DE69431747D1 - Hochlösliche multikomponenten-inklusionskomplexe, welche ein basisches arzneimittel, eine säure und ein zyklodextrin enthalten - Google Patents
Hochlösliche multikomponenten-inklusionskomplexe, welche ein basisches arzneimittel, eine säure und ein zyklodextrin enthaltenInfo
- Publication number
- DE69431747D1 DE69431747D1 DE69431747T DE69431747T DE69431747D1 DE 69431747 D1 DE69431747 D1 DE 69431747D1 DE 69431747 T DE69431747 T DE 69431747T DE 69431747 T DE69431747 T DE 69431747T DE 69431747 D1 DE69431747 D1 DE 69431747D1
- Authority
- DE
- Germany
- Prior art keywords
- acid
- extrin
- cyclode
- medicinal product
- highly soluble
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
- A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nanotechnology (AREA)
- Epidemiology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Medical Informatics (AREA)
- Biotechnology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Biophysics (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI930141A IT1263831B (it) | 1993-01-29 | 1993-01-29 | Complessi di inclusione multicomponente ad elevata solubilita' costituiti da un farmaco di tipo basico, un acido ed una ciclodestrina |
| PCT/EP1994/000205 WO1994016733A1 (en) | 1993-01-29 | 1994-01-26 | Highly soluble multicomponent inclusion complexes containing a base type drug, an acid and a cyclodextrin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE69431747D1 true DE69431747D1 (de) | 2003-01-02 |
Family
ID=11364792
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69431747T Expired - Lifetime DE69431747D1 (de) | 1993-01-29 | 1994-01-26 | Hochlösliche multikomponenten-inklusionskomplexe, welche ein basisches arzneimittel, eine säure und ein zyklodextrin enthalten |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US5855916A (de) |
| EP (1) | EP0681481B1 (de) |
| JP (1) | JPH08508711A (de) |
| KR (1) | KR960700074A (de) |
| AT (1) | ATE228013T1 (de) |
| AU (1) | AU691115B2 (de) |
| BR (1) | BR9406779A (de) |
| CA (1) | CA2154874A1 (de) |
| CZ (1) | CZ284606B6 (de) |
| DE (1) | DE69431747D1 (de) |
| FI (1) | FI953590A (de) |
| HU (1) | HU218796B (de) |
| IL (1) | IL108460A (de) |
| IT (1) | IT1263831B (de) |
| NO (1) | NO952981L (de) |
| NZ (1) | NZ261115A (de) |
| WO (1) | WO1994016733A1 (de) |
| ZA (1) | ZA94572B (de) |
Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5646131A (en) * | 1994-02-22 | 1997-07-08 | The Arab Company For Drug Industries And Medical Applicances (Acdima) | Method for solubilizing drugs using cyclodextrins and carboxylic acids |
| AUPM456894A0 (en) * | 1994-03-18 | 1994-04-14 | Glyzinc Pharmaceuticals Limited | Treatment for gastric disorders |
| IT1269578B (it) * | 1994-04-22 | 1997-04-08 | Chiesi Farma Spa | Complessi di inclusione multicomponente ad elevata solubilita' costituiti da un farmaco di tipo acido, una ciclodestrina e una base. |
| US5750147A (en) * | 1995-06-07 | 1998-05-12 | Emisphere Technologies, Inc. | Method of solubilizing and encapsulating itraconazole |
| UA57734C2 (uk) | 1996-05-07 | 2003-07-15 | Пфайзер Інк. | Комплекси включення арилгетероциклічних солей |
| BR9710289A (pt) | 1996-07-11 | 1999-08-17 | Farmarc Nederland Bv | Composi-Æo farmac-utica contendo sal cido de adi-Æo de medicamento b sico |
| GB9711643D0 (en) * | 1997-06-05 | 1997-07-30 | Janssen Pharmaceutica Nv | Glass thermoplastic systems |
| KR19990001564A (ko) | 1997-06-16 | 1999-01-15 | 유충식 | 용해도를 개선한 아졸계 항진균제 및 이를 함유하는 제제 |
| DE69804169T2 (de) * | 1997-06-27 | 2002-08-29 | Akzo Nobel N.V., Arnheim/Arnhem | Oral anzuwendende flüssige Arzneilösung |
| US6077871A (en) * | 1997-11-26 | 2000-06-20 | Pfizer Inc. | Droloxifene pharmaceutical compositions |
| DK172860B1 (da) * | 1998-03-25 | 1999-08-16 | Pharmacosmos Holding As | Jerndextranforbindelse til anvendelse som komponent i et terapeutisk middel til forebyggelse af eller behandling af jernman |
| JP2000080123A (ja) * | 1998-09-03 | 2000-03-21 | Toagosei Co Ltd | シアノアクリレート用硬化促進剤 |
| GB9822170D0 (en) * | 1998-10-13 | 1998-12-02 | Danbioyst Uk Ltd | Novel formulations of fexofenadine |
| FI109332B (fi) | 1998-12-17 | 2002-07-15 | Orion Yhtymae Oyj | Toremifeenin liukoisia koostumuksia |
| FI982733A (fi) * | 1998-12-17 | 2000-06-18 | Orion Yhtymae Oyj | Trifenyylietyleeniantiestrogeenien liukoisia koostumuksia |
| US6740639B1 (en) * | 2000-03-29 | 2004-05-25 | Council Of Scientific & Industrial Research | Inclusion complees of a high potent opioid peptide, pharmaceutical compositions and method of treatment |
| GB0015239D0 (en) * | 2000-06-21 | 2000-08-16 | Biochemie Gmbh | Organic compounds |
| US6663897B2 (en) | 2001-02-06 | 2003-12-16 | Dsm Ip Assets B.V. | Oral itraconazole formulations and methods of making the same |
| JP2003063965A (ja) * | 2001-06-13 | 2003-03-05 | Otsuka Pharmaceut Factory Inc | 注射用シロスタゾール水性製剤 |
| WO2003052117A2 (en) * | 2001-09-19 | 2003-06-26 | Massachusetts Institute Of Technology | Methods and products related to non-viral transfection |
| US7446107B2 (en) | 2002-02-15 | 2008-11-04 | Transform Pharmaceuticals, Inc. | Crystalline forms of conazoles and methods of making and using the same |
| US7790905B2 (en) | 2002-02-15 | 2010-09-07 | Mcneil-Ppc, Inc. | Pharmaceutical propylene glycol solvate compositions |
| US7927613B2 (en) | 2002-02-15 | 2011-04-19 | University Of South Florida | Pharmaceutical co-crystal compositions |
| US20030224006A1 (en) | 2002-03-01 | 2003-12-04 | Zaworotko Michael J. | Multiple-component solid phases containing at least one active pharmaceutical ingredient |
| EP1511490A4 (de) * | 2002-05-31 | 2009-03-11 | Transform Pharmaceuticals Inc | Neue kristalline conazol-formen und verwandte prozesse, pharmazeutische zusammensetzungen und verfahren |
| CN100360117C (zh) | 2002-06-21 | 2008-01-09 | 转化医药公司 | 具有提高的溶出度的药物组合物 |
| KR101043866B1 (ko) | 2002-08-20 | 2011-06-22 | 브리스톨-마이어스 스큅 컴퍼니 | 아리피프라졸 복합체 제제 및 방법 |
| US7648678B2 (en) | 2002-12-20 | 2010-01-19 | Dako Denmark A/S | Method and system for pretreatment of tissue slides |
| US8183290B2 (en) | 2002-12-30 | 2012-05-22 | Mcneil-Ppc, Inc. | Pharmaceutically acceptable propylene glycol solvate of naproxen |
| US20050085446A1 (en) * | 2003-04-14 | 2005-04-21 | Babu M.K. M. | Fluoroquinolone formulations and methods of making and using the same |
| US7157446B2 (en) * | 2003-05-02 | 2007-01-02 | Bristol Myers Squibb Company | Complex of ras-farnesyltransferase inhibitor, a cyclodextrin, and ethanol |
| CN1515260B (zh) * | 2003-06-26 | 2010-05-05 | 沈阳药科大学 | 含hpcd的桂利嗪粉针剂和其固体制剂及其制备方法 |
| CN1723220A (zh) | 2003-11-13 | 2006-01-18 | 韩美药品工业株式会社 | 含有免疫球蛋白fc区作为载体的药物组合物 |
| US20070020299A1 (en) | 2003-12-31 | 2007-01-25 | Pipkin James D | Inhalant formulation containing sulfoalkyl ether cyclodextrin and corticosteroid |
| EP1570862A1 (de) * | 2004-02-25 | 2005-09-07 | JPM - The Jordanian Pharmaceutical Manufacturing Co. Ltd. | Hochlösliche binäre Cyclodextrineinschlusskomplexe |
| EP1718640A4 (de) * | 2004-02-26 | 2008-01-09 | Transform Pharmaceuticals Inc | Neue kristalline formen von conazolen und verfahren zu deren herstellung und anwendung |
| US9492446B2 (en) * | 2004-06-24 | 2016-11-15 | Ctc Bio, Inc. | Manufacturing method of solid dispersion containing itraconazole |
| US20060105045A1 (en) * | 2004-11-08 | 2006-05-18 | Buchanan Charles M | Cyclodextrin solubilizers for liquid and semi-solid formulations |
| US20060105992A1 (en) * | 2004-11-08 | 2006-05-18 | Buchanan Charles M | Pharmaceutical formulations of cyclodextrins and selective estrogen receptor modulator compounds |
| DE102005041860A1 (de) * | 2005-09-02 | 2007-03-08 | Schering Ag | Nanopartikulärer Einschluss- und Ladungskomplex für pharmazeutische Formulierungen |
| WO2007047253A2 (en) * | 2005-10-11 | 2007-04-26 | Eastman Chemical Company | Pharmaceutical formulations of cyclodextrins and antifungal azole compounds |
| CN101990542A (zh) * | 2008-02-08 | 2011-03-23 | 德克萨斯大学董事会 | 环巴胺酒石酸盐及其用途 |
| CN101314045B (zh) * | 2008-05-09 | 2013-01-23 | 沈阳药科大学 | 桂利嗪的磺丁基醚-β-环糊精包合物及其制剂和制备方法 |
| EP2306971B1 (de) | 2008-07-03 | 2015-02-25 | University Of Virginia Patent Foundation | Einheitsdosis von apadenoson |
| US9492417B2 (en) | 2008-08-21 | 2016-11-15 | The Johns Hopkins University | Methods and compositions for administration of 3-halopyruvate and related compounds for the treatment of cancer |
| US11020363B2 (en) | 2009-05-29 | 2021-06-01 | Cydex Pharmaceuticals, Inc. | Injectable nitrogen mustard compositions comprising a cyclodextrin derivative and methods of making and using the same |
| US20100311838A1 (en) | 2009-05-29 | 2010-12-09 | Pipkin James D | Injectable Melphalan Compositions Comprising a Cyclodextrin Derivative and Methods of Making and Using the Same |
| JP5803150B2 (ja) * | 2011-03-02 | 2015-11-04 | 三菱瓦斯化学株式会社 | ピロロキノリンキノンーシクロデキストリン包接体 |
| EP3043810B1 (de) | 2013-09-09 | 2019-10-23 | CanImGuide Therapeutics AB | Immunsystemmodulatoren |
| AU2015206629B2 (en) * | 2014-01-14 | 2020-03-05 | The Johns Hopkins University | Cyclodextrin compositions encapsulating a selective ATP inhibitor and uses thereof |
| US9896614B2 (en) | 2014-11-05 | 2018-02-20 | Halliburton Energy Services, Inc. | Delayed acid breaker systems for filtercakes |
| CA2978617A1 (en) | 2015-03-06 | 2016-09-15 | Canimguide Therapeutics Ab | Immune system modulators and compositions |
| CN106539752B (zh) * | 2015-09-18 | 2019-10-29 | 成都康弘药业集团股份有限公司 | 一种含有阿立哌唑的口服溶液及其制备方法 |
| EP3370712A4 (de) | 2015-11-06 | 2019-10-09 | The Johns Hopkins University | Verfahren zur behandlung von leberfibrose durch verabreichung von 3-brompyruvat |
| US20230233572A1 (en) | 2020-06-11 | 2023-07-27 | Sentiss Pharma Private Limited | Ophthalmic compositions comprising a combination of fluoroquinolone antibacterial agent and an anti-inflammatory agent |
| KR102356618B1 (ko) * | 2021-11-17 | 2022-02-08 | 명지대학교 산학협력단 | 신규 포접복합체 및 이의 용도 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU182217B (en) * | 1980-10-17 | 1983-12-28 | Chinoin Gyogyszer Es Vegyeszet | Process for producing inclusive complexes of cyclodextrines and strong inorganic oxyacids |
| JPS60185772A (ja) * | 1984-03-05 | 1985-09-21 | Mitsui Pharmaceut Inc | 安定なカルモフ−ル−β−シクロデキストリンの包接化合物 |
| US5091171B2 (en) * | 1986-12-23 | 1997-07-15 | Tristrata Inc | Amphoteric compositions and polymeric forms of alpha hydroxyacids and their therapeutic use |
| JP2571199B2 (ja) * | 1987-11-25 | 1997-01-16 | 塩水港精糖株式会社 | 溶解性の高いサイクロデキストリンの製造方法 |
| US5646131A (en) * | 1994-02-22 | 1997-07-08 | The Arab Company For Drug Industries And Medical Applicances (Acdima) | Method for solubilizing drugs using cyclodextrins and carboxylic acids |
-
1993
- 1993-01-29 IT ITMI930141A patent/IT1263831B/it active IP Right Grant
-
1994
- 1994-01-26 CA CA002154874A patent/CA2154874A1/en not_active Abandoned
- 1994-01-26 NZ NZ261115A patent/NZ261115A/en unknown
- 1994-01-26 US US08/481,519 patent/US5855916A/en not_active Expired - Fee Related
- 1994-01-26 CZ CZ951943A patent/CZ284606B6/cs not_active IP Right Cessation
- 1994-01-26 DE DE69431747T patent/DE69431747D1/de not_active Expired - Lifetime
- 1994-01-26 KR KR1019950702913A patent/KR960700074A/ko active IP Right Grant
- 1994-01-26 BR BR9406779A patent/BR9406779A/pt not_active Application Discontinuation
- 1994-01-26 EP EP94905707A patent/EP0681481B1/de not_active Expired - Lifetime
- 1994-01-26 HU HU9502251A patent/HU218796B/hu not_active IP Right Cessation
- 1994-01-26 AU AU59710/94A patent/AU691115B2/en not_active Ceased
- 1994-01-26 WO PCT/EP1994/000205 patent/WO1994016733A1/en active IP Right Grant
- 1994-01-26 JP JP6516681A patent/JPH08508711A/ja not_active Ceased
- 1994-01-26 AT AT94905707T patent/ATE228013T1/de not_active IP Right Cessation
- 1994-01-27 ZA ZA94572A patent/ZA94572B/xx unknown
- 1994-01-27 IL IL10846094A patent/IL108460A/en not_active IP Right Cessation
-
1995
- 1995-07-27 FI FI953590A patent/FI953590A/fi unknown
- 1995-07-27 NO NO952981A patent/NO952981L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2154874A1 (en) | 1994-08-04 |
| AU691115B2 (en) | 1998-05-07 |
| FI953590A (fi) | 1995-09-14 |
| ITMI930141A0 (it) | 1993-01-29 |
| WO1994016733A1 (en) | 1994-08-04 |
| IL108460A (en) | 1999-01-26 |
| ITMI930141A1 (it) | 1994-07-30 |
| CZ194395A3 (en) | 1996-01-17 |
| CZ284606B6 (cs) | 1999-01-13 |
| EP0681481B1 (de) | 2002-11-20 |
| KR960700074A (ko) | 1996-01-19 |
| IL108460A0 (en) | 1994-04-12 |
| NZ261115A (en) | 1996-11-26 |
| IT1263831B (it) | 1996-09-04 |
| NO952981D0 (no) | 1995-07-27 |
| NO952981L (no) | 1995-07-27 |
| BR9406779A (pt) | 1996-02-06 |
| JPH08508711A (ja) | 1996-09-17 |
| ATE228013T1 (de) | 2002-12-15 |
| EP0681481A1 (de) | 1995-11-15 |
| ZA94572B (en) | 1994-09-13 |
| US5855916A (en) | 1999-01-05 |
| HU9502251D0 (en) | 1995-09-28 |
| AU5971094A (en) | 1994-08-15 |
| HU218796B (hu) | 2000-12-28 |
| HUT72500A (en) | 1996-05-28 |
| FI953590A0 (fi) | 1995-07-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8332 | No legal effect for de |