DE69229393D1 - METHOD FOR PURIFYING HMG-COA REDUCTASE INHIBITORS - Google Patents

METHOD FOR PURIFYING HMG-COA REDUCTASE INHIBITORS

Info

Publication number
DE69229393D1
DE69229393D1 DE69229393T DE69229393T DE69229393D1 DE 69229393 D1 DE69229393 D1 DE 69229393D1 DE 69229393 T DE69229393 T DE 69229393T DE 69229393 T DE69229393 T DE 69229393T DE 69229393 D1 DE69229393 D1 DE 69229393D1
Authority
DE
Germany
Prior art keywords
coa reductase
reductase inhibitors
hmg
purifying
purifying hmg
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69229393T
Other languages
German (de)
Inventor
Peter Haytko
Arthur Wildman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24683910&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69229393(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Application granted granted Critical
Publication of DE69229393D1 publication Critical patent/DE69229393D1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/32—Bonded phase chromatography
    • B01D15/322—Normal bonded phase
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/32—Bonded phase chromatography
    • B01D15/325—Reversed phase

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

A process for the purification of an HMG-CoA reductase inhibitor employing preparative high performance liquid chromatography is described.
DE69229393T 1991-03-13 1992-03-09 METHOD FOR PURIFYING HMG-COA REDUCTASE INHIBITORS Expired - Lifetime DE69229393D1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/668,831 US5202029A (en) 1991-03-13 1991-03-13 Process for purification of hmg-coa reductase inhibitors
PCT/US1992/001864 WO1992016276A1 (en) 1991-03-13 1992-03-09 PROCESS FOR PURIFICATION OF HMG-CoA REDUCTASE INHIBITORS

Publications (1)

Publication Number Publication Date
DE69229393D1 true DE69229393D1 (en) 1999-07-15

Family

ID=24683910

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69229393T Expired - Lifetime DE69229393D1 (en) 1991-03-13 1992-03-09 METHOD FOR PURIFYING HMG-COA REDUCTASE INHIBITORS

Country Status (9)

Country Link
US (1) US5202029A (en)
EP (1) EP0578723B1 (en)
JP (1) JPH06506210A (en)
AT (1) ATE180986T1 (en)
CA (1) CA2104232A1 (en)
DE (1) DE69229393D1 (en)
ES (1) ES2132121T3 (en)
GR (1) GR3030446T3 (en)
WO (1) WO1992016276A1 (en)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5308479A (en) * 1989-05-26 1994-05-03 Isamu Iwai Sewage disposal apparatus employing circulating filter media
DE4414537A1 (en) * 1994-04-26 1995-11-02 Klinge Co Chem Pharm Fab Combination preparations containing a p-oxybenzoic acid derivative and an HMG-CoA reductase inhibitor
SI9800046A (en) 1998-02-18 1999-08-31 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Process for obtaining of HMG-CoA reductase inhibitors of high purity
SI20072A (en) * 1998-09-18 2000-04-30 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. PROCEDURE OF PREPARATION OF INHIBITORS OF HMG-CoA REDUCTASE
US7141602B2 (en) * 1998-09-18 2006-11-28 Lek Pharmaceuticals D.D. Process for obtaining HMG-CoA reductase inhibitors of high purity
EP1228057A2 (en) 1999-10-27 2002-08-07 Merck & Co., Inc. Lactonization process
DE60031447T2 (en) 1999-11-30 2007-08-30 Teva Gyogyszergyar Zartköruen Muködo Reszvenytarsasag METHOD FOR THE RECOVERY OF STATIN COMPOUNDS FROM A FERMENTATION BREW
SK8312002A3 (en) * 1999-12-14 2003-05-02 Biogal Gyogyszergyar Novel forms of pravastatin sodium
IL151290A0 (en) 2000-02-24 2003-04-10 Biogal Pharmaceutical Co Ltd Method of purifying a fermentation broth
JP2003525935A (en) 2000-03-03 2003-09-02 ビオガル ジョジセルジャール アール テー． Method for purifying lovastatin and simvastatin with reduced levels of dimeric impurities
JP4945876B2 (en) * 2000-04-05 2012-06-06 東レ株式会社 High mobility group protein adsorbent and body fluid purification column
US6936731B2 (en) * 2000-10-05 2005-08-30 TEVA Gyógyszergyár Részvénytársaság Pravastatin sodium substantially free of pravastatin lactone and epi-pravastatin, and compositions containing same
US20050215636A1 (en) * 2000-10-05 2005-09-29 Vilmos Keri Pravastatin sodium substantially free of pravastatin lactone and EPI-pravastatin, and compositions containing same
SK5232003A3 (en) * 2000-10-05 2004-06-08 Biogal Gyogyszergyar Pravastatin sodium substantially free of pravastatin lactone and epi-pravastatin, and compositions containing same
JP3236282B1 (en) * 2000-10-16 2001-12-10 三共株式会社 How to purify pravastatin
EP1726583A3 (en) * 2003-06-18 2007-05-09 Teva Pharmaceutical Industries Ltd Fluvastatin sodium crystal form LXXIX, processes for preparing it, compositions containing it and methods of using it.
US7368468B2 (en) * 2003-06-18 2008-05-06 Teva Pharmaceutical Industries Ltd. Fluvastatin sodium crystal forms XIV, LXXIII, LXXIX, LXXX and LXXXVII, processes for preparing them, compositions containing them and methods of using them
EP1601658A1 (en) * 2003-11-24 2005-12-07 Teva Pharmaceutical Industries Limited Crystalline ammonium salts of rosuvastatin
WO2005051372A2 (en) 2003-11-24 2005-06-09 Teva Gyógyszergyár Zártköruen Muködo Részvénytársaság Method of purifying pravastatin
US20070179166A1 (en) * 2003-12-24 2007-08-02 Valerie Niddam-Hildesheim Process for preparation of statins with high syn to anti ratio
US7851624B2 (en) * 2003-12-24 2010-12-14 Teva Pharamaceutical Industries Ltd. Triol form of rosuvastatin and synthesis of rosuvastatin
ES2239533B1 (en) * 2004-03-01 2006-12-16 Ercros Industrial, S.A. PROCEDURE FOR OBTAINING COMPACTINE.
WO2006035295A1 (en) * 2004-09-27 2006-04-06 Ranbaxy Laboratories Limited Process for the purification of lovastatin
CA2591439C (en) * 2005-02-22 2013-03-26 Teva Pharmaceutical Industries Ltd. Rosuvastatin and salts thereof free of rosuvastatin alkylether and a process for the preparation thereof
WO2009078033A2 (en) * 2007-12-18 2009-06-25 Themis Medicare Limited Isolation and recovery of simvastatin in lactone form or in the form of an acid salt from the harvested fermentation broth
US9078849B2 (en) 2009-04-08 2015-07-14 Nanyang Polytechnic Plant extract comprising statins and preparation techniques and uses thereof
CN102043030A (en) * 2009-10-22 2011-05-04 北京万全阳光医学技术有限公司 Method for measuring materials associated with niacin simvastatin sustained-release tablets by high performance liquid chromatography
EP2590722A4 (en) * 2010-07-07 2015-06-24 Ironstone Separations Inc Chromatography methods
EP2597092A1 (en) 2011-11-24 2013-05-29 Sterling Biotech Limited A process for purification of lovastatin
CN112657231B (en) * 2020-12-24 2022-06-10 西安蓝晓科技新材料股份有限公司 Purification process of panax notoginseng saponins

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4231938A (en) * 1979-06-15 1980-11-04 Merck & Co., Inc. Hypocholesteremic fermentation products and process of preparation
JPS58140024A (en) * 1982-02-15 1983-08-19 Eisai Co Ltd Purification method of secretin
US4833258A (en) * 1987-02-17 1989-05-23 Merck & Co., Inc. Intermediates useful in the preparation of HMG-COA reductase inhibitors
US4719229A (en) * 1987-05-13 1988-01-12 Merck & Co., Inc. Antihypercholesterolemic agents
US4778600A (en) * 1987-06-17 1988-10-18 Dow Corning Corporation Liquid chromatography dual zone packing materials
US4997755A (en) * 1988-04-15 1991-03-05 Merck & Co., Inc. HMG-CoA reductase inhibitors produced by Nocardia sp. (MA 6455)
US5099035A (en) * 1989-02-27 1992-03-24 E. R. Squibb & Sons, Inc. Mevinic acid derivatives useful as antihypercholesterolemic agents and method for preparing same
US5102911A (en) * 1989-06-09 1992-04-07 Merck & Co, Inc. 4-Substituted HMG-CoA reductase inhibitors
US4965200A (en) * 1989-06-23 1990-10-23 Merck & Co., Inc. Process for the preparation of 3-keto, 5-hydroxy simvastatin analogs
US4997849A (en) * 1989-06-23 1991-03-05 Merck & Co., Inc. Microbial transformation of simvastatin
US5089523A (en) * 1990-05-11 1992-02-18 E. R. Squibb & Sons, Inc. Fluorinated derivatives of mevinic acids

Also Published As

Publication number Publication date
GR3030446T3 (en) 1999-09-30
EP0578723A1 (en) 1994-01-19
CA2104232A1 (en) 1992-09-14
EP0578723B1 (en) 1999-06-09
WO1992016276A1 (en) 1992-10-01
JPH06506210A (en) 1994-07-14
ATE180986T1 (en) 1999-06-15
EP0578723A4 (en) 1994-06-22
ES2132121T3 (en) 1999-08-16
US5202029A (en) 1993-04-13

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Legal Events

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