DE69401045D1 - Stereoselektives Verfahren zur Herstellung von Beta-Anomer angereicherten 2-deoxy-2,2-difluoro-D-ribofuranosyl-3,5-hydroxy-geschützten 1-alkyl und aryl-sulfonat-Zwischenprodukten - Google Patents
Stereoselektives Verfahren zur Herstellung von Beta-Anomer angereicherten 2-deoxy-2,2-difluoro-D-ribofuranosyl-3,5-hydroxy-geschützten 1-alkyl und aryl-sulfonat-ZwischenproduktenInfo
- Publication number
- DE69401045D1 DE69401045D1 DE69401045T DE69401045T DE69401045D1 DE 69401045 D1 DE69401045 D1 DE 69401045D1 DE 69401045 T DE69401045 T DE 69401045T DE 69401045 T DE69401045 T DE 69401045T DE 69401045 D1 DE69401045 D1 DE 69401045D1
- Authority
- DE
- Germany
- Prior art keywords
- ribofuranosyl
- deoxy
- difluoro
- alkyl
- beta
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/08—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/111,578 US5424416A (en) | 1993-08-25 | 1993-08-25 | Process for preparation of 2-deoxy-2,2-difluoro-D-ribofuranosyl-3,5-hydroxy protected-1-alkyl and aryl sulfonates and their use in preparation of 2',2'-difluoro-2'-deoxy nucleosides |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69401045D1 true DE69401045D1 (de) | 1997-01-16 |
DE69401045T2 DE69401045T2 (de) | 1997-04-10 |
Family
ID=22339311
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69401045T Expired - Fee Related DE69401045T2 (de) | 1993-08-25 | 1994-08-24 | Stereoselektives Verfahren zur Herstellung von Beta-Anomer angereicherten 2-deoxy-2,2-difluoro-D-ribofuranosyl-3,5-hydroxy-geschützten 1-alkyl und aryl-sulfonat-Zwischenprodukten |
Country Status (9)
Country | Link |
---|---|
US (1) | US5424416A (de) |
EP (1) | EP0640614B1 (de) |
JP (1) | JP3659989B2 (de) |
AT (1) | ATE145916T1 (de) |
CA (1) | CA2130618C (de) |
DE (1) | DE69401045T2 (de) |
DK (1) | DK0640614T3 (de) |
ES (1) | ES2094623T3 (de) |
GR (1) | GR3022477T3 (de) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5521294A (en) * | 1995-01-18 | 1996-05-28 | Eli Lilly And Company | 2,2-difluoro-3-carbamoyl ribose sulfonate compounds and process for the preparation of beta nucleosides |
KR100954390B1 (ko) * | 1998-02-25 | 2010-04-26 | 에모리 유니버시티 | 2'-플루오로뉴클레오사이드 |
US6949522B2 (en) | 2001-06-22 | 2005-09-27 | Pharmasset, Inc. | β-2′- or 3′-halonucleosides |
US6884880B2 (en) * | 2002-08-21 | 2005-04-26 | Ash Stevens, Inc. | Process for the preparation of 9-β-anomeric nucleoside analogs |
US7214791B2 (en) * | 2004-07-01 | 2007-05-08 | Shenzhen Hande Technology Co., Ltd. | Method for preparation of 2′-deoxy-2′, 2′-difluoro-β-cytidine or pharmaceutically acceptable salts thereof by using 1,6-anhydro-β-d-glucose as raw material |
EP1812457A1 (de) * | 2004-07-30 | 2007-08-01 | Pharmaessentia Corp. | Stereoselektive synthese von b-nukleosiden |
WO2006119347A1 (en) * | 2005-05-02 | 2006-11-09 | Pharmaessentia Corp. | STEREOSELECTIVE SYNTHESIS OF β-NUCLEOSIDES |
US8895531B2 (en) * | 2006-03-23 | 2014-11-25 | Rfs Pharma Llc | 2′-fluoronucleoside phosphonates as antiviral agents |
AU2008323923A1 (en) * | 2007-11-06 | 2009-05-14 | Pharmaessentia Corporation | Novel synthesis of beta-nucleosides |
US20090274686A1 (en) * | 2008-05-02 | 2009-11-05 | Yat Sun Or | Nucleoside phosphonate derivatives |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3282921A (en) * | 1964-06-04 | 1966-11-01 | Syntex Corp | Halo-deoxynucleosides and processes for the preparation thereof |
DE2628202A1 (de) * | 1976-06-23 | 1977-12-29 | Max Planck Gesellschaft | Verfahren zur herstellung von 2'-substituierten-d-ribofuranosylpurinderivaten |
US4211773A (en) * | 1978-10-02 | 1980-07-08 | Sloan Kettering Institute For Cancer Research | 5-Substituted 1-(2'-Deoxy-2'-substituted-β-D-arabinofuranosyl)pyrimidine nucleosides |
FR2531962B1 (fr) * | 1982-08-17 | 1986-11-14 | Sandoz Sa | Nouveaux derives de la desoxyuridine, leur preparation et leur utilisation comme medicaments |
US4526988A (en) * | 1983-03-10 | 1985-07-02 | Eli Lilly And Company | Difluoro antivirals and intermediate therefor |
US4625020A (en) * | 1983-11-18 | 1986-11-25 | Bristol-Myers Company | Nucleoside process |
IL77133A (en) * | 1984-12-04 | 1991-01-31 | Lilly Co Eli | Antineoplastic pharmaceutical compositions containing pentofuranoside derivatives,some new such compounds and their preparation |
CA1295998C (en) * | 1985-07-29 | 1992-02-18 | Sai P. Sunkara | Nucleosides and their use as antineoplastic agents |
US4751221A (en) * | 1985-10-18 | 1988-06-14 | Sloan-Kettering Institute For Cancer Research | 2-fluoro-arabinofuranosyl purine nucleosides |
US4965374A (en) * | 1987-08-28 | 1990-10-23 | Eli Lilly And Company | Process for and intermediates of 2',2'-difluoronucleosides |
EP0339161A1 (de) * | 1988-04-01 | 1989-11-02 | Merrell Dow Pharmaceuticals Inc. | Derivate von Fluorphosphonat-Nukleotiden |
JPH0232093A (ja) * | 1988-06-08 | 1990-02-01 | Merrell Dow Pharmaceut Inc | 抗レトロウィルスジフルオロ化ヌクレオシド類 |
HU906976D0 (en) * | 1989-11-13 | 1991-05-28 | Bristol Myers Squibb Co | Process for producing 2', 3'-didesoxy-2'-fluoarabinonucleoside analogues |
UA41261C2 (uk) * | 1992-06-22 | 2001-09-17 | Елі Ліллі Енд Компані | Спосіб одержання збагачених бета-аномером нуклеозидів |
US5256798A (en) * | 1992-06-22 | 1993-10-26 | Eli Lilly And Company | Process for preparing alpha-anomer enriched 2-deoxy-2,2-difluoro-D-ribofuranosyl sulfonates |
US5401861A (en) * | 1992-06-22 | 1995-03-28 | Eli Lilly And Company | Low temperature process for preparing alpha-anomer enriched 2-deoxy-2,2-difluoro-D-ribofuranosyl sulfonates |
-
1993
- 1993-08-25 US US08/111,578 patent/US5424416A/en not_active Expired - Lifetime
-
1994
- 1994-08-22 CA CA002130618A patent/CA2130618C/en not_active Expired - Fee Related
- 1994-08-23 JP JP19836194A patent/JP3659989B2/ja not_active Expired - Fee Related
- 1994-08-24 DK DK94306253.9T patent/DK0640614T3/da active
- 1994-08-24 DE DE69401045T patent/DE69401045T2/de not_active Expired - Fee Related
- 1994-08-24 ES ES94306253T patent/ES2094623T3/es not_active Expired - Lifetime
- 1994-08-24 EP EP94306253A patent/EP0640614B1/de not_active Expired - Lifetime
- 1994-08-24 AT AT94306253T patent/ATE145916T1/de not_active IP Right Cessation
-
1997
- 1997-02-05 GR GR970400179T patent/GR3022477T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
EP0640614A2 (de) | 1995-03-01 |
CA2130618A1 (en) | 1995-02-26 |
JP3659989B2 (ja) | 2005-06-15 |
EP0640614B1 (de) | 1996-12-04 |
JPH07165782A (ja) | 1995-06-27 |
CA2130618C (en) | 2006-02-14 |
DK0640614T3 (da) | 1997-04-14 |
GR3022477T3 (en) | 1997-05-31 |
ES2094623T3 (es) | 1997-01-16 |
ATE145916T1 (de) | 1996-12-15 |
EP0640614A3 (de) | 1995-05-03 |
DE69401045T2 (de) | 1997-04-10 |
US5424416A (en) | 1995-06-13 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |