DE69327659T2 - Therapeutische und diagnostische bilderzeugungzusammensetzung und verfahren zur herstellung - Google Patents
Therapeutische und diagnostische bilderzeugungzusammensetzung und verfahren zur herstellungInfo
- Publication number
- DE69327659T2 DE69327659T2 DE69327659T DE69327659T DE69327659T2 DE 69327659 T2 DE69327659 T2 DE 69327659T2 DE 69327659 T DE69327659 T DE 69327659T DE 69327659 T DE69327659 T DE 69327659T DE 69327659 T2 DE69327659 T2 DE 69327659T2
- Authority
- DE
- Germany
- Prior art keywords
- therapeutic
- producing
- same
- image generation
- diagnostic image
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/595—Polyamides, e.g. nylon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Optics & Photonics (AREA)
- Physics & Mathematics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US96074592A | 1992-10-14 | 1992-10-14 | |
PCT/US1993/009645 WO1994008624A2 (en) | 1992-10-14 | 1993-10-07 | Therapeutic and diagnostic imaging compositions and methods |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69327659D1 DE69327659D1 (de) | 2000-02-24 |
DE69327659T2 true DE69327659T2 (de) | 2000-09-21 |
Family
ID=25503562
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69327659T Expired - Fee Related DE69327659T2 (de) | 1992-10-14 | 1993-10-07 | Therapeutische und diagnostische bilderzeugungzusammensetzung und verfahren zur herstellung |
Country Status (8)
Country | Link |
---|---|
US (1) | US5932188A (de) |
EP (1) | EP0664713B1 (de) |
JP (1) | JPH08502300A (de) |
AU (1) | AU5355094A (de) |
CA (1) | CA2147151A1 (de) |
DE (1) | DE69327659T2 (de) |
ES (1) | ES2140469T3 (de) |
WO (1) | WO1994008624A2 (de) |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9216082D0 (en) * | 1992-07-28 | 1992-09-09 | Univ Nottingham | Lymphatic delivery composition |
ES2199226T3 (es) * | 1992-09-04 | 2004-02-16 | The General Hospital Corporation | Polimeros biocompatibles que contienen mitades diagnosticas o terapeuticas. |
US5730968A (en) * | 1994-03-31 | 1998-03-24 | Sterling Winthrop Inc. | Segmented chelating polymers as imaging and therapeutic agents |
DE19505960A1 (de) * | 1995-02-21 | 1996-08-22 | Deutsches Krebsforsch | Konjugat zur individuellen Dosierung von Arzneimitteln |
KR20060025233A (ko) * | 1996-04-01 | 2006-03-20 | 에픽스 메디칼, 인코포레이티드 | 생체활성화 진단용 영상 콘트라스트 제제 |
US20040170563A1 (en) * | 1997-10-27 | 2004-09-02 | Meade Thomas J. | Magnetic resonance imaging agents for the delivery of therapeutic agents |
US6361759B1 (en) * | 1998-05-26 | 2002-03-26 | Wisconsin Alumni Research Foundation | MR signal-emitting coatings |
US6896874B2 (en) * | 1998-05-26 | 2005-05-24 | Wisconsin Alumni Research Foundation | MR-signal emitting coatings |
US6500630B2 (en) * | 2001-01-12 | 2002-12-31 | Mayo Foundation For Medical Education And Research | Marker for inflammatory conditions |
JP3822479B2 (ja) | 2001-10-10 | 2006-09-20 | 株式会社カネカ | 還元型補酵素q水溶液の安定化組成 |
CA2472578A1 (en) * | 2002-01-24 | 2003-07-31 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Anti-cancer combination and use thereof |
US20040253292A1 (en) * | 2003-04-23 | 2004-12-16 | Wisconsin Alumni Research Foundation | MR-signal emitting coatings |
WO2005049096A2 (en) * | 2003-11-14 | 2005-06-02 | Dow Global Technologies Inc. | Protein and polymer conjugates as chelants with enhanced blood retention |
MXPA06010764A (es) * | 2004-03-23 | 2006-12-15 | Amgen Inc | Metodos y composiciones de proteinas quimicamente modificadas. |
JP5645361B2 (ja) * | 2005-08-02 | 2014-12-24 | エクスバイオテク インコーポレーティッド | IL−1α自己抗体を用いた血管障害の診断、処置、および予防 |
US20070156042A1 (en) * | 2005-12-30 | 2007-07-05 | Orhan Unal | Medical device system and method for tracking and visualizing a medical device system under MR guidance |
US8457712B2 (en) * | 2005-12-30 | 2013-06-04 | Wisconsin Alumni Research Foundation | Multi-mode medical device system and methods of manufacturing and using same |
US20070179094A1 (en) | 2006-01-31 | 2007-08-02 | Bayer Schering Pharma Ag | Modulation of MDL-1 activity for treatment of inflammatory disease |
US20110008282A1 (en) * | 2006-05-15 | 2011-01-13 | Xbiotech, Inc. | IL-1alpha immunization induces autoantibodies protective against atherosclerosis |
CN102580086A (zh) * | 2006-05-22 | 2012-07-18 | 埃克斯生物科技公司 | 使用抗IL-1α抗体治疗癌症 |
US8532742B2 (en) * | 2006-11-15 | 2013-09-10 | Wisconsin Alumni Research Foundation | System and method for simultaneous 3DPR device tracking and imaging under MR-guidance for therapeutic endovascular interventions |
JP5539725B2 (ja) * | 2006-11-27 | 2014-07-02 | アクタマックス サージカル マテリアルズ リミテッド ライアビリティ カンパニー | 分岐末端反応物及びそれから製造されるポリマーヒドロゲル組織接着剤 |
US20080183070A1 (en) * | 2007-01-29 | 2008-07-31 | Wisconsin Alumni Research Foundation | Multi-mode medical device system with thermal ablation capability and methods of using same |
US8412306B2 (en) * | 2007-02-28 | 2013-04-02 | Wisconsin Alumni Research Foundation | Voltage standing wave suppression for MR-guided therapeutic interventions |
EP2005970A1 (de) | 2007-06-22 | 2008-12-24 | Berlin Science Partners GmbH i.V. | Bildgebende Diagnostik durch Kombination von Kontrastmitteln |
EP2072060A1 (de) | 2007-12-18 | 2009-06-24 | Institut Curie | Verfahren und Zusammensetzungen zur Herstellung und Verwendung von Toxinkonjugaten |
WO2009108891A2 (en) * | 2008-02-29 | 2009-09-03 | Egen, Inc. | Modified poloxamers for gene expression and associated methods |
CN105467136B (zh) * | 2008-05-30 | 2018-02-16 | 埃克斯生物科技公司 | 白细胞介素‑1α抗体及使用方法 |
WO2010030979A2 (en) * | 2008-09-12 | 2010-03-18 | Xbiotech, Inc. | Targeting pathogenic monocytes |
KR20130098279A (ko) | 2010-06-18 | 2013-09-04 | 엑스바이오테크, 인크. | 관절염 치료 |
EP3075394B1 (de) | 2010-08-23 | 2018-11-28 | XBiotech, Inc | Behandlung von neoplasieerkrankungen |
US9724409B2 (en) | 2011-04-01 | 2017-08-08 | Xbiotech, Inc. | Treatment of inflammatory skin disease |
KR20190090046A (ko) | 2011-04-01 | 2019-07-31 | 엑스바이오테크, 인크. | 피부과학적 병리의 치료 |
AU2012312225B2 (en) | 2011-09-23 | 2017-10-05 | Xbiotech Inc. | Cachexia treatment |
US9545441B2 (en) | 2012-09-18 | 2017-01-17 | Xbiotech, Inc. | Treatment of diabetes |
EP3582813A4 (de) | 2017-02-16 | 2020-12-30 | XBiotech, Inc | Behandlung von hidradenitis suppurativa |
Family Cites Families (41)
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US3859337A (en) * | 1969-06-11 | 1975-01-07 | Stauffer Chemical Co | Ethylenediaminetetraacetic acid anhydride derivatives |
US4647447A (en) * | 1981-07-24 | 1987-03-03 | Schering Aktiengesellschaft | Diagnostic media |
US4957939A (en) * | 1981-07-24 | 1990-09-18 | Schering Aktiengesellschaft | Sterile pharmaceutical compositions of gadolinium chelates useful enhancing NMR imaging |
CS226911B1 (en) * | 1981-10-28 | 1984-04-16 | Jaroslav Kahovec | Polymere polydonor komplexons and method of their manufacture polymere polydonor |
US4423158A (en) * | 1983-01-27 | 1983-12-27 | Gelinnovation Handelsaktiebolag | Ion adsorbent for metals having a coordination number greater than two |
US4972837A (en) * | 1983-04-26 | 1990-11-27 | Regents Of The University Of California | Contrast agents for nuclear magnetic resonance imaging |
JPS59215321A (ja) * | 1983-05-23 | 1984-12-05 | Sumitomo Chem Co Ltd | 二官能性配位子化合物を結合した反応性高分子 |
FR2550449B1 (fr) * | 1983-08-12 | 1986-01-31 | Commissariat Energie Atomique | Agents de relaxation specifiques d'organes ou de pathologies, utilisables pour modifier les contrastes en imagerie medicale par resonance magnetique nucleaire |
US4615879A (en) * | 1983-11-14 | 1986-10-07 | Vanderbilt University | Particulate NMR contrast agents for gastrointestinal application |
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US4980148A (en) * | 1985-02-06 | 1990-12-25 | Mallinckrodt, Inc. | Methods for enhancing magnetic resonance imaging |
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IT1213029B (it) * | 1986-01-30 | 1989-12-07 | Bracco Ind Chimica Spa | Chelati di ioni metallici paramagnetici. |
US4909257A (en) * | 1986-05-01 | 1990-03-20 | The Regents Of The University Of California | Method for attaining in vivo tissue-specific contrast by nuclear magnetic resonance imaging |
US4814098A (en) * | 1986-09-06 | 1989-03-21 | Bellex Corporation | Magnetic material-physiologically active substance conjugate |
DE3701665A1 (de) * | 1987-01-19 | 1988-07-28 | Schering Ag | Polymer-komplexe, verfahren zu deren herstellung und diese enthaltende pharmazeutische mittel |
US4933441A (en) * | 1987-01-27 | 1990-06-12 | Gibby Wendell A | Contrast enhancing agents for magnetic resonance images |
US4822594A (en) * | 1987-01-27 | 1989-04-18 | Gibby Wendell A | Contrast enhancing agents for magnetic resonance images |
US5057302A (en) * | 1987-02-13 | 1991-10-15 | Abbott Laboratories | Bifunctional chelating agents |
DE3855239T2 (de) * | 1987-07-16 | 1996-10-31 | Nycomed Imaging As | Aminocarbonsäure und Derivate |
US5137711A (en) * | 1988-07-19 | 1992-08-11 | Mallickrodt Medical, Inc. | Paramagnetic dtpa and edta alkoxyalkylamide complexes as mri agents |
GB8824593D0 (en) * | 1988-10-20 | 1988-11-23 | Royal Free Hosp School Med | Liposomes |
US5283339A (en) * | 1988-11-23 | 1994-02-01 | California Institute Of Technology | Immobilized metal aqueous two-phase extraction and precipitation |
US5364613A (en) * | 1989-04-07 | 1994-11-15 | Sieving Paul F | Polychelants containing macrocyclic chelant moieties |
GB8923843D0 (en) * | 1989-10-23 | 1989-12-13 | Salutar Inc | Compounds |
DE3938992A1 (de) * | 1989-11-21 | 1991-05-23 | Schering Ag | Kaskadenpolymer-gebundene komplexbildner, deren komplexe und konjugate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel |
SE465155B (sv) * | 1989-12-19 | 1991-08-05 | Exploaterings Ab Tbf | Metallkelatbildande hydrofil polymer foer adsorption etc samt ett saett foer framstaellning av polymeren |
DE4011684A1 (de) * | 1990-04-06 | 1991-10-10 | Schering Ag | Dtpa-monoamide, diese verbindungen enthaltende pharmazeutische mittel, ihre verwendung und verfahren zu deren herstellung |
EP0526503B1 (de) * | 1990-04-10 | 1997-06-04 | Imarx Pharmaceutical Corp. | Polymere und ihre verwendung als kontrastmittel bei der bilderzeugung mit magnetischer resonanz |
JP2640293B2 (ja) * | 1990-05-30 | 1997-08-13 | ドイチエス クレープスフオルシユングスツエントルム ステイフツング デス アフエントリヒエン レヒトス | ポリエーテル置換抗腫瘍剤 |
US5077037A (en) * | 1990-08-03 | 1991-12-31 | Mallinckrodt Medical, Inc. | Novel compositions for magnetic resonance imaging |
US5385719A (en) * | 1991-09-24 | 1995-01-31 | Unger; Evan C. | Copolymers and their use as contrast agents in magnetic resonance imaging and in other applications |
DE69314613T3 (de) * | 1992-07-03 | 2002-07-04 | Welfide Corp | Neues chelatisierungsmittel, komplexverbindungen, die aus diesem mittel und metallatomen aufgebaut sind, und diagnostische mittel, die diese verbindungen enthalten |
-
1993
- 1993-10-07 WO PCT/US1993/009645 patent/WO1994008624A2/en active IP Right Grant
- 1993-10-07 JP JP6510155A patent/JPH08502300A/ja active Pending
- 1993-10-07 AU AU53550/94A patent/AU5355094A/en not_active Abandoned
- 1993-10-07 ES ES93923819T patent/ES2140469T3/es not_active Expired - Lifetime
- 1993-10-07 EP EP93923819A patent/EP0664713B1/de not_active Expired - Lifetime
- 1993-10-07 DE DE69327659T patent/DE69327659T2/de not_active Expired - Fee Related
- 1993-10-07 CA CA002147151A patent/CA2147151A1/en not_active Abandoned
-
1997
- 1997-10-28 US US08/963,125 patent/US5932188A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
WO1994008624A3 (en) | 1994-05-26 |
DE69327659D1 (de) | 2000-02-24 |
ES2140469T3 (es) | 2000-03-01 |
AU5355094A (en) | 1994-05-09 |
US5932188A (en) | 1999-08-03 |
JPH08502300A (ja) | 1996-03-12 |
WO1994008624A2 (en) | 1994-04-28 |
EP0664713B1 (de) | 2000-01-19 |
EP0664713A1 (de) | 1995-08-02 |
CA2147151A1 (en) | 1994-04-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |