DE69324494T2 - 4,7-dichlorofluoroszein-farbestoffe als molekulare sonden - Google Patents
4,7-dichlorofluoroszein-farbestoffe als molekulare sondenInfo
- Publication number
- DE69324494T2 DE69324494T2 DE69324494T DE69324494T DE69324494T2 DE 69324494 T2 DE69324494 T2 DE 69324494T2 DE 69324494 T DE69324494 T DE 69324494T DE 69324494 T DE69324494 T DE 69324494T DE 69324494 T2 DE69324494 T2 DE 69324494T2
- Authority
- DE
- Germany
- Prior art keywords
- dichlorofluoroszein
- dyes
- molecular probe
- probe
- molecular
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/78—Ring systems having three or more relevant rings
- C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
- C07D311/82—Xanthenes
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B11/00—Diaryl- or thriarylmethane dyes
- C09B11/04—Diaryl- or thriarylmethane dyes derived from triarylmethanes, i.e. central C-atom is substituted by amino, cyano, alkyl
- C09B11/06—Hydroxy derivatives of triarylmethanes in which at least one OH group is bound to an aryl nucleus and their ethers or esters
- C09B11/08—Phthaleins; Phenolphthaleins; Fluorescein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pyrane Compounds (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US93981392A | 1992-09-03 | 1992-09-03 | |
PCT/US1993/008227 WO1994005688A1 (en) | 1992-09-03 | 1993-09-01 | 4,7-dichlorofluorescein dyes as molecular probes |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69324494D1 DE69324494D1 (de) | 1999-05-20 |
DE69324494T2 true DE69324494T2 (de) | 1999-09-23 |
Family
ID=25473780
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69324494T Expired - Lifetime DE69324494T2 (de) | 1992-09-03 | 1993-09-01 | 4,7-dichlorofluoroszein-farbestoffe als molekulare sonden |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP0658167B1 (de) |
JP (4) | JPH08505121A (de) |
DE (1) | DE69324494T2 (de) |
WO (1) | WO1994005688A1 (de) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH08505121A (ja) * | 1992-09-03 | 1996-06-04 | アプライド バイオシステムズ,インコーポレイテッド | 分子プローブとしての4,7−ジクロロフルオレセイン染料 |
US5658751A (en) * | 1993-04-13 | 1997-08-19 | Molecular Probes, Inc. | Substituted unsymmetrical cyanine dyes with selected permeability |
US6020481A (en) | 1996-04-01 | 2000-02-01 | The Perkin-Elmer Corporation | Asymmetric benzoxanthene dyes |
US6162931A (en) * | 1996-04-12 | 2000-12-19 | Molecular Probes, Inc. | Fluorinated xanthene derivatives |
WO1997040033A1 (en) * | 1996-04-19 | 1997-10-30 | Lexigen Pharmaceuticals Corp. | Inhibition of the binding of human ige to its receptor by tetracyclic compounds for the alleviation of ige-mediated immune response |
US5945526A (en) | 1996-05-03 | 1999-08-31 | Perkin-Elmer Corporation | Energy transfer dyes with enhanced fluorescence |
US5800996A (en) * | 1996-05-03 | 1998-09-01 | The Perkin Elmer Corporation | Energy transfer dyes with enchanced fluorescence |
US5847162A (en) * | 1996-06-27 | 1998-12-08 | The Perkin Elmer Corporation | 4, 7-Dichlororhodamine dyes |
US7825237B2 (en) | 1996-05-03 | 2010-11-02 | Applied Biosystems, Llc | Oligonucleotides and analogs labeled with energy transfer dyes |
US7388092B2 (en) | 1996-05-03 | 2008-06-17 | Applera Corporation | Oligonucleotides and analogs labeled with energy transfer dyes |
US6080852A (en) | 1996-06-27 | 2000-06-27 | The Perkin-Elmer Corporation | 4,7-dichlororhodamine dyes |
US6017712A (en) * | 1996-06-27 | 2000-01-25 | Lee; Linda | 4,7-dichlororhodamine dyes |
US5830912A (en) * | 1996-11-15 | 1998-11-03 | Molecular Probes, Inc. | Derivatives of 6,8-difluoro-7-hydroxycoumarin |
US5696157A (en) * | 1996-11-15 | 1997-12-09 | Molecular Probes, Inc. | Sulfonated derivatives of 7-aminocoumarin |
US6130101A (en) * | 1997-09-23 | 2000-10-10 | Molecular Probes, Inc. | Sulfonated xanthene derivatives |
US6008379A (en) * | 1997-10-01 | 1999-12-28 | The Perkin-Elmer Corporation | Aromatic-substituted xanthene dyes |
US6583168B1 (en) | 1997-11-25 | 2003-06-24 | Applera Corporation | Sulfonated diarylrhodamine dyes |
US5936087A (en) * | 1997-11-25 | 1999-08-10 | The Perkin-Elmer Corporation | Dibenzorhodamine dyes |
US6664047B1 (en) | 1999-04-30 | 2003-12-16 | Molecular Probes, Inc. | Aza-benzazolium containing cyanine dyes |
US6420131B1 (en) | 1999-08-19 | 2002-07-16 | Gentest Corporation | Use of fluorescein aryl ethers in high throughput cytochrome P450 inhibition assays |
US6221604B1 (en) | 2000-02-07 | 2001-04-24 | Pe Corporation | Electron-deficient nitrogen heterocycle-substituted fluorescein dyes |
US7169922B2 (en) | 2000-08-04 | 2007-01-30 | Invitrogen Corporation | Derivatives of 1,2-dihydro-7-hydroxyquinolines containing fused rings |
US6716979B2 (en) | 2000-08-04 | 2004-04-06 | Molecular Probes, Inc. | Derivatives of 1,2-dihydro-7-hydroxyquinolines containing fused rings |
ATE352586T2 (de) | 2000-09-29 | 2007-02-15 | Molecular Probes Inc | Modifizierte carbocyaninfarbstoffe und deren konjugate |
DE10106682A1 (de) | 2001-02-14 | 2002-08-29 | Clariant Gmbh | Farbmittelkomposition |
US7005518B2 (en) | 2002-10-25 | 2006-02-28 | Li-Cor, Inc. | Phthalocyanine dyes |
US7417726B2 (en) | 2003-09-19 | 2008-08-26 | Applied Biosystems Inc. | Normalization of data using controls |
US7432372B2 (en) | 2003-10-31 | 2008-10-07 | Invitrogen Corporation | Fluorinated resorufin compounds and their application |
US20050214807A1 (en) | 2003-11-19 | 2005-09-29 | Iain Johnson | Environmental sensitive fluorogenic compounds and their application for singlet oxygen and protein detection |
US7776529B2 (en) | 2003-12-05 | 2010-08-17 | Life Technologies Corporation | Methine-substituted cyanine dye compounds |
US8039642B2 (en) | 2003-12-09 | 2011-10-18 | Life Technologies Corporation | Pyrenyloxysulfonic acid fluorescent agents |
JP5306811B2 (ja) | 2005-05-11 | 2013-10-02 | ライフ テクノロジーズ コーポレーション | 2本鎖dnaへの高い選択性を有する蛍光化学物質及びそれらの使用 |
US7888506B2 (en) | 2007-01-26 | 2011-02-15 | Duquesne University Of The Holy Spirit | Composition, synthesis, and use of a new class of fluorophores |
US8586743B2 (en) | 2007-01-30 | 2013-11-19 | Life Technologies Corporation | Labeling reagents and methods of their use |
EP2175275A4 (de) | 2007-07-31 | 2010-09-01 | Univ Osaka | Zusammensetzung zur messung der bindungsaffinität zwischen nukleinsäure und substanz sowie ihre verwendung |
EP2473563B1 (de) | 2009-08-31 | 2019-06-19 | Promega Corporation | Reaktive cyaninverbindungen |
US8623324B2 (en) | 2010-07-21 | 2014-01-07 | Aat Bioquest Inc. | Luminescent dyes with a water-soluble intramolecular bridge and their biological conjugates |
WO2013078244A1 (en) | 2011-11-21 | 2013-05-30 | Promega Corporation | Carboxy x rhodamine analogs |
JP6367307B2 (ja) | 2013-03-15 | 2018-08-01 | プロメガ コーポレイションPromega Corporation | 遺伝的同一性における使用のための新規ケイ素およびゲルマニウム色素 |
WO2015175870A1 (en) | 2014-05-16 | 2015-11-19 | Life Technologies Corporation | Carbopyronone compounds useful as diagnostic adjuvants |
CN108473505B (zh) | 2016-03-28 | 2019-11-05 | 阿特生物探索公司 | 聚芴并[4,5-cde]氧杂环庚三烯偶联物及其在分析物检测方法中的用途 |
WO2021154933A1 (en) | 2020-01-30 | 2021-08-05 | Aat Bioquest, Inc. | Uv excitable polyfluorene based conjugates and their use in methods of analyte detection |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4230558A (en) | 1978-10-02 | 1980-10-28 | Coulter Electronics, Inc. | Single drop separator |
US4318846A (en) * | 1979-09-07 | 1982-03-09 | Syva Company | Novel ether substituted fluorescein polyamino acid compounds as fluorescers and quenchers |
JPS5782387A (en) * | 1980-10-29 | 1982-05-22 | Syva Co | Novel ether substituted fluorescein compound |
US4439356A (en) | 1981-03-03 | 1984-03-27 | Syva Company | Unsymmetrical fluorescein derivatives |
DE3382290D1 (de) | 1983-08-31 | 1991-06-20 | Lumex | Traegersystem zur verlagerung von daempferfluessigkeit und methode zu dessen herstellung. |
US5188934A (en) * | 1989-11-14 | 1993-02-23 | Applied Biosystems, Inc. | 4,7-dichlorofluorescein dyes as molecular probes |
JPH08505121A (ja) * | 1992-09-03 | 1996-06-04 | アプライド バイオシステムズ,インコーポレイテッド | 分子プローブとしての4,7−ジクロロフルオレセイン染料 |
-
1993
- 1993-09-01 JP JP6507415A patent/JPH08505121A/ja not_active Withdrawn
- 1993-09-01 EP EP93920447A patent/EP0658167B1/de not_active Expired - Lifetime
- 1993-09-01 WO PCT/US1993/008227 patent/WO1994005688A1/en active IP Right Grant
- 1993-09-01 DE DE69324494T patent/DE69324494T2/de not_active Expired - Lifetime
-
2004
- 2004-01-30 JP JP2004024814A patent/JP4554224B2/ja active Active
-
2008
- 2008-07-07 JP JP2008177253A patent/JP2009000119A/ja not_active Withdrawn
-
2011
- 2011-03-11 JP JP2011054840A patent/JP2011162548A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
JP2011162548A (ja) | 2011-08-25 |
EP0658167A1 (de) | 1995-06-21 |
JP2009000119A (ja) | 2009-01-08 |
JP4554224B2 (ja) | 2010-09-29 |
JP2004225049A (ja) | 2004-08-12 |
EP0658167B1 (de) | 1999-04-14 |
JPH08505121A (ja) | 1996-06-04 |
DE69324494D1 (de) | 1999-05-20 |
WO1994005688A1 (en) | 1994-03-17 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8327 | Change in the person/name/address of the patent owner |
Owner name: APPLERA CORP., FOSTER CITY, CALIF., US |
|
8327 | Change in the person/name/address of the patent owner |
Owner name: APPLIED BIOSYSTEMS, LLC (N. D. GES. D. STAATES, US |
|
8380 | Miscellaneous part iii |
Free format text: PFANDRECHT |
|
8380 | Miscellaneous part iii |
Free format text: PFANDRECHT AUFGEHOBEN |