DE69515177T2 - Tetrahydropyridinylmethylderivate von pyrrolo[2,3-b]pyridine - Google Patents

Tetrahydropyridinylmethylderivate von pyrrolo[2,3-b]pyridine

Info

Publication number: DE69515177T2
Authority: DE; Germany
Prior art keywords: pct; pyrrolo; pyridine; tetrahydropyridinyl; image
Prior art date: 1994-08-10
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE69515177T

Other languages

English (en)

Other versions

DE69515177D1 (de

Inventor

Roy Curtis

Jozef Kulagowski

David Leeson

Peter Ridgill

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Organon Pharma UK Ltd

Original Assignee

Merck Sharp and Dohme Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-08-10

Filing date

1995-08-01

Publication date

2000-10-05

1994-08-10 Priority claimed from GB9416160A external-priority patent/GB9416160D0/en

1994-08-10 Priority claimed from GB9416161A external-priority patent/GB9416161D0/en

1995-03-23 Priority claimed from GBGB9505888.9A external-priority patent/GB9505888D0/en

1995-08-01 Application filed by Merck Sharp and Dohme Ltd filed Critical Merck Sharp and Dohme Ltd

2000-03-30 Publication of DE69515177D1 publication Critical patent/DE69515177D1/de

2000-10-05 Application granted granted Critical

2000-10-05 Publication of DE69515177T2 publication Critical patent/DE69515177T2/de

2015-08-02 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

-1 TETRAHYDROPYRIDINYL METHYL DERIVATIVES OF PYRROLO [2,3-B] PYRIDINE Chemical class 0.000 title 1
VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 abstract 2
MVXVYAKCVDQRLW-UHFFFAOYSA-N 1h-pyrrolo[2,3-b]pyridine Chemical class C1=CN=C2NC=CC2=C1 MVXVYAKCVDQRLW-UHFFFAOYSA-N 0.000 abstract 1
102000003962 Dopamine D4 receptors Human genes 0.000 abstract 1
108090000357 Dopamine D4 receptors Proteins 0.000 abstract 1
102000015554 Dopamine receptor Human genes 0.000 abstract 1
108050004812 Dopamine receptor Proteins 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
229960003638 dopamine Drugs 0.000 abstract 1
239000003446 ligand Substances 0.000 abstract 1
230000002265 prevention Effects 0.000 abstract 1
201000000980 schizophrenia Diseases 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, ***e
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

DE69515177T 1994-08-10 1995-08-01 Tetrahydropyridinylmethylderivate von pyrrolo[2,3-b]pyridine Expired - Lifetime DE69515177T2 (de)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
GB9416160A GB9416160D0 (en)	1994-08-10	1994-08-10	Therapeutic agents
GB9416161A GB9416161D0 (en)	1994-08-10	1994-08-10	Therapeutic agents
GBGB9505888.9A GB9505888D0 (en)	1995-03-23	1995-03-23	Therapeutic agents
PCT/GB1995/001820 WO1996005200A1 (en)	1994-08-10	1995-08-01	TETRAHYDROPYRIDINYLMETHYL DERIVATIVES OF PYRROLO[2,3-b]PYRIDINE

Publications (2)

Publication Number	Publication Date
DE69515177D1 DE69515177D1 (de)	2000-03-30
DE69515177T2 true DE69515177T2 (de)	2000-10-05

Family

ID=27267327

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE69515177T Expired - Lifetime DE69515177T2 (de)	1994-08-10	1995-08-01	Tetrahydropyridinylmethylderivate von pyrrolo[2,3-b]pyridine

Country Status (8)

Country	Link
US (1)	US5830901A (de)
EP (1)	EP0775138B1 (de)
JP (1)	JP3911012B2 (de)
AT (1)	ATE189895T1 (de)
AU (1)	AU699196B2 (de)
DE (1)	DE69515177T2 (de)
ES (1)	ES2145289T3 (de)
WO (1)	WO1996005200A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE184008T1 (de) *	1993-03-01	1999-09-15	Merck Sharp & Dohme	Pyrrolopyridinderivate als dopaminrezeptor liganden
US6362009B1 (en)	1997-11-21	2002-03-26	Merck & Co., Inc.	Solid phase synthesis of heterocycles
EP1606630A2 (de) *	2003-03-18	2005-12-21	Bayer HealthCare AG	Diagnose und therapie von erkrankungen, die mit dem humanen dopamin rezeptor d4 (drd4) assoziiert sind
CA2550361C (en)	2003-12-19	2014-04-29	Prabha Ibrahim	Compounds and methods for development of ret modulators
US7498342B2 (en)	2004-06-17	2009-03-03	Plexxikon, Inc.	Compounds modulating c-kit activity
GB0503646D0 (en) *	2005-02-22	2005-03-30	Novartis Ag	Organic compounds
GB0508319D0 (en)	2005-04-25	2005-06-01	Novartis Ag	Organic compounds
GB0508318D0 (en) *	2005-04-25	2005-06-01	Novartis Ag	Organic compounds
GB0508314D0 (en) *	2005-04-25	2005-06-01	Novartis Ag	Organic compounds
WO2008063888A2 (en)	2006-11-22	2008-05-29	Plexxikon, Inc.	Compounds modulating c-fms and/or c-kit activity and uses therefor
US20100190777A1 (en)	2007-07-17	2010-07-29	Plexxikon Inc.	Compounds and methods for kinase modulation, and indications therefor
EP2414356B1 (de)	2009-04-03	2015-09-02	F.Hoffmann-La Roche Ag	Propan-1-sulfonsäure-{3-[5-(4- chlorphenyl)-1h-pyrrolo[2,3-b]pyridin-3-carbonyl]-2,4-difluorphenyl} amidzusammensetzungen und anwendungen davon
MX2012005284A (es)	2009-11-06	2012-06-28	Plexxikon Inc	Compuestos y metodos para la modulacion de cinasas. e indicaciones para ello.
AU2012214762B2 (en)	2011-02-07	2015-08-13	Plexxikon Inc.	Compounds and methods for kinase modulation, and indications therefor
TWI558702B (zh)	2011-02-21	2016-11-21	普雷辛肯公司	醫藥活性物質的固態形式
US9150570B2 (en)	2012-05-31	2015-10-06	Plexxikon Inc.	Synthesis of heterocyclic compounds
US10300155B2 (en)	2015-12-31	2019-05-28	Washington University	Alpha-synuclein ligands

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB2044254B (en) *	1979-01-26	1983-01-26	Wyeth John & Brother Ltd	Piperidine derivatives
JPH09500357A (ja) *	1993-03-01	1997-01-14	メルクシヤープエンドドームリミテツド	ピロロ−ピリジン誘導体
GB9416162D0 (en) *	1994-08-10	1994-09-28	Merck Sharp & Dohme	Therapeutic agents

1995
- 1995-08-01 DE DE69515177T patent/DE69515177T2/de not_active Expired - Lifetime
- 1995-08-01 AU AU31825/95A patent/AU699196B2/en not_active Ceased
- 1995-08-01 US US08/776,486 patent/US5830901A/en not_active Expired - Fee Related
- 1995-08-01 ES ES95927817T patent/ES2145289T3/es not_active Expired - Lifetime
- 1995-08-01 EP EP95927817A patent/EP0775138B1/de not_active Expired - Lifetime
- 1995-08-01 AT AT95927817T patent/ATE189895T1/de not_active IP Right Cessation
- 1995-08-01 JP JP50683596A patent/JP3911012B2/ja not_active Expired - Fee Related
- 1995-08-01 WO PCT/GB1995/001820 patent/WO1996005200A1/en active IP Right Grant

Also Published As

Publication number	Publication date
JP3911012B2 (ja)	2007-05-09
DE69515177D1 (de)	2000-03-30
WO1996005200A1 (en)	1996-02-22
EP0775138A1 (de)	1997-05-28
JPH10503774A (ja)	1998-04-07
US5830901A (en)	1998-11-03
ATE189895T1 (de)	2000-03-15
AU3182595A (en)	1996-03-07
ES2145289T3 (es)	2000-07-01
EP0775138B1 (de)	2000-02-23
AU699196B2 (en)	1998-11-26

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Legal Events

Date	Code	Title	Description
2001-03-15	8364	No opposition during term of opposition