DE69502855T2 - (Pyrrolidinyl)phenylcarbamate und Zwischenverbindungen, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikamente - Google Patents

(Pyrrolidinyl)phenylcarbamate und Zwischenverbindungen, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikamente

Info

Publication number
DE69502855T2
DE69502855T2 DE69502855T DE69502855T DE69502855T2 DE 69502855 T2 DE69502855 T2 DE 69502855T2 DE 69502855 T DE69502855 T DE 69502855T DE 69502855 T DE69502855 T DE 69502855T DE 69502855 T2 DE69502855 T2 DE 69502855T2
Authority
DE
Germany
Prior art keywords
pyrrolidinyl
processes
preparation
medicines
intermediates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69502855T
Other languages
English (en)
Other versions
DE69502855D1 (de
Inventor
David Dr Wettlaufer
Peter Allen Nemoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Hoechst Marion Roussel Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Marion Roussel Inc filed Critical Hoechst Marion Roussel Inc
Application granted granted Critical
Publication of DE69502855D1 publication Critical patent/DE69502855D1/de
Publication of DE69502855T2 publication Critical patent/DE69502855T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Psychiatry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE69502855T 1994-03-10 1995-03-06 (Pyrrolidinyl)phenylcarbamate und Zwischenverbindungen, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikamente Expired - Fee Related DE69502855T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/208,554 US5338739A (en) 1994-03-10 1994-03-10 (Pyrrolidinyl)phenyl carbamates, compositions and use

Publications (2)

Publication Number Publication Date
DE69502855D1 DE69502855D1 (de) 1998-07-16
DE69502855T2 true DE69502855T2 (de) 1998-11-26

Family

ID=22775020

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69502855T Expired - Fee Related DE69502855T2 (de) 1994-03-10 1995-03-06 (Pyrrolidinyl)phenylcarbamate und Zwischenverbindungen, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikamente

Country Status (8)

Country Link
US (3) US5338739A (de)
EP (1) EP0671388B1 (de)
JP (1) JP3453211B2 (de)
AT (1) ATE167182T1 (de)
CA (1) CA2144294C (de)
DE (1) DE69502855T2 (de)
DK (1) DK0671388T3 (de)
ES (1) ES2119244T3 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19648011A1 (de) * 1996-11-20 1998-05-28 Bayer Ag Cyclische Imine
AR041885A1 (es) * 2002-11-06 2005-06-01 Smithkline Beecham Corp Compuesto de sulfonamida, composicion farmaceutica que lo comprende y su uso para preparar dicha composicion
US20060020285A1 (en) * 2004-07-22 2006-01-26 Volker Niermann Method for filtering blood in a vessel with helical elements
WO2010011302A1 (en) * 2008-07-22 2010-01-28 Chdi, Inc. Certain kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof
EA027451B1 (ru) 2011-08-30 2017-07-31 Схди Фаундейшн, Инк. Ингибиторы кинуренин-3-монооксигеназы, фармацевтические композиции и их применение
AU2012300246A1 (en) 2011-08-30 2014-03-06 Chdi Foundation, Inc. Kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof
SG11201700341PA (en) 2014-07-17 2017-02-27 Chdi Foundation Inc Methods and compositions for treating hiv-related disorders
JP2019510820A (ja) * 2016-03-21 2019-04-18 ワインスタイン，デイビッド 創傷治癒及び瘢痕予防のための方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3149123A (en) * 1961-01-04 1964-09-15 Parke Davis & Co 1, 3-dialkyl-3-oxyphenylpyrrolidine compounds
CH484103A (de) * 1966-09-02 1970-01-15 Ciba Geigy Verfahren zur Herstellung von neuen Carbamaten
GB1178400A (en) * 1966-12-13 1970-01-21 Delalande Sa Nitrogen Substituted Amines and their process of Preparation.
US3674806A (en) * 1969-04-30 1972-07-04 Reynolds Tobacco Co R 1,3,3,4,4-pentasubstituted pyrrolidines
DE2413935A1 (de) * 1974-03-20 1975-10-16 Schering Ag 4-(polyalkoxy-phenyl)-2-pyrrolidone
US5001142A (en) * 1989-07-19 1991-03-19 American Cyanamid Company 1-substituted-2-(3-amino-1-propynyl)pyrrolidine derivatives
US5015741A (en) * 1989-10-03 1991-05-14 Philip Morris Incorporated Nicotine analogs
AU653837B2 (en) * 1991-04-17 1994-10-13 Pharmacia & Upjohn Company Substituted phenylazacycloalkanes as CNS agents
JP3708957B2 (ja) * 1991-09-26 2005-10-19 アメリカ合衆国 （−）−エゼロリン、（−）−ｎ１−ノルエゼロリンおよび（−）−ｎ１−ベンジルノルエゼロリンの置換フェンゼリンおよびフェニルカルバミン酸塩：特異的アセチルコリンエステラーゼ阻害薬としての使用

Also Published As

Publication number Publication date
ES2119244T3 (es) 1998-10-01
DK0671388T3 (da) 1999-02-15
US5405845A (en) 1995-04-11
ATE167182T1 (de) 1998-06-15
CA2144294A1 (en) 1995-09-11
EP0671388A1 (de) 1995-09-13
CA2144294C (en) 2002-11-12
JP3453211B2 (ja) 2003-10-06
JPH07278103A (ja) 1995-10-24
EP0671388B1 (de) 1998-06-10
DE69502855D1 (de) 1998-07-16
US5338739A (en) 1994-08-16
US5591856A (en) 1997-01-07

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee