DE69433831D1 - Modifizierung von Pertussistoxin - Google Patents
Modifizierung von PertussistoxinInfo
- Publication number
- DE69433831D1 DE69433831D1 DE69433831T DE69433831T DE69433831D1 DE 69433831 D1 DE69433831 D1 DE 69433831D1 DE 69433831 T DE69433831 T DE 69433831T DE 69433831 T DE69433831 T DE 69433831T DE 69433831 D1 DE69433831 D1 DE 69433831D1
- Authority
- DE
- Germany
- Prior art keywords
- modification
- pertussis toxin
- pertussis
- toxin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/235—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bordetella (G)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Food Science & Technology (AREA)
- Pathology (AREA)
- Organic Chemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11094793A | 1993-08-24 | 1993-08-24 | |
US110947 | 1993-08-24 | ||
US25112194A | 1994-05-31 | 1994-05-31 | |
US251121 | 1994-05-31 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69433831D1 true DE69433831D1 (de) | 2004-07-15 |
DE69433831T2 DE69433831T2 (de) | 2005-06-23 |
Family
ID=26808533
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69433831T Expired - Fee Related DE69433831T2 (de) | 1993-08-24 | 1994-08-23 | Modifizierung von Pertussistoxin |
Country Status (3)
Country | Link |
---|---|
US (5) | US5856122A (de) |
EP (1) | EP0646599B1 (de) |
DE (1) | DE69433831T2 (de) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2169724T3 (es) * | 1992-10-02 | 2002-07-16 | Alberta Res Council | Propiedades antiinflamatorias, tolerogenicas e inmunoestimulantes de peptidos que enlazan carbohidratos. |
US5856122A (en) * | 1993-08-24 | 1999-01-05 | University Of Alberta | Modification of pertussis toxin |
GB9326174D0 (en) * | 1993-12-22 | 1994-02-23 | Biocine Sclavo | Mucosal adjuvant |
DE19543569C2 (de) * | 1995-11-22 | 1998-01-22 | Atou Lo | Verwendung des Lectins Sambucus nigra zur Quantifizierung der endständigen Sialinsäurereste des Human-Transferrin-Moleküls mittels einer vollimmunoenzymatischen Methode (EIA) |
CA2244228A1 (en) | 1996-01-22 | 1997-07-24 | Creative Biomolecules, Inc. | Morphogen analogs and methods for producing them |
US6818222B1 (en) | 1997-03-21 | 2004-11-16 | Chiron Corporation | Detoxified mutants of bacterial ADP-ribosylating toxins as parenteral adjuvants |
US6842704B2 (en) | 1998-02-04 | 2005-01-11 | Immunex Corporation | Crystalline TNF-α-converting enzyme and uses thereof |
JP2003506411A (ja) * | 1999-08-09 | 2003-02-18 | トリペップ アクチ ボラゲット | タンパク質重合阻害剤および使用方法 |
US7135173B2 (en) * | 2000-07-13 | 2006-11-14 | Idaho Research Foundation, Inc. | Antiviral activity of Shiga toxin |
US6541013B1 (en) | 2000-07-13 | 2003-04-01 | Idaho Research Foundation, Inc. | Methods and compositions for suppressing bovine leukemia virus with a Shiga toxin polypeptide |
EP1351982B1 (de) | 2000-12-09 | 2008-02-13 | The Regents Of The University Of California | Röntgenkristallstruktur mit 5.5 a auflösung von funktionalen komplexen des bakteriellen ribosoms, beinhaltend transfer-rna und modell boten-rna |
WO2003024995A1 (en) * | 2001-09-19 | 2003-03-27 | Tripep Ab | Molecules that block viral infectivity and methods of use thereof |
US8032347B2 (en) * | 2001-11-01 | 2011-10-04 | The University Of British Columbia | Methods and apparatus for protein sequence analysis |
US20040180893A1 (en) * | 2003-02-21 | 2004-09-16 | Balzarini Jan Maria Rene | Identification of compounds that inhibit replication of human immunodeficiency virus |
US20050096319A1 (en) * | 2003-02-21 | 2005-05-05 | Balzarini Jan M.R. | Identification of compounds that inhibit replication of human immunodeficiency virus |
KR101337320B1 (ko) * | 2003-11-20 | 2013-12-06 | 사노피 파스퇴르 인크 | 백일해 독소의 정제방법 및 이에 유용한 펩타이드 |
WO2008154456A2 (en) * | 2007-06-06 | 2008-12-18 | Nationwide Children's Hospital, Inc. | Methods and compositions relating to viral fusion proteins |
AU2008279550B2 (en) * | 2007-06-21 | 2012-08-09 | Angelica Therapeutics, Inc. | Modified toxins |
WO2009110944A1 (en) * | 2008-02-29 | 2009-09-11 | Angelica Therapeutics, Inc. | Modified toxins |
US10059750B2 (en) | 2013-03-15 | 2018-08-28 | Angelica Therapeutics, Inc. | Modified toxins |
PL404247A1 (pl) | 2013-06-07 | 2014-12-08 | Wrocławskie Centrum Badań Eit + Spółka Z Ograniczoną Odpowiedzialnością | Koniugat oligocukru LOS Bordetella pertussis i toksyny krztuśca i jego zastosowanie w profilaktyce i leczeniu zakażeń wywoływanych przez Bordetella pertussis |
US9616114B1 (en) | 2014-09-18 | 2017-04-11 | David Gordon Bermudes | Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity |
US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
JP7059776B2 (ja) | 2018-04-24 | 2022-04-26 | 株式会社デンソー | 並列化方法、並列化ツール、及びマルチコアマイコン |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1340373C (en) * | 1986-01-28 | 1999-02-02 | Rino Rappuoli | Cloning and sequencing of the dna fragment which codes for the five subunits of the pertussis toxin, a hybrid plasmid containing the dna fragment and micro-organisms transformed by the hybrid plasmid and capable of expressing all or some of the subunits of the pertussis toxin |
US4883761A (en) * | 1986-03-25 | 1989-11-28 | The United States Of America As Represented By The Department Of Health And Human Services | Pertussis toxin gene: cloning and expression of protective antigen |
IT1223334B (it) * | 1987-11-02 | 1990-09-19 | Sclavo Spa | Polipeptidi immunologicamente attivi con una tossicita' alterata utili per la preparazione di un vaccino antipertosse |
GB8727489D0 (en) * | 1987-11-24 | 1987-12-23 | Connaught Lab | Detoxification of pertussis toxin |
IT1223529B (it) * | 1987-12-18 | 1990-09-19 | Sclavo Spa | Epitopo immunodominante protettivo contenuto nella subunita' s1 della tossina della pertosse |
AU631351B2 (en) * | 1988-04-20 | 1992-11-26 | Massachusetts Health Research Institute, Inc. (Mhri) | Pertussis toxoid vaccine |
IT1229766B (it) * | 1989-05-19 | 1991-09-10 | Sclavo Spa | Peptidi sintetici capaci di stimolare una immunita' t cellulare. |
JPH05503628A (ja) * | 1989-11-29 | 1993-06-17 | スミスクライン ビーチヤム バイオロジカルズ(エス ア) | 新規なワクチン |
IT1248735B (it) * | 1990-06-21 | 1995-01-26 | Sclavo Spa | Vaccini acellulari contro la pertosse |
IL101692A0 (en) * | 1991-05-03 | 1992-12-30 | Amgen Inc | Recombinant b oligomer of pertussis toxin |
US5817617A (en) * | 1991-05-03 | 1998-10-06 | The Rockefeller University | Selectin and pertussis toxin derived peptides and uses thereof |
US5856122A (en) * | 1993-08-24 | 1999-01-05 | University Of Alberta | Modification of pertussis toxin |
-
1994
- 1994-08-22 US US08/292,968 patent/US5856122A/en not_active Expired - Fee Related
- 1994-08-23 DE DE69433831T patent/DE69433831T2/de not_active Expired - Fee Related
- 1994-08-23 EP EP94306219A patent/EP0646599B1/de not_active Expired - Lifetime
-
1995
- 1995-06-06 US US08/467,974 patent/US5965385A/en not_active Expired - Fee Related
- 1995-06-06 US US08/467,976 patent/US6018022A/en not_active Expired - Fee Related
- 1995-06-06 US US08/467,536 patent/US5977304A/en not_active Expired - Fee Related
-
1998
- 1998-05-21 US US09/082,514 patent/US6168928B1/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP0646599A3 (de) | 1996-05-15 |
US5856122A (en) | 1999-01-05 |
EP0646599B1 (de) | 2004-06-09 |
US5977304A (en) | 1999-11-02 |
US6018022A (en) | 2000-01-25 |
US6168928B1 (en) | 2001-01-02 |
DE69433831T2 (de) | 2005-06-23 |
US5965385A (en) | 1999-10-12 |
EP0646599A2 (de) | 1995-04-05 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |