DE69232963D1 - Verwendung von HPV-16 E6 und E7-Gen gewonnen Peptiden für den diagnostischen Zweck - Google Patents
Verwendung von HPV-16 E6 und E7-Gen gewonnen Peptiden für den diagnostischen ZweckInfo
- Publication number
- DE69232963D1 DE69232963D1 DE69232963T DE69232963T DE69232963D1 DE 69232963 D1 DE69232963 D1 DE 69232963D1 DE 69232963 T DE69232963 T DE 69232963T DE 69232963 T DE69232963 T DE 69232963T DE 69232963 D1 DE69232963 D1 DE 69232963D1
- Authority
- DE
- Germany
- Prior art keywords
- hpv
- derived peptides
- gene derived
- diagnostic purposes
- fot
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/081—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from DNA viruses
- C07K16/084—Papovaviridae, e.g. papillomavirus, polyomavirus, SV40, BK virus, JC virus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Virology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP91111720 | 1991-07-13 | ||
EP91111720 | 1991-07-13 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69232963D1 true DE69232963D1 (de) | 2003-04-24 |
DE69232963T2 DE69232963T2 (de) | 2004-03-04 |
Family
ID=8206929
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69232963T Expired - Fee Related DE69232963T2 (de) | 1991-07-13 | 1992-06-19 | Verwendung von HPV-16 E6 und E7-Gen gewonnen Peptiden für den diagnostischen Zweck |
Country Status (10)
Country | Link |
---|---|
US (1) | US5629161A (de) |
EP (1) | EP0523391B1 (de) |
JP (1) | JP3366350B2 (de) |
AT (1) | ATE234860T1 (de) |
AU (1) | AU667470B2 (de) |
CA (1) | CA2073616C (de) |
DE (1) | DE69232963T2 (de) |
DK (1) | DK0523391T3 (de) |
ES (1) | ES2193133T3 (de) |
PT (1) | PT523391E (de) |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2097916C (en) * | 1990-12-12 | 2001-08-21 | Robert Tindle | Subunit papillomavirus vaccine and peptides for use therein |
US5736318A (en) * | 1995-03-17 | 1998-04-07 | President And Fellows Of Harvard College | Method and kit for evaluating human papillomavirus transformed cells |
DE19925235A1 (de) | 1999-06-01 | 2000-12-07 | Medigene Ag | Zytotoxische T-Zellepitope des Papillomavirus L1-Proteins und ihre Verwendung in Diagnostik und Therapie |
DE19925199A1 (de) | 1999-06-01 | 2000-12-07 | Medigene Ag | Zytotoxische T-Zellepitope des Papillomavirus L1-Proteins und ihre Verwendung in Diagnostik und Therapie |
FR2794370B1 (fr) | 1999-06-03 | 2003-10-17 | Biovector Therapeutics | Fragments proteiques polyepitopiques, leur obtention et leurs utilisations notamment en vaccination |
US6641994B2 (en) | 1999-08-25 | 2003-11-04 | Pharmacia & Upjohn Company | Methods of identifying anti-viral agents |
US6200746B1 (en) | 1999-08-25 | 2001-03-13 | Pharmacia & Upjohn Company | Methods of identifying anti-viral agents |
JP2003509035A (ja) * | 1999-09-16 | 2003-03-11 | ザイコス インク. | ポリエピトープポリペプチドをコードする核酸 |
US20050100928A1 (en) * | 1999-09-16 | 2005-05-12 | Zycos Inc., A Delaware Corporation | Nucleic acids encoding polyepitope polypeptides |
FR2794371B1 (fr) * | 1999-10-07 | 2004-06-18 | Biovector Therapeutics | Fragments proteiquespolyepitopiques, leur obtention et leurs utilisations notamment en vaccination |
US8128922B2 (en) * | 1999-10-20 | 2012-03-06 | Johns Hopkins University | Superior molecular vaccine linking the translocation domain of a bacterial toxin to an antigen |
CN1433428A (zh) * | 2000-04-05 | 2003-07-30 | 冲击诊断公司 | 辨别人***瘤病毒的免疫学方法 |
AU2001290520A1 (en) * | 2000-08-01 | 2002-02-13 | The Johns Hokpins University | Intercellular transport protein linked to an antigen as a molecular vaccine |
ES2454640T3 (es) * | 2000-08-03 | 2014-04-11 | Johns Hopkins University | Vacuna molecular que lleva unida un polipéptido de chaperona del retículo endoplasmático a un antígeno |
US7312041B2 (en) | 2001-02-16 | 2007-12-25 | Arbor Vita Corporation | Methods of diagnosing cervical cancer |
US6933123B2 (en) * | 2001-04-05 | 2005-08-23 | Yao Xiong Hu | Peptides from the E2, E6, and E7 proteins of human papilloma viruses 16 and 18 for detecting and/or diagnosing cervical and other human papillomavirus associated cancers |
FR2824326B1 (fr) * | 2001-05-04 | 2004-03-19 | Commissariat Energie Atomique | Melange de peptides issus des proteines e6 et/ou e7 de papillomavirus et leurs applications |
US20060147906A1 (en) * | 2002-03-22 | 2006-07-06 | Amynon Biotech Gmbh | Anti-hpv-16 e7 antibodies and their use |
EP1537415B1 (de) * | 2002-09-09 | 2008-12-17 | Arbor Vita Corporation | Verfahren zur diagnose von gebärmutterhalskrebs |
EP1644048B1 (de) * | 2003-05-05 | 2015-04-29 | Johns Hopkins University | Anti-krebs-dna-vakzine mit einer für plasmide kodierenden signalsequenz, mutiertes onkoprotein-antigen und hitzeschockprotein |
LT5228B (lt) | 2003-07-16 | 2005-06-27 | Uždaroji akcinė bendrovė Melofarma | Gimdos kaklelio displazijų ir vėžio, susijusių su žmogaus papilomos virusais ankstyvos diagnostikos in vitro būdas |
AU2004308964B2 (en) * | 2003-12-23 | 2010-09-16 | Arbor Vita Corporation | Antibodies for oncogenic strains of HPV and methods of their use |
CA2594040A1 (en) * | 2005-01-06 | 2006-07-13 | The Johns Hopkins University | Rna interference that blocks expression of pro-apoptotic proteins potentiates immunity induced by dna and transfected dendritic cell vaccines |
EP1846026A4 (de) * | 2005-01-26 | 2008-07-02 | Univ Johns Hopkins | Antikrebs-dna-impfstoff mit plasmiden zur kodierung eines mutierten onkoprotein-antigens und von calreticulin |
US7732166B2 (en) * | 2005-11-15 | 2010-06-08 | Oncohealth Corporation | Detection method for human pappilomavirus (HPV) and its application in cervical cancer |
US7972776B2 (en) * | 2005-11-15 | 2011-07-05 | Oncohealth Corporation | Protein chips for HPV detection |
US20100330105A1 (en) * | 2006-08-22 | 2010-12-30 | John Hopkins University | Anticancer Combination Therapies |
WO2010129821A1 (en) | 2009-05-07 | 2010-11-11 | Oncohealth Corporation | Identification of high grade or ≥cin2 for early stages and late stages detection, screening, and diagnosis of human papillomavirus (hpv) and hpv-associated cancers |
US8968995B2 (en) * | 2008-11-12 | 2015-03-03 | Oncohealth Corp. | Detection, screening, and diagnosis of HPV-associated cancers |
US20100003704A1 (en) * | 2008-06-13 | 2010-01-07 | Shuling Cheng | IN SITU detection of early stages and late stages HPV infection |
US9085638B2 (en) | 2007-03-07 | 2015-07-21 | The Johns Hopkins University | DNA vaccine enhancement with MHC class II activators |
US20080260765A1 (en) * | 2007-03-15 | 2008-10-23 | Johns Hopkins University | HPV DNA Vaccines and Methods of Use Thereof |
WO2008124091A2 (en) * | 2007-04-05 | 2008-10-16 | Genera Biosystems Limited | Compositions and methods of detection |
AU2015213420B2 (en) * | 2007-05-31 | 2017-02-16 | Isa Pharmaceuticals B.V. | HPV epitopes targeted by T cells infiltrating cervical malignancies for use in vaccines |
ES2496916T3 (es) | 2007-05-31 | 2014-09-22 | Academisch Ziekenhuis Leiden H.O.D.N. Lumc | Epítopo de HPV al que se dirigen células T que infiltran tumores malignos cervicales para su uso en vacunas |
US20090285861A1 (en) * | 2008-04-17 | 2009-11-19 | Tzyy-Choou Wu | Tumor cell-based cancer immunotherapeutic compositions and methods |
WO2011084598A1 (en) | 2010-01-08 | 2011-07-14 | Oncohealth Corporation | High throughput cell-based hpv immunoassays for diagnosis and screening of hpv-associated cancers |
CN104004067B (zh) * | 2013-02-22 | 2017-09-01 | 艾托金生物医药(苏州)有限公司 | 用于检测抗人***瘤病毒抗体的抗原及相关免疫检测试剂盒 |
CN109053879B (zh) * | 2018-08-22 | 2020-12-25 | 深圳市宝安区中心医院 | 一种治疗***的scFv抗体及其应用 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4777239A (en) * | 1986-07-10 | 1988-10-11 | The Board Of Trustees Of The Leland Stanford Junior University | Diagnostic peptides of human papilloma virus |
US5180806A (en) * | 1988-05-16 | 1993-01-19 | The Scripps Research Institute | Polypeptides and compositions of human papillomavirus latent proteins, diagnostic systems and methods |
FR2641081A1 (de) * | 1988-12-23 | 1990-06-29 | Medgenix Group | |
DE3907721A1 (de) * | 1989-03-10 | 1990-09-20 | Behringwerke Ag | Immunogene regionen auf dem e7-protein des humanen papillomvierus typ 16 |
US5045447A (en) * | 1989-03-15 | 1991-09-03 | Minson Anthony C | Method of producing antibodies to HPV |
PT97073A (pt) * | 1990-03-20 | 1991-10-31 | Behringwerke Ag | Processo para a preparacao de epitopos soro-reactivos de proteinas de papillomavirus 16 humano (hpv) |
SE9001705D0 (sv) * | 1990-05-11 | 1990-05-11 | Medscand Ab | Saett foer diagnostik av virusbaerande tumoerer genom immunoassay |
WO1992005248A1 (en) * | 1990-09-26 | 1992-04-02 | Bristol-Myers Squibb Company | Human papilloma viral protein expression for use in vaccine compositions |
-
1992
- 1992-06-19 AT AT92110367T patent/ATE234860T1/de not_active IP Right Cessation
- 1992-06-19 DK DK92110367T patent/DK0523391T3/da active
- 1992-06-19 ES ES92110367T patent/ES2193133T3/es not_active Expired - Lifetime
- 1992-06-19 EP EP92110367A patent/EP0523391B1/de not_active Expired - Lifetime
- 1992-06-19 PT PT92110367T patent/PT523391E/pt unknown
- 1992-06-19 DE DE69232963T patent/DE69232963T2/de not_active Expired - Fee Related
- 1992-07-10 AU AU19590/92A patent/AU667470B2/en not_active Ceased
- 1992-07-10 CA CA002073616A patent/CA2073616C/en not_active Expired - Fee Related
- 1992-07-13 JP JP20840792A patent/JP3366350B2/ja not_active Expired - Fee Related
-
1994
- 1994-12-23 US US08/363,586 patent/US5629161A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
JPH06169781A (ja) | 1994-06-21 |
PT523391E (pt) | 2003-08-29 |
EP0523391A1 (de) | 1993-01-20 |
JP3366350B2 (ja) | 2003-01-14 |
EP0523391B1 (de) | 2003-03-19 |
CA2073616C (en) | 2003-11-04 |
DK0523391T3 (da) | 2003-06-23 |
DE69232963T2 (de) | 2004-03-04 |
AU667470B2 (en) | 1996-03-28 |
ES2193133T3 (es) | 2003-11-01 |
AU1959092A (en) | 1993-01-14 |
ATE234860T1 (de) | 2003-04-15 |
US5629161A (en) | 1997-05-13 |
CA2073616A1 (en) | 1993-01-14 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |