DE69328092D1 - Bereitstellung einer für krebszellen cytotoxischen verbindung unter verwendung des weges von plasminogenaktivatormaterial - Google Patents

Bereitstellung einer für krebszellen cytotoxischen verbindung unter verwendung des weges von plasminogenaktivatormaterial

Info

Publication number
DE69328092D1
DE69328092D1 DE69328092T DE69328092T DE69328092D1 DE 69328092 D1 DE69328092 D1 DE 69328092D1 DE 69328092 T DE69328092 T DE 69328092T DE 69328092 T DE69328092 T DE 69328092T DE 69328092 D1 DE69328092 D1 DE 69328092D1
Authority
DE
Germany
Prior art keywords
plasminogen activator
cytotoxic
providing
way
connection
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69328092T
Other languages
English (en)
Other versions
DE69328092T2 (de
Inventor
Jerzy Jankun
Richard Hart
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Toledo
Original Assignee
University of Toledo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Toledo filed Critical University of Toledo
Application granted granted Critical
Publication of DE69328092D1 publication Critical patent/DE69328092D1/de
Publication of DE69328092T2 publication Critical patent/DE69328092T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
DE69328092T 1992-05-28 1993-05-27 Bereitstellung einer für krebszellen cytotoxischen verbindung unter verwendung des weges von plasminogenaktivatormaterial Expired - Fee Related DE69328092T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US88978392A 1992-05-28 1992-05-28
US5981393A 1993-05-10 1993-05-10
PCT/US1993/005034 WO1993024141A1 (en) 1992-05-28 1993-05-27 Delivery of a cytotoxic compound to a cancer cell using a pathway of plasminogen activator material

Publications (2)

Publication Number Publication Date
DE69328092D1 true DE69328092D1 (de) 2000-04-20
DE69328092T2 DE69328092T2 (de) 2000-07-20

Family

ID=26739215

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69328092T Expired - Fee Related DE69328092T2 (de) 1992-05-28 1993-05-27 Bereitstellung einer für krebszellen cytotoxischen verbindung unter verwendung des weges von plasminogenaktivatormaterial

Country Status (6)

Country Link
EP (1) EP0643584B1 (de)
AT (1) ATE190501T1 (de)
AU (1) AU4394293A (de)
DE (1) DE69328092T2 (de)
ES (1) ES2143504T3 (de)
WO (1) WO1993024141A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001519647A (ja) * 1995-12-28 2001-10-23 カイロン コーポレイション 標的細胞中へのウイルスおよび粒子の取り込みおよびインターナリゼーションのためのレセプター特異的キメラウイルス表面ポリペプチド
US6277818B1 (en) 1998-10-29 2001-08-21 Angstrom Pharmaceuticals, Inc. Cyclic peptide ligands that target urokinase plasminogen activator receptor
US5994309A (en) 1997-07-25 1999-11-30 Angstrom Pharmaceuticals, Inc. Anti-invasive and anti-angiogenic compositions and methods
EP1691664A4 (de) * 2003-11-18 2008-04-30 Attenuon Llc Antikörper und/oder ihre konjugate, die an das aminoterminale fragment von urokinase binden, zusammensetzungen daraus und ihre verwendungen
WO2007044892A2 (en) * 2005-10-10 2007-04-19 American Diagnostica, Inc. Upar-binding molecule-drug conjugates and uses thereof
ES2636451T3 (es) 2006-12-08 2017-10-05 Monopar Therapeutics Inc. Epítopo del receptor del activador del plasminógeno tipo uroquinasa
US8877156B2 (en) 2007-06-26 2014-11-04 New York University Contrast agents anchored by thiols on nanoparticles

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN165717B (de) * 1986-08-07 1989-12-23 Battelle Memorial Institute
ATE197067T1 (de) * 1989-04-07 2000-11-15 Cancerforskningsfonden Af 1989 Plasminogen-aktivator-rezeptor vom urokinasetyp

Also Published As

Publication number Publication date
DE69328092T2 (de) 2000-07-20
EP0643584B1 (de) 2000-03-15
EP0643584A4 (de) 1995-07-26
ES2143504T3 (es) 2000-05-16
AU4394293A (en) 1993-12-30
WO1993024141A1 (en) 1993-12-09
EP0643584A1 (de) 1995-03-22
ATE190501T1 (de) 2000-04-15

Similar Documents

Publication Publication Date Title
PH22075A (en) New complex compounds of piroxicam with cyclodextrin having antiinflammatory activity and pharmaceutical compositions containing them
EP0670735A1 (de) Periphäralisierung hämatopoietischer stammzellen.
JPS5535019A (en) Carbostyryl derivative
HUT34348A (en) New process for producing immunotoxin conjugates
IT1260656B (it) Articolo assorbente comprendente un materiale per il controllo dell'odore e relativo impiego.
ZA942720B (en) Isolation, selection and propagation of animal stem cells; genetically modified animals and animal cells, and constructs for their production
ES449284A1 (es) Perfeccionamientos introducidos en un tubo de envase.
DE69328092D1 (de) Bereitstellung einer für krebszellen cytotoxischen verbindung unter verwendung des weges von plasminogenaktivatormaterial
ATE47711T1 (de) Biologisch aktive verbindung mit anti-prolyl endopeptidasewirkung.
HUT73846A (en) Vitamin d3 analogues with a modified side chain at 17-position, process for producing them and pharmaceutical compositions
DE3173520D1 (en) Shampoo composition
ES482808A1 (es) Un procedimiento para el mezclado continuo y uniforme de cantidades relativamente pequenas de aditivo liquido o li- cuado con cantidades relativamente grandes de material gra- nulado solido
UA27764C2 (uk) Спосіб відновлення дрібнодисперсного залізоокисного матеріалу у псевдозрідженому шарі та установка для його здійснення
AU5976494A (en) Oxidising agents
ES8401335A1 (es) Procedimiento y dispositivo para encolar material particulado especialmente virutas lignocelulosicas.
ES2109182A1 (es) Formulacion liquida a base de cepas de los hongos filamentosos trichoderma harzianum y trichoderma viride.
UA29392C2 (uk) Пакувальний контейнер
AU3332389A (en) Monoclonal antibodies to tissue plasminogen activator (t-pa) which prolong its functional half-life
MX9303136A (es) Metodo de entrega de un compuesto citotoxico a una celula cancerosa, que usa una trayectoria de material activo biologicamente.
ES2059836T3 (es) Granulados portadores que contienen substancias activas liquidas.
DE69321134D1 (de) Plasminogen-derivate die durch thrombin aktivierbar sind
TW336230B (en) Process for the production of olefinic unsaturated compounds
FR2703262B1 (fr) Mélanges gazeux.
UA6412A1 (uk) Спосіб аерації рідини при флотації
JPS6439499A (en) Back-filling material

Legal Events

Date Code Title Description
8328 Change in the person/name/address of the agent

Free format text: PATENTANWAELTE RUFF, WILHELM, BEIER, DAUSTER & PARTNER, 70173 STUTTGART

8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee