265573B1 (en) 1999-05-26 2001-07-24 Schlumberger Technology Corporation Purification process
US6194571B1 (en) 1999-05-26 2001-02-27 Schlumberger Technology Corporation HMX compositions and processes for their preparation
KR20020057946A (ko) 1999-07-29 2002-07-12 로퍼, 랜달 비. 다부위 결합을 통해 멀티머 영상제를 표적화하는 방법
US7560520B1 (en) 2004-11-08 2009-07-14 The United States Of America As Represented By The Secretary Of The Army Interface-directed branched polymer transports and methods for producing same
US7645854B2 (en) * 2005-03-04 2010-01-12 Central Michigan University Board Of Trustees Conjugate addition products of primary amines and activated acceptors
EP1955712A1 (de) * 2007-02-09 2008-08-13 Scil proteins GmbH Multimeres Konjugat
EP2125920B1 (de) 2007-03-15 2014-12-31 Huntsman Petrochemical LLC Hochfunktionelle aminverbindungen und ihre verwendung
WO2011123031A1 (en) * 2010-03-30 2011-10-06 Spago Imaging Ab Branched, compact polyethyleneglycol derivatives
US8816099B2 (en) * 2010-03-31 2014-08-26 Nof Corporation Polyfunctional polyoxyalkylene compound, and producing method and intermediate thereof
US9133114B2 (en) * 2012-01-31 2015-09-15 University Of Maryland, Baltimore Dendrimers and methods of preparing same through proportionate branching

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4568737A (en) * 1983-01-07 1986-02-04 The Dow Chemical Company Dense star polymers and dendrimers
US4737550A (en) * 1983-01-07 1988-04-12 The Dow Chemical Company Bridged dense star polymers
US5099042A (en) * 1989-03-14 1992-03-24 Thiokol Corporation Synthesis of tetrafunctional polyethers and compositions formed therefrom
US5041516A (en) * 1989-06-21 1991-08-20 Cornell Research Foundation, Inc. Dendritic molecules and method of production
US5294365A (en) * 1991-12-12 1994-03-15 Basf Corporation Hydroxypolyethers as low-foam surfactants

Also Published As

Publication number Publication date
IL113004A0 (en) 1995-06-29
JPH09510489A (ja) 1997-10-21
CA2185647A1 (en) 1995-09-28
US5780644A (en) 1998-07-14
WO1995025763A1 (en) 1995-09-28
FI963646A0 (fi) 1996-09-16
ITMI940512A0 (it) 1994-03-18
KR970701748A (ko) 1997-04-12
EP0750649A1 (de) 1997-01-02
IL113004A (en) 2000-08-31
ITMI940512A1 (it) 1995-09-18
EP0750649B1 (de) 2001-12-19
NO312901B1 (no) 2002-07-15
ATE211155T1 (de) 2002-01-15
NO963872D0 (no) 1996-09-16
IT1270994B (it) 1997-05-26
ZA952165B (en) 1995-12-14
NO963872L (no) 1996-09-16
FI963646A (fi) 1996-09-16
DE69524738T2 (de) 2002-06-13
AU689244B2 (en) 1998-03-26
AU2070395A (en) 1995-10-09

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