DE69410112D1 - 26,28-methylen-1alpha,25-dihydroxy-vitamin-d2-verbindungen - Google Patents

26,28-methylen-1alpha,25-dihydroxy-vitamin-d2-verbindungen

Info

Publication number
DE69410112D1
DE69410112D1 DE69410112T DE69410112T DE69410112D1 DE 69410112 D1 DE69410112 D1 DE 69410112D1 DE 69410112 T DE69410112 T DE 69410112T DE 69410112 T DE69410112 T DE 69410112T DE 69410112 D1 DE69410112 D1 DE 69410112D1
Authority
DE
Germany
Prior art keywords
compounds
vitamin
1alpha
dihydroxy
methylene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69410112T
Other languages
English (en)
Other versions
DE69410112T2 (de
Inventor
Hector Deluca
Naoshi Nakagawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wisconsin Alumni Research Foundation
Original Assignee
Wisconsin Alumni Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wisconsin Alumni Research Foundation filed Critical Wisconsin Alumni Research Foundation
Publication of DE69410112D1 publication Critical patent/DE69410112D1/de
Application granted granted Critical
Publication of DE69410112T2 publication Critical patent/DE69410112T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE69410112T 1993-11-24 1994-10-19 26,28-methylen-1alpha,25-dihydroxy-vitamin-d2-verbindungen Expired - Fee Related DE69410112T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/157,970 US5373004A (en) 1993-11-24 1993-11-24 26,28-methylene-1α, 25-dihydroxyvitamin D2 compounds
PCT/US1994/012092 WO1995014662A1 (en) 1993-11-24 1994-10-19 26,28-methylene-1alpha,25-dihydroxyvitamin d2 compounds

Publications (2)

Publication Number Publication Date
DE69410112D1 true DE69410112D1 (de) 1998-06-10
DE69410112T2 DE69410112T2 (de) 1999-01-14

Family

ID=22566140

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69410112T Expired - Fee Related DE69410112T2 (de) 1993-11-24 1994-10-19 26,28-methylen-1alpha,25-dihydroxy-vitamin-d2-verbindungen

Country Status (9)

Country Link
US (2) US5373004A (de)
EP (1) EP0730577B1 (de)
JP (1) JP3681390B2 (de)
AT (1) ATE165819T1 (de)
AU (1) AU8086494A (de)
DE (1) DE69410112T2 (de)
DK (1) DK0730577T3 (de)
ES (1) ES2115267T3 (de)
WO (1) WO1995014662A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040167106A1 (en) * 1993-06-04 2004-08-26 Rodriguez Gustavo C. Prevention of ovarian cancer by administration of a Vitamin D compound
US6407082B1 (en) 1996-09-13 2002-06-18 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of a vitamin D compound
US5716946A (en) * 1996-02-13 1998-02-10 Wisconsin Alumni Research Foundation Multiple sclerosis treatment
US6765002B2 (en) 2000-03-21 2004-07-20 Gustavo Rodriguez Prevention of ovarian cancer by administration of products that induce transforming growth factor-β and/or apoptosis in the ovarian epithelium
US6034074A (en) * 1996-09-13 2000-03-07 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of a Vitamin D compound
US6511970B1 (en) 1996-09-13 2003-01-28 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of products that induce transforming growth factor-beta and/or apoptosis in the ovarian epithelium
US6028064A (en) 1996-09-13 2000-02-22 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of progestin products
US6028208A (en) * 1997-06-25 2000-02-22 Teijin Limited Vitamin D3 derivative and treating agent for inflammatory respiratory disease using same
WO2000038692A1 (fr) * 1998-12-24 2000-07-06 Teijin Limited Remedes contre la mucoviscidose contenant des derives de la vitamine d¿3?
US6479474B2 (en) * 1999-07-08 2002-11-12 Wisconsin Alumni Research Foundation Dietary calcium as a supplement to vitamin D compound treatment of multiple sclerosis
JP2003519682A (ja) 2000-01-10 2003-06-24 レオ・ファーマ・アクティーゼルスカブ 新規ビタミンｄ類似体
US20010044431A1 (en) * 2000-03-21 2001-11-22 Rodriguez Gustavo C. Prevention of ovarian cancer by administration of products that induce biologic effects in the ovarian epithelium
US20020123485A1 (en) * 2000-07-27 2002-09-05 Alexander John C. Epoxy steroidal aldosterone antagonist and beta-adrenergic antagonist combination therapy for treatment of congestive heart failure
JP5932339B2 (ja) 2009-01-27 2016-06-08 バーグ エルエルシー 化学療法に付随する副作用を軽減するためのビタミンｄ３およびその類似体
IN2012DN02137A (de) 2009-08-14 2015-08-07 Berg Biosystems Llc
SG10201709894RA (en) 2013-05-29 2018-01-30 Berg Llc Preventing or mitigating chemotherapy induced alopecia using vitamin d

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3247836A1 (de) * 1981-12-29 1983-07-07 Teijin Ltd., Osaka Arzneimittel und verwendung derselben zur steuerung der serumcalciumkonzentration bei warmbluetern
US4512925A (en) * 1983-09-14 1985-04-23 Wisconsin Alumini Research Foundation 1,23-Dihydroxyvitamin D compounds
US4769181A (en) * 1983-11-07 1988-09-06 Wisconsin Alumni Research Foundation 1,25-dihydroxyvitamin D2 compounds
US4588716A (en) * 1984-05-04 1986-05-13 Wisconsin Alumni Research Foundation Method for treating metabolic bone disease in mammals
WO1987000834A1 (en) * 1985-08-02 1987-02-12 Leo Pharmaceutical Products Ltd. A/S Novel vitamin d analogues
KR0144358B1 (ko) * 1988-04-21 1998-07-15 피. 라이달 크리스텐슨 비타민 d 동족체
US5250523A (en) * 1988-04-29 1993-10-05 Wisconsin Alumni Research Foundation Side chain unsaturated 1α-hydroxyvitanim D homologs
US4851401A (en) * 1988-07-14 1989-07-25 Wisconsin Alumni Research Foundation Novel cyclopentano-vitamin D analogs
US4973584A (en) * 1989-03-09 1990-11-27 Deluca Hector F Novel 1α-hydroxyvitamin D2 epimer and derivatives
GB8915770D0 (en) * 1989-07-10 1989-08-31 Leo Pharm Prod Ltd Chemical compounds
AU656829B2 (en) * 1991-12-26 1995-02-16 Wisconsin Alumni Research Foundation 26, 27-dimethylene-1 alpha, 25-dihydroxyvitamin D2 and 26,27-dihydroxyvitamin D2 and methods for preparing same
US5194431A (en) * 1992-07-08 1993-03-16 Wisconsin Alumni Research Foundation 24-cyclopropane vitamin D derivatives

Also Published As

Publication number Publication date
JP3681390B2 (ja) 2005-08-10
EP0730577B1 (de) 1998-05-06
WO1995014662A1 (en) 1995-06-01
ES2115267T3 (es) 1998-06-16
JPH09506343A (ja) 1997-06-24
EP0730577A1 (de) 1996-09-11
US5373004A (en) 1994-12-13
ATE165819T1 (de) 1998-05-15
DK0730577T3 (da) 1999-01-18
DE69410112T2 (de) 1999-01-14
US5457217A (en) 1995-10-10
AU8086494A (en) 1995-06-13

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee