DE69226022T2 - Hydroxamat- und hydrazidderivate von polyaminen und ihre medizinische verwendung als chelatierende wirkstoffe - Google Patents

Hydroxamat- und hydrazidderivate von polyaminen und ihre medizinische verwendung als chelatierende wirkstoffe

Info

Publication number
DE69226022T2
DE69226022T2 DE69226022T DE69226022T DE69226022T2 DE 69226022 T2 DE69226022 T2 DE 69226022T2 DE 69226022 T DE69226022 T DE 69226022T DE 69226022 T DE69226022 T DE 69226022T DE 69226022 T2 DE69226022 T2 DE 69226022T2
Authority
DE
Germany
Prior art keywords
pct
chelative
hydroxamate
polyamines
active substances
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69226022T
Other languages
English (en)
Other versions
DE69226022D1 (de
Inventor
Richard Himmelsbach
P L Rongved
Jo Klaveness
Per Strande
Harald Dugstad
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Amersham Health Salutar Inc
Original Assignee
Nycomed Salutar Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nycomed Salutar Inc filed Critical Nycomed Salutar Inc
Application granted granted Critical
Publication of DE69226022D1 publication Critical patent/DE69226022D1/de
Publication of DE69226022T2 publication Critical patent/DE69226022T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C07C243/24—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids
    • C07C243/26—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C243/34—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of a carbon skeleton further substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Materials For Medical Uses (AREA)
DE69226022T 1991-07-17 1992-07-16 Hydroxamat- und hydrazidderivate von polyaminen und ihre medizinische verwendung als chelatierende wirkstoffe Expired - Fee Related DE69226022T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB919115375A GB9115375D0 (en) 1991-07-17 1991-07-17 Compounds
PCT/EP1992/001598 WO1993002045A1 (en) 1991-07-17 1992-07-16 Hydroxamate and hydrazide derivatives of polyamines and their medical use as chelating agents

Publications (2)

Publication Number Publication Date
DE69226022D1 DE69226022D1 (de) 1998-07-30
DE69226022T2 true DE69226022T2 (de) 1999-04-01

Family

ID=10698465

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69226022T Expired - Fee Related DE69226022T2 (de) 1991-07-17 1992-07-16 Hydroxamat- und hydrazidderivate von polyaminen und ihre medizinische verwendung als chelatierende wirkstoffe

Country Status (9)

Country Link
US (1) US5869651A (de)
EP (1) EP0594734B1 (de)
JP (1) JPH07500574A (de)
AT (1) ATE167665T1 (de)
AU (1) AU2320392A (de)
DE (1) DE69226022T2 (de)
ES (1) ES2117670T3 (de)
GB (1) GB9115375D0 (de)
WO (1) WO1993002045A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06502858A (ja) * 1990-11-21 1994-03-31 マリンクロッド・メディカル・インコーポレイテッド 磁気共鳴イメージング用錯体および組成物，並びにこれらの使用法
GB2267494B (en) * 1992-06-02 1995-09-20 Ciba Geigy Ag Trisamidodithionodiphosphates
DK0686142T3 (da) * 1993-02-23 1999-08-30 Merrell Pharma Inc Polyaminderivater som radioprotektive midler
DE4340809C2 (de) * 1993-11-24 2000-08-03 Schering Ag 1.4,7,10-Tetraazacyclododecan-Derivate, diese enthaltende pharmazeutische Mittel und Verfahren zu deren Herstellung
JPH08507548A (ja) * 1993-12-27 1996-08-13 チバ−ガイギー アクチェンゲゼルシャフト 抗癌剤および抗原生動物剤として使用するための不飽和アミノ化合物
DE69501981T2 (de) * 1994-01-12 1998-12-10 Bracco Int Bv Liganden und deren metallkomplexe
ES2096517B1 (es) * 1994-02-21 1998-02-01 Diaz Agustin Espina Equipo para el control de suministro de servicios a viviendas, locales y similares.
US5476644A (en) * 1994-04-13 1995-12-19 Sterling Winthrop Inc. Cyclic triamine chelating agents
US6693190B1 (en) 1994-05-11 2004-02-17 Bracco International B.V. Enhanced relaxivity monomeric and multimeric compounds
US20020123163A1 (en) * 2000-04-24 2002-09-05 Takehiro Fujii Edge-emitting light-emitting semiconductor device and method of manufacture thereof
NO20051911D0 (no) * 2005-04-19 2005-04-19 Amersham Health As Synthesis
EP1954319A2 (de) * 2005-11-29 2008-08-13 Mallinckrodt, Inc. Bifunktionelle metall-chelatbildende konjugate
US8361438B2 (en) * 2008-01-08 2013-01-29 Lantheus Medical Imaging, Inc. N-alkoxyamide conjugates as imaging agents
US8877157B2 (en) 2009-07-08 2014-11-04 Lantheus Medical Imaging, Inc. N-alkoxyamide conjugates as imaging agents
JP2023506447A (ja) 2019-12-13 2023-02-16 ブラッコ・イメージング・ソシエタ・ペル・アチオニ 保護されたｄｏ３ａの製造

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1197798A (en) * 1967-08-18 1970-07-08 Frederick Charles Bersworth Chelating Compounds Derived from Amino Acid Derivatives
US4609757A (en) * 1983-08-10 1986-09-02 Nuclear Technology Corporation Hydrazides of amino-polyacetic acids as chelants
ES2033433T3 (es) * 1987-07-16 1993-03-16 Nycomed As Procedimiento para preparar acidos aminopolicarboxilicos y sus derivados.
GB8900732D0 (en) * 1989-01-13 1989-03-08 Nycomed As Agents
US5384108A (en) * 1989-04-24 1995-01-24 Mallinckrodt Medical, Inc. Magnetic resonance imaging agents
ATE120374T1 (de) * 1989-07-20 1995-04-15 Sandoz Ag Markierte polypeptidderivate.
JP3131219B2 (ja) * 1990-01-19 2001-01-31 ニユコメド・イメージング・アクシエセルカペト キレート化合物

Also Published As

Publication number Publication date
WO1993002045A1 (en) 1993-02-04
ES2117670T3 (es) 1998-08-16
JPH07500574A (ja) 1995-01-19
EP0594734A1 (de) 1994-05-04
US5869651A (en) 1999-02-09
ATE167665T1 (de) 1998-07-15
DE69226022D1 (de) 1998-07-30
EP0594734B1 (de) 1998-06-24
GB9115375D0 (en) 1991-09-04
AU2320392A (en) 1993-02-23

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee