DE69309702T2 - Modifizierte ciliare neurotrophische faktoren (cntf) - Google Patents

Modifizierte ciliare neurotrophische faktoren (cntf)

Info

Publication number
DE69309702T2
DE69309702T2 DE69309702T DE69309702T DE69309702T2 DE 69309702 T2 DE69309702 T2 DE 69309702T2 DE 69309702 T DE69309702 T DE 69309702T DE 69309702 T DE69309702 T DE 69309702T DE 69309702 T2 DE69309702 T2 DE 69309702T2
Authority
DE
Germany
Prior art keywords
modified
neurotrophic factors
ciliare
cntf
screening
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69309702T
Other languages
English (en)
Other versions
DE69309702D1 (de
Inventor
Nikos Panayotatos
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Regeneron Pharmaceuticals Inc
Original Assignee
Regeneron Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharmaceuticals Inc filed Critical Regeneron Pharmaceuticals Inc
Application granted granted Critical
Publication of DE69309702D1 publication Critical patent/DE69309702D1/de
Publication of DE69309702T2 publication Critical patent/DE69309702T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475Growth factors; Growth regulators
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00Peptide or protein sequence
    • Y10S930/01Peptide or protein sequence
    • Y10S930/12Growth hormone, growth factor other than t-cell or b-cell growth factor, and growth hormone releasing factor; related peptides
DE69309702T 1992-10-09 1993-10-08 Modifizierte ciliare neurotrophische faktoren (cntf) Expired - Lifetime DE69309702T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/959,284 US5349056A (en) 1992-10-09 1992-10-09 Modified ciliary neurotrophic factors
PCT/US1993/009649 WO1994009134A2 (en) 1992-10-09 1993-10-08 Modified ciliary neurotrophic factors

Publications (2)

Publication Number Publication Date
DE69309702D1 DE69309702D1 (de) 1997-05-15
DE69309702T2 true DE69309702T2 (de) 1997-10-30

Family

ID=25501875

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69309702T Expired - Lifetime DE69309702T2 (de) 1992-10-09 1993-10-08 Modifizierte ciliare neurotrophische faktoren (cntf)

Country Status (14)

Country Link
US (5) US5349056A (de)
EP (1) EP0666912B1 (de)
JP (1) JP2702811B2 (de)
AT (1) ATE151460T1 (de)
AU (1) AU667996B2 (de)
CA (1) CA2132954C (de)
DE (1) DE69309702T2 (de)
DK (1) DK0666912T3 (de)
ES (1) ES2099981T3 (de)
GR (1) GR3024039T3 (de)
HK (1) HK1007767A1 (de)
IL (1) IL107213A0 (de)
WO (1) WO1994009134A2 (de)
ZA (1) ZA937482B (de)

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IT1284867B1 (it) 1996-07-10 1998-05-22 Angeletti P Ist Richerche Bio Varianti del fattore neurotrofico ciliare umano (hcntf) con uno spettro di azione differente dalla molecola di tipo selvatico
WO1998010785A1 (fr) * 1996-09-13 1998-03-19 Advanced Medicine Research Institute Compositions ophtalmiques de facteurs neurotrophiques, remedes pour troubles fonctionnels du nerf optique et procede de traitement de tels troubles
IT1288388B1 (it) 1996-11-19 1998-09-22 Angeletti P Ist Richerche Bio Uso di sostanze che attivano il recettore del cntf ( fattore neurotrofico ciliare) per la preparazione di farmaci per la terapia
US20040120891A1 (en) * 1998-12-21 2004-06-24 Craig Hill Compounds for intracellular delivery of therapeutic moieties to nerve cells
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US20100086997A1 (en) * 2006-12-20 2010-04-08 Rinat Enuroscience Corp TrkB Agonists for Treating Autoimmune Disorders
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WO2009079837A1 (fr) * 2007-12-18 2009-07-02 Hangzhou Jiuyuan Gene Engineering Co., Ltd. Formulation pharmaceutique contenant une protéine de fusion sérum albumine humaine recombinante-interféron alpha
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AR243237A1 (es) * 1990-03-14 1993-07-30 Fidia Spa Un vector de expresion recombinante que contiene una secuencia de adn que codifica el factor neurotrofico ciliar humano,un microorganismo e.coli transformado,y linea celulares transformadas.
HUT67352A (en) * 1991-07-23 1995-03-28 Syntex Inc Recombinant ciliary neurotrophic factor and c-ferminal truncated ciliary neurotrophic factor, their production, and pharmaceutical products for treatment of peripheral nerveinjury, containing them
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US5349056A (en) * 1992-10-09 1994-09-20 Regeneron Pharmaceuticals Modified ciliary neurotrophic factors

Also Published As

Publication number Publication date
EP0666912B1 (de) 1997-04-09
WO1994009134A2 (en) 1994-04-28
US5349056A (en) 1994-09-20
JPH07506005A (ja) 1995-07-06
US5846935A (en) 1998-12-08
HK1007767A1 (en) 1999-04-23
GR3024039T3 (en) 1997-10-31
CA2132954C (en) 2000-01-18
US20030220484A1 (en) 2003-11-27
CA2132954A1 (en) 1994-04-28
US20030092129A1 (en) 2003-05-15
AU667996B2 (en) 1996-04-18
AU5326094A (en) 1994-05-09
EP0666912A1 (de) 1995-08-16
WO1994009134A3 (en) 1994-05-26
ZA937482B (en) 1994-04-26
DK0666912T3 (da) 1997-09-29
DE69309702D1 (de) 1997-05-15
US6440702B1 (en) 2002-08-27
ATE151460T1 (de) 1997-04-15
IL107213A0 (en) 1994-01-25
JP2702811B2 (ja) 1998-01-26
ES2099981T3 (es) 1997-06-01

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