DE69233791D1 - Verfahren zur Manipulation der Zelldifferenzierung - Google Patents

Verfahren zur Manipulation der Zelldifferenzierung

Info

Publication number
DE69233791D1
DE69233791D1 DE69233791T DE69233791T DE69233791D1 DE 69233791 D1 DE69233791 D1 DE 69233791D1 DE 69233791 T DE69233791 T DE 69233791T DE 69233791 T DE69233791 T DE 69233791T DE 69233791 D1 DE69233791 D1 DE 69233791D1
Authority
DE
Germany
Prior art keywords
cell differentiation
toporythmic protein
fragment
cell
manipulating cell
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69233791T
Other languages
English (en)
Inventor
Spyridon Artavanis-Tsakonas
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yale University
Indiana University Foundation
Original Assignee
Yale University
Indiana University Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27105529&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69233791(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Yale University, Indiana University Foundation filed Critical Yale University
Application granted granted Critical
Publication of DE69233791D1 publication Critical patent/DE69233791D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/839—Nerves; brain

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Use Of Switch Circuits For Exchanges And Methods Of Control Of Multiplex Exchanges (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DE69233791T 1991-05-03 1992-05-01 Verfahren zur Manipulation der Zelldifferenzierung Expired - Lifetime DE69233791D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US69518991A 1991-05-03 1991-05-03
US79192391A 1991-11-14 1991-11-14

Publications (1)

Publication Number Publication Date
DE69233791D1 true DE69233791D1 (de) 2010-08-26

Family

ID=27105529

Family Applications (4)

Application Number Title Priority Date Filing Date
DE69232832T Expired - Lifetime DE69232832T3 (de) 1991-05-03 1992-05-01 Bindungsdomänen in notch- und delta-proteinen
DE69233735T Expired - Lifetime DE69233735D1 (de) 1991-05-03 1992-05-01 Bindungsdomänen des Delta-proteins
DE69233791T Expired - Lifetime DE69233791D1 (de) 1991-05-03 1992-05-01 Verfahren zur Manipulation der Zelldifferenzierung
DE69233724T Expired - Lifetime DE69233724T2 (de) 1991-05-03 1992-05-01 Bindungsdomänen des Serrate-Proteins

Family Applications Before (2)

Application Number Title Priority Date Filing Date
DE69232832T Expired - Lifetime DE69232832T3 (de) 1991-05-03 1992-05-01 Bindungsdomänen in notch- und delta-proteinen
DE69233735T Expired - Lifetime DE69233735D1 (de) 1991-05-03 1992-05-01 Bindungsdomänen des Delta-proteins

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69233724T Expired - Lifetime DE69233724T2 (de) 1991-05-03 1992-05-01 Bindungsdomänen des Serrate-Proteins

Country Status (12)

Country Link
US (1) US5849869A (de)
EP (4) EP0933082B1 (de)
JP (7) JPH07503123A (de)
AT (4) ATE386116T1 (de)
AU (1) AU675203B2 (de)
CA (1) CA2102208C (de)
DE (4) DE69232832T3 (de)
DK (4) DK0933082T3 (de)
ES (4) ES2303363T3 (de)
IE (2) IE85350B1 (de)
IL (1) IL101728A (de)
WO (1) WO1992019734A1 (de)

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IL101728A (en) * 1991-05-03 2007-08-19 Univ Yale Human Abandonment and Delta, Restrictive Areas of Effect in Tophoric Proteins, and Methods Based on Them
US5869282A (en) * 1991-12-11 1999-02-09 Imperial Cancer Research Technology, Ltd. Nucleotide and protein sequences of the serrate gene and methods based thereon
US6004924A (en) 1991-12-11 1999-12-21 Imperial Cancer Research Technology, Ltd. Protein sequences of serrate gene products
US5786158A (en) * 1992-04-30 1998-07-28 Yale University Therapeutic and diagnostic methods and compositions based on notch proteins and nucleic acids
US20050112121A1 (en) * 1992-04-30 2005-05-26 Yale University Therapeutic and diagnostic methods and compositions based on notch proteins and nucleic acids
US5750652A (en) * 1994-01-21 1998-05-12 Yale University Deltex proteins
DK0861261T3 (da) 1995-06-28 2009-12-14 Imp Cancer Res Tech Nukleotid- og proteinsekvenser af hvirveldyrs-Delta-gener og fremgangsmåder baseret derpå
US20050158859A1 (en) * 1995-09-29 2005-07-21 Yale University Manipulation of non-terminally differentiated cells using the Notch pathway
US5780300A (en) * 1995-09-29 1998-07-14 Yale University Manipulation of non-terminally differentiated cells using the notch pathway
ATE319827T1 (de) 1995-11-17 2006-03-15 Asahi Chemical Ind Polypeptid, das die differenzierung unterdrueckt
CA2238404A1 (en) * 1995-11-22 1997-05-29 Yale University Vertebrate deltex proteins, nucleic acids, and antibodies, and related methods and compositions
EP0913404B1 (de) 1996-07-16 2006-06-14 Asahi Kasei Kabushiki Kaisha Differenzierungsinhibitor
US6887475B1 (en) 1996-11-07 2005-05-03 Lorantis Limited Notch
IL129531A0 (en) * 1996-11-07 2000-02-29 Lorantis Ltd Ligands to notch proteins
US6121045A (en) * 1997-04-04 2000-09-19 Millennium Biotherapeutics, Inc. Human Delta3 nucleic acid molecules
AU6952498A (en) 1997-04-04 1998-10-30 Millenium Pharmaceuticals, Inc. Novel human delta3 compositions and therapeutic and diagnostic uses therefor
US20060122373A1 (en) 1997-04-04 2006-06-08 Millennium Pharmaceuticals, Inc. Delta3, FTHMA-070, Tango85, Tango77, SPOIL,NEOKINE, Tango129 and integrin alpha subunit protein and nucleic acid molecules and uses thereof
DK1004669T3 (da) * 1997-05-14 2007-08-27 Asahi Chemical Ind Hidtil ukendte differentieringsinhibitor
US6436650B1 (en) 1997-07-23 2002-08-20 Yale University Activated forms of notch and methods based thereon
US6692919B1 (en) 1997-07-23 2004-02-17 Yale University Activated forms of notch and methods based thereon
US6392019B1 (en) 1997-11-22 2002-05-21 John Ford Antibodies specific for EGF motif proteins
US6808890B2 (en) 1999-07-28 2004-10-26 Nuvelo, Inc. Method of detecting a cancerous cell expressing EGFL6, and EGF mutif protein
EP1032666A1 (de) 1997-11-22 2000-09-06 Hyseq, Inc. Protein mit egf-motif aus foetaler leber-milz cdna genbank
WO1999061614A2 (en) * 1998-05-28 1999-12-02 Incyte Pharmaceuticals, Inc. Human socs proteins
US8084258B2 (en) 1999-07-12 2011-12-27 University Of Basel Manipulation of tissue of organ type using the notch pathway
GB9927328D0 (en) 1999-11-18 2000-01-12 Lorantis Ltd Immunotherapy
US6448197B1 (en) * 2000-07-13 2002-09-10 Exxonmobil Chemical Patents Inc. Method for making a metal containing small pore molecular sieve catalyst
US6984522B2 (en) 2000-08-03 2006-01-10 Regents Of The University Of Michigan Isolation and use of solid tumor stem cells
US8044259B2 (en) 2000-08-03 2011-10-25 The Regents Of The University Of Michigan Determining the capability of a test compound to affect solid tumor stem cells
WO2002018544A2 (en) * 2000-08-31 2002-03-07 Loyola University Chicago Method and reagents for treatment of skin disorders by modulating the notch pathway
WO2002059285A1 (en) * 2000-10-27 2002-08-01 Fred Hutchinson Cancer Research Center Methods for immortalizing cells
GB0118155D0 (en) 2001-07-25 2001-09-19 Lorantis Ltd Superantigen
EP1461023A4 (de) * 2001-12-07 2005-08-31 Univ Michigan Prospektive identifizierung und charakterisierung von brustkrebs-stammzellen
EP2003196A3 (de) * 2003-06-09 2009-01-07 The Regents of the University of Michigan Zusammensetzungen und Verfahren zur Behandlung und Diagnose von Krebs
CA2554779A1 (en) * 2004-02-03 2005-08-18 The Regents Of The University Of Michigan Compositions and methods for characterizing, regulating, diagnosing, and treating cancer
US20060252073A1 (en) * 2005-04-18 2006-11-09 Regents Of The University Of Michigan Compositions and methods for the treatment of cancer
WO2006138275A2 (en) * 2005-06-13 2006-12-28 The Regents Of The University Of Michigan Compositions and methods for treating and diagnosing cancer
US20070099209A1 (en) * 2005-06-13 2007-05-03 The Regents Of The University Of Michigan Compositions and methods for treating and diagnosing cancer
US7723477B2 (en) 2005-10-31 2010-05-25 Oncomed Pharmaceuticals, Inc. Compositions and methods for inhibiting Wnt-dependent solid tumor cell growth
EP1945754B1 (de) * 2005-10-31 2014-07-23 The Regents Of The University Of Michigan Zusammensetzungen und verfahren zur behandlung und diagnostizierung von krebs
PT2500360E (pt) 2005-10-31 2015-10-15 Oncomed Pharm Inc Composições e métodos para diagnóstico e tratamento do cancro
US7919092B2 (en) 2006-06-13 2011-04-05 Oncomed Pharmaceuticals, Inc. Antibodies to notch receptors
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US8148147B2 (en) 2007-01-24 2012-04-03 The Regents Of The University Of Michigan Compositions and methods for treating and diagnosing pancreatic cancer
JP5618544B2 (ja) 2007-01-24 2014-11-05 オンコメッドファーマシューティカルズ インコーポレイテッド 癌の診断および処置のための組成物および方法
PE20090321A1 (es) 2007-06-04 2009-04-20 Genentech Inc Anticuerpos anti-notch1 nrr, metodo de preparacion y composicion farmaceutica
US8068607B2 (en) 2007-07-31 2011-11-29 Ricoh Company, Limited Information processing apparatus and information processing method
WO2009063838A1 (ja) 2007-11-12 2009-05-22 Gs Yuasa Corporation リチウム二次電池用活物質、リチウム二次電池及びその製造方法
MY155603A (en) 2008-07-08 2015-11-13 Oncomed Pharm Inc Notch-binding agents and antagonists and methods of use thereof
US9132189B2 (en) 2008-07-08 2015-09-15 Oncomed Pharmaceuticals, Inc. Notch1 binding agents and methods of use thereof
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HUE029661T2 (en) 2009-10-16 2017-03-28 Oncomed Pharm Inc A therapeutic combination and use of DLL4 antagonist antibodies and antihypertensive agents
TWI535445B (zh) 2010-01-12 2016-06-01 安可美德藥物股份有限公司 Ｗｎｔ拮抗劑及治療和篩選方法
JP2013530929A (ja) 2010-04-01 2013-08-01 オンコメッド ファーマシューティカルズ インコーポレイテッド ｆｒｉｚｚｌｅｄ結合剤およびその使用
WO2011127472A1 (en) 2010-04-09 2011-10-13 Fred Hutchinson Cancer Research Center Compositions and methods for providing hematopoietic function
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US8551479B2 (en) 2010-09-10 2013-10-08 Oncomed Pharmaceuticals, Inc. Methods for treating melanoma
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US9599620B2 (en) 2012-10-31 2017-03-21 Oncomed Pharmaceuticals, Inc. Methods and monitoring of treatment with a DLL4 antagonist
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US3884853A (en) * 1973-11-14 1975-05-20 Staley Mfg Co A E Alkali-curable cationic/anionic starch for paper coating binders
US5115096A (en) * 1988-04-15 1992-05-19 Oncogen Amphiregulin: a bifunctional growth modulating glycoprotein
US5098833A (en) * 1989-02-23 1992-03-24 Genentech, Inc. DNA sequence encoding a functional domain of a lymphocyte homing receptor
US5368712A (en) * 1989-11-02 1994-11-29 Synporin Technologies, Inc. Biologically mimetic synthetic ion channel transducers
WO1992010518A1 (en) * 1990-12-07 1992-06-25 Yale University Purified slit protein and sequence elements thereof
IL101728A (en) * 1991-05-03 2007-08-19 Univ Yale Human Abandonment and Delta, Restrictive Areas of Effect in Tophoric Proteins, and Methods Based on Them
WO1993012141A1 (en) * 1991-12-11 1993-06-24 Yale University Nucleotide and protein sequences of the serrate gene and methods based thereon
EP0673390B1 (de) * 1992-12-11 2000-07-12 THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by the SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES Delta ähnliches gen welches in neuroendokrinen tumoren exprimiert wird

Also Published As

Publication number Publication date
DK0933082T3 (da) 2010-10-25
IL101728A0 (en) 1992-12-30
ATE226633T1 (de) 2002-11-15
ES2181674T3 (es) 2003-03-01
CA2102208C (en) 2003-04-29
DK0576623T3 (da) 2003-02-24
ES2348919T3 (es) 2010-12-16
EP0576623B2 (de) 2007-10-03
ATE386116T1 (de) 2008-03-15
ATE397661T1 (de) 2008-06-15
IE85350B1 (en) 2009-10-14
JP4604228B2 (ja) 2011-01-05
EP0930366B1 (de) 2008-06-04
ATE473754T1 (de) 2010-07-15
ES2310933T3 (es) 2009-01-16
DE69232832T3 (de) 2008-02-28
EP0930365A2 (de) 1999-07-21
EP0576623A1 (de) 1994-01-05
JP2011155979A (ja) 2011-08-18
IE20030774A1 (en) 2003-12-10
JP2007330258A (ja) 2007-12-27
DE69232832T2 (de) 2003-06-18
AU1919792A (en) 1992-12-21
DE69233724D1 (de) 2008-03-27
JP2004065243A (ja) 2004-03-04
EP0930366A3 (de) 1999-07-28
EP0930365B1 (de) 2008-02-13
DE69233724T2 (de) 2009-04-02
DK0930365T3 (da) 2008-06-02
EP0576623A4 (de) 1995-01-18
IL101728A (en) 2007-08-19
DE69232832D1 (de) 2002-11-28
JPH07503123A (ja) 1995-04-06
JP4604227B2 (ja) 2011-01-05
IE921367A1 (en) 1992-11-04
AU675203B2 (en) 1997-01-30
CA2102208A1 (en) 1992-11-12
JP4430891B2 (ja) 2010-03-10
DK0576623T4 (da) 2008-01-02
EP0933082B1 (de) 2010-07-14
JP2011135886A (ja) 2011-07-14
ES2181674T5 (es) 2008-03-01
DE69233735D1 (de) 2008-07-17
WO1992019734A1 (en) 1992-11-12
EP0930366A2 (de) 1999-07-21
DK0930366T3 (da) 2008-10-13
US5849869A (en) 1998-12-15
EP0933082A1 (de) 1999-08-04
EP0930365A3 (de) 1999-07-28
ES2303363T3 (es) 2008-08-01
JP2007330259A (ja) 2007-12-27
JP2008005843A (ja) 2008-01-17
EP0576623B1 (de) 2002-10-23

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