DE69432075T2 - Intrazellulaere bindungs proteine und deren anwendungen - Google Patents

Intrazellulaere bindungs proteine und deren anwendungen

Info

Publication number
DE69432075T2
DE69432075T2 DE69432075T DE69432075T DE69432075T2 DE 69432075 T2 DE69432075 T2 DE 69432075T2 DE 69432075 T DE69432075 T DE 69432075T DE 69432075 T DE69432075 T DE 69432075T DE 69432075 T2 DE69432075 T2 DE 69432075T2
Authority
DE
Germany
Prior art keywords
pct
binding proteins
date dec
applications
intracellular binding
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69432075T
Other languages
English (en)
Other versions
DE69432075D1 (de
Inventor
Fabien Schweighoffer
Bruno Tocque
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharma SA
Original Assignee
Aventis Pharma SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma SA filed Critical Aventis Pharma SA
Publication of DE69432075D1 publication Critical patent/DE69432075D1/de
Application granted granted Critical
Publication of DE69432075T2 publication Critical patent/DE69432075T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/081—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from DNA viruses
    • C07K16/084—Papovaviridae, e.g. papillomavirus, polyomavirus, SV40, BK virus, JC virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1036—Retroviridae, e.g. leukemia viruses
    • C07K16/1045—Lentiviridae, e.g. HIV, FIV, SIV
    • C07K16/1072—Regulatory proteins, e.g. tat, rev, vpt
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • AIDS & HIV (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
DE69432075T 1993-06-16 1994-06-15 Intrazellulaere bindungs proteine und deren anwendungen Expired - Lifetime DE69432075T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9307241A FR2706486B1 (fr) 1993-06-16 1993-06-16 Séquences nucléiques, vecteurs les contenant, compositions pharmaceutiques et utilisations thérapeutiques.
PCT/FR1994/000714 WO1994029446A2 (fr) 1993-06-16 1994-06-15 Proteines intracellulaires de liaison (pil) et leurs utilisations

Publications (2)

Publication Number Publication Date
DE69432075D1 DE69432075D1 (de) 2003-03-06
DE69432075T2 true DE69432075T2 (de) 2003-09-04

Family

ID=9448183

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69432075T Expired - Lifetime DE69432075T2 (de) 1993-06-16 1994-06-15 Intrazellulaere bindungs proteine und deren anwendungen

Country Status (24)

Country Link
US (1) US6159947A (de)
EP (1) EP0703980B1 (de)
JP (1) JP4384260B2 (de)
KR (1) KR100342233B1 (de)
CN (1) CN1076052C (de)
AT (1) ATE231916T1 (de)
AU (1) AU7076394A (de)
BR (1) BR9407512A (de)
CA (1) CA2165458C (de)
CZ (1) CZ289039B6 (de)
DE (1) DE69432075T2 (de)
DK (1) DK0703980T3 (de)
ES (1) ES2191031T3 (de)
FI (1) FI120311B (de)
FR (1) FR2706486B1 (de)
HU (1) HU219138B (de)
NO (1) NO319466B1 (de)
NZ (1) NZ268038A (de)
PL (1) PL180760B1 (de)
RU (1) RU2218400C2 (de)
SK (1) SK285169B6 (de)
UA (1) UA46709C2 (de)
WO (1) WO1994029446A2 (de)
ZA (1) ZA944303B (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6790633B1 (en) * 1990-04-18 2004-09-14 Michael S. Brown Method of inhibiting a farnesyl transferase enzyme
US8003342B1 (en) 1990-04-18 2011-08-23 Board Of Regents, The University Of Texas System Method for identifying farnesyl transferase inhibitors
FR2724320B1 (fr) * 1994-09-13 1996-12-20 Transgene Sa Nouvel implant pour le traitement des maladies acquises
US5518042A (en) * 1994-09-16 1996-05-21 Huyck Licensco, Inc. Papermaker's forming fabric with additional cross machine direction locator and fiber supporting yarns
FR2738151B1 (fr) * 1995-09-04 1997-09-26 Rhone Poulenc Rorer Sa Antagonistes de l'activite oncogenique de la proteine mdm2, et leur utilisation dans le traitement des cancers
US7008776B1 (en) 1996-12-06 2006-03-07 Aventis Pharmaceuticals Inc. Compositions and methods for effecting the levels of high density lipoprotein (HDL) cholesterol and apolipoprotein AI very low density lipoprotein (VLDL) cholesterol and low density lipoprotein (LDL) cholesterol
IL129986A0 (en) 1996-12-06 2000-02-29 Rhone Poulenc Rorer Pharma Polypeptides encoded by a human lipase-like gene compositions and methods
FR2758569B1 (fr) * 1997-01-20 1999-04-02 Centre Nat Rech Scient Materiel biologique pour le traitement d'un mammifere par transfert de gene d'anticorps et composition pharmaceutique le concernant
WO2000050089A2 (en) * 1999-02-26 2000-08-31 Mindset Biopharmaceuticals (Usa) Ltd. Regulation of the stability of recombinant proteins and antiboodies
FR2794771B1 (fr) 1999-06-11 2001-08-10 Aventis Pharma Sa Adenovirus recombinants codant pour le transporteur specifique de l'iode (nis)
MXPA02009481A (es) 2000-03-31 2004-05-14 Aventis Pharma Inc Factor inductor del factor nuclear kb.
GB0018307D0 (en) 2000-07-26 2000-09-13 Aventis Pharm Prod Inc Polypeptides
US20030104402A1 (en) * 2001-01-23 2003-06-05 University Of Rochester Methods of producing or identifying intrabodies in eukaryotic cells
US9328142B2 (en) 2011-05-25 2016-05-03 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Lipopeptide inhibitors of RAS oncoproteins
KR101602876B1 (ko) 2014-07-22 2016-03-11 아주대학교산학협력단 완전한 이뮤노글로불린 형태의 세포질 침투능을 갖는 항체를 이용하여 세포내 활성화된 ras를 억제하는 방법 및 그의 이용
KR101602870B1 (ko) 2014-07-22 2016-03-21 아주대학교산학협력단 완전한 이뮤노글로불린 형태의 항체를 세포막을 투과하여 세포질에 위치시키는 방법 및 그의 이용
US20180072815A1 (en) 2014-10-23 2018-03-15 Singh Biotechnology, Llc Single Domain Antibodies Directed Against Intracellular Antigens
KR102207381B1 (ko) * 2014-10-23 2021-01-27 싱 몰레큘러 메디신, 엘엘씨 세포내 항원에 대해 지향된 단일 도메인 항체
TWI746473B (zh) 2015-11-02 2021-11-21 美商辛分子醫藥有限公司 針對細胞內抗原之單域抗體
BR112018074275A2 (pt) 2016-05-27 2019-10-01 Orum Therapeutics Inc anticorpo de penetração no citosol e método de produção do mesmo
US10787487B2 (en) 2018-06-21 2020-09-29 Orum Therapeutics Inc. Cell/tissue-specific cell-penetrating antibodies
CN110981943B (zh) * 2019-12-02 2021-08-03 清华大学 多肽及其在制备药物中的用途和药物

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4946778A (en) * 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
DE3915952A1 (de) * 1989-05-12 1990-12-06 Peter Werner Wirkstoff/medikament/biotechnologisches verfahren zur behandlung von erkrankungen, die mit exo- oder endogenen intrazellulaeren proteinen (onkogene etc.) assoziert sind
JPH06503714A (ja) * 1990-09-25 1994-04-28 ユニバーシティ オブ コネチカット 細胞内に導入されたポリヌクレオチドの長時間発現
CA2072249C (en) * 1991-06-28 2003-06-17 Saiko Hosokawa Human monoclonal antibody specifically binding to surface antigen of cancer cell membrane
CA2120153C (en) * 1991-09-30 2006-06-06 Ira Pastan Recombinant immunotoxins
EP0618970A1 (de) * 1991-12-10 1994-10-12 Dana Farber Cancer Institute Reaktive neutralisierende humane anti-gp120 rekombinante antikörper, entsprechend kodierende dna und ihre verwendung
EP0651805B1 (de) * 1992-07-17 2006-12-13 Dana Farber Cancer Institute Method eder intrazellularen bindung von zielgerichteten molekülen

Also Published As

Publication number Publication date
CA2165458A1 (fr) 1994-12-22
HU219138B (hu) 2001-02-28
NO319466B1 (no) 2005-08-15
DE69432075D1 (de) 2003-03-06
AU7076394A (en) 1995-01-03
SK156895A3 (en) 1996-05-08
HUT74266A (en) 1996-11-28
NZ268038A (en) 1997-12-19
FR2706486A1 (fr) 1994-12-23
JPH08511162A (ja) 1996-11-26
PL312213A1 (en) 1996-04-01
FI956057A (fi) 1995-12-15
NO955011D0 (no) 1995-12-11
KR100342233B1 (ko) 2002-12-05
SK285169B6 (sk) 2006-07-07
FI120311B (fi) 2009-09-15
FI956057A0 (fi) 1995-12-15
WO1994029446A2 (fr) 1994-12-22
BR9407512A (pt) 1997-01-07
WO1994029446A3 (fr) 1995-02-02
CZ289039B6 (cs) 2001-10-17
PL180760B1 (pl) 2001-04-30
JP4384260B2 (ja) 2009-12-16
US6159947A (en) 2000-12-12
EP0703980A1 (de) 1996-04-03
UA46709C2 (uk) 2002-06-17
NO955011L (no) 1995-12-11
HU9503615D0 (en) 1996-02-28
FR2706486B1 (fr) 1995-09-01
RU2218400C2 (ru) 2003-12-10
DK0703980T3 (da) 2003-05-19
ZA944303B (en) 1995-02-14
CN1076052C (zh) 2001-12-12
ES2191031T3 (es) 2003-09-01
CN1126491A (zh) 1996-07-10
CA2165458C (fr) 2011-05-10
EP0703980B1 (de) 2003-01-29
ATE231916T1 (de) 2003-02-15
CZ329595A3 (en) 1996-03-13

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8328 Change in the person/name/address of the agent

Representative=s name: PFENNING MEINIG & PARTNER GBR, 80339 MUENCHEN

8328 Change in the person/name/address of the agent

Representative=s name: MAIWALD PATENTANWALTSGESELLSCHAFT MBH, 80335 MUENC