DE69417087T2 - Wässrige Arzneizubereitungen enthaltend Argatroban und Cyclodextrin oder Coffein - Google Patents
Wässrige Arzneizubereitungen enthaltend Argatroban und Cyclodextrin oder CoffeinInfo
- Publication number
- DE69417087T2 DE69417087T2 DE69417087T DE69417087T DE69417087T2 DE 69417087 T2 DE69417087 T2 DE 69417087T2 DE 69417087 T DE69417087 T DE 69417087T DE 69417087 T DE69417087 T DE 69417087T DE 69417087 T2 DE69417087 T2 DE 69417087T2
- Authority
- DE
- Germany
- Prior art keywords
- caffeine
- cyclodextrin
- water
- arginine amide
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/40—Cyclodextrins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Inorganic Chemistry (AREA)
- Ophthalmology & Optometry (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP9627593 | 1993-04-22 | ||
JP32476093 | 1993-12-22 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69417087D1 DE69417087D1 (de) | 1999-04-22 |
DE69417087T2 true DE69417087T2 (de) | 1999-07-15 |
Family
ID=26437498
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69417087T Expired - Fee Related DE69417087T2 (de) | 1993-04-22 | 1994-04-20 | Wässrige Arzneizubereitungen enthaltend Argatroban und Cyclodextrin oder Coffein |
Country Status (8)
Country | Link |
---|---|
US (1) | US5605892A (de) |
EP (1) | EP0621036B1 (de) |
KR (1) | KR100215533B1 (de) |
CN (1) | CN1054744C (de) |
AT (1) | ATE177635T1 (de) |
CA (1) | CA2121723A1 (de) |
DE (1) | DE69417087T2 (de) |
TW (1) | TW256831B (de) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5558876A (en) * | 1995-03-29 | 1996-09-24 | Alcon Laboratories, Inc. | Topical ophthalmic acidic drug formulations |
US5840733A (en) * | 1996-07-01 | 1998-11-24 | Redcell, Canada, Inc. | Methods and compositions for producing novel conjugates of thrombin inhibitors and endogenous carriers resulting in anti-thrombins with extended lifetimes |
US6476004B1 (en) | 1996-07-18 | 2002-11-05 | Mitsubishi Pharma Corporation | Pharmaceutical composition |
US6274592B1 (en) | 1997-02-04 | 2001-08-14 | Senju Pharmaceutical Co., Ltd. | Method for stabilizing arylcarboxylic acid, stabilizer thereof and aqueous solution containing stabilized arylcarboxylic acid |
FR2793412B1 (fr) * | 1999-05-11 | 2001-07-27 | Synthelabo | Formulations galeniques d'argatroban pour administration sous-cutanee |
KR20150108430A (ko) | 2005-09-01 | 2015-09-25 | 백스터 인터내셔널 인코포레이티드 | 가용화제로서의 산을 포함하는 아가트로반 제제 |
CA2669727C (en) | 2006-09-27 | 2014-10-28 | Eagle Pharmaceuticals, Inc. | Alcohol free formulation of argatroban |
US7687516B2 (en) | 2006-09-27 | 2010-03-30 | Eagle Pharmaceuticals, Inc. | Alcohol free formulation of argatroban |
CN100467022C (zh) * | 2007-04-13 | 2009-03-11 | 天津市炜杰科技有限公司 | 21(s)阿加曲班的应用 |
US7915290B2 (en) | 2008-02-29 | 2011-03-29 | Baxter International Inc. | Argatroban formulations and methods for making and using same |
WO2012110971A2 (en) | 2011-02-17 | 2012-08-23 | Promed Exports Pvt. Ltd. | Method and composition to retard sorption of preservatives to plastics |
NL1040474C2 (en) * | 2013-10-31 | 2015-05-04 | Veramed B V | Nasal compositions stimulating ciliary activity. |
ES2914305T3 (es) | 2017-12-26 | 2022-06-09 | Ind Tech Res Inst | Composición para mejorar la solubilidad de sustancias poco solubles, uso de la misma y formulación compleja que contiene la misma |
TW202317132A (zh) * | 2021-06-11 | 2023-05-01 | 澳大利亞商布萊恩荷登視覺協會 | 眼用組合物及/或用於老花眼、瞳孔放大及/或眼部不適管理之方法 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1817417C3 (de) * | 1968-12-30 | 1974-04-11 | Kalle Ag, 6202 Wiesbaden-Biebrich | Z weikomponenten-Diazotypiematerial |
IE48623B1 (en) * | 1978-08-31 | 1985-03-20 | Mitsubishi Chem Ind | Alpha-(n-arylsulfonyl-l-argininamides,processes for their preparation and pharmaceutical compositions containing these substances |
US4517995A (en) * | 1981-10-23 | 1985-05-21 | Lyles Mark B | Filters for polynuclear aromatic hydrocarbon-containing smoke |
US4728509A (en) * | 1985-08-19 | 1988-03-01 | Takeda Chemical Industries, Ltd. | Aqueous liquid preparation |
JPS6431727A (en) * | 1987-07-28 | 1989-02-02 | Mitsubishi Chem Ind | Dissolution of argininamide and drug composition containing argininamides |
US5002935A (en) * | 1987-12-30 | 1991-03-26 | University Of Florida | Improvements in redox systems for brain-targeted drug delivery |
US5180747A (en) * | 1989-02-28 | 1993-01-19 | Nisshin Flour Milling Co., Ltd. | Stabilized fat-soluble vitamin compositions |
DE69118834T2 (de) * | 1990-11-27 | 1996-09-26 | Toyoda Chuo Kenkyusho Kk | Lösung zur chemischen Polierung und Glanzerzeugung für gehärtete Stahlkörper und Verfahren zu deren Verwendung |
US5356897A (en) * | 1991-09-09 | 1994-10-18 | Fujisawa Pharmaceutical Co., Ltd. | 3-(heteroaryl)-pyrazololi[1,5-a]pyrimidines |
CA2091715A1 (en) * | 1992-03-18 | 1993-09-19 | Mitsubishi Kasei Corporation | Argatroban preparations for ophthalmic use |
US5324718A (en) * | 1992-07-14 | 1994-06-28 | Thorsteinn Loftsson | Cyclodextrin/drug complexation |
-
1994
- 1994-04-20 TW TW083103497A patent/TW256831B/zh active
- 1994-04-20 EP EP94106094A patent/EP0621036B1/de not_active Expired - Lifetime
- 1994-04-20 DE DE69417087T patent/DE69417087T2/de not_active Expired - Fee Related
- 1994-04-20 CA CA002121723A patent/CA2121723A1/en not_active Abandoned
- 1994-04-20 AT AT94106094T patent/ATE177635T1/de not_active IP Right Cessation
- 1994-04-21 KR KR1019940008470A patent/KR100215533B1/ko not_active IP Right Cessation
- 1994-04-22 CN CN94104044A patent/CN1054744C/zh not_active Expired - Fee Related
-
1996
- 1996-04-05 US US08/626,146 patent/US5605892A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
ATE177635T1 (de) | 1999-04-15 |
CN1054744C (zh) | 2000-07-26 |
US5605892A (en) | 1997-02-25 |
KR100215533B1 (ko) | 1999-08-16 |
EP0621036B1 (de) | 1999-03-17 |
CA2121723A1 (en) | 1994-10-23 |
AU672879B2 (en) | 1996-10-17 |
DE69417087D1 (de) | 1999-04-22 |
AU6059794A (en) | 1994-10-27 |
CN1105857A (zh) | 1995-08-02 |
TW256831B (de) | 1995-09-11 |
EP0621036A1 (de) | 1994-10-26 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |