DE69405086T2 - Mangan-komplexe von stickstoff-enthaltenden macrozyklischen liganden und ihre verwendung als superoxiddismutase katalysatoren - Google Patents

Mangan-komplexe von stickstoff-enthaltenden macrozyklischen liganden und ihre verwendung als superoxiddismutase katalysatoren

Info

Publication number
DE69405086T2
DE69405086T2 DE69405086T DE69405086T DE69405086T2 DE 69405086 T2 DE69405086 T2 DE 69405086T2 DE 69405086 T DE69405086 T DE 69405086T DE 69405086 T DE69405086 T DE 69405086T DE 69405086 T2 DE69405086 T2 DE 69405086T2
Authority
DE
Germany
Prior art keywords
superoxide
disismutase
manganic
complexes
catalysts
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69405086T
Other languages
English (en)
Other versions
DE69405086D1 (de
Inventor
Karl Aston
Patrick Lennon
Anil Modak
William Neumann
Dennis Riley
Randy Weiss
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Monsanto Co
Original Assignee
Monsanto Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Monsanto Co filed Critical Monsanto Co
Publication of DE69405086D1 publication Critical patent/DE69405086D1/de
Application granted granted Critical
Publication of DE69405086T2 publication Critical patent/DE69405086T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D259/00—Heterocyclic compounds containing rings having more than four nitrogen atoms as the only ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
    • C07F13/005—Compounds without a metal-carbon linkage

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Catalysts (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyrane Compounds (AREA)
DE69405086T 1993-01-14 1994-01-05 Mangan-komplexe von stickstoff-enthaltenden macrozyklischen liganden und ihre verwendung als superoxiddismutase katalysatoren Expired - Fee Related DE69405086T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/004,444 US6204259B1 (en) 1993-01-14 1993-01-14 Manganese complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide
PCT/US1994/000169 WO1994015925A1 (en) 1993-01-14 1994-01-05 Manganese complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide

Publications (2)

Publication Number Publication Date
DE69405086D1 DE69405086D1 (de) 1997-09-25
DE69405086T2 true DE69405086T2 (de) 1998-03-26

Family

ID=21710837

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69405086T Expired - Fee Related DE69405086T2 (de) 1993-01-14 1994-01-05 Mangan-komplexe von stickstoff-enthaltenden macrozyklischen liganden und ihre verwendung als superoxiddismutase katalysatoren

Country Status (11)

Country Link
US (1) US6204259B1 (de)
EP (1) EP0679155B1 (de)
JP (1) JPH08505622A (de)
AT (1) ATE157090T1 (de)
AU (1) AU5964894A (de)
CA (1) CA2151262A1 (de)
DE (1) DE69405086T2 (de)
DK (1) DK0679155T3 (de)
ES (1) ES2107184T3 (de)
GR (1) GR3025447T3 (de)
WO (1) WO1994015925A1 (de)

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US6127356A (en) 1993-10-15 2000-10-03 Duke University Oxidant scavengers
HUT76318A (en) * 1994-04-22 1997-08-28 Searle & Co Diagnostic image analysis with metal complexes
US6245758B1 (en) 1994-05-13 2001-06-12 Michael K. Stern Methods of use for peroxynitrite decomposition catalysts, pharmaceutical compositions therefor
CN1222286C (zh) * 1994-05-13 2005-10-12 孟山都公司 过亚硝酸盐分解催化剂的应用方法及其药物组合物
US6525041B1 (en) 1995-06-06 2003-02-25 Pharmacia Corporation Manganese or iron complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide
EP0830351A1 (de) * 1995-06-07 1998-03-25 Monsanto Company Verfahren zur herstellung von substituierten polyazamacroringen
BR9610241A (pt) * 1995-08-17 1999-06-29 Monsanto Co Processos para análise de imagem de diagnóstico utilizando bioconjgados de complexos de metal de ligandos macrocíclicos contendo nitrogênio
CN1200039A (zh) * 1995-08-17 1998-11-25 孟山都公司 可用作岐化超氧化物催化剂的、含氮大环配体的锰配合物的生物结合物
GB9613182D0 (en) * 1996-06-24 1996-08-28 Nycomed Imaging As Method
US6214817B1 (en) 1997-06-20 2001-04-10 Monsanto Company Substituted pyridino pentaazamacrocyle complexes having superoxide dismutase activity
US20050171198A1 (en) * 1997-06-20 2005-08-04 Metaphore Pharmaceuticals, Inc. SODm therapy for treatment, prevention, inhibition and reversal of inflammatory disease
US6180620B1 (en) * 1997-06-20 2001-01-30 G.D. Searle & Co. Analgesic methods using synthetic catalysts for the dismutation of superoxide radicals
JP2001521939A (ja) 1997-11-03 2001-11-13 デューク・ユニバーシティー 置換されたポルフィリン類
US6429197B1 (en) * 1998-10-08 2002-08-06 Bionebraska, Inc. Metabolic intervention with GLP-1 or its biologically active analogues to improve the function of the ischemic and reperfused brain
US6284725B1 (en) 1998-10-08 2001-09-04 Bionebraska, Inc. Metabolic intervention with GLP-1 to improve the function of ischemic and reperfused tissue
US7259136B2 (en) 1999-04-30 2007-08-21 Amylin Pharmaceuticals, Inc. Compositions and methods for treating peripheral vascular disease
WO2000043395A1 (en) 1999-01-25 2000-07-27 National Jewish Medical And Research Center Substituted porphyrins
ATE291446T1 (de) 1999-05-27 2005-04-15 Monsanto Co Biomaterialien, modifiziert mit superoxid- dismutase imitatoren
GB9930422D0 (en) 1999-12-22 2000-02-16 Unilever Plc Bleach catalysts
FR2806911B1 (fr) * 2000-03-28 2003-01-10 Univ Rene Descartes Utilisation de mimetiques de la sod dans le traitement d'insuffisances hepatocellulaires
US20030069281A1 (en) * 2000-06-14 2003-04-10 Irwin Fridovich Tetrapyrroles
ATE470448T1 (de) 2000-10-20 2010-06-15 Amylin Pharmaceuticals Inc Behandlung von hypoaktivem myokard und diabetischer herzmyopathie mit einem glp-1 peptid
ES2330728T3 (es) * 2001-01-19 2009-12-15 National Jewish Health Medicamento para proteccion en radioterapia.
AU2002312194B8 (en) * 2001-06-01 2008-05-15 Aeolus Sciences, Inc. Oxidant scavengers for treatment of diabetes or use in transplantation or induction of immune tolerance
JP2006501163A (ja) * 2002-06-07 2006-01-12 デューク・ユニバーシティー 置換ポルフィリン
US20030232784A1 (en) * 2002-06-14 2003-12-18 Benedict James J. Hyaluronic acid-associated superoxide dismutase mimics and their use in the treatment of joint pain
KR100648618B1 (ko) * 2003-11-19 2006-11-23 주식회사 웰스킨 활성 산소 억제제
KR20060135922A (ko) * 2004-03-29 2006-12-29 이노텍 파마슈티컬스 코포레이션 피리딜 치환된 포르피린 화합물 및 이의 사용 방법
US20120301403A1 (en) 2007-06-21 2012-11-29 Galera Therapeutics, Llc Polyethylene glycolated superoxide dismutase mimetics
US8217166B2 (en) * 2005-05-05 2012-07-10 Galera Therapeutics, Llc Polyethylene glycolated superoxide dismutase mimetics
KR100724586B1 (ko) 2005-12-09 2007-06-04 세종대학교산학협력단 수퍼옥사이드 디스뮤타아제 활성을 갖는 고리화합물
EP2056675B1 (de) * 2006-10-12 2019-01-09 Galera Labs, LLC Methode zur behandlung oraler mukositis
CA2724550C (en) 2008-05-22 2017-01-03 Kereos, Inc. Combination antitumor therapy
RU2506083C2 (ru) 2008-05-23 2014-02-10 Нэшнл Джуиш Хелт Способ лечения поражений, ассоциированных с воздействием алкилирующих веществ
US9149483B2 (en) 2011-09-26 2015-10-06 Galera Labs, Llc Methods for treatment of diseases
EP2800755B1 (de) 2012-01-05 2018-05-30 Pledpharma AB Calmangafodipir, eine neue chemische einheit und andere gemischte metallkomplexe, verfahren zur herstellung, zusammensetzungen und verfahren zur behandlung
DK3334744T3 (da) 2015-08-11 2020-07-27 Galera Labs Llc Makrocykliske pentaaza-ringkomplekser med oral biotilgængelighed
IL295620B2 (en) 2017-04-13 2024-01-01 Galera Labs Llc Cancer immunotherapy combined with a macrocyclic ring pentase complex
CA3090129A1 (en) 2018-01-31 2019-08-08 Galera Labs, Llc Combination cancer therapy with pentaaza macrocyclic ring complex and platinum-based anticancer agent

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Publication number Priority date Publication date Assignee Title
US4001212A (en) 1973-10-03 1977-01-04 E. I. Du Pont De Nemours And Company Macrocyclic polyamines
US3930867A (en) 1974-01-07 1976-01-06 E. I. Du Pont De Nemours And Company Macrocyclic polyamines as sensitizers for silver halide emulsions
JPS61226751A (ja) 1985-03-30 1986-10-08 Konishiroku Photo Ind Co Ltd ハロゲン化銀写真感光材料用処理液及びその処理方法
US4885363A (en) 1987-04-24 1989-12-05 E. R. Squibb & Sons, Inc. 1-substituted-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs
US5223538A (en) 1987-03-31 1993-06-29 Duke University Superoxide dismutase mimic
US5227405A (en) * 1987-03-31 1993-07-13 Duke University Superoxide dismutase mimic
FR2614020B1 (fr) 1987-04-14 1989-07-28 Guerbet Sa Nouveaux ligands cycliques azotes, complexes metalliques formes par ces ligands, compositions de diagnostic contenant ces complexes et procede de preparation des ligands.
US5096724A (en) 1988-06-03 1992-03-17 Aquanautics Corporation Methods, compositions, and systems for ligand extraction
WO1990007261A2 (en) 1988-12-22 1990-07-12 The Dow Chemical Company Process for preparing mono-n-alkylated polyazamacrocycles
FR2644785B1 (fr) 1989-03-24 1991-07-05 Guerbet Sa Nouveaux ligands macrocycliques azotes, procede de preparation, complexes metalliques formes par ces ligands et composition de diagnostic les contenant
CA2032559C (en) 1989-12-28 2001-11-06 Kiyofumi Ishikawa Endothelin antagonistic cyclic pentapeptides
JP3155552B2 (ja) * 1991-07-19 2001-04-09 モンサント カンパニー 超酸化物の不均斉変化に有効な触媒としての窒素含有−大環状リガンドのマンガン錯体

Also Published As

Publication number Publication date
AU5964894A (en) 1994-08-15
CA2151262A1 (en) 1994-07-21
JPH08505622A (ja) 1996-06-18
ES2107184T3 (es) 1997-11-16
WO1994015925A1 (en) 1994-07-21
EP0679155B1 (de) 1997-08-20
ATE157090T1 (de) 1997-09-15
GR3025447T3 (en) 1998-02-27
US6204259B1 (en) 2001-03-20
DE69405086D1 (de) 1997-09-25
DK0679155T3 (da) 1997-12-29
EP0679155A1 (de) 1995-11-02

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee