DE69422637T2 - Transdermale zusammensetzung von n-(n-(5-(4-(aminoiminomethyl)phenyl-1-oxopentyl)-l-alpha-aspartyl)-l-phenylalanin oder deren esterderivaten und ihre pharmazeutischverwendbaren salze - Google Patents

Transdermale zusammensetzung von n-(n-(5-(4-(aminoiminomethyl)phenyl-1-oxopentyl)-l-alpha-aspartyl)-l-phenylalanin oder deren esterderivaten und ihre pharmazeutischverwendbaren salze

Info

Publication number
DE69422637T2
DE69422637T2 DE69422637T DE69422637T DE69422637T2 DE 69422637 T2 DE69422637 T2 DE 69422637T2 DE 69422637 T DE69422637 T DE 69422637T DE 69422637 T DE69422637 T DE 69422637T DE 69422637 T2 DE69422637 T2 DE 69422637T2
Authority
DE
Germany
Prior art keywords
aminoiminomethyl
oxopentyl
aspartyl
phenylalanine
alpha
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69422637T
Other languages
English (en)
Other versions
DE69422637D1 (de
Inventor
P Feigen
John Griffin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GD Searle LLC
Original Assignee
GD Searle LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GD Searle LLC filed Critical GD Searle LLC
Publication of DE69422637D1 publication Critical patent/DE69422637D1/de
Application granted granted Critical
Publication of DE69422637T2 publication Critical patent/DE69422637T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE69422637T 1993-11-19 1994-10-24 Transdermale zusammensetzung von n-(n-(5-(4-(aminoiminomethyl)phenyl-1-oxopentyl)-l-alpha-aspartyl)-l-phenylalanin oder deren esterderivaten und ihre pharmazeutischverwendbaren salze Expired - Fee Related DE69422637T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15504493A 1993-11-19 1993-11-19
PCT/US1994/011921 WO1995013825A1 (en) 1993-11-19 1994-10-24 TRANSDERMAL COMPOSITION OF N-[N-[5-[4-(AMINOIMINOMETHYL)PHENYL]-1-OXOPENTYL]-L-α-ASPARTYL]-L-PHENYLALANINE OR ITS ESTERS AND THEIR PHARMACEUTICALLY ACCEPTABLE SALTS

Publications (2)

Publication Number Publication Date
DE69422637D1 DE69422637D1 (de) 2000-02-17
DE69422637T2 true DE69422637T2 (de) 2000-06-08

Family

ID=22553912

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69422637T Expired - Fee Related DE69422637T2 (de) 1993-11-19 1994-10-24 Transdermale zusammensetzung von n-(n-(5-(4-(aminoiminomethyl)phenyl-1-oxopentyl)-l-alpha-aspartyl)-l-phenylalanin oder deren esterderivaten und ihre pharmazeutischverwendbaren salze

Country Status (11)

Country Link
EP (1) EP0729362B1 (de)
JP (1) JPH09505290A (de)
AT (1) ATE188611T1 (de)
AU (1) AU8083894A (de)
CA (1) CA2176462A1 (de)
DE (1) DE69422637T2 (de)
DK (1) DK0729362T3 (de)
ES (1) ES2141849T3 (de)
GR (1) GR3032697T3 (de)
PT (1) PT729362E (de)
WO (1) WO1995013825A1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2298378T3 (es) 2001-06-28 2008-05-16 Novo Nordisk A/S Formulacion estable de glp-1 modificado.
ES2380437T3 (es) 2003-06-03 2012-05-11 Novo Nordisk A/S Composiciones farmacéuticas de péptido GLP-1 estabilizadas
JP2007524592A (ja) 2003-06-03 2007-08-30 ノボ・ノルデイスク・エー／エス 安定化された薬学的ペプチド組成物
RU2421238C2 (ru) 2003-11-20 2011-06-20 Ново Нордиск А/С Пептидная композиция, содержащая пропиленгликоль, являющаяся оптимальной для изготовления и применения в инъекционных устройствах
WO2006024631A2 (en) 2004-08-31 2006-03-09 Novo Nordisk A/S Use of tris(hydroxymethyl) aminomethane for the stabilization of peptides, polypeptides and proteins
AU2005303777B2 (en) 2004-11-12 2010-12-16 Novo Nordisk A/S Stable formulations of insulinotropic peptides
PE20211202A1 (es) 2017-08-24 2021-07-05 Novo Nordisk As Composiciones de glp-1 y sus usos
WO2021144476A1 (en) 2020-02-18 2021-07-22 Novo Nordisk A/S Pharmaceutical formulations

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0506956B1 (de) * 1990-10-19 1995-02-22 Shiseido Company Limited Hautpräparat zur äusserlichen anwendung
DE69200766T2 (de) * 1991-03-06 1995-05-04 G.D. Searle & Co., Chicago, Ill. Phenylamidinderivate als plättchenaggregationsinhibitoren.
DE69213546T2 (de) * 1991-05-13 1997-02-27 Fujisawa Pharmaceutical Co Neue Peptid-Verbindungen und Verfahren zur Herstellung davon
WO1993018058A1 (en) * 1992-03-06 1993-09-16 G.D. Searle & Co. Peptides mimics useful as platelet aggregation inhibitors
KR100297184B1 (ko) * 1992-06-04 2001-10-22 슈테펜엘.네스비트 항혈소판제로서의입체배좌적으로억제된펩타이드동족체및이를포함하는약제학적조성물
US5354738A (en) * 1992-09-04 1994-10-11 G. D. Searle & Co. Platelet aggregation inhibitors

Also Published As

Publication number Publication date
DE69422637D1 (de) 2000-02-17
AU8083894A (en) 1995-06-06
ES2141849T3 (es) 2000-04-01
CA2176462A1 (en) 1995-05-26
JPH09505290A (ja) 1997-05-27
EP0729362B1 (de) 2000-01-12
DK0729362T3 (da) 2000-05-08
GR3032697T3 (en) 2000-06-30
ATE188611T1 (de) 2000-01-15
WO1995013825A1 (en) 1995-05-26
PT729362E (pt) 2000-06-30
EP0729362A1 (de) 1996-09-04

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