DE69433504D1 - ALPHAvBETA3 INTEGRIN ALS INDIKATOR FÜR ENDOMETRIOSE - Google Patents
ALPHAvBETA3 INTEGRIN ALS INDIKATOR FÜR ENDOMETRIOSEInfo
- Publication number
- DE69433504D1 DE69433504D1 DE69433504T DE69433504T DE69433504D1 DE 69433504 D1 DE69433504 D1 DE 69433504D1 DE 69433504 T DE69433504 T DE 69433504T DE 69433504 T DE69433504 T DE 69433504T DE 69433504 D1 DE69433504 D1 DE 69433504D1
- Authority
- DE
- Germany
- Prior art keywords
- integrin
- sample
- endometriosis
- indicator
- monitoring
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D19/00—Instruments or methods for reproduction or fertilisation
- A61D19/04—Instruments or methods for reproduction or fertilisation for embryo transplantation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/48—Reproductive organs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
- C07K16/065—Purification, fragmentation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
- C07K16/2848—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta3-subunit-containing molecules, e.g. CD41, CD51, CD61
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
- G01N33/567—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds utilising isolate of tissue or organ as binding agent
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57442—Specifically defined cancers of the uterus and endometrial
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6887—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids from muscle, cartilage or connective tissue
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/70546—Integrin superfamily, e.g. VLAs, leuCAM, GPIIb/GPIIIa, LPAM
- G01N2333/70557—Integrin beta3-subunit-containing molecules, e.g. CD41, CD51, CD61
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2474/00—Immunochemical assays or immunoassays characterised by detection mode or means of detection
- G01N2474/20—Immunohistochemistry assay
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/36—Gynecology or obstetrics
- G01N2800/364—Endometriosis, i.e. non-malignant disorder in which functioning endometrial tissue is present outside the uterine cavity
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Food Science & Technology (AREA)
- Microbiology (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Physics & Mathematics (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Reproductive Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Developmental Biology & Embryology (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Transplantation (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US155435 | 1993-11-19 | ||
US08/155,435 US5478725A (en) | 1992-06-12 | 1993-11-19 | αv β3 integrin as a predictor of endometriosis |
PCT/US1994/013299 WO1995013821A1 (en) | 1993-11-19 | 1994-11-18 | αvβ3 INTEGRIN AS A PREDICTOR OF ENDOMETRIOSIS |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69433504D1 true DE69433504D1 (de) | 2004-02-26 |
DE69433504T2 DE69433504T2 (de) | 2004-12-23 |
Family
ID=22555419
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69435147T Expired - Lifetime DE69435147D1 (de) | 1993-11-19 | 1994-11-18 | ß3-Integrin als Indikator für Endometriose |
DE69433504T Expired - Lifetime DE69433504T2 (de) | 1993-11-19 | 1994-11-18 | ALPHAvBETA3 INTEGRIN ALS INDIKATOR FÜR ENDOMETRIOSE |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69435147T Expired - Lifetime DE69435147D1 (de) | 1993-11-19 | 1994-11-18 | ß3-Integrin als Indikator für Endometriose |
Country Status (9)
Country | Link |
---|---|
US (1) | US5478725A (de) |
EP (3) | EP1394551B1 (de) |
JP (1) | JP4155592B2 (de) |
AT (2) | ATE258058T1 (de) |
AU (1) | AU684582B2 (de) |
CA (1) | CA2176926C (de) |
DE (2) | DE69435147D1 (de) |
ES (2) | ES2312703T3 (de) |
WO (1) | WO1995013821A1 (de) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6979533B2 (en) * | 1992-06-12 | 2005-12-27 | The Trustees Of The University Of Pennsylvania | Determination of endometrial receptivity toward embryo implantation |
US6733979B2 (en) | 1993-11-01 | 2004-05-11 | The Trustees Of The University Of Pennsylvania | Determination of endometrial receptivity toward embryo implantation |
US5863954A (en) * | 1992-06-30 | 1999-01-26 | John B. Davidson | Contraceptive method using ajoene |
NZ283658A (en) * | 1994-04-04 | 1999-09-29 | William R Freeman | Compositions and treatment of increased intraocular pressure with phosphonyl-alkyloxy-pyrimidines/purines (nucleosides) |
US5654145A (en) * | 1994-10-04 | 1997-08-05 | La Jolla Cancer Research Foundation | Trophinin and trophinin-assisting nucleic acids and methods of detection thereof |
US5599918A (en) * | 1994-10-04 | 1997-02-04 | La Jolla Cancer Research Foundation | Nucleic acids encoding trophinin and trophinin-assisting proteins |
US6743595B1 (en) | 1999-01-25 | 2004-06-01 | Metriogene Biosciences Inc. | Method and diagnostic kit for diagnosis of endometriosis |
AU4056000A (en) * | 1999-04-02 | 2000-10-23 | Center For Molecular Medicine And Immunology | Method of detecting endometriosis |
US6777182B2 (en) * | 2000-02-25 | 2004-08-17 | Metriogene Biosciences Inc. | Methods for determining the likelihood of endometriosis in a female subject |
EP1801236B1 (de) * | 2000-02-25 | 2009-11-18 | Siemens Healthcare Diagnostics Inc. | Endometriose Marker und Verwendung derselben |
US7045663B2 (en) * | 2001-07-10 | 2006-05-16 | Billings Pharmaceuticals, Inc. | Chiral integrin modulators and methods of use thereof |
DE10048633A1 (de) * | 2000-09-25 | 2002-04-18 | Schering Ag | Methode zur in vitro Diagnostik von Endometriose |
US6780594B2 (en) * | 2000-09-25 | 2004-08-24 | Schering Aktiengesellschaft | Method for in vitro diagnosis of endometriosis |
MXPA03007878A (es) * | 2001-03-02 | 2004-07-08 | Medimmune Inc | Metodos de prevencion o tratamiento de alteraciones inflamatorias o autoinmunes mediante la administracion de los antagonistas alfav, beta3 de integrina. |
KR100523835B1 (ko) * | 2002-02-19 | 2005-10-25 | 주식회사 바이오인프라 | PrxⅡ 단백질을 진단 마커로 사용하여 자성 포유동물의불임을 진단하는 방법 |
WO2003075741A2 (en) * | 2002-03-04 | 2003-09-18 | Medimmune, Inc. | METHODS OF PREVENTING OR TREATING DISORDERS BY ADMINISTERING AN INTEGRIN αvβ3 ANTAGONIST IN COMBINATION WITH AN HMG-CoA REDUCTASE INHIBITOR OR A BISPHOSPHONATE |
CA2478239A1 (en) * | 2002-03-04 | 2003-09-18 | Medimmune, Inc. | The prevention or treatment of cancer using integrin alphavbeta3 antagonists in combination with other agents |
AU2003226065B2 (en) * | 2002-04-12 | 2009-02-26 | Ludwig Institute For Cancer Research, Ltd | Recombinant anti-interleukin-9 antibodies |
CA2489568A1 (en) * | 2002-05-14 | 2004-07-22 | The Board Of Trustees Of The Leland Stanford Junior University | Endometrial genes in endometrial disorders |
AU2004207002A1 (en) * | 2003-01-30 | 2004-08-12 | Medimmune, Inc. | Uses of integrin alphavbeta3 antagonists |
KR20120035234A (ko) * | 2003-04-11 | 2012-04-13 | 메디뮨 엘엘씨 | 재조합 il?9 항체 및 그의 용도 |
US7268117B2 (en) * | 2003-07-11 | 2007-09-11 | Praecis Pharmaceuticals Incorporated | Compositions, kits, and methods for identification, assessment, prevention, and therapy of endometriosis |
US20080234388A1 (en) * | 2004-03-10 | 2008-09-25 | Davidson John B | Integrin Modulators and Methods for their Use |
US7351739B2 (en) * | 2004-04-30 | 2008-04-01 | Wellgen, Inc. | Bioactive compounds and methods of uses thereof |
EP2422811A2 (de) | 2004-10-27 | 2012-02-29 | MedImmune, LLC | Modulation von Antikörperspezifität mittels Anpassung der Affinität zu verwandten Antigenen |
EP2043603A4 (de) | 2006-07-11 | 2010-10-27 | Arubor Corp | Prävention und therapie von rhinosinusitis mit proinflammatorischen zytokinhemmern |
HUE048024T2 (hu) | 2006-08-10 | 2020-05-28 | Roy C Levitt | Anakinra bronchiolitis obliterans szindróma kezelésében való alkalmazásra |
WO2008137591A2 (en) * | 2007-05-02 | 2008-11-13 | Biocept, Inc. | Non-invasive detection of endometrial cancer |
US7846680B2 (en) | 2008-01-29 | 2010-12-07 | Albert Einstein College Of Medicine Of Yeshiva University | Detection of the nucleolar channel system of human endometrium and uses thereof |
DE102012002929A1 (de) | 2012-02-14 | 2013-08-14 | Jürgen Lewald | Minimalinvasives Verfahren für die Diagnose und die Therapieverlaufskontrolle der Endometriose |
US10234465B2 (en) * | 2014-03-19 | 2019-03-19 | The University Of North Carolina At Chapel Hill | BCL6 expression in eutopic endometrium as a marker for endometriosis and subfertility |
US11474105B2 (en) | 2016-03-31 | 2022-10-18 | The University Of North Carolina At Chapel Hill | Methods and compositions for SIRT1 expression as a marker for endometriosis and subfertility |
IT201900013992A1 (it) * | 2019-08-05 | 2021-02-05 | Telea Electronic Eng Srl | Metodo per stimolare l’espressione genica in cellule endometriali |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5057604A (en) * | 1988-08-03 | 1991-10-15 | Washington University | Novel monoclonal antibodies |
US5279941A (en) * | 1992-06-12 | 1994-01-18 | Trustees Of The University Of Pennsylvania | Determination of endometrial receptivity toward embryo implantation |
-
1993
- 1993-11-19 US US08/155,435 patent/US5478725A/en not_active Expired - Lifetime
-
1994
- 1994-11-18 AT AT95902592T patent/ATE258058T1/de active
- 1994-11-18 CA CA002176926A patent/CA2176926C/en not_active Expired - Fee Related
- 1994-11-18 DE DE69435147T patent/DE69435147D1/de not_active Expired - Lifetime
- 1994-11-18 ES ES03020599T patent/ES2312703T3/es not_active Expired - Lifetime
- 1994-11-18 ES ES95902592T patent/ES2214495T3/es not_active Expired - Lifetime
- 1994-11-18 EP EP03020599A patent/EP1394551B1/de not_active Expired - Lifetime
- 1994-11-18 DE DE69433504T patent/DE69433504T2/de not_active Expired - Lifetime
- 1994-11-18 AU AU11809/95A patent/AU684582B2/en not_active Ceased
- 1994-11-18 JP JP51460395A patent/JP4155592B2/ja not_active Expired - Fee Related
- 1994-11-18 EP EP08002178A patent/EP1927362A3/de not_active Withdrawn
- 1994-11-18 AT AT03020599T patent/ATE409864T1/de not_active IP Right Cessation
- 1994-11-18 EP EP95902592A patent/EP0734263B1/de not_active Expired - Lifetime
- 1994-11-18 WO PCT/US1994/013299 patent/WO1995013821A1/en active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
EP1927362A3 (de) | 2009-01-21 |
AU684582B2 (en) | 1997-12-18 |
ATE409864T1 (de) | 2008-10-15 |
JPH09505569A (ja) | 1997-06-03 |
EP0734263A4 (de) | 1997-12-03 |
ES2312703T3 (es) | 2009-03-01 |
JP4155592B2 (ja) | 2008-09-24 |
EP1394551B1 (de) | 2008-10-01 |
EP0734263A1 (de) | 1996-10-02 |
CA2176926A1 (en) | 1995-05-26 |
ES2214495T3 (es) | 2004-09-16 |
US5478725A (en) | 1995-12-26 |
EP1394551A2 (de) | 2004-03-03 |
EP1927362A2 (de) | 2008-06-04 |
EP1394551A3 (de) | 2004-06-16 |
EP0734263B1 (de) | 2004-01-21 |
WO1995013821A1 (en) | 1995-05-26 |
DE69435147D1 (de) | 2008-11-13 |
CA2176926C (en) | 2004-06-22 |
DE69433504T2 (de) | 2004-12-23 |
AU1180995A (en) | 1995-06-06 |
ATE258058T1 (de) | 2004-02-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |