DE69230433D1 - Cdns-klonierungsverfahren für rezeptortyrosinkinasezielprotein und hgrb-proteine - Google Patents

Cdns-klonierungsverfahren für rezeptortyrosinkinasezielprotein und hgrb-proteine

Info

Publication number
DE69230433D1
DE69230433D1 DE69230433T DE69230433T DE69230433D1 DE 69230433 D1 DE69230433 D1 DE 69230433D1 DE 69230433 T DE69230433 T DE 69230433T DE 69230433 T DE69230433 T DE 69230433T DE 69230433 D1 DE69230433 D1 DE 69230433D1
Authority
DE
Germany
Prior art keywords
proteins
grb
tyrosine
cloning method
hgrb
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69230433T
Other languages
English (en)
Inventor
Joseph Schlessinger
Edward Skolnik
Benjamin Margolis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
New York University NYU
Original Assignee
New York University NYU
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by New York University NYU filed Critical New York University NYU
Application granted granted Critical
Publication of DE69230433D1 publication Critical patent/DE69230433D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4705—Regulators; Modulating activity stimulating, promoting or activating activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/575—Hormones
    • G01N2333/62—Insulins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/91—Transferases (2.)
    • G01N2333/912—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • G01N2333/91205—Phosphotransferases in general
    • G01N2333/9121—Phosphotransferases in general with an alcohol group as acceptor (2.7.1), e.g. general tyrosine, serine or threonine kinases

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DE69230433T 1991-01-18 1992-01-17 Cdns-klonierungsverfahren für rezeptortyrosinkinasezielprotein und hgrb-proteine Expired - Lifetime DE69230433D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US64323791A 1991-01-18 1991-01-18
PCT/US1992/000434 WO1992013001A1 (en) 1991-01-18 1992-01-17 A RECEPTOR TYROSINE KINASE TARGET PROTEIN cDNA CLONING METHOD AND hGRB PROTEINS

Publications (1)

Publication Number Publication Date
DE69230433D1 true DE69230433D1 (de) 2000-01-20

Family

ID=24579945

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69230433T Expired - Lifetime DE69230433D1 (de) 1991-01-18 1992-01-17 Cdns-klonierungsverfahren für rezeptortyrosinkinasezielprotein und hgrb-proteine

Country Status (12)

Country Link
US (3) US5434064A (de)
EP (1) EP0567567B1 (de)
JP (2) JP3462498B2 (de)
AT (1) ATE187772T1 (de)
AU (1) AU667803B2 (de)
CA (1) CA2100860C (de)
DE (1) DE69230433D1 (de)
HK (1) HK1014554A1 (de)
IE (1) IE920151A1 (de)
MX (1) MX9200246A (de)
PT (1) PT100037B (de)
WO (1) WO1992013001A1 (de)

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US5677421A (en) * 1991-01-18 1997-10-14 New York University Target proteins for eukaryotic tyrosine kinases
ATE187772T1 (de) * 1991-01-18 2000-01-15 Univ New York Cdns-klonierungsverfahren für rezeptortyrosinkinasezielprotein und hgrb- proteine
US5667980A (en) * 1991-10-31 1997-09-16 Mount Sinai Hospital Corporation Method for assaying for a substance that affects an SH2 phosphorylated ligand regulatory system
US5378809A (en) * 1992-08-25 1995-01-03 The United States Of America As Represented By The Department Of Health And Human Services Polynucleotides and substrate for the epidermal growth factor receptor kinase (eps8)
US5459036A (en) * 1993-03-19 1995-10-17 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Extracellular signal-regulated kinase, sequences, and methods of production and use
FR2710074B1 (fr) * 1993-09-15 1995-12-08 Rhone Poulenc Rorer Sa Gène GRB3-3, ses variants et leurs utilisations.
JPH09512704A (ja) * 1994-03-17 1997-12-22 ナシヨナル・ジユーイツシユ・センター・フオー・イミユノロジー・アンド・レスピラトリー・メデイシン シグナル変換経路を調節するための産物および方法
US5541109A (en) * 1994-04-19 1996-07-30 Rhone-Poulenc Rorer Pharmaceuticals Inc. Expression cloning of c-src SH3-domain binding proteins
US5612471A (en) * 1994-05-25 1997-03-18 The Regents Of The University Of California Nematode-induced genes in tomato
US5650293A (en) * 1994-06-10 1997-07-22 Joslin Diabetes Center, Inc. Nucleic acid encoding pp60PIK and the methods of making pp60PIK
US5744313A (en) * 1994-12-09 1998-04-28 The Regents Of The University Of California Assay employing novel protein domain which binds tyrosine phosphorylated proteins
US6280964B1 (en) 1995-04-14 2001-08-28 The Regents Of The University Of California Binding sites for phosphotyrosine binding domains
US6171800B1 (en) * 1995-06-07 2001-01-09 Biogen, Inc. Method of making and binding CAIP polypeptides
US6423824B1 (en) * 1995-06-07 2002-07-23 Biogen, Inc. CAIP-like gene family
WO1997010253A1 (en) * 1995-09-15 1997-03-20 Merck & Co., Inc. A high throughput assay using fusion proteins
US5783398A (en) * 1995-09-15 1998-07-21 Merck & Co., Inc. High throughput assay using fusion proteins
US5922842A (en) * 1995-10-13 1999-07-13 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Tyrosine kinase associated polypeptides
US5945523A (en) * 1995-10-13 1999-08-31 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Diagnosis and treatment of TKA-1 related disorders
US5895813A (en) * 1995-10-13 1999-04-20 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Diagnosis and treatment of TKA-1 related disorders
US6028053A (en) * 1995-10-27 2000-02-22 Mount Sinai Hospital Corporation Peptide inhibitors of a phosphotyrosine-binding domain containing protein
AU4510396A (en) * 1995-12-04 1997-06-27 Human Genome Sciences, Inc. Growth factor receptor-binding protein 2 homolog
US5891857A (en) * 1996-02-20 1999-04-06 Vanderbilt University Characterized BRCA1 and BRCA2 proteins and screening and therapeutic methods based on characterized BRCA1 and BRCA2 proteins
US5981220A (en) * 1996-03-27 1999-11-09 Human Genome Sciences, Inc. Epidermal differentiation factor
JP2000509986A (ja) * 1996-05-06 2000-08-08 ノボ ノルディスク アクティーゼルスカブ ホスファチジルイノシトール３―キナーゼのｐ８５αサブユニットをコードする突然変異体ｃＤＮＡ
WO1998001475A1 (en) * 1996-07-09 1998-01-15 Smithkline Beecham Corporation Growth factor receptor-binding insulin receptor
US5840536A (en) * 1996-07-09 1998-11-24 Dunnington; Damien J. Growth factor receptor-binding insulin receptor
US5942415A (en) * 1996-09-13 1999-08-24 Schraven; Burkhart SKAP55 compositions and methods of use therefor
US7078375B1 (en) * 1996-10-25 2006-07-18 Peter Mose Larsen Diabetes-mediating proteins and therapeutic uses thereof
US6300081B1 (en) 1996-11-15 2001-10-09 Cornell Research Foundation, Inc. Activated ras interaction assay
US5955277A (en) * 1997-05-05 1999-09-21 Novo Nordisk A/S Mutant cDNA encoding the p85α subunit of phosphatidylinositol 3-kinase
US6312941B1 (en) 1997-11-26 2001-11-06 The Regents Of The University Of Michigan Compositions and methods for identifying signaling pathway agonists and antagonists
US6177410B1 (en) 1997-12-05 2001-01-23 Vanderbilt University Therapeutic methods for prostate cancer
CA2347653A1 (en) * 1998-10-13 2000-04-20 Onyx Pharmaceuticals, Inc. Novel cell signaling polypeptides and nucleic acids
US20020009762A1 (en) * 2000-02-14 2002-01-24 Flint Andrew J. Assay for protein tyrosine phosphatases
US7919276B1 (en) 2000-02-22 2011-04-05 Mount Sinai School Of Medicine ZA loops of bromodomains
US20040009613A1 (en) * 2001-02-16 2004-01-15 Ming-Ming Zhou Methods of identifying modulators of bromodomains
US7589167B2 (en) * 2000-02-22 2009-09-15 J. David Gladstone Institutes ZA loops of bromodomains
AU2003233630A1 (en) * 2002-05-17 2003-12-02 Ciphergen Biosystems, Inc. Detection of kinase substrates and products using ion mass spectrometry
JP5766948B2 (ja) 2007-10-12 2015-08-19 カリス ライフ サイエンシズ スウィッツァーランド ホールディングスゲーエムベーハー プロテオミクスにおけるアプタマーの使用
US20100216718A1 (en) * 2007-10-19 2010-08-26 Cell Signaling Technology, Inc. Cancer Classification and Methods of Use
US9115352B2 (en) 2008-03-31 2015-08-25 Sloning Biotechnology Gmbh Method for the preparation of a nucleic acid library
US10942184B2 (en) 2012-10-23 2021-03-09 Caris Science, Inc. Aptamers and uses thereof
WO2014068408A2 (en) 2012-10-23 2014-05-08 Caris Life Sciences Switzerland Holdings, S.A.R.L. Aptamers and uses thereof
US9939443B2 (en) 2012-12-19 2018-04-10 Caris Life Sciences Switzerland Holdings Gmbh Compositions and methods for aptamer screening

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US4675285A (en) * 1984-09-19 1987-06-23 Genetics Institute, Inc. Method for identification and isolation of DNA encoding a desired protein
WO1990008160A1 (en) * 1989-01-20 1990-07-26 Imperial Cancer Research Technology Ltd. Growth factor receptor-like peptides without tyrosine-kinase activity
NL8900529A (nl) * 1989-03-03 1990-10-01 Eurodiagnostics B V Werkwijze en kit voor het bepalen van tyrosine fosforylerende en defosforylerende activiteit.
ATE187772T1 (de) * 1991-01-18 2000-01-15 Univ New York Cdns-klonierungsverfahren für rezeptortyrosinkinasezielprotein und hgrb- proteine
CA2054602C (en) * 1991-10-31 2003-04-22 Anthony Pawson Method for assaying for a substance that affects an sh2-phosphorylated ligand regulatory system

Also Published As

Publication number Publication date
PT100037A (pt) 1993-03-31
HK1014554A1 (en) 1999-09-30
PT100037B (pt) 1999-06-30
EP0567567A1 (de) 1993-11-03
EP0567567A4 (en) 1994-05-11
IE920151A1 (en) 1992-07-29
US5434064A (en) 1995-07-18
JP2003199566A (ja) 2003-07-15
JPH06505561A (ja) 1994-06-23
AU1234692A (en) 1992-08-27
WO1992013001A1 (en) 1992-08-06
CA2100860A1 (en) 1992-07-19
CA2100860C (en) 2003-11-25
JP3561268B2 (ja) 2004-09-02
US5858686A (en) 1999-01-12
EP0567567B1 (de) 1999-12-15
US5618691A (en) 1997-04-08
JP3462498B2 (ja) 2003-11-05
MX9200246A (es) 1994-03-31
AU667803B2 (en) 1996-04-18
ATE187772T1 (de) 2000-01-15

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