DE69415050T2 - Hexahydronaphthalenesterderivate, ihre Herstellung und ihre therapeutischen Anwendungen - Google Patents

Hexahydronaphthalenesterderivate, ihre Herstellung und ihre therapeutischen Anwendungen

Info

Publication number
DE69415050T2
DE69415050T2 DE69415050T DE69415050T DE69415050T2 DE 69415050 T2 DE69415050 T2 DE 69415050T2 DE 69415050 T DE69415050 T DE 69415050T DE 69415050 T DE69415050 T DE 69415050T DE 69415050 T2 DE69415050 T2 DE 69415050T2
Authority
DE
Germany
Prior art keywords
preparation
therapeutic applications
ester derivatives
hydrogen
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69415050T
Other languages
English (en)
Other versions
DE69415050D1 (de
Inventor
Sadao Ishihara
Hiroshi Kogen
Teiichiro Koga
Eiichi Kitazawa
Nobufusa Serizawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd
Publication of DE69415050D1 publication Critical patent/DE69415050D1/de
Application granted granted Critical
Publication of DE69415050T2 publication Critical patent/DE69415050T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/62Carboxylic acid esters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/734Ethers
    • C07C69/736Ethers the hydroxy group of the ester being etherified with a hydroxy compound having the hydroxy group bound to a carbon atom of a six-membered aromatic ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D309/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30Oxygen atoms, e.g. delta-lactones
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • C07F7/18Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804Compounds having Si-O-C linkages
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pyrane Compounds (AREA)
DE69415050T 1993-01-29 1994-01-26 Hexahydronaphthalenesterderivate, ihre Herstellung und ihre therapeutischen Anwendungen Expired - Fee Related DE69415050T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP1306393 1993-01-29

Publications (2)

Publication Number Publication Date
DE69415050D1 DE69415050D1 (de) 1999-01-21
DE69415050T2 true DE69415050T2 (de) 1999-08-12

Family

ID=11822687

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69415050T Expired - Fee Related DE69415050T2 (de) 1993-01-29 1994-01-26 Hexahydronaphthalenesterderivate, ihre Herstellung und ihre therapeutischen Anwendungen

Country Status (22)

Country Link
US (1) US5491167A (de)
EP (1) EP0609058B1 (de)
JP (1) JPH06279280A (de)
KR (1) KR100293335B1 (de)
CN (1) CN1070487C (de)
AT (1) ATE174324T1 (de)
AU (1) AU664323B2 (de)
CA (1) CA2114450A1 (de)
CZ (1) CZ285658B6 (de)
DE (1) DE69415050T2 (de)
DK (1) DK0609058T3 (de)
ES (1) ES2126057T3 (de)
FI (1) FI940424A (de)
HK (1) HK1011678A1 (de)
HU (1) HU221852B1 (de)
IL (1) IL108432A (de)
NO (1) NO300769B1 (de)
NZ (1) NZ250771A (de)
PH (1) PH31662A (de)
RU (1) RU2114101C1 (de)
TW (1) TW411337B (de)
ZA (1) ZA94548B (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ250609A (en) * 1992-12-28 1995-07-26 Sankyo Co Hexahydronaphthalene esters and ring closed lactones; preparation and medicaments
US6043064A (en) * 1993-10-22 2000-03-28 Bristol-Myers Squibb Company Enzymatic hydroxylation process for the preparation of HMG-CoA reductase inhibitors and intermediates thereof
US5942423A (en) * 1995-06-07 1999-08-24 Massachusetts Institute Of Technology Conversion of compactin to pravastatin by actinomadura
AU2002211805A1 (en) * 2000-09-06 2002-03-22 Emisphere Technologies, Inc. Cyanophenoxy carboxylic acid compounds and compositions for delivering active agents
MX2009011365A (es) 2007-04-27 2009-11-05 Actelion Pharmaceuticals Ltd Compuestos anulares de seis miembros en puente.

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK149080C (da) * 1980-06-06 1986-07-28 Sankyo Co Fremgangsmaade til fremstilling af derivater af ml-236b-carboxylsyre
JPS57185275A (en) * 1981-05-07 1982-11-15 Sankyo Co Ltd Tetrahydro-dum-4 and tetrahydro-isodum-4 and their derivatives
US4668699A (en) * 1985-08-05 1987-05-26 Merck & Co., Inc. Novel HMG-CoA reductase inhibitors
US4937263A (en) * 1986-05-05 1990-06-26 Merck & Co., Inc. Antihypercholesterolemic compounds
US4937264A (en) * 1986-05-05 1990-06-26 Merck & Co., Inc. Antihypercholesterolemic compounds
US4876279A (en) * 1986-05-05 1989-10-24 Merck & Co., Inc. Antihypercholesterolemic compounds
US4902709A (en) * 1987-03-17 1990-02-20 Merck & Co., Inc. Novel antihypercholesterolemic compounds
US4885314A (en) * 1987-06-29 1989-12-05 Merck & Co., Inc. Novel HMG-CoA reductase inhibitors
US4997848A (en) * 1987-10-27 1991-03-05 Sankyo Company, Limited Octahydronaphthalene oxime derivatives for cholesterol synthesis inhibition
US4946864A (en) * 1988-02-01 1990-08-07 Merck & Co., Inc. Novel HMG-CoA reductase inhibitors
US5021453A (en) * 1988-03-02 1991-06-04 Merck & Co., Inc. 3-keto HMG-CoA reductase inhibitors
US5180589A (en) * 1988-03-31 1993-01-19 E. R. Squibb & Sons, Inc. Pravastatin pharmaceuatical compositions having good stability
US4963538A (en) * 1988-06-29 1990-10-16 Merck & Co., Inc. 5-oxygenated HMG-CoA reductase inhibitors
US5130306A (en) * 1989-03-13 1992-07-14 Merck & Co., Inc. 5-Oxygenated HMG-COA reductase inhibitors
US5010105A (en) * 1989-06-09 1991-04-23 Merck & Co., Inc. Antihypercholesterolemic compounds
US5102911A (en) * 1989-06-09 1992-04-07 Merck & Co, Inc. 4-Substituted HMG-CoA reductase inhibitors
EP0415488B1 (de) * 1989-08-31 1994-04-20 Merck & Co. Inc. 7-Subsituierte HMG-CoA-Reduktase-Inhibitoren

Also Published As

Publication number Publication date
CN1098099A (zh) 1995-02-01
ES2126057T3 (es) 1999-03-16
AU664323B2 (en) 1995-11-09
KR100293335B1 (ko) 2001-09-17
ZA94548B (en) 1994-08-29
PH31662A (en) 1999-01-12
CA2114450A1 (en) 1994-07-30
NO300769B1 (no) 1997-07-21
IL108432A0 (en) 1994-04-12
HK1011678A1 (en) 1999-07-16
CZ285658B6 (cs) 1999-10-13
EP0609058B1 (de) 1998-12-09
TW411337B (en) 2000-11-11
EP0609058A2 (de) 1994-08-03
US5491167A (en) 1996-02-13
CN1070487C (zh) 2001-09-05
AU5472894A (en) 1994-08-04
EP0609058A3 (de) 1995-04-19
DE69415050D1 (de) 1999-01-21
NO940309D0 (no) 1994-01-28
RU2114101C1 (ru) 1998-06-27
KR940018352A (ko) 1994-08-16
HUT67740A (en) 1995-04-28
CZ18694A3 (en) 1995-03-15
HU9400242D0 (en) 1994-05-30
NO940309L (no) 1994-08-01
HU221852B1 (hu) 2003-02-28
JPH06279280A (ja) 1994-10-04
NZ250771A (en) 1995-07-26
ATE174324T1 (de) 1998-12-15
FI940424A0 (fi) 1994-01-28
IL108432A (en) 1997-09-30
FI940424A (fi) 1994-11-07
DK0609058T3 (da) 1999-08-16

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee