DE69427551D1 - Nalbuphinester und diese enthaltende Arzneimittel mit verzögerter Wirkstoffabgabe - Google Patents
Nalbuphinester und diese enthaltende Arzneimittel mit verzögerter WirkstoffabgabeInfo
- Publication number
- DE69427551D1 DE69427551D1 DE69427551T DE69427551T DE69427551D1 DE 69427551 D1 DE69427551 D1 DE 69427551D1 DE 69427551 T DE69427551 T DE 69427551T DE 69427551 T DE69427551 T DE 69427551T DE 69427551 D1 DE69427551 D1 DE 69427551D1
- Authority
- DE
- Germany
- Prior art keywords
- drug delivery
- medicines containing
- delayed drug
- nalbuphine
- esters
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
- C07D489/08—Oxygen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP5053840A JPH06271578A (ja) | 1993-03-15 | 1993-03-15 | 鎮痛剤ナルブフィン前薬の誘導体 |
US16125793A | 1993-12-02 | 1993-12-02 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69427551D1 true DE69427551D1 (de) | 2001-08-02 |
DE69427551T2 DE69427551T2 (de) | 2002-05-16 |
Family
ID=26394562
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE1994627551 Expired - Lifetime DE69427551T2 (de) | 1993-03-15 | 1994-02-21 | Nalbuphinester und diese enthaltende Arzneimittel mit verzögerter Wirkstoffabgabe |
Country Status (2)
Country | Link |
---|---|
EP (1) | EP0615756B1 (de) |
DE (1) | DE69427551T2 (de) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU686203B2 (en) * | 1993-07-23 | 1998-02-05 | Toray Industries, Inc. | Morphinan derivative and medicinal use |
US6225321B1 (en) * | 1997-06-05 | 2001-05-01 | Oliver Yoa-Pu Hu | Long analgesic acting nalbuphine polyester derivative and method of use |
EP1149836B1 (de) * | 2000-04-27 | 2003-02-26 | Oliver Yoa-Pu Hu | Polynalbuphinderivat |
WO2007022535A2 (en) | 2005-08-19 | 2007-02-22 | Pharmacofore, Inc. | Prodrugs of active agents |
US8394812B2 (en) | 2005-08-24 | 2013-03-12 | Penwest Pharmaceuticals Co. | Sustained release formulations of nalbuphine |
ES2441766T3 (es) | 2005-08-24 | 2014-02-06 | Endo Pharmaceuticals Inc. | Formulaciones de nalbufina de liberación sostenida |
EP2307420B1 (de) * | 2008-04-24 | 2011-11-30 | Janssen Pharmaceutica NV | Nalmefendiesterprodrugs |
DK2291380T3 (da) * | 2008-04-24 | 2011-12-05 | Janssen Pharmaceutica Nv | Nalmefen-prodrugs |
US9918980B2 (en) | 2011-04-29 | 2018-03-20 | Rutgers, The State University Of New Jersey | Method of treating dyskinesia |
ES2829223T3 (es) | 2011-04-29 | 2021-05-31 | Univ Rutgers | Método de tratamiento de la discinesia |
US10736889B2 (en) | 2011-04-29 | 2020-08-11 | Rutgers, The State University Of New Jersey | Method of treating dyskinesia |
US11234974B2 (en) | 2015-05-28 | 2022-02-01 | Lumosa Therapeutics Co., Ltd. | Pharmaceutical formulations for sustained release of sebacoyl dinalbuphine ester |
MX2017015138A (es) * | 2015-05-28 | 2018-03-28 | Lumosa Therapeutics Co Ltd | Formulaciones farmaceuticas para liberacion sostenida de ester de sebacoil dinalbufina. |
EP3703694A4 (de) * | 2017-11-03 | 2021-08-18 | Nirsum Laboratories, Inc. | Opioidrezeptorantagonist-prodrugs |
US11186585B2 (en) | 2018-08-17 | 2021-11-30 | Kappa-Pharma LLC | Compositions and methods of enhancing opioid receptor engagement by opioid hexadienoates and optionally substituted hexadienoates |
CN114828961B (zh) * | 2019-08-11 | 2024-03-29 | 卡帕制药有限责任公司 | 通过阿片类己二烯酸酯和任选取代的己二烯酸酯增强阿片受体结合的组合物及方法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4464378A (en) * | 1981-04-28 | 1984-08-07 | University Of Kentucky Research Foundation | Method of administering narcotic antagonists and analgesics and novel dosage forms containing same |
US4668685A (en) * | 1984-07-05 | 1987-05-26 | E.I. Du Pont De Nemours And Company | Substituted benzoate ester prodrug derivatives of 3-hydroxymorphinans, which are analgesics or narcotic antagonists |
US4722928A (en) * | 1985-12-02 | 1988-02-02 | E. I. Du Pont De Nemours And Company | N-oxide prodrug derivatives of 3-hydroxy morphinans and partial morphinans having improved oral bioavailability, pharmaceutical compositions, and processes |
US4673679A (en) * | 1986-05-14 | 1987-06-16 | E. I. Du Pont De Nemours And Company | Use of prodrugs of 3-hydroxymorphinans to prevent bitter taste upon buccal, nasal or sublingual administration |
-
1994
- 1994-02-21 DE DE1994627551 patent/DE69427551T2/de not_active Expired - Lifetime
- 1994-02-21 EP EP19940102571 patent/EP0615756B1/de not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP0615756A1 (de) | 1994-09-21 |
EP0615756B1 (de) | 2001-06-27 |
DE69427551T2 (de) | 2002-05-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |