DE69429868D1 - Verfahren zur herstellung eines inter-alpha-trypsin inhibitor konzentrats mit therapeutischer anwendung und so erhaltenes konzentrat - Google Patents

Verfahren zur herstellung eines inter-alpha-trypsin inhibitor konzentrats mit therapeutischer anwendung und so erhaltenes konzentrat

Info

Publication number
DE69429868D1
DE69429868D1 DE69429868T DE69429868T DE69429868D1 DE 69429868 D1 DE69429868 D1 DE 69429868D1 DE 69429868 T DE69429868 T DE 69429868T DE 69429868 T DE69429868 T DE 69429868T DE 69429868 D1 DE69429868 D1 DE 69429868D1
Authority
DE
Germany
Prior art keywords
concentrate
pct
alpha
inter
trypsin inhibitor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69429868T
Other languages
English (en)
Other versions
DE69429868T2 (de
Inventor
Catherine Michalski
Jacques Mizon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
L'ETABLISSEMENT FRANCAIS DU SANG, LA PLAINE SA, FR
Original Assignee
AETSRN
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AETSRN filed Critical AETSRN
Publication of DE69429868D1 publication Critical patent/DE69429868D1/de
Application granted granted Critical
Publication of DE69429868T2 publication Critical patent/DE69429868T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8114—Kunitz type inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/57—Protease inhibitors from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DE69429868T 1993-10-18 1994-10-17 Verfahren zur herstellung eines inter-alpha-trypsin inhibitor konzentrats mit therapeutischer anwendung und so erhaltenes konzentrat Expired - Lifetime DE69429868T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9312346A FR2711371B1 (fr) 1993-10-18 1993-10-18 Procédé de préparation d'un concentré d'inter-alpha-trypsine inhibiteur à usage thérapeutique et concentré obtenu.
PCT/FR1994/001197 WO1995011260A1 (fr) 1993-10-18 1994-10-17 Procede de preparation d'un concentre d'inter-alpha-trypsine inhibiteur a usage therapeutique et concentre obtenu

Publications (2)

Publication Number Publication Date
DE69429868D1 true DE69429868D1 (de) 2002-03-21
DE69429868T2 DE69429868T2 (de) 2002-09-19

Family

ID=9451908

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69429868T Expired - Lifetime DE69429868T2 (de) 1993-10-18 1994-10-17 Verfahren zur herstellung eines inter-alpha-trypsin inhibitor konzentrats mit therapeutischer anwendung und so erhaltenes konzentrat

Country Status (12)

Country Link
US (1) US5777081A (de)
EP (1) EP0724600B1 (de)
JP (1) JP3650937B2 (de)
AT (1) ATE213252T1 (de)
AU (1) AU7996294A (de)
CA (1) CA2174231C (de)
DE (1) DE69429868T2 (de)
DK (1) DK0724600T3 (de)
ES (1) ES2173927T3 (de)
FR (1) FR2711371B1 (de)
PT (1) PT724600E (de)
WO (1) WO1995011260A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3626982B2 (ja) * 1997-08-29 2005-03-09 アークレイ株式会社 タンパク質分解酵素阻害物質の測定方法およびそれに用いる測定キット
US6596705B1 (en) 1998-02-09 2003-07-22 The Regents Of The University Of California Inhibition of L-selectin and P-selection mediated binding using heparin
US6660482B1 (en) 2000-02-28 2003-12-09 Rhode Island Hospital Inter-alpha-trypsin inhibitor as a marker for sepsis
WO2002030983A2 (de) * 2000-10-13 2002-04-18 Octapharma Ag Bikunin enthaltende plasmafraktion, verfahren zu ihrer herstellung und ihrer verwendung
US20040072796A1 (en) * 2002-04-18 2004-04-15 Embury Stephen H. Method and composition for preventing pain in sickle cell patients
EP3087991A1 (de) * 2003-11-08 2016-11-02 Prothera Biologics Zusammensetzung von inter-alpha-hemmer-proteinen aus plasma zur therapeutische verwendung
BR122020017577B1 (pt) 2008-05-28 2021-10-26 Prothera Biologics, Inc Método para purificar proteínas inibidoras inter-alfa
WO2011150284A2 (en) 2010-05-26 2011-12-01 Baxter International Inc. Removal of serine proteases by treatment with finely divided silicon dioxide
AU2010202125B1 (en) 2010-05-26 2010-09-02 Takeda Pharmaceutical Company Limited A method to produce an immunoglobulin preparation with improved yield
WO2012012773A1 (en) 2010-07-23 2012-01-26 Baxter International Inc. Manufacture of inter -alpha - inhibitor proteins (iaip) from plasma
WO2014039987A2 (en) 2012-09-09 2014-03-13 Prothera Biologics, Inc. Treatment of disease using inter-alpha inhibitor proteins
CN103880951B (zh) * 2014-03-31 2016-03-30 南昌市万华生化制品有限公司 一种通过乌司他丁亲和层析介质制备纯品乌司他丁的方法
CN115925781A (zh) * 2015-10-15 2023-04-07 普莱泽玛科技有限公司 从血浆中提取蛋白质的方法
CN109776674B (zh) * 2019-02-19 2020-01-17 广东天普生化医药股份有限公司 纯化的乌司他丁及其制备方法和含有该乌司他丁的药物组合物
US11725043B2 (en) 2020-03-05 2023-08-15 DiaMedica USA Inc. Ulinastatin polypeptides

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1434199A (fr) * 1964-01-10 1966-04-08 Behringwerke Ag Procédé d'isolement d'inhibiteurs de la plasmine et de la trypsine à partir de liquides organiques d'origine humaine ou animale
US4119774A (en) * 1976-03-05 1978-10-10 Ab Kabi Heparin purification method
AT368883B (de) * 1980-07-22 1982-11-25 Immuno Ag Verfahren zur herstellung einer neuen blutgerinnungsfoerdernden praeparation auf basis von humanproteinen
US4760130A (en) * 1984-12-06 1988-07-26 Synergen Biologicals, Inc. Serine protease inhibitors and methods for isolation of same
US4629567A (en) * 1986-03-07 1986-12-16 Smithkline-Rit Alpha-1-antiprotease purification
EP0317376B2 (de) * 1987-10-23 1996-04-03 Centre Regional De Transfusion Sanguine De Lille Herstellung von hoch-gereingtem menschlichen Faktor IX sowie anderem Plasmaproteinkonzentrat
US5445958A (en) * 1987-12-22 1995-08-29 National Blood Authority Process for purifying blood clotting factors

Also Published As

Publication number Publication date
ATE213252T1 (de) 2002-02-15
PT724600E (pt) 2002-07-31
JP3650937B2 (ja) 2005-05-25
ES2173927T3 (es) 2002-11-01
FR2711371B1 (fr) 1995-12-29
CA2174231A1 (fr) 1995-04-27
DE69429868T2 (de) 2002-09-19
WO1995011260A1 (fr) 1995-04-27
EP0724600B1 (de) 2002-02-13
JPH09503775A (ja) 1997-04-15
CA2174231C (fr) 2004-06-01
EP0724600A1 (de) 1996-08-07
AU7996294A (en) 1995-05-08
US5777081A (en) 1998-07-07
DK0724600T3 (da) 2002-05-27
FR2711371A1 (fr) 1995-04-28

Similar Documents

Publication Publication Date Title
DE69424545D1 (de) Verfahren zur herstellung von immunoglobulin g konzentrat
DE69429868D1 (de) Verfahren zur herstellung eines inter-alpha-trypsin inhibitor konzentrats mit therapeutischer anwendung und so erhaltenes konzentrat
EP1839657A3 (de) Verfahren zur Behandlung vaskulärer Kopfschmerzen
ATE135908T1 (de) Optisch reines r(-)albuterol zur behandlung von asthma
DE60016461D1 (de) Verfahren zur behandlung von glassubstraten und glassubstraten zur herstellung von anzeigeschirmen
ZA966240B (en) Methods for treatment of allergic asthma.
DE59003771D1 (de) Verfahren zur Herstellung von cyclischen Aminosäurederivaten sowie Zwischenprodukte.
DE69637593D1 (de) Arteriovenöse und venöse transplantatbehandlungen: methoden und zusammensetzungen
NO951761L (no) Stabilt preparat for behandling av blodkoagulasjonssykdommer
NO963785L (no) Fremgangsmåte for behandling av 5HT2B-reseptor-relaterte betingelser
ATE166230T1 (de) Verwendung von anti-icam antikörpern zur herstellung eines präparats für die behandlung von endotoxinschock
DE69502675T2 (de) Verfahren zur Herstellung von Bis(Aminomethyl)Cyclohexan
ATE268166T1 (de) Zusammenstellungen zur behandlung von lungenkrankheiten mit optisch reinem s-salmeterol
AU4876196A (en) A process for the preparation of factor ix from biological sources
ATE239470T1 (de) Melatonin-derivate zur verwendung in der behandlung von desynchronisierungs-erkankungen
ATE152722T1 (de) Verfahren zur herstellung von 9-(2-hydroxy)- ethoxy-guanin
ATE171620T1 (de) Verwendung von verzweigtkettigen aminosäuren zur herstellung eines arzneimittels zur behandlung von tardiver dyskinesia
NO973366L (no) Fremgangsmåte for behandling av multippel sklerose
ATE320263T1 (de) Verwendung von menschliche protein c zur herstellung eines arzneimittels zur behandlung von heparininduzierter thrombozytopenie
AU3360000A (en) Use of 4-amino pyridine for treatment of peripheral neuropathies
DE69424415D1 (de) Verwendung von efaroxan und dessen derivaten zur herstellung eines arzneimittels zur behandlung parkinsonscher krankheit
DE69421705D1 (de) Verwendung von Efaroxan und dessen Derivaten zur Herstellung eines Arzneimittels zur Behandlung neurogenerativer Erkrankungen
DE69624114D1 (de) Verwendung einer retinoide zur herstellung eines antibakteriellen mittels
DE69625819T2 (de) Die verwendung von ondansetron zur herstellung eines medikamentes zur behandlung von tremor
RU93035807A (ru) Способ лечения юношеского эпифизиолиса

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: L'ETABLISSEMENT FRANCAIS DU SANG, LA PLAINE SA, FR

8328 Change in the person/name/address of the agent

Representative=s name: CABINET HIRSCH & ASSOCIES, PARIS, FR