DE69428886D1 - Verfahren zur herstellung von acryl-piperidin-carbinolen - Google Patents

Verfahren zur herstellung von acryl-piperidin-carbinolen

Info

Publication number
DE69428886D1
DE69428886D1 DE69428886T DE69428886T DE69428886D1 DE 69428886 D1 DE69428886 D1 DE 69428886D1 DE 69428886 T DE69428886 T DE 69428886T DE 69428886 T DE69428886 T DE 69428886T DE 69428886 D1 DE69428886 D1 DE 69428886D1
Authority
DE
Germany
Prior art keywords
producing acrylic
piperidine carbinols
acrylic piperidine
carbinols
producing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69428886T
Other languages
English (en)
Other versions
DE69428886T2 (de
Inventor
Edward Callander
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Ltd
Original Assignee
SmithKline Beecham Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Ltd filed Critical SmithKline Beecham Ltd
Publication of DE69428886D1 publication Critical patent/DE69428886D1/de
Application granted granted Critical
Publication of DE69428886T2 publication Critical patent/DE69428886T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
DE69428886T 1993-03-13 1994-03-08 Verfahren zur herstellung von acryl-piperidin-carbinolen Expired - Fee Related DE69428886T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB939305175A GB9305175D0 (en) 1993-03-13 1993-03-13 Novel process
PCT/EP1994/000694 WO1994021609A1 (en) 1993-03-13 1994-03-08 Process for preparing acryl-piperidine carbinols

Publications (2)

Publication Number Publication Date
DE69428886D1 true DE69428886D1 (de) 2001-12-06
DE69428886T2 DE69428886T2 (de) 2002-04-25

Family

ID=10731995

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69428886T Expired - Fee Related DE69428886T2 (de) 1993-03-13 1994-03-08 Verfahren zur herstellung von acryl-piperidin-carbinolen

Country Status (27)

Country Link
US (1) US5681962A (de)
EP (1) EP0688317B1 (de)
JP (1) JPH08507540A (de)
KR (1) KR100296719B1 (de)
CN (2) CN1041918C (de)
AP (1) AP452A (de)
AT (1) ATE207898T1 (de)
AU (1) AU682497B2 (de)
BR (1) BR9406035A (de)
CA (1) CA2158175A1 (de)
CZ (1) CZ235595A3 (de)
DE (1) DE69428886T2 (de)
DZ (1) DZ1758A1 (de)
ES (1) ES2164700T3 (de)
FI (1) FI954272A (de)
GB (1) GB9305175D0 (de)
HU (1) HUT72087A (de)
IL (1) IL108946A (de)
MA (1) MA23134A1 (de)
NO (1) NO306717B1 (de)
NZ (1) NZ262735A (de)
PH (1) PH31434A (de)
PL (1) PL176907B1 (de)
RU (1) RU2141477C1 (de)
SK (1) SK281977B6 (de)
WO (1) WO1994021609A1 (de)
ZA (1) ZA941716B (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6444190B2 (en) 1995-08-03 2002-09-03 Fmc Corporation Reduction compositions and processes for making the same
ES2121685B1 (es) * 1996-04-10 1999-09-16 Vita Invest Sa Procedimiento para la obtencion de (+)-trans-4(4-fluoro-fenil)-3-hidroximetil-1-metilpiperidina.
JP3446468B2 (ja) 1996-04-15 2003-09-16 旭硝子株式会社 ピペリジンカルビノール類の製造方法
US5936090A (en) * 1996-05-24 1999-08-10 Fmc Corporation Processes for the reduction of imide ester functionality
EP1384720A1 (de) 1996-06-13 2004-01-28 SUMIKA FINE CHEMICALS Co., Ltd. Verfahren zur Trocknung von Paroxetinhydrochlorid
GB9623359D0 (en) * 1996-11-09 1997-01-08 Smithkline Beecham Plc Novel process
GB9710004D0 (en) * 1997-05-17 1997-07-09 Knoll Ag Chemical process
JP2002514222A (ja) * 1997-05-29 2002-05-14 スミスクライン・ビーチャム・コーポレイション 新規方法
ES2149687B1 (es) * 1998-04-08 2001-05-16 Medichem Sa Procedimiento de obtencion de (+-)-trans-4-(4-fluorofenil)-3-hidroximetilpiperidinas e intermedios de sintesis para las mismas.
GB0003232D0 (en) * 2000-02-11 2000-04-05 Smithkline Beecham Plc Novel composition
US6720003B2 (en) * 2001-02-16 2004-04-13 Andrx Corporation Serotonin reuptake inhibitor formulations
IL160694A0 (en) * 2001-09-14 2004-08-31 Medichem Sa Intermediate compounds for the preparation of mirtazapine and the production methods thereof
JP5165951B2 (ja) * 2006-07-24 2013-03-21 住友化学株式会社 （±）−トランス−４−（４−フルオロフェニル）−３−ヒドロキシメチルピペリジンの製造方法
WO2008013248A1 (fr) * 2006-07-24 2008-01-31 Sumitomo Chemical Company, Limited Procédé de production de (±)-trans-4-(4- fluorophényl)-3-hydroxyméthylpipéridine
CN109020872B (zh) * 2018-06-26 2020-05-12 浙江邦富生物科技有限责任公司 一种盐酸帕罗西汀关键中间体的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1422263A (en) * 1973-01-30 1976-01-21 Ferrosan As 4-phenyl-piperidine compounds
JPS5470262A (en) * 1977-11-09 1979-06-05 Daiichi Kagaku Yakuhin Kk Manufacture of pyrrolidinee22methanol
FR2581242B1 (fr) * 1985-04-24 1988-08-26 Telemecanique Electrique Dispositif de commande electrique adaptable a un dispositif de commutation a deux etats
EP0223334B1 (de) * 1985-08-10 1991-07-10 Beecham Group Plc Verfahren zur Herstellung von Arylpiperidincarbinol
DK716088D0 (da) * 1988-12-22 1988-12-22 Ferrosan As Reduktion af piperidin-dion-derivater samt intermediat
US5258517A (en) * 1992-08-06 1993-11-02 Sepracor, Inc. Method of preparing optically pure precursors of paroxetine

Also Published As

Publication number Publication date
PL310469A1 (en) 1995-12-11
DZ1758A1 (fr) 2002-02-17
HUT72087A (en) 1996-03-28
US5681962A (en) 1997-10-28
PH31434A (en) 1998-11-03
AP452A (en) 1996-01-19
AP9400624A0 (en) 1994-04-30
FI954272A0 (fi) 1995-09-12
NO953598L (no) 1995-09-12
EP0688317A1 (de) 1995-12-27
NZ262735A (en) 1996-10-28
SK114095A3 (en) 1996-01-10
JPH08507540A (ja) 1996-08-13
NO306717B1 (no) 1999-12-13
ATE207898T1 (de) 2001-11-15
IL108946A (en) 1997-11-20
AU682497B2 (en) 1997-10-09
EP0688317B1 (de) 2001-10-31
CZ235595A3 (en) 1996-01-17
CN1119012A (zh) 1996-03-20
CA2158175A1 (en) 1994-09-29
DE69428886T2 (de) 2002-04-25
NO953598D0 (no) 1995-09-12
ZA941716B (en) 1995-01-13
AU6258794A (en) 1994-10-11
MA23134A1 (fr) 1994-10-01
FI954272A (fi) 1995-09-12
GB9305175D0 (en) 1993-04-28
WO1994021609A1 (en) 1994-09-29
CN1041918C (zh) 1999-02-03
CN1055470C (zh) 2000-08-16
PL176907B1 (pl) 1999-08-31
SK281977B6 (sk) 2001-09-11
IL108946A0 (en) 1994-06-24
CN1203226A (zh) 1998-12-30
KR100296719B1 (ko) 2001-10-24
RU2141477C1 (ru) 1999-11-20
ES2164700T3 (es) 2002-03-01
BR9406035A (pt) 1996-01-02

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee