DE69509888T2 - IMIDAZO[1,2-a]INDENO [1,2-e] PYRAZINONE ANTAGONISTEN DER AMPA UND NMDA REZEPTOREN - Google Patents
IMIDAZO[1,2-a]INDENO [1,2-e] PYRAZINONE ANTAGONISTEN DER AMPA UND NMDA REZEPTORENInfo
- Publication number
- DE69509888T2 DE69509888T2 DE69509888T DE69509888T DE69509888T2 DE 69509888 T2 DE69509888 T2 DE 69509888T2 DE 69509888 T DE69509888 T DE 69509888T DE 69509888 T DE69509888 T DE 69509888T DE 69509888 T2 DE69509888 T2 DE 69509888T2
- Authority
- DE
- Germany
- Prior art keywords
- pct
- ampa
- receptor
- antagonists
- pyrazinone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9403581A FR2717812B1 (fr) | 1994-03-28 | 1994-03-28 | Indeno[1,2-e]pyrazine-4-ones, leur préparation et les médicaments les contenant. |
PCT/FR1995/000357 WO1995026349A1 (fr) | 1994-03-28 | 1995-03-23 | INDENO[1,2-e]PYRAZINE-4-ONES, LEUR PREPARATION ET LES MEDICAMENTS LES CONTENANT |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69509888D1 DE69509888D1 (de) | 1999-07-01 |
DE69509888T2 true DE69509888T2 (de) | 1999-09-30 |
Family
ID=9461466
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69509888T Expired - Fee Related DE69509888T2 (de) | 1994-03-28 | 1995-03-23 | IMIDAZO[1,2-a]INDENO [1,2-e] PYRAZINONE ANTAGONISTEN DER AMPA UND NMDA REZEPTOREN |
Country Status (13)
Country | Link |
---|---|
US (1) | US5789406A (de) |
EP (1) | EP0752991B1 (de) |
JP (1) | JPH09510726A (de) |
AT (1) | ATE180483T1 (de) |
AU (1) | AU2141295A (de) |
DE (1) | DE69509888T2 (de) |
DK (1) | DK0752991T3 (de) |
ES (1) | ES2134459T3 (de) |
FR (1) | FR2717812B1 (de) |
GR (1) | GR3030273T3 (de) |
IL (1) | IL113147A0 (de) |
WO (1) | WO1995026349A1 (de) |
ZA (1) | ZA952531B (de) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2743366B1 (fr) * | 1996-01-10 | 1998-02-06 | Rhone Poulenc Rorer Sa | Derives de 5h,10h-imidazo(1,2-a)indeno(1,2-e)pyrazine-4-one, leur preparation, leurs intermediaires et les medicaments les contenant |
DE50212652D1 (de) * | 2001-03-14 | 2008-09-25 | Gruenenthal Gmbh | Substituierte Thiazolopyrimidine als Analgetika |
US7732162B2 (en) | 2003-05-05 | 2010-06-08 | Probiodrug Ag | Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases |
US7320992B2 (en) * | 2003-08-25 | 2008-01-22 | Amgen Inc. | Substituted 2,3-dihydro-1h-isoindol-1-one derivatives and methods of use |
WO2008055945A1 (en) | 2006-11-09 | 2008-05-15 | Probiodrug Ag | 3-hydr0xy-1,5-dihydr0-pyrr0l-2-one derivatives as inhibitors of glutaminyl cyclase for the treatment of ulcer, cancer and other diseases |
WO2008065141A1 (en) | 2006-11-30 | 2008-06-05 | Probiodrug Ag | Novel inhibitors of glutaminyl cyclase |
ZA200905537B (en) | 2007-03-01 | 2010-10-27 | Probiodrug Ag | New use of glutaminyl cyclase inhibitors |
JP5667440B2 (ja) | 2007-04-18 | 2015-02-12 | プロビオドルグ エージー | グルタミニルシクラーゼ阻害剤としてのチオ尿素誘導体 |
MX2012002993A (es) | 2009-09-11 | 2012-04-19 | Probiodrug Ag | Derivados heterociclicos como inhibidores de ciclasa glutaminilo. |
JP6026284B2 (ja) | 2010-03-03 | 2016-11-16 | プロビオドルグ エージー | グルタミニルシクラーゼの阻害剤 |
MX2012010470A (es) | 2010-03-10 | 2012-10-09 | Probiodrug Ag | Inhibidores heterociclicos d ciclasa de glutaminilo (qc, ec .3 2. 5). |
US8541596B2 (en) | 2010-04-21 | 2013-09-24 | Probiodrug Ag | Inhibitors |
WO2012123563A1 (en) | 2011-03-16 | 2012-09-20 | Probiodrug Ag | Benz imidazole derivatives as inhibitors of glutaminyl cyclase |
EP3461819B1 (de) | 2017-09-29 | 2020-05-27 | Probiodrug AG | Hemmer der glutaminylcyclase |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4668678A (en) * | 1980-05-09 | 1987-05-26 | Usv Pharmaceutical Corporation | Triazoloquinoxalin-1,4-diones |
US4400382A (en) * | 1980-05-09 | 1983-08-23 | Usv Pharmaceutical Corporation | Thiazoloquinoxalin-1,4-diones for treating allergy |
US4507300A (en) * | 1980-05-09 | 1985-03-26 | Usv Pharmaceutical Corporation | Pyridotriazolopyrazine-diones for treating allergy |
US4354027A (en) * | 1980-05-19 | 1982-10-12 | Usv Pharmaceutical Corporation | Triazoloquinoxalin-4-ones |
US5191197A (en) * | 1988-05-11 | 1993-03-02 | Symbol Technologies, Inc. | Arm mounted scanner actuatable by hand movement |
US5196421A (en) * | 1991-06-05 | 1993-03-23 | Eli Lilly And Company | Excitatory amino acid receptor antagonists in methods for the use thereof |
US5153196A (en) * | 1991-06-05 | 1992-10-06 | Eli Lilly And Company | Excitatory amino acid receptor antagonists and methods for the use thereof |
DK162491D0 (da) * | 1991-09-20 | 1991-09-20 | Novo Nordisk As | Heterocycliske forbindelser, deres fremstilling og farmaceutiske praeparater indeholdende forbindelserne |
WO1994000124A1 (en) * | 1992-06-22 | 1994-01-06 | Eckard Weber | Glycine receptor antagonists and the use thereof |
FR2696466B1 (fr) * | 1992-10-02 | 1994-11-25 | Rhone Poulenc Rorer Sa | Dérivés de 5H,10H-imidazo[1,2-a]indeno[1,2-e]pyrazine-4-one, leur préparation et les médicaments les contenant. |
DK12293D0 (da) * | 1993-02-02 | 1993-02-02 | Novo Nordisk As | Heterocykliske forbindelser og deres fremstilling og anvendelse |
FR2707645B1 (fr) * | 1993-07-16 | 1995-08-11 | Rhone Poulenc Rorer Sa | Dérivés d'imidazo[1,2-a]pirazine-4-one, leur préparation et les médicaments les contenant. |
FR2707643B1 (fr) * | 1993-07-16 | 1995-08-11 | Rhone Poulenc Rorer Sa | Dérivés d'imidazo[1,2-a]pyrazine-4-one, leur préparation et les médicaments les contenant. |
-
1994
- 1994-03-28 FR FR9403581A patent/FR2717812B1/fr not_active Expired - Fee Related
-
1995
- 1995-03-23 EP EP95914403A patent/EP0752991B1/de not_active Expired - Lifetime
- 1995-03-23 AU AU21412/95A patent/AU2141295A/en not_active Abandoned
- 1995-03-23 WO PCT/FR1995/000357 patent/WO1995026349A1/fr active Search and Examination
- 1995-03-23 DE DE69509888T patent/DE69509888T2/de not_active Expired - Fee Related
- 1995-03-23 US US08/714,163 patent/US5789406A/en not_active Expired - Fee Related
- 1995-03-23 AT AT95914403T patent/ATE180483T1/de not_active IP Right Cessation
- 1995-03-23 JP JP7524994A patent/JPH09510726A/ja active Pending
- 1995-03-23 DK DK95914403T patent/DK0752991T3/da active
- 1995-03-23 ES ES95914403T patent/ES2134459T3/es not_active Expired - Lifetime
- 1995-03-27 IL IL11314795A patent/IL113147A0/xx unknown
- 1995-03-28 ZA ZA952531A patent/ZA952531B/xx unknown
-
1999
- 1999-05-27 GR GR980402937T patent/GR3030273T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
DE69509888D1 (de) | 1999-07-01 |
EP0752991B1 (de) | 1999-05-26 |
ATE180483T1 (de) | 1999-06-15 |
ES2134459T3 (es) | 1999-10-01 |
AU2141295A (en) | 1995-10-17 |
EP0752991A1 (de) | 1997-01-15 |
JPH09510726A (ja) | 1997-10-28 |
DK0752991T3 (da) | 1999-11-08 |
IL113147A0 (en) | 1995-06-29 |
GR3030273T3 (en) | 1999-08-31 |
WO1995026349A1 (fr) | 1995-10-05 |
FR2717812B1 (fr) | 1996-05-10 |
FR2717812A1 (fr) | 1995-09-29 |
US5789406A (en) | 1998-08-04 |
ZA952531B (en) | 1996-01-11 |
Similar Documents
Publication | Publication Date | Title |
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DE69509888T2 (de) | IMIDAZO[1,2-a]INDENO [1,2-e] PYRAZINONE ANTAGONISTEN DER AMPA UND NMDA REZEPTOREN | |
ATE180476T1 (de) | 5h-indeno(1,2-b>pyrazin-2,3-dion-derivate antagonisten der ampa und nmda rezeptoren | |
DE69804966T2 (de) | Neue verbindungen | |
DK0752992T3 (da) | Imidazo[1,2-a]indeno[1,2-e]pyrazin-4-on-derivater og farmaceutiske præparater indeholdende disse derivater | |
DE69508421D1 (de) | SPIRO[HETEROZYCLISCHE-IMIDAZO[1,2-a]INDENO[1,2-e]PYRAZIN]-4'-ONE, IHRE HERSTELLUNG UND DIESE ENTHALTENDE ARZNEIMITTEL | |
DE69525738D1 (de) | Heterocyclische verbindungen und ihre herstellung und verwendung | |
ATE188214T1 (de) | Pyrrolyl-tetrahydrobenzochinoxalindione, ihre herstellung und verwendung als glutamatrezeptor- antagonisten |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |