DE69228813T2 - Verwendung von 2-(2-nitro-4-trifluormethylbenzoyl)-1,3-cyclohexandion zur behandlung von tyrosinämie sowie pharmazeutische zusammensetzungen - Google Patents

Verwendung von 2-(2-nitro-4-trifluormethylbenzoyl)-1,3-cyclohexandion zur behandlung von tyrosinämie sowie pharmazeutische zusammensetzungen

Info

Publication number: DE69228813T2
Authority: DE; Germany
Prior art keywords: pharmaceutical compositions; tyrosinemia; trifluormethylbenzoyl; cyclohexandion; nitro
Prior art date: 1991-06-24
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE69228813T

Other languages

English (en)

Other versions

DE122005000032I2 (de

DE69228813D1 (de

DE122005000032I1 (de

Inventor

Martin Keith Ellis

Sven Torvald Lindstedt

Edward Alan Lock

Maj Elisabeth Holme Markstedt

Linda Carol Mutter

Michael Paul Prisbylla

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Syngenta Ltd

Original Assignee

Zeneca Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-06-24

Filing date

1992-06-18

Publication date

1999-08-05

1991-06-24 Priority claimed from GB919113622A external-priority patent/GB9113622D0/en

1992-03-24 Priority claimed from GB929206412A external-priority patent/GB9206412D0/en

1992-06-18 Application filed by Zeneca Ltd filed Critical Zeneca Ltd

1999-05-06 Application granted granted Critical

1999-05-06 Publication of DE69228813D1 publication Critical patent/DE69228813D1/de

1999-08-05 Publication of DE69228813T2 publication Critical patent/DE69228813T2/de

2012-06-19 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

239000008194 pharmaceutical composition Substances 0.000 title abstract 2
201000011296 tyrosinemia Diseases 0.000 title abstract 2
OUBCNLGXQFSTLU-UHFFFAOYSA-N nitisinone Chemical compound [O-][N+](=O)C1=CC(C(F)(F)F)=CC=C1C(=O)C1C(=O)CCCC1=O OUBCNLGXQFSTLU-UHFFFAOYSA-N 0.000 title 1
108010068327 4-hydroxyphenylpyruvate dioxygenase Proteins 0.000 abstract 3
102100028626 4-hydroxyphenylpyruvate dioxygenase Human genes 0.000 abstract 2
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
QMNFICMPAXFAPC-UHFFFAOYSA-N 2-benzoylcyclohexane-1,3-dione Chemical compound C=1C=CC=CC=1C(=O)C1C(=O)CCCC1=O QMNFICMPAXFAPC-UHFFFAOYSA-N 0.000 abstract 1
208000032001 Tyrosinemia type 1 Diseases 0.000 abstract 1
239000004480 active ingredient Substances 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000035475 disorder Diseases 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1
230000002503 metabolic effect Effects 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
201000007972 tyrosinemia type I Diseases 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Gastroenterology & Hepatology (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Inorganic Compounds Of Heavy Metals (AREA)
Hydrogenated Pyridines (AREA)

DE69228813T 1991-06-24 1992-06-18 Verwendung von 2-(2-nitro-4-trifluormethylbenzoyl)-1,3-cyclohexandion zur behandlung von tyrosinämie sowie pharmazeutische zusammensetzungen Expired - Lifetime DE69228813T2 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GB919113622A GB9113622D0 (en)	1991-06-24	1991-06-24	Medicinal agents
GB929206412A GB9206412D0 (en)	1992-03-24	1992-03-24	Pharmaceutical compositions
PCT/GB1992/001094 WO1993000080A1 (en)	1991-06-24	1992-06-18	Use of 2-(2-nitro-4-trifluoromethylbenzoyl)-1,3-cyclohexanedione in the treatment of tyrosinaemia and pharmaceutical compositions

Publications (2)

Publication Number	Publication Date
DE69228813D1 DE69228813D1 (de)	1999-05-06
DE69228813T2 true DE69228813T2 (de)	1999-08-05

Family

ID=26299120

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DE69228813T Expired - Lifetime DE69228813T2 (de)	1991-06-24	1992-06-18	Verwendung von 2-(2-nitro-4-trifluormethylbenzoyl)-1,3-cyclohexandion zur behandlung von tyrosinämie sowie pharmazeutische zusammensetzungen
DE1992628813 Active DE122005000032I2 (de)	1991-06-24	1992-06-18	Verwendung von 2-(2-Nitro-4-Trifluormethylbenzoyl)-1,3-Cyclohexandion zur Behandlung von Tyrosin{miesowie Pharmazeutische Zusammensetzungen

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
DE1992628813 Active DE122005000032I2 (de)	1991-06-24	1992-06-18	Verwendung von 2-(2-Nitro-4-Trifluormethylbenzoyl)-1,3-Cyclohexandion zur Behandlung von Tyrosin{miesowie Pharmazeutische Zusammensetzungen

Country Status (17)

Country	Link
US (1)	US5550165A (de)
EP (1)	EP0591275B1 (de)
JP (1)	JP3130935B2 (de)
AT (1)	ATE178207T1 (de)
AU (1)	AU672361B2 (de)
CA (1)	CA2072047C (de)
DE (2)	DE69228813T2 (de)
DK (1)	DK0591275T3 (de)
ES (1)	ES2129448T3 (de)
GR (1)	GR3029841T3 (de)
HK (1)	HK1008662A1 (de)
IE (1)	IE922024A1 (de)
LU (1)	LU91180I2 (de)
NL (1)	NL300198I2 (de)
NO (3)	NO304923B1 (de)
PT (1)	PT100619B (de)
WO (1)	WO1993000080A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE4305696A1 (de) *	1993-02-25	1994-09-01	Hoechst Ag	Nachweisverfahren zur Identifizierung von Inhibitoren
US6248904B1 (en)	1998-07-21	2001-06-19	Cytovia, Inc.	Fluorescence dyes and their applications for whole-cell fluorescence screening assays for caspases, peptidases, proteases and other enzymes and the use thereof
JP2010501532A (ja) *	2006-08-18	2010-01-21	シンジェンタリミテッド	うつ病、および／または常習性薬物の使用に伴う禁断症状の治療のための、ｈｐｐｄ阻害薬の使用
AU2011211223B2 (en) *	2010-01-29	2014-10-23	Toray Industries, Inc.	Therapeutic or prophylactic agent for biliary diseases
EP2723320B1 (de) *	2011-06-23	2016-01-13	Swedish Orphan Biovitrum International AB	Flüssige pharmazeutische zusammensetzung mit nitisinon
WO2013181292A1 (en) *	2012-05-29	2013-12-05	Biotie Therapies, Inc.	Nitisinone formulations
CN102976948B (zh) *	2012-11-28	2014-07-09	郑州大明药物科技有限公司	尼替西农的制备方法
GB201400117D0 (en)	2014-01-03	2014-02-19	Cycle Pharmaceuticals Ltd	Pharmaceutical composition
ITUB20160650A1 (it) *	2016-02-11	2017-08-11	Dipharma S A	Formulazioni farmaceutiche solide stabili contenenti 2-(2-nitro-4-trifluorometilbenzoil)-1,3-cicloesandione
US9783485B1 (en)	2016-11-30	2017-10-10	Dipharma S.A.	Crystalline inhibitor of 4-hydroxyphenylpyruvate dioxygenase, and a process of synthesis and crystallization thereof
WO2024047657A1 (en) *	2022-08-28	2024-03-07	Brawn Laboratories Ltd	Process for the preparation of nitisinone

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4780127A (en) *	1982-03-25	1988-10-25	Stauffer Chemical Company	Certain 2-(substituted benzoyl)-1,3-cyclohexanediones and their use as herbicides
IL77349A (en) *	1984-12-20	1990-07-12	Stauffer Chemical Co	2-(2'-nitrobenzoyl)-1,3-cyclohexanediones,their preparation and their use as herbicides
US4774360A (en) *	1987-06-29	1988-09-27	Stauffer Chemical Company	Converting enol ester precursor of a benzoyl-1,3-cycloalkyldione to a benzoyl-1,3-cycloalkyldione

1992
- 1992-06-18 DK DK92912215T patent/DK0591275T3/da active
- 1992-06-18 EP EP92912215A patent/EP0591275B1/de not_active Expired - Lifetime
- 1992-06-18 AU AU19860/92A patent/AU672361B2/en not_active Expired
- 1992-06-18 DE DE69228813T patent/DE69228813T2/de not_active Expired - Lifetime
- 1992-06-18 ES ES92912215T patent/ES2129448T3/es not_active Expired - Lifetime
- 1992-06-18 WO PCT/GB1992/001094 patent/WO1993000080A1/en active IP Right Grant
- 1992-06-18 JP JP05501383A patent/JP3130935B2/ja not_active Expired - Lifetime
- 1992-06-18 AT AT92912215T patent/ATE178207T1/de active
- 1992-06-18 DE DE1992628813 patent/DE122005000032I2/de active Active
- 1992-06-23 CA CA002072047A patent/CA2072047C/en not_active Expired - Lifetime
- 1992-06-24 PT PT100619A patent/PT100619B/pt not_active IP Right Cessation
- 1992-07-01 IE IE202492A patent/IE922024A1/en not_active IP Right Cessation
1993
- 1993-12-23 NO NO934798A patent/NO304923B1/no active Protection Beyond IP Right Term
1994
- 1994-12-19 US US08/359,361 patent/US5550165A/en not_active Expired - Lifetime
1998
- 1998-07-27 HK HK98109412A patent/HK1008662A1/xx not_active IP Right Cessation
1999
- 1999-04-01 GR GR990400803T patent/GR3029841T3/el unknown
2005
- 2005-06-09 NL NL300198C patent/NL300198I2/nl unknown
- 2005-07-06 LU LU91180C patent/LU91180I2/fr unknown
- 2005-08-31 NO NO2005018C patent/NO2005018I2/no unknown
2017
- 2017-08-23 NO NO2017045C patent/NO2017045I1/no unknown

Also Published As

Publication number	Publication date
NL300198I2 (nl)	2005-09-01
DK0591275T3 (da)	1999-10-11
NO2017045I1 (no)	2017-08-23
PT100619B (pt)	1999-07-30
DE122005000032I2 (de)	2006-06-08
EP0591275A1 (de)	1994-04-13
NL300198I1 (nl)	2005-08-01
CA2072047A1 (en)	1992-12-25
JP3130935B2 (ja)	2001-01-31
CA2072047C (en)	2003-06-10
ES2129448T3 (es)	1999-06-16
JPH06508628A (ja)	1994-09-29
GR3029841T3 (en)	1999-07-30
AU1986092A (en)	1993-01-25
HK1008662A1 (en)	1999-05-14
DE69228813D1 (de)	1999-05-06
ATE178207T1 (de)	1999-04-15
IE922024A1 (en)	1992-12-30
NO304923B1 (no)	1999-03-08
NO934798D0 (no)	1993-12-23
NO2005018I2 (no)	2008-02-11
LU91180I2 (fr)	2005-09-06
US5550165A (en)	1996-08-27
EP0591275B1 (de)	1999-03-31
NO2005018I1 (no)	2005-09-26
PT100619A (pt)	1994-01-31
WO1993000080A1 (en)	1993-01-07
NO934798L (no)	1993-12-23
DE122005000032I1 (de)	2005-09-29
AU672361B2 (en)	1996-10-03

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MX9501849A (es)	1997-02-28	Nuevos compuestos biciclicos-aromaticos, composiciones farmaceuticas y cosmeticas que los contienen y sus usos.
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