DE69229254T2 - Verfahren zur Herstellung von menschlichen Lymphozyten und menschlichen Antikörpern; und so hergestellte Antikörper - Google Patents
Verfahren zur Herstellung von menschlichen Lymphozyten und menschlichen Antikörpern; und so hergestellte AntikörperInfo
- Publication number
- DE69229254T2 DE69229254T2 DE69229254T DE69229254T DE69229254T2 DE 69229254 T2 DE69229254 T2 DE 69229254T2 DE 69229254 T DE69229254 T DE 69229254T DE 69229254 T DE69229254 T DE 69229254T DE 69229254 T2 DE69229254 T2 DE 69229254T2
- Authority
- DE
- Germany
- Prior art keywords
- antibodies
- human
- processes
- produced
- production
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
- A01K67/027—New breeds of vertebrates
- A01K67/0271—Chimeric animals, e.g. comprising exogenous cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/01—Animal expressing industrially exogenous proteins
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/035—Animal model for multifactorial diseases
- A01K2267/0381—Animal model for diseases of the hematopoietic system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP31166591 | 1991-10-30 | ||
JP7018792 | 1992-02-20 | ||
JP4244250A JPH05304988A (ja) | 1992-02-20 | 1992-08-20 | 抗hdモノクローナル抗体及びそれを産生する細胞株 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69229254D1 DE69229254D1 (de) | 1999-07-01 |
DE69229254T2 true DE69229254T2 (de) | 1999-09-23 |
Family
ID=27300259
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69229254T Expired - Fee Related DE69229254T2 (de) | 1991-10-30 | 1992-10-29 | Verfahren zur Herstellung von menschlichen Lymphozyten und menschlichen Antikörpern; und so hergestellte Antikörper |
Country Status (3)
Country | Link |
---|---|
US (2) | US5681729A (de) |
EP (1) | EP0539970B1 (de) |
DE (1) | DE69229254T2 (de) |
Families Citing this family (75)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5550020A (en) * | 1994-07-08 | 1996-08-27 | Visible Genetics Inc. | Method, reagents and kit for diagnosis and targeted screening for retinoblastoma |
US5783186A (en) * | 1995-12-05 | 1998-07-21 | Amgen Inc. | Antibody-induced apoptosis |
AU9374198A (en) * | 1997-09-08 | 1999-03-29 | Idec Pharmaceuticals Corporation | Methods for producing human antibodies in scid mice using dendritic cells |
CA2333147C (en) | 1998-07-13 | 2012-02-07 | Board Of Regents, The University Of Texas System | Cancer treatment methods using antibodies to aminophospholipids |
US6794494B1 (en) | 2003-04-14 | 2004-09-21 | Arius Research, Inc. | Cancerous disease modifying antibodies |
US20080124327A1 (en) * | 1999-10-08 | 2008-05-29 | Arius Research, Inc. | Cytotoxicity mediation of cells evidencing surface expression of CD44 |
US7419792B2 (en) * | 1999-10-08 | 2008-09-02 | Arius Research Inc. | Laminin Receptor 1 Precursor Protein (37LRP) epitope delineated by an Hepatocellular carcinoma specific antibody |
US7947496B2 (en) * | 1999-10-08 | 2011-05-24 | Hoffmann-La Roche Inc. | Cytotoxicity mediation of cells evidencing surface expression of CD44 |
US7256271B2 (en) | 2003-01-21 | 2007-08-14 | Arius Research Inc. | Cancerous disease modifying antibodies |
US7252821B2 (en) | 1999-10-08 | 2007-08-07 | Arius Research Inc. | Cancerous disease modifying antibodies |
US8071072B2 (en) * | 1999-10-08 | 2011-12-06 | Hoffmann-La Roche Inc. | Cytotoxicity mediation of cells evidencing surface expression of CD44 |
US6657048B2 (en) * | 1999-10-08 | 2003-12-02 | Arius Research, Inc. | Individualized anti-cancer antibodies |
US20040105816A1 (en) * | 1999-10-08 | 2004-06-03 | Young David S. F. | Cancerous disease modifying antibodies |
US7442776B2 (en) * | 1999-10-08 | 2008-10-28 | Young David S F | Cancerous disease modifying antibodies |
US6180357B1 (en) * | 1999-10-08 | 2001-01-30 | Arius Research, Inc. | Individualized patient-specific anti-cancer antibodies |
US20090004103A1 (en) * | 1999-10-08 | 2009-01-01 | Young David S F | Cytotoxicity mediation of cells evidencing surface expression of CD44 |
US8048416B2 (en) | 1999-10-08 | 2011-11-01 | Hoffmann-La Roche Inc. | Cytotoxicity mediation of cells evidencing surface expression of CD44 |
US7189397B2 (en) * | 1999-10-08 | 2007-03-13 | Arius Research Inc. | Cytotoxicity mediation of cells evidencing surface expression of CD44 |
US20040001789A1 (en) * | 1999-10-08 | 2004-01-01 | Young David S. F. | Cytotoxicity mediation of cells evidencing surface expression of gp96 or precursors thereof |
US20050100542A1 (en) * | 1999-10-08 | 2005-05-12 | Young David S. | Cytotoxicity mediation of cells evidencing surface expression of CD44 |
US7534429B2 (en) * | 2000-11-29 | 2009-05-19 | Hoffmann-La Roche Inc. | Cytotoxicity mediation of cells evidencing surface expression of CD63 |
US20060210474A1 (en) * | 2000-11-29 | 2006-09-21 | Young David S | Cytotoxicity mediation of cells evidencing surface expression of CD63 |
US7361343B2 (en) * | 2003-01-21 | 2008-04-22 | Arius Research Inc. | Cytotoxicity mediation of cells evidencing surface expression of CD63 |
US7009040B2 (en) * | 2003-01-21 | 2006-03-07 | Arius Research, Inc. | Cancerous disease modifying antibodies |
US7431923B2 (en) * | 2005-01-03 | 2008-10-07 | Arius Research Inc. | Cytotoxicity mediation of cells evidencing surface expression of CD63 |
US7442777B2 (en) * | 2000-11-29 | 2008-10-28 | Arius Research Inc. | Cytotoxicity mediation of cells evidencing surface expression of CD63 |
ES2358730T3 (es) | 2002-07-15 | 2011-05-13 | Board Of Regents, The University Of Texas System | Anticuerpos seleccionados y péptidos de duramicina que se enlazan a fosfolípidos aniónicos y aminofosfolípidos y sus usos en el tratamiento de infecciones virales y del cáncer. |
EP1565571B1 (de) | 2002-11-19 | 2014-01-08 | CLLUONE Diagnostics A/S | Verfahren zur diagnose der chronischen lymphatischen b-zell leukämie (b-cll) |
US7488475B2 (en) | 2003-01-21 | 2009-02-10 | Arius Research, Inc. | Antibody therapy of tumors |
US7393531B2 (en) * | 2003-01-21 | 2008-07-01 | Arius Research Inc. | Cytotoxicity mediation of cells evidencing surface expression of MCSP |
US7175846B2 (en) * | 2003-01-21 | 2007-02-13 | Arius Research Inc. | Cancerous disease modifying antibodies |
US7468254B2 (en) * | 2003-01-21 | 2008-12-23 | Arius Research Inc. | Cytotoxicity mediation of cells evidencing surface expression of MCSP |
US7361342B2 (en) * | 2003-01-21 | 2008-04-22 | Arius Research Inc. | Cancerous disease modifying antibodies |
EP1597367B1 (de) * | 2003-02-19 | 2010-07-07 | Novartis AG | In metastatischen menschlichen tumorzellen exprimiertes glycoproteinantigen sima135 |
US20080213169A1 (en) * | 2003-04-14 | 2008-09-04 | Arius Research, Inc. | Cytotoxicity mediation of cells evidencing surface expression of CD59 |
US7195764B2 (en) | 2003-04-14 | 2007-03-27 | Arius Research Inc. | Cancerous disease modifying antibodies |
US7399835B2 (en) * | 2004-02-26 | 2008-07-15 | Arius Research Inc. | Cancerous disease modifying antibodies |
AU2004231094A1 (en) * | 2003-04-14 | 2004-10-28 | Board Of Regents, The University Of Texas System | Methods for ex vivo hybridoma-free production of polyclonal and monoclonal antibodies and generation of immortalized cell populations |
US20080025977A1 (en) * | 2003-04-14 | 2008-01-31 | Arius Research, Inc. | Cytotoxicity mediation of cells evidencing surface expression of CD59 |
US20060140963A1 (en) * | 2003-04-14 | 2006-06-29 | Arius Research, Inc. | Cytotoxicity mediation of cells evidencing surface expression of CD59 |
US20050027106A1 (en) * | 2003-07-28 | 2005-02-03 | Young David S. F. | Cancerous disease modifying antibodies |
US7348413B2 (en) * | 2004-02-26 | 2008-03-25 | Arius Research Inc. | Cancerous disease modifying antibodies |
US20050255041A1 (en) * | 2004-05-13 | 2005-11-17 | Arius Research, Inc. | Cancerous disease modifying antibodies |
US7394210B2 (en) * | 2004-09-29 | 2008-07-01 | Tir Technology Lp | System and method for controlling luminaires |
US7494648B2 (en) * | 2005-08-02 | 2009-02-24 | Hoffmann-La Roche Inc. | Cancerous disease modifying antibodies |
US7456258B2 (en) | 2005-08-02 | 2008-11-25 | Arius Research, Inc. | Cancerous disease modifying antibodies |
US7452978B2 (en) | 2005-08-02 | 2008-11-18 | Arius Research, Inc. | Cancerous disease modifying antibodies |
US7456259B2 (en) | 2005-08-02 | 2008-11-25 | Arius Research, Inc. | Cancerous disease modifying antibodies |
US7452979B2 (en) | 2005-08-02 | 2008-11-18 | Arius Research, Inc. | Cancerous disease modifying antibodies |
US7411046B2 (en) | 2005-08-02 | 2008-08-12 | Arius Research Inc | Cancerous disease modifying antibodies |
US7420041B2 (en) * | 2006-02-24 | 2008-09-02 | Arius Research Inc. | Cytotoxicity mediation of cells evidencing surface expression of TROP-2 |
CA2643063A1 (en) * | 2006-02-24 | 2007-08-30 | Arius Research, Inc. | Cancerous disease modifying antibody 141205-02 |
WO2007095746A1 (en) | 2006-02-24 | 2007-08-30 | Arius Research Inc. | Cancerous disease modifying antibodies |
US20080305104A1 (en) * | 2006-02-24 | 2008-12-11 | Young David S F | Cytotoxicity mediation of cells evidencing surface expression of TROP-2 |
US20080213267A1 (en) * | 2006-02-24 | 2008-09-04 | Arius Research, Inc. | Cytotoxicity mediation of cells evidencing surface expression of TROP-2 |
US20080089891A1 (en) * | 2006-07-26 | 2008-04-17 | Arius Research, Inc. | Cancerous disease modifying antibodies |
AU2007321664A1 (en) * | 2006-11-13 | 2008-05-22 | F. Hoffmann-La Roche Ag | Cancerous disease modifying antibodies |
BRPI0718609A8 (pt) * | 2006-11-13 | 2015-09-29 | Arius Res Inc | Anticorpos modificadores de doença cancerosa. |
US8129502B2 (en) * | 2006-11-13 | 2012-03-06 | Hoffmann-La Roche Inc. | Cancerous disease modifying antibodies |
US8003761B2 (en) * | 2007-01-23 | 2011-08-23 | Hoffmann-La Roche Inc. | Cancerous disease modifying antibodies |
US20080206133A1 (en) * | 2007-01-23 | 2008-08-28 | Young David S F | Cancerous Disease Modifying Antibodies |
KR20090114454A (ko) * | 2007-03-26 | 2009-11-03 | 에프. 호프만-라 로슈 아게 | 하이브리도마 세포주 ar51a630.3 에 의해 생성된 암 질환 조절 항체 010207-01. |
WO2008134876A1 (en) * | 2007-05-07 | 2008-11-13 | F. Hoffmann-La Roche Ag | Cancerous disease modifying antibodies |
EP2185718B1 (de) | 2007-08-03 | 2017-10-04 | MUSC Foundation For Research Development | Menschliche monoklonale antikörper und verfahren zu ihrer herstellung |
US20090191197A1 (en) * | 2008-01-28 | 2009-07-30 | Young David S F | Cancerous disease modifying antibodies |
US20090285751A1 (en) * | 2008-04-10 | 2009-11-19 | Young David S F | Cancerous disease modifying antibodies |
WO2009140754A1 (en) * | 2008-05-19 | 2009-11-26 | F. Hoffmann-La Roche Ag | An anti-cancer cytotoxic monoclonal antibody |
CA2731129A1 (en) * | 2008-07-17 | 2010-01-21 | Helen P. Findlay | Cancerous disease modifying antibodies |
WO2011004899A1 (en) | 2009-07-06 | 2011-01-13 | Takeda Pharmaceutical Company Limited | Cancerous disease modifying antibodies |
US8541646B2 (en) | 2009-10-06 | 2013-09-24 | Regeneron Pharmaceuticals, Inc. | Genetically modified mice and engraftment |
KR102109172B1 (ko) | 2011-02-15 | 2020-05-12 | 리제너론 파마슈티칼스 인코포레이티드 | 인간화된 m-csf 마우스 |
IL282472B2 (en) | 2012-09-07 | 2024-04-01 | Regeneron Pharma | Genetically modified non-human animals and methods of their use |
SG10201707449TA (en) | 2012-11-05 | 2017-10-30 | Regeneron Pharma | Genetically modified non-human animals and methods of use thereof |
ES2854276T3 (es) | 2014-05-19 | 2021-09-21 | Regeneron Pharma | Animales no humanos modificados genéticamente que expresan EPO humana |
WO2016168212A1 (en) | 2015-04-13 | 2016-10-20 | Regeneron Pharmaceuticals, Inc. | Humanized sirpa-il15 knockin mice and methods of use thereof |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5780327A (en) * | 1980-11-05 | 1982-05-19 | Toyobo Co Ltd | Carcinostatic agent |
EP0322240B1 (de) * | 1987-12-23 | 1995-03-01 | The Board Of Trustees Of The Leland Stanford Junior University | Schimäre immunkompromittierende Säugetiere und ihre Verwendung |
JPH01202295A (ja) * | 1988-02-05 | 1989-08-15 | Eisai Co Ltd | 抗hdモノクロナール抗体及びその製法 |
JPH01216267A (ja) * | 1988-02-25 | 1989-08-30 | Shinotesuto Kenkyusho:Kk | Hd抗原の酵素免疫測定法 |
EP0438053B1 (de) * | 1990-01-15 | 1999-06-16 | Yeda Research And Development Company Limited | Dauerhafte Verpflanzung und Entwicklung menschlicher hämatopoietischer Zellinien bei normalen Säugetieren |
JPH03240498A (ja) * | 1990-02-16 | 1991-10-25 | Nobuyoshi Shimizu | 抗体およびそれを使用した免疫分析方法 |
CA2063408A1 (en) * | 1990-05-03 | 1991-11-04 | Susan Mayo | Human lymphoid tissue in an immunocompromised host |
WO1991018615A1 (en) * | 1990-05-25 | 1991-12-12 | Systemix, Inc. | Human peripheral blood cells in an immunocompromised host |
EP0491057B1 (de) * | 1990-07-10 | 1998-12-30 | Nkk Corporation | Geflügelspezifischen immunglobulin g produzierende hybridomas |
WO1993005796A1 (en) * | 1991-09-19 | 1993-04-01 | The Scripps Research Institute | Method for producing human antibodies in a non-human animal, and animals therefor |
-
1992
- 1992-10-29 EP EP92118482A patent/EP0539970B1/de not_active Expired - Lifetime
- 1992-10-29 DE DE69229254T patent/DE69229254T2/de not_active Expired - Fee Related
- 1992-10-30 US US07/969,336 patent/US5681729A/en not_active Expired - Fee Related
-
1997
- 1997-03-13 US US08/815,953 patent/US5869268A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US5869268A (en) | 1999-02-09 |
US5681729A (en) | 1997-10-28 |
EP0539970B1 (de) | 1999-05-26 |
EP0539970A2 (de) | 1993-05-05 |
DE69229254D1 (de) | 1999-07-01 |
EP0539970A3 (en) | 1994-05-25 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |